Functional heterogeneity within the rodent lateral orbitofrontal cortex dissociates outcome devaluation and reversal learning deficits.

abstract：:After paralyzing spinal cord injury the adult nervous system has little ability to 'heal' spinal connections, and it is assumed to be unable to develop extra-spinal recovery strategies to bypass the lesion. We challenge this assumption, showing that completely spinalized adult rats can recover unassisted hindlimb weig...

journal_title：eLife

authors： Manohar A,Foffani G,Ganzer PD,Bethea JR,Moxon KA

更新日期：2017-06-29 00:00:00

abstract：:There has been a longstanding debate on whether original fear memory is inhibited or erased after extinction. One possibility that reconciles this uncertainty is that the inhibition and erasure mechanisms are engaged in different phases (early or late) of extinction. In this study, using single-session extinction trai...

journal_title：eLife

authors： An B,Kim J,Park K,Lee S,Song S,Choi S

更新日期：2017-07-03 00:00:00

abstract：:Autoinducers are small signaling molecules that mediate intercellular communication in microbial populations and trigger coordinated gene expression via 'quorum sensing'. Elucidating the mechanisms that control autoinducer production is, thus, pertinent to understanding collective microbial behavior, such as virulence...

journal_title：eLife

authors： Bauer M,Knebel J,Lechner M,Pickl P,Frey E

更新日期：2017-07-25 00:00:00

abstract：:In yeast, DNA breaks are usually repaired by homologous recombination (HR). An early step for HR pathways is formation of a heteroduplex, in which a single-strand from the broken DNA molecule pairs with a strand derived from an intact DNA molecule. If the two strands of DNA are not identical, there will be mismatches ...

journal_title：eLife

authors： Yin Y,Dominska M,Yim E,Petes TD

更新日期：2017-07-17 00:00:00

abstract：:Positive-strand RNA viruses, the largest genetic class of viruses, include numerous important pathogens such as Zika virus. These viruses replicate their RNA genomes in novel, membrane-bounded mini-organelles, but the organization of viral proteins and RNAs in these compartments has been largely unknown. We used cryo-...

journal_title：eLife

authors： Ertel KJ,Benefield D,Castaño-Diez D,Pennington JG,Horswill M,den Boon JA,Otegui MS,Ahlquist P

更新日期：2017-06-27 00:00:00

abstract：:Human ascariasis is a major neglected tropical disease caused by the nematode Ascaris lumbricoides. We report a 296 megabase (Mb) reference-quality genome comprised of 17,902 protein-coding genes derived from a single, representative Ascaris worm. An additional 68 worms were collected from 60 human hosts in Kenyan vil...

journal_title：eLife

authors： Easton A,Gao S,Lawton SP,Bennuru S,Khan A,Dahlstrom E,Oliveira RG,Kepha S,Porcella SF,Webster J,Anderson R,Grigg ME,Davis RE,Wang J,Nutman TB

更新日期：2020-11-06 00:00:00

abstract：:Understanding the relationships between different properties of data, such as whether a genome or connectome has information about disease status, is increasingly important. While existing approaches can test whether two properties are related, they may require unfeasibly large sample sizes and often are not interpret...

journal_title：eLife

authors： Vogelstein JT,Bridgeford EW,Wang Q,Priebe CE,Maggioni M,Shen C

更新日期：2019-01-15 00:00:00

abstract：:GPIHBP1, a GPI-anchored protein of capillary endothelial cells, binds lipoprotein lipase (LPL) within the subendothelial spaces and shuttles it to the capillary lumen. GPIHBP1-bound LPL is essential for the margination of triglyceride-rich lipoproteins (TRLs) along capillaries, allowing the lipolytic processing of TRL...

journal_title：eLife

authors： Hu X,Matsumoto K,Jung RS,Weston TA,Heizer PJ,He C,Sandoval NP,Allan CM,Tu Y,Vinters HV,Liau LM,Ellison RM,Morales JE,Baufeld LJ,Bayley NA,He L,Betsholtz C,Beigneux AP,Nathanson DA,Gerhardt H,Young SG,Fong LG,J

更新日期：2019-06-06 00:00:00

abstract：:The human insular cortex is a heterogeneous brain structure which plays an integrative role in guiding behavior. The cytoarchitectonic organization of the human insula has been investigated over the last century using postmortem brains but there has been little progress in noninvasive in vivo mapping of its microstruc...

journal_title：eLife

authors： Menon V,Gallardo G,Pinsk MA,Nguyen VD,Li JR,Cai W,Wassermann D

更新日期：2020-06-04 00:00:00

abstract：:Ribonucleotide reductases (RNRs) convert ribonucleotides into deoxyribonucleotides, a reaction essential for DNA replication and repair. Human RNR requires two subunits for activity, the α subunit contains the active site, and the β subunit houses the radical cofactor. Here, we present a 3.3-Å resolution structure by ...

journal_title：eLife

authors： Brignole EJ,Tsai KL,Chittuluru J,Li H,Aye Y,Penczek PA,Stubbe J,Drennan CL,Asturias F

更新日期：2018-02-20 00:00:00

abstract：:A strain of budding yeast that contains one large chromosome reveals how the telomere capping complex CST maintains linear but not circular chromosomes. ...

journal_title：eLife

authors： Nugent C,Sugimoto K

更新日期：2020-08-05 00:00:00

abstract：:Actin filaments assemble inside the nucleus in response to multiple cellular perturbations, including heat shock, protein misfolding, integrin engagement, and serum stimulation. We find that DNA damage also generates nuclear actin filaments-detectable by phalloidin and live-cell actin probes-with three characteristic ...

journal_title：eLife

authors： Belin BJ,Lee T,Mullins RD

更新日期：2015-08-19 00:00:00

abstract：:Voltage-gated sodium channels are targets for a range of pharmaceutical drugs developed for the treatment of neurological diseases. Cannabidiol (CBD), the non-psychoactive compound isolated from cannabis plants, was recently approved for treatment of two types of epilepsy associated with sodium channel mutations. This...

journal_title：eLife

authors： Sait LG,Sula A,Ghovanloo MR,Hollingworth D,Ruben PC,Wallace BA

更新日期：2020-10-22 00:00:00

abstract：:Peptidoglycan (PG) is the main component of bacterial cell walls and the target for many antibiotics. PG biosynthesis is tightly coordinated with cell wall growth and turnover, and many of these control activities depend upon PASTA-domain containing eukaryotic-like serine/threonine protein kinases (PASTA-eSTK) that se...

journal_title：eLife

authors： Wamp S,Rutter ZJ,Rismondo J,Jennings CE,Möller L,Lewis RJ,Halbedel S

更新日期：2020-05-29 00:00:00

abstract：:Two different cell signals often affect transcription of the same gene. In such cases, it is natural to ask how the combined transcriptional response compares to the individual responses. The most commonly used mechanistic models predict additive or multiplicative combined responses, but a systematic genome-wide evalu...

journal_title：eLife

authors： Sanford EM,Emert BL,Coté A,Raj A

更新日期：2020-12-07 00:00:00

abstract：:Glucose-6-phosphate dehydrogenase (G6PD) deficiency is believed to confer protection against Plasmodium falciparum malaria, but the precise nature of the protective effecthas proved difficult to define as G6PD deficiency has multiple allelic variants with different effects in males and females, and it has heterogeneou...

journal_title：eLife

authors： Clarke GM,Rockett K,Kivinen K,Hubbart C,Jeffreys AE,Rowlands K,Jallow M,Conway DJ,Bojang KA,Pinder M,Usen S,Sisay-Joof F,Sirugo G,Toure O,Thera MA,Konate S,Sissoko S,Niangaly A,Poudiougou B,Mangano VD,Bougouma EC

更新日期：2017-01-09 00:00:00

abstract：:While host immune receptors detect pathogen-associated molecular patterns to activate immunity, pathogens attempt to deregulate host immunity through secreted effectors. Fungi employ LysM effectors to prevent recognition of cell wall-derived chitin by host immune receptors, although the mechanism to compete for chitin...

journal_title：eLife

authors： Sánchez-Vallet A,Saleem-Batcha R,Kombrink A,Hansen G,Valkenburg DJ,Thomma BP,Mesters JR

更新日期：2013-07-02 00:00:00

abstract：:New studies examine how the different sub-structures in the cerebellum are organized to receive information during complex behavioral tasks. ...

journal_title：eLife

authors： Holloway AL,Lerner TN

更新日期：2019-11-14 00:00:00

abstract：:Previously we identified Lam/GramD1 proteins, a family of endoplasmic reticulum membrane proteins with sterol-binding StARkin domains that are implicated in intracellular sterol homeostasis. Here, we show how these proteins exchange sterol molecules with membranes. An aperture at one end of the StARkin domain enables ...

journal_title：eLife

authors： Khelashvili G,Chauhan N,Pandey K,Eliezer D,Menon AK

更新日期：2019-12-04 00:00:00

abstract：:Sleep oscillations in the neocortex and hippocampus are critical for the integration of new memories into stable generalized representations in neocortex. However, the role of the thalamus in this process is poorly understood. To determine the thalamic contribution to non-REM oscillations (sharp-wave ripples, SWRs; sl...

journal_title：eLife

authors： Varela C,Wilson MA

更新日期：2020-06-11 00:00:00

abstract：:India comprises much of the persisting global childhood measles mortality. India implemented a mass second-dose measles immunization campaign in 2010. We used interrupted time series and multilevel regression to quantify the campaign's impact on measles mortality using the nationally representative Million Death Study...

journal_title：eLife

authors： Wong BK,Fadel SA,Awasthi S,Khera A,Kumar R,Menon G,Jha P

更新日期：2019-03-05 00:00:00

abstract：:We reveal a novel mechanism that explains how preparatory activity can evolve in motor-related cortical areas without prematurely inducing movement. The smooth eye movement region of the frontal eye fields (FEFSEM) is a critical node in the neural circuit controlling smooth pursuit eye movement. Preparatory activity e...

journal_title：eLife

authors： Darlington TR,Lisberger SG

更新日期：2020-02-21 00:00:00

abstract：:Sex-specific synaptic connectivity is beginning to emerge as a remarkable, but little explored feature of animal brains. We describe here a novel mechanism that promotes sexually dimorphic neuronal function and synaptic connectivity in the nervous system of the nematode Caenorhabditis elegans. We demonstrate that a ph...

journal_title：eLife

authors： Bayer EA,Stecky RC,Neal L,Katsamba PS,Ahlsen G,Balaji V,Hoppe T,Shapiro L,Oren-Suissa M,Hobert O

更新日期：2020-10-06 00:00:00

abstract：:AKT is implicated in neurological disorders. AKT has three isoforms, AKT1/AKT2/AKT3, with brain cell type-specific expression that may differentially influence behavior. Therefore, we examined single Akt isoform, conditional brain-specific Akt1, and double Akt1/3 mutant mice in behaviors relevant to neuropsychiatric d...

journal_title：eLife

authors： Wong H,Levenga J,LaPlante L,Keller B,Cooper-Sansone A,Borski C,Milstead R,Ehringer M,Hoeffer C

更新日期：2020-12-16 00:00:00

abstract：:Clinical trials are currently underway to assess the efficacy of forniceal deep brain stimulation (DBS) for improvement of memory in Alzheimer's patients, and forniceal DBS has been shown to improve learning and memory in a mouse model of Rett syndrome (RTT), an intellectual disability disorder caused by loss-of-funct...

journal_title：eLife

authors： Pohodich AE,Yalamanchili H,Raman AT,Wan YW,Gundry M,Hao S,Jin H,Tang J,Liu Z,Zoghbi HY

更新日期：2018-03-23 00:00:00

abstract：:Hippocampal oscillations are dynamic, with unique oscillatory frequencies present during different behavioral states. To examine the extent to which these oscillations reflect neuron engagement in distinct local circuit processes that are important for memory, we recorded single cell and local field potential activity...

journal_title：eLife

authors： Rangel LM,Rueckemann JW,Riviere PD,Keefe KR,Porter BS,Heimbuch IS,Budlong CH,Eichenbaum H

更新日期：2016-01-11 00:00:00

abstract：:Chronic endoplasmic reticulum (ER) stress results in toxicity that contributes to multiple human disorders. We report a stress resolution pathway initiated by the nuclear receptor LRH-1 that is independent of known unfolded protein response (UPR) pathways. Like mice lacking primary UPR components, hepatic Lrh-1-null m...

journal_title：eLife

authors： Mamrosh JL,Lee JM,Wagner M,Stambrook PJ,Whitby RJ,Sifers RN,Wu SP,Tsai MJ,Demayo FJ,Moore DD

更新日期：2014-04-15 00:00:00

abstract：:In most animals, the brain controls the body via a set of descending neurons (DNs) that traverse the neck. DN activity activates, maintains or modulates locomotion and other behaviors. Individual DNs have been well-studied in species from insects to primates, but little is known about overall connectivity patterns acr...

journal_title：eLife

authors： Namiki S,Dickinson MH,Wong AM,Korff W,Card GM

更新日期：2018-06-26 00:00:00

abstract：:Intermittent hypoxia (IH) is the predominant pathophysiological disturbance in obstructive sleep apnea (OSA), known to be independently associated with cardiovascular diseases. However, the effect of IH on cardiac fibrosis and molecular events involved in this process are unclear. Here, we tested IH in angiotensin II ...

journal_title：eLife

authors： Bao Q,Zhang B,Suo Y,Liu C,Yang Q,Zhang K,Yuan M,Yuan M,Zhang Y,Li G

更新日期：2020-01-14 00:00:00

abstract：:Autophagy has been linked to longevity in many species, but the underlying mechanisms are unclear. Using a GFP-tagged and a new tandem-tagged Atg8/LGG-1 reporter, we quantified autophagic vesicles and performed autophagic flux assays in multiple tissues of wild-type Caenorhabditis elegans and long-lived daf-2/insulin/...

journal_title：eLife

authors： Chang JT,Kumsta C,Hellman AB,Adams LM,Hansen M

更新日期：2017-07-04 00:00:00