Fungal effector Ecp6 outcompetes host immune receptor for chitin binding through intrachain LysM dimerization.

abstract：:Cells deficient in the pro-death Bcl-2 family members Bax and Bak are known to be resistant to apoptotic cell death, and previous we have shown that these two effectors are also needed for mitochondrial-dependent cellular necrosis (Karch et al., 2013). Here we show that mouse embryonic fibroblasts deficient in Bax/Bak...

journal_title：eLife

authors： Karch J,Schips TG,Maliken BD,Brody MJ,Sargent MA,Kanisicak O,Molkentin JD

更新日期：2017-11-17 00:00:00

abstract：:The Deleted in Colorectal Carcinoma (Dcc) receptor plays a critical role in optic nerve development. Whilst Dcc is expressed postnatally in the eye, its function remains unknown as Dcc knockouts die at birth. To circumvent this drawback, we generated an eye-specific Dcc mutant. To study the organization of the retina ...

journal_title：eLife

authors： Vigouroux RJ,Cesar Q,Chédotal A,Nguyen-Ba-Charvet KT

更新日期：2020-02-25 00:00:00

abstract：:Vitamin B12 (cobalamin) is the most complex B-type vitamin and is synthetized exclusively in a limited number of prokaryotes. Its biologically active variants contain rare organometallic bonds, which are used by enzymes in a variety of central metabolic pathways such as L-methionine synthesis and ribonucleotide reduct...

journal_title：eLife

authors： Santos JA,Rempel S,Mous ST,Pereira CT,Ter Beek J,de Gier JW,Guskov A,Slotboom DJ

更新日期：2018-05-29 00:00:00

abstract：:Altered insulin signaling has been linked to widespread nervous system dysfunction including cognitive dysfunction, neuropathy and susceptibility to neurodegenerative disease. However, knowledge of the cellular mechanisms underlying the effects of insulin on neuronal function is incomplete. Here, we show that cell aut...

journal_title：eLife

authors： Mahoney RE,Azpurua J,Eaton BA

更新日期：2016-08-15 00:00:00

abstract：:Humans employ different strategies when making decisions. Previous research has reported reduced reliance on model-based strategies with aging, but it remains unclear whether this is due to cognitive or motivational factors. Moreover, it is not clear how aging affects the metacontrol of decision making, that is the dy...

journal_title：eLife

authors： Bolenz F,Kool W,Reiter AM,Eppinger B

更新日期：2019-08-09 00:00:00

abstract：:Slo2 potassium channels play important roles in neuronal function, and their mutations in humans may cause epilepsies and cognitive defects. However, it is largely unknown how Slo2 is regulated by other proteins. Here we show that the function of C. elegans Slo2 (SLO-2) depends on adr-1, a gene important to RNA editin...

journal_title：eLife

authors： Niu LG,Liu P,Wang ZW,Chen B

更新日期：2020-04-21 00:00:00

abstract：:Eukaryotic small ribosomal subunits are first assembled into 90S pre-ribosomes. The complete 90S is a gigantic complex with a molecular mass of approximately five megadaltons. Here, we report the nearly complete architecture of Saccharomyces cerevisiae 90S determined from three cryo-electron microscopy single particle...

journal_title：eLife

authors： Sun Q,Zhu X,Qi J,An W,Lan P,Tan D,Chen R,Wang B,Zheng S,Zhang C,Chen X,Zhang W,Chen J,Dong MQ,Ye K

更新日期：2017-02-28 00:00:00

abstract：:Rhythmic actions benefit from synchronization with external events. Auditory-paced finger tapping studies indicate the two cerebral hemispheres preferentially control different rhythms. It is unclear whether left-lateralized processing of faster rhythms and right-lateralized processing of slower rhythms bases upon hem...

journal_title：eLife

authors： Pflug A,Gompf F,Muthuraman M,Groppa S,Kell CA

更新日期：2019-11-07 00:00:00

abstract：:A fluorescent imaging technique called fastFISH has been used to track the various steps involved in the transcription of a single DNA molecule. ...

journal_title：eLife

authors： Monnet J,Strick TR

更新日期：2014-01-01 00:00:00

abstract：:The HIF (hypoxia-inducible factor) transcription factor is the master regulator of the metazoan response to chronic hypoxia. In addition to promoting adaptations to low oxygen, HIF drives cytoprotective mechanisms in response to stresses and modulates neural circuit function. How most HIF targets act in the control of...

journal_title：eLife

authors： Pender CL,Horvitz HR

更新日期：2018-07-16 00:00:00

abstract：:Cardiac conduction defects decrease life expectancy in myotonic dystrophy type 1 (DM1), a CTG repeat disorder involving misbalance between two RNA binding factors, MBNL1 and CELF1. However, how DM1 condition translates into conduction disorders remains poorly understood. Here we simulated MBNL1 and CELF1 misbalance in...

journal_title：eLife

authors： Auxerre-Plantié E,Nakamori M,Renaud Y,Huguet A,Choquet C,Dondi C,Miquerol L,Takahashi MP,Gourdon G,Junion G,Jagla T,Zmojdzian M,Jagla K

更新日期：2019-12-12 00:00:00

abstract：:Multiple studies have reported a male bias in incidence and/or prevalence of malaria infection in males compared to females. To test the hypothesis that sex-based differences in host-parasite interactions affect the epidemiology of malaria, we intensively followed Plasmodium falciparum infections in a cohort in a mala...

journal_title：eLife

authors： Briggs J,Teyssier N,Nankabirwa JI,Rek J,Jagannathan P,Arinaitwe E,Bousema T,Drakeley C,Murray M,Crawford E,Hathaway N,Staedke SG,Smith D,Rosenthal PJ,Kamya M,Dorsey G,Rodriguez-Barraquer I,Greenhouse B

更新日期：2020-10-27 00:00:00

abstract：:During mitosis chromosomes reorganise into highly compact, rod-shaped forms, thought to consist of consecutive chromatin loops around a central protein scaffold. Condensin complexes are involved in chromatin compaction, but the contribution of other chromatin proteins, DNA sequence and histone modifications is less un...

journal_title：eLife

authors： Fitz-James MH,Tong P,Pidoux AL,Ozadam H,Yang L,White SA,Dekker J,Allshire RC

更新日期：2020-09-11 00:00:00

abstract：:The human insular cortex is a heterogeneous brain structure which plays an integrative role in guiding behavior. The cytoarchitectonic organization of the human insula has been investigated over the last century using postmortem brains but there has been little progress in noninvasive in vivo mapping of its microstruc...

journal_title：eLife

authors： Menon V,Gallardo G,Pinsk MA,Nguyen VD,Li JR,Cai W,Wassermann D

更新日期：2020-06-04 00:00:00

abstract：:Malaria infection starts with injection of Plasmodium sporozoites by an Anopheles mosquito into the skin of the mammalian host. How sporozoites locate and enter a blood vessel is a critical, but poorly understood process. In this study, we examine sporozoite motility and their interaction with dermal blood vessels, us...

journal_title：eLife

authors： Hopp CS,Chiou K,Ragheb DR,Salman AM,Khan SM,Liu AJ,Sinnis P

更新日期：2015-08-13 00:00:00

abstract：:Transposable elements (TEs), the movement of which can damage the genome, are epigenetically silenced in eukaryotes. Intriguingly, TEs are activated in the sperm companion cell - vegetative cell (VC) - of the flowering plant Arabidopsis thaliana. However, the extent and mechanism of this activation are unknown. Here w...

journal_title：eLife

authors： He S,Vickers M,Zhang J,Feng X

更新日期：2019-05-28 00:00:00

abstract：:Efficient precision genome engineering requires high frequency and specificity of integration at the genomic target site. Here, we describe a set of resources to streamline reporter gene knock-ins in zebrafish and demonstrate the broader utility of the method in mammalian cells. Our approach uses short homology of 24-...

journal_title：eLife

authors： Wierson WA,Welker JM,Almeida MP,Mann CM,Webster DA,Torrie ME,Weiss TJ,Kambakam S,Vollbrecht MK,Lan M,McKeighan KC,Levey J,Ming Z,Wehmeier A,Mikelson CS,Haltom JA,Kwan KM,Chien CB,Balciunas D,Ekker SC,Clark KJ,We

更新日期：2020-05-15 00:00:00

abstract：:Recent work draws attention to community-community encounters ('coalescence') as likely an important factor shaping natural ecosystems. This work builds on MacArthur's classic model of competitive coexistence to investigate such community-level competition in a minimal theoretical setting. It is shown that the ability...

journal_title：eLife

authors： Tikhonov M

更新日期：2016-06-16 00:00:00

abstract：:Armor plate changes in sticklebacks are a classic example of repeated adaptive evolution. Previous studies identified ectodysplasin (EDA) gene as the major locus controlling recurrent plate loss in freshwater fish, though the causative DNA alterations were not known. Here we show that freshwater EDA alleles have cis-a...

journal_title：eLife

authors： O'Brown NM,Summers BR,Jones FC,Brady SD,Kingsley DM

更新日期：2015-01-28 00:00:00

abstract：:Though neurotransmitters are essential elements in neuronal signal transduction, techniques for in vivo analysis are still limited. Here, we describe an organic electrochemical transistor array (OECT-array) technique for monitoring catecholamine neurotransmitters (CA-NTs) in rat brains. The OECT-array is an active sen...

journal_title：eLife

authors： Xie K,Wang N,Lin X,Wang Z,Zhao X,Fang P,Yue H,Kim J,Luo J,Cui S,Yan F,Shi P

更新日期：2020-02-11 00:00:00

abstract：:Anxiety results in sub-optimal motor learning, but the precise mechanisms through which this effect occurs remain unknown. Using a motor sequence learning paradigm with separate phases for initial exploration and reward-based learning, we show that anxiety states in humans impair learning by attenuating the update of ...

journal_title：eLife

authors： Sporn S,Hein T,Herrojo Ruiz M

更新日期：2020-05-19 00:00:00

abstract：:Jellyfish, with their tetraradial symmetry, offer a novel paradigm for addressing patterning mechanisms during regeneration. Here we show that an interplay between mechanical forces, cell migration and proliferation allows jellyfish fragments to regain shape and functionality rapidly, notably by efficient restoration ...

journal_title：eLife

authors： Sinigaglia C,Peron S,Eichelbrenner J,Chevalier S,Steger J,Barreau C,Houliston E,Leclère L

更新日期：2020-09-07 00:00:00

abstract：:Sleep oscillations in the neocortex and hippocampus are critical for the integration of new memories into stable generalized representations in neocortex. However, the role of the thalamus in this process is poorly understood. To determine the thalamic contribution to non-REM oscillations (sharp-wave ripples, SWRs; sl...

journal_title：eLife

authors： Varela C,Wilson MA

更新日期：2020-06-11 00:00:00

abstract：:MarR (multiple antibiotic resistance repressor) family proteins are bacterial repressors that regulate transcription in response to a wide range of chemical signals. Although specific features of MarR family function have been described, the role of atomic motions in MarRs remains unexplored thus limiting insights int...

journal_title：eLife

authors： Capdevila DA,Huerta F,Edmonds KA,Le MT,Wu H,Giedroc DP

更新日期：2018-10-17 00:00:00

abstract：:Generating recombinant monoclonal antibodies (R-mAbs) from mAb-producing hybridomas offers numerous advantages that increase the effectiveness, reproducibility, and transparent reporting of research. We report here the generation of a novel resource in the form of a library of recombinant R-mAbs validated for neurosci...

journal_title：eLife

authors： Andrews NP,Boeckman JX,Manning CF,Nguyen JT,Bechtold H,Dumitras C,Gong B,Nguyen K,van der List D,Murray KD,Engebrecht J,Trimmer JS

更新日期：2019-01-22 00:00:00

abstract：:Although pain is a common symptom of various diseases and disorders, its contribution to disease pathogenesis is not well understood. Here we show using murine experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis (MS), that pain induces EAE relapse. Mechanistic analysis showed that pain indu...

journal_title：eLife

authors： Arima Y,Kamimura D,Atsumi T,Harada M,Kawamoto T,Nishikawa N,Stofkova A,Ohki T,Higuchi K,Morimoto Y,Wieghofer P,Okada Y,Mori Y,Sakoda S,Saika S,Yoshioka Y,Komuro I,Yamashita T,Hirano T,Prinz M,Murakami M

更新日期：2015-08-11 00:00:00

abstract：:Host-virus arms races are inherently asymmetric; viruses evolve much more rapidly than host genomes. Thus, there is high interest in discovering mechanisms by which host genomes keep pace with rapidly evolving viruses. One family of restriction factors, the APOBEC3 (A3) cytidine deaminases, has undergone positive sele...

journal_title：eLife

authors： Yang L,Emerman M,Malik HS,McLaughlin RN Jnr

更新日期：2020-06-01 00:00:00

abstract：:Weight loss and anorexia are common symptoms in cancer patients that occur prior to initiation of cancer therapy. Inflammation in the brain is a driver of these symptoms, yet cellular sources of neuroinflammation during malignancy are unknown. In a mouse model of pancreatic ductal adenocarcinoma (PDAC), we observed ea...

journal_title：eLife

authors： Burfeind KG,Zhu X,Norgard MA,Levasseur PR,Huisman C,Buenafe AC,Olson B,Michaelis KA,Torres ER,Jeng S,McWeeney S,Raber J,Marks DL

更新日期：2020-05-11 00:00:00

abstract：:Postsynaptic compartments can be specifically modulated during various forms of synaptic plasticity, but it is unclear whether this precision is shared at presynaptic terminals. Presynaptic homeostatic plasticity (PHP) stabilizes neurotransmission at the Drosophila neuromuscular junction, where a retrograde enhancemen...

journal_title：eLife

authors： Li X,Goel P,Chen C,Angajala V,Chen X,Dickman DK

更新日期：2018-04-05 00:00:00

abstract：:Oncogenic human papillomaviruses (HPV) are small DNA viruses that infect keratinocytes. After HPV binding to cell surface receptors, a cascade of molecular interactions mediates the infectious cellular internalization of virus particles. Aside from the virus itself, important molecular players involved in virus entry ...

journal_title：eLife

authors： Mikuličić S,Finke J,Boukhallouk F,Wüstenhagen E,Sons D,Homsi Y,Reiss K,Lang T,Florin L

更新日期：2019-05-20 00:00:00