Mechanisms that allow cortical preparatory activity without inappropriate movement.

Abstract:

:We reveal a novel mechanism that explains how preparatory activity can evolve in motor-related cortical areas without prematurely inducing movement. The smooth eye movement region of the frontal eye fields (FEFSEM) is a critical node in the neural circuit controlling smooth pursuit eye movement. Preparatory activity evolves in the monkey FEFSEM during fixation in parallel with an objective measure of visual-motor gain. We propose that the use of FEFSEM output as a gain signal rather than a movement command allows for preparation to progress in pursuit without causing movement. We also show that preparatory modulation of firing rate in FEFSEM predicts movement, providing evidence against the 'movement-null' space hypothesis as an explanation of how preparatory activity can progress without movement. Finally, there is a partial reorganization of FEFSEM population activity between preparation and movement that would allow for a directionally non-specific component of preparatory visual-motor gain enhancement in pursuit.

journal_name

Elife

journal_title

eLife

authors

Darlington TR,Lisberger SG

doi

10.7554/eLife.50962

subject

Has Abstract

pub_date

2020-02-21 00:00:00

issn

2050-084X

pii

50962

journal_volume

9

pub_type

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