Development of gene-based markers for use in construction of the chickpea (Cicer arietinum L.) genetic linkage map and identification of QTLs associated with seed weight and plant height.

abstract：:Bacterial artificial chromosome (BAC) library is an important genomic resource useful in targeted marker development, positional cloning, physical mapping and a substrate for genome sequencing for better understanding the genome organization of a species. The present manuscript elucidates the improvement in protocols ...

journal_title：Molecular biology reports

authors： Kumar R,Baisvar VS,Kushwaha B,Murali S,Singh VK

更新日期：2020-03-01 00:00:00

abstract：:Cardiomyocytes possess the ability to respond to mechanical stimuli by reprogramming their gene expression. This study investigated the effects of different loading protocols on signaling and expression responses of myogenic, anabolic, inflammatory, atrophy and pro-apoptotic genes in cardiomyocyte-like H9C2 cells. Dif...

journal_title：Molecular biology reports

authors： Zevolis E,Philippou A,Moustogiannis A,Chatzigeorgiou A,Koutsilieris M

更新日期：2021-01-04 00:00:00

abstract：:The purpose of this study was to analyze the temporal gene expression in salivary and lacrimal glands of Sjögren's syndrome (SS) based on time-series microarray data. We downloaded gene expression data GSE15640 and GSE48139 from gene expression omnibus and identified differentially expressed genes (DEGs) at varying ti...

journal_title：Molecular biology reports

authors： Wang D,Xue L,Yang Y,Hu J,Li G,Piao X

更新日期：2014-09-01 00:00:00

abstract：:Telomeres are protective cap on the ends of DNA of non-coding tandem repeats of TTAGGG. Human telomerase reverse transcriptase (hTERT) is a catalytic subunit of telomerase that maintains the structure of telomeres. Type 2 diabetes (T2D) affects multi-organ and telomere length by altering telomerase activity. We aimed ...

journal_title：Molecular biology reports

authors： Goswami A,Huda N,Yasmin T,Hosen MI,Hasan AKMM,Nabi AHMN

更新日期：2021-01-03 00:00:00

abstract：:Beta(2)-microglobulin (beta(2)m), a protein necessary for proper folding, peptide binding, and surface display of class I antigens plays an important role in immune response. The full-length cDNA containing beta(2)m was cloned from the spleen cDNA library of large yellow croaker Pseudosciaena crocea (Pscr-beta ( 2 ) m...

journal_title：Molecular biology reports

authors： Yu S,Chen X,Ao J

更新日期：2009-09-01 00:00:00

abstract：:C2H2 proteins belong to a group of transcription factors (TFs) existing as a superfamily that plays important roles in defense responses and various other physiological processes in plants. The present study aimed to screen for and identify C2H2 proteins associated with defense responses to abiotic and biotic stresses...

journal_title：Molecular biology reports

authors： Jiang L,Pan LJ

更新日期：2012-06-01 00:00:00

abstract：:Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) plays a pivotal role in regulating T cell activation, which is believably critical for the outcome of hepatitis B virus (HBV) infection. The expression and function of CTLA-4 may be affected by gene polymorphisms. This study investigated the influence of CTLA-4 poly...

journal_title：Molecular biology reports

authors： Duan S,Zhang G,Han Q,Li Z,Liu Z,Chen J,Lv Y,Li N,Wang Y,Li M,Lou S,Yang M,Zhu Q,Xing F

更新日期：2011-11-01 00:00:00

abstract：:Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are autoimmune, inflammatory diseases with substantial genetic contributions. Matrix metalloproteinase (MMP)-2, tumor necrosis factor (TNF)-α and NLR family pyrin domain-containing 1 (NLRP1) play important roles in the immune response. We studied the MMP-2 rs24...

journal_title：Molecular biology reports

authors： Sun R,Huang Y,Zhang H,Liu R

更新日期：2013-11-01 00:00:00

abstract：:The complete sequence of mitochondrial genome of Siamensis Crocodile (Crocodylus siamensis) is determined by using PCR amplification, clone and primer-walking sequencing methods. The genome is 16836 bp in size, containing 13 protein-coding, 2 ribosomal and 22 transfer RNA genes. The mtDNA genome of Siamensis Crocodile...

journal_title：Molecular biology reports

authors： Ji X,Wu X,Yan P,Amato G

更新日期：2008-06-01 00:00:00

abstract：:Dyggve melchior clausen syndrome (DMC, MIM 223800) is a very rare autosomal recessive form of skeletal dysplasia associated with various degrees of mental retardation. It is characterized by a progressive spondyloepimetaphyseal dysplasia (SEMD) with disproportionate short stature, generalized platyspondyly and lacy il...

journal_title：Molecular biology reports

authors： Abdullah,Shah PW,Nawaz S,Hussain S,Ullah A,Basit S,Ahmad W

更新日期：2020-09-01 00:00:00

abstract：:Statins have shown pleiotropic effects, many of them independent of their impact on lipids. Angiogenesis can be beneficial in the acute myocardial infarction to improve circulation. However, it also can be harmful due to worsening of atherosclerosis. Here, we established a new minimal invasive rabbit model to study is...

journal_title：Molecular biology reports

authors： Shen W,Shi HM,Fan WH,Luo XP,Jin B,Li Y

更新日期：2011-08-01 00:00:00

abstract：:The influence of peptidyl-tRNA on the dissociation of yeast 80 S ribosomes into subunits was studied. For this purpose temperature-sensitive (ts) suppressor strain of yeast Saccharomyces cervisiae carrying a defect in peptide chain termination was used. It was found that peptidyl-tRNA did not influence the dissociatio...

journal_title：Molecular biology reports

authors： Surguchov AP,Fominykch ES,Lyzlova LV

更新日期：1978-06-16 00:00:00

abstract：:Proton beam therapy is widely used for treating brain tumor. Despite the efficacy of treatment, the use of this therapy has met some limitations associated with possible damage to normal brain tissues located beyond the tumor site. In this context, the exploration of the harmful effects of protons on the normal brain ...

journal_title：Molecular biology reports

authors： Abdullaev S,Bulanova T,Timoshenko G,Gaziev AI

更新日期：2020-06-01 00:00:00

abstract：:Telomerase activity is repressed in normal human somatic cells, but is activated in most cancers, suggesting that telomerase may be an important target for cancer therapy. Agents that interact selectively with telomerase are anticipated to exert specific action on cancer cells. In this study, we evaluated maleimide de...

journal_title：Molecular biology reports

authors： Huang PR,Yeh YM,Pao CC,Chen CY,Wang TC

更新日期：2012-09-01 00:00:00

abstract：:Movement assisted by muscles forms the basis of various behavioural traits seen in Drosophila. Myogenesis involves developmental processes like cellular specification, differentiation, migration, fusion, adherence to tendons and neuronal innervation in a series of coordinated event well defined in body space and time....

journal_title：Molecular biology reports

authors： Dubey M,Ain U,Firdaus H

更新日期：2020-12-01 00:00:00

abstract：:As a paired class homeodomain transcription factor, mutations of PROP1 (Prophet of POU1F1) are responsible for deficiencies of GH, PRL, TSH, LH and FSH. Regarding mutations of GH, PRL, and POU1F1 genes significantly associating with different production traits, PROP1 gene is a novel important candidate gene for detect...

journal_title：Molecular biology reports

authors： Lan X,Pan C,Zhang L,Zhao M,Zhang C,Lei C,Chen H

更新日期：2009-11-01 00:00:00

abstract：:Growing data supported that epigenetic modifications, including altered DNA methylation have a potential role in the pathogenesis of autoimmune thyroid diseases (AITD). In the present study we aimed to investigate the methylation status of ICAM-1 gene promoter in patients with AITD. Forty patients with Graves' disease...

journal_title：Molecular biology reports

authors： Shalaby SM,Mackawy AMH,Atef DM,Atef RM,Saeed J

更新日期：2019-10-01 00:00:00

abstract：:Brassica oleracea var. capitata (cabbage) is an economically important crop affected by black rot disease caused by Xanthomonas campestris pv. campestris (Xcc). MicroRNAs (miRNAs) play an important role in plant defense modulation and therefore the analysis of these molecules can help better understand plant-pathogen ...

journal_title：Molecular biology reports

authors： Santos LS,Maximiano MR,Megias E,Pappas M,Ribeiro SG,Mehta A

更新日期：2019-06-01 00:00:00

abstract：:One-third of all individuals with epilepsy are resistant to antiepileptic drug (AED) treatment. Antiepileptic treatment response has been suggested to be modulated by genetic polymorphisms of drug efflux transporters. Several polymorphic variants within the multidrug resistance 1 (MDR1) gene, which encodes the major t...

journal_title：Molecular biology reports

authors： Seven M,Batar B,Unal S,Yesil G,Yuksel A,Guven M

更新日期：2014-01-01 00:00:00

abstract：:Coactivator CBP (CREB-binding protein) has been implicated in the regulation of transcription for all signal transducer and activator of transcription factors (STATs); however, the mechanism remains unclear. Using yeast two-hybrid screening and immunoprecipitation techniques, we investigated the direct interaction of ...

journal_title：Molecular biology reports

authors： Zhang M,Fu Z,Tian D,Liu E,Dai J,Wang L

更新日期：2011-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that function in transcriptional and post-transcriptional regulation of gene expression. Several miRNAs have been implicated in regulating prostate cancer (PCa) progression. Deregulations of miRNA regulatory networks have been reported in ERG positive PCa, which accounts fo...

journal_title：Molecular biology reports

authors： Bakkar A,Alshalalfa M,Petersen LF,Abou-Ouf H,Al-Mami A,Hegazy SA,Feng F,Alhajj R,Bijian K,Alaoui-Jamali MA,Bismar TA

更新日期：2016-04-01 00:00:00

abstract：:Two DREB-like genes, designated as DmDREBa and DmDREBb, were isolated from chrysanthemum by RACE approach. The DmDREBa and DmDREBb genes encoded proteins of 191 and 185 amino acid residues with the predicted molecular mass of 21.66 and 20.99 kDa, respectively. Both DmDREBs proteins comprised a typical EREBP/AP2 domain...

journal_title：Molecular biology reports

authors： Yang Y,Wu J,Zhu K,Liu L,Chen F,Yu D

更新日期：2009-01-01 00:00:00

abstract：:β-Catenin plays a crucial role in embryonic development and responds to the activation of several signal transduction pathways. In this paper, in order to understand the functions of β-catenin gene in early embryonic development of Artemia sinica, the complete cDNA sequence was cloned for the first time using RACE tec...

journal_title：Molecular biology reports

authors： Li X,Hou L,Ma J,Liu Y,Zheng L,Zou X

更新日期：2012-01-01 00:00:00

abstract：:The cyclin-dependent kinases (CDKs) are a family of serine/threonine kinases, playing an essential role in regulating cell-cycle progression. In our present work, human CDK5 and a novel CDK5 splicing variant, named as CDK5-SV, were cloned from the cDNA library of human testis. CDK5-SV lacking the exon 7 of CDK5 encode...

journal_title：Molecular biology reports

authors： Li Q,Liu X,Zhang M,Ye G,Qiao Q,Ling Y,Wu Y,Zhang Y,Yu L

更新日期：2010-06-01 00:00:00

abstract：:Ran is a multifunctional small GTPase involved in important cellular activities like nucleocytoplasmic transport, mitotic spindle assembly, nuclear envelope formation, etc., but is also known to be differentially expressed in response to abiotic stress, particularly low temperature. We have over-expressed Lepidium lat...

journal_title：Molecular biology reports

authors： Sinha VB,Grover A,Singh S,Pande V,Ahmed Z

更新日期：2014-09-01 00:00:00

abstract：:We utilized Percoll density gradient centrifugation to isolate and fractionate chloroplasts of Korean winter wheat cultivar cv. Kumgang (Triticum aestivum L.). The resulting protein fractions were separated by one dimensional polyacrylamide gel electrophoresis (1D-PAGE) coupled with LTQ-FTICR mass spectrometry. This e...

journal_title：Molecular biology reports

authors： Kamal AH,Cho K,Komatsu S,Uozumi N,Choi JS,Woo SH

更新日期：2012-05-01 00:00:00

abstract：:The response of glycolysis to exposure of glucose in non-growing S. cerevisiae cells from diauxic shift was monitored. The result was compared to a kinetic model of glycolysis with branches to glycogen, trehalose, glycerol, and succinate. Experimental data at steady-state concentrations of metabolites in the upper par...

journal_title：Molecular biology reports

authors： Albers E,Bakker BM,Gustafsson L

更新日期：2002-01-01 00:00:00

abstract：:Ebselen, an organoselenium compound, mimics glutathione peroxidase activity. It is a multifunctional compound, which catalyzes several essential reactions for the protection of cellular components from oxidative and free radical damage. Based on a number of in vitro and in vivo studies, various mechanisms are proposed...

journal_title：Molecular biology reports

authors： Azad GK,Tomar RS

更新日期：2014-08-01 00:00:00

abstract：:To investigate mechanisms of rat glutathione S-transferase P1 gene (rGSTP1) expression regulation during chemical carcinogenesis. we studied enhancer elements located in the region between -2.5 kb to -2.2 kb. The region was upstream from the start site of transcription and was divided into two major fragments, GPEI an...

journal_title：Molecular biology reports

authors： Liu D,Liao M,Zuo J,Henner WD,Fan F

更新日期：2001-03-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy. Genetic polymorphisms in the 3'UTR region of the CXCL12 (rs1801157) and TP53 codon 72 (rs1042522) genes may contribute to susceptibility to childhood ALL because they affect some important processes, such as metastasis regulation and tumor sup...

journal_title：Molecular biology reports

authors： de Lourdes Perim A,Guembarovski RL,Oda JM,Lopes LF,Ariza CB,Amarante MK,Fungaro MH,de Oliveira KB,Watanabe MA

更新日期：2013-07-01 00:00:00