Temporal gene expression analysis of Sjögren's syndrome in C57BL/6.NOD-Aec1Aec2 mice based on microarray time-series data using an improved empirical Bayes approach.

abstract：:Three members of Brassica napus TRANSPARENT TESTA 2 (BnTT2) gene family encoding potential R2R3-MYB regulatory proteins of proanthocyanidin biosynthesis were isolated. BnTT2-1, BnTT2-2, and BnTT2-3 are 1102 bp with two introns, and have a 938-bp full-length cDNA with a 260 amino acid open reading frame. They share 98....

journal_title：Molecular biology reports

authors： Wei YL,Li JN,Lu J,Tang ZL,Pu DC,Chai YR

更新日期：2007-06-01 00:00:00

abstract：:Ebselen, an organoselenium compound, mimics glutathione peroxidase activity. It is a multifunctional compound, which catalyzes several essential reactions for the protection of cellular components from oxidative and free radical damage. Based on a number of in vitro and in vivo studies, various mechanisms are proposed...

journal_title：Molecular biology reports

authors： Azad GK,Tomar RS

更新日期：2014-08-01 00:00:00

abstract：:Kidney transplantation to treat end-stage renal disease has evolved rapidly from the first successful transplantations to the current widespread use of grafts from both cadaveric and living donors. But acute rejection is still a strong risk factor for chronic rejection in recipients of renal grafts. To investigate pos...

journal_title：Molecular biology reports

authors： Chen G,Mi J,Xiao MZ,Fu YR

更新日期：2012-05-01 00:00:00

abstract：:The majority of the genomic DNA sequence in mammalian and other higher organisms can be transcribed into abundant functional RNA transcripts, especially regulatory non-coding RNAs (ncRNAs) that are expressed in a developmentally and species-specific regulated manner. Here, we review various regulatory non-coding RNAs,...

journal_title：Molecular biology reports

authors： Huang B,Zhang R

更新日期：2014-06-01 00:00:00

abstract：:Stable inheritance and expression of transgene are important parameters for successful use of a transgenic crop. We previously transformed a Bt cry1Ba3 gene into cabbage inbred line CA21-3. To evaluate the stability of our Bt cabbage lineages, transgene inheritance and expression were examined in four successive gener...

journal_title：Molecular biology reports

authors： Yi DX,Fang ZY,Yang LM

更新日期：2020-04-01 00:00:00

abstract：:In plants, pathogenesis-related 1 protein (PR1) is considered as important defense protein. The production and accumulation of PR proteins in plants are one of the important responses to several biotic and abiotic stresses. In this regard, PR1 gene was isolated from Triticum turgidum ssp durum and was named as TdPR1.2...

journal_title：Molecular biology reports

authors： Ghorbel M,Zribi I,Missaoui K,Drira-Fakhfekh M,Azzouzi B,Brini F

更新日期：2020-12-13 00:00:00

abstract：:Testis development is a highly regulated sequence of developmental process that spans from the establishment of germ cell lineage during embryonic development to the periodic wave of spermatogenesis in adulthood. The normal development of testes and the fertility of male animals require specific cell types to respond ...

journal_title：Molecular biology reports

authors： Fan YS,Hu YJ,Yang WX

更新日期：2012-04-01 00:00:00

abstract：:Cytochrome P450 1B1 (CYP1B1) is a key P450 enzyme involved in the metabolism of exogenous and endogenous substrates in endocrine-mediated tumors such as prostate cancer. The potential significance of nonsynonymous SNP Leu432Val (rs1056836) as a risk factor in prostate cancer has been extensively studied. The objective...

journal_title：Molecular biology reports

authors： Cui L,Dillehay K,Chen W,Shen D,Dong Z,Li W

更新日期：2012-07-01 00:00:00

abstract：:According to the stem cell theory for cancer, hepatocellular carcinomas are sustained by a group of cancer stem cells (CSCs) which are responsible for resistance to chemotherapy. In the present study we aimed to examine lipid metabolism in cancer stem cells induced by long-term treatment with sorafenib and its relatio...

journal_title：Molecular biology reports

authors： Bort A,Sánchez BG,de Miguel I,Mateos-Gómez PA,Diaz-Laviada I

更新日期：2020-04-01 00:00:00

abstract：:Maize is one of the world's most important crops and a model for grass genome research. Long terminal repeat (LTR) retrotransposons comprise most of the maize genome; their ability to produce new copies makes them efficient high-throughput genetic markers. Inter-retrotransposon-amplified polymorphisms (IRAPs) were use...

journal_title：Molecular biology reports

authors： Ghonaim M,Kalendar R,Barakat H,Elsherif N,Ashry N,Schulman AH

更新日期：2020-03-01 00:00:00

abstract：:Molecular DNA markers are used for detection of polymorphisms in individuals. As they are independent of developmental stage of the plant and environmental influences, they can be useful tools in taxonomy. The alleles of simple sequence repeat (SSR) markers (or microsatellites) are traditionally used to identify taxon...

journal_title：Molecular biology reports

authors： Tuler AC,Carrijo TT,Nóia LR,Ferreira A,Peixoto AL,da Silva Ferreira MF

更新日期：2015-11-01 00:00:00

abstract：:Growing data supported that epigenetic modifications, including altered DNA methylation have a potential role in the pathogenesis of autoimmune thyroid diseases (AITD). In the present study we aimed to investigate the methylation status of ICAM-1 gene promoter in patients with AITD. Forty patients with Graves' disease...

journal_title：Molecular biology reports

authors： Shalaby SM,Mackawy AMH,Atef DM,Atef RM,Saeed J

更新日期：2019-10-01 00:00:00

abstract：:In the present work, Site-directed mutagenesis to insert the Glu50Lys amino acid substitution was achieved by PCR using plasmid pBluescript-OPTN. Mutated human OPTN(E50K) gene-driven mouse c-kit promoter was constructed and confirmed by endonuclease digestion and sequence analysis. Transgenic mice were generated via t...

journal_title：Molecular biology reports

authors： Meng Q,Xiao Z,Yuan H,Xue F,Zhu Y,Zhou X,Yang B,Sun J,Meng B,Sun X,Cheng F

更新日期：2012-02-01 00:00:00

abstract：:The differentially expressed genes in the chickpea pod wall have been identified for the first time using a forward suppression subtractive hybridization (SSH) library. In all, 226 clones of SSH library were sequenced and analyzed. A total of 179 high-quality expressed sequence tags (ESTs) were generated and based on ...

journal_title：Molecular biology reports

authors： Vasantrao JM,Baruah IK,Panda D,Bhattacharjee M,Acharjee S,Sarmah BK

更新日期：2019-12-01 00:00:00

abstract：:A full-length cDNA encoding wheat peroxisomal ascorbate peroxidase (pAPX) was cloned by Suppression Subtractive Hybridization (SSH) and in silico approach. The cDNA was 1027 bp in length and contained a complete ORF of 876 bp, which encodes a protein of 292 amino acid residues. Its deduced amino acids sequence had 84%...

journal_title：Molecular biology reports

authors： Chen Y,Wang H,Wang X,Cao A,Chen P

更新日期：2006-09-01 00:00:00

abstract：:Bacterial leaf streak (BLS) caused by Xanthomonas oryzae pv. oryzicola (Xoc) is an important disease of rice, which is responsible for the economic losses worldwide. Functional investigation of differentially expressed protein genes (DEPGs) from rice (Oryza sativa L.) upon Xoc infection provides insight into the molec...

journal_title：Molecular biology reports

authors： Guo L,Guo C,Li M,Wang W,Luo C,Zhang Y,Chen L

更新日期：2014-01-01 00:00:00

abstract：:Previous studies from our group have brought forward the concept of angiogenic regeneration during radiotherapy (RT), as a major cause of RT failure. This process was examined herein in rectal cancer patients undergoing preoperative chemo-radiotherapy. Out of 25 patients with stage II/III rectal adenocarcinoma, 15 had...

journal_title：Molecular biology reports

authors： Koukourakis MI,Koukourakis IM,Arelaki S,Kouroupi M,Domoxoudis S,Giatromanolaki A

更新日期：2019-04-01 00:00:00

abstract：:Nuclear magnetic resonance (NMR) spectroscopy is a useful biophysical technique to study the ligand-protein interaction. In this report, we have used bacterially produced ERβ and its domains for studying the functional analysis of ligand-protein interaction. Briefly, ERβ and its transactivation domain (TAD) and ligand...

journal_title：Molecular biology reports

authors： Paramanik V,Thakur MK

更新日期：2011-10-01 00:00:00

abstract：:Graft versus host disease (GVHD) is a major complication of bone marrow transplantation (BMT). Numerous studies have shown the potential role of cytokine genotypes in the occurrence of GVHD. In this retrospective, case-control study we aimed to investigate the association between 13 cytokine genes and acute GVHD (aGVH...

journal_title：Molecular biology reports

authors： Noori-Daloii MR,Jalilian N,Izadi P,Sobhani M,Rabii-Gilani Z,Yekaninejad MS

更新日期：2013-08-01 00:00:00

abstract：:Start codon targeted (SCoT) polymorphic markers were used to assess genetic relationships among 64 grape varieties. Seventeen informative primers were selected from 36 SCoT primers based on their ability to produce clear and repeatable polymorphic and unambiguous bands among the varieties. A total of 131 bands were pr...

journal_title：Molecular biology reports

authors： Guo DL,Zhang JY,Liu CH

更新日期：2012-05-01 00:00:00

abstract：:One mutant transgenic line displaying homeotic conversion of sepals to petals with other phenotypic aberrations was selected and characterized at molecular level. The increased transcript level of gene encoding anthocyanidin synthase and petal specific class B genes, GLOBOSA and DEFECIENS in sepals of mutant line may ...

journal_title：Molecular biology reports

authors： Mahajan M,Yadav SK

更新日期：2014-02-01 00:00:00

abstract：:Mucopolysaccharidosis IV A (MPS IV A) is a lysosomal storage disease produced by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS) enzyme. Although genotype-phenotype correlations have been reported, these approaches have not enabled to establish a complete genotype-phenotype correlation, and they ha...

journal_title：Molecular biology reports

authors： Olarte-Avellaneda S,Rodríguez-López A,Alméciga-Díaz CJ,Barrera LA

更新日期：2014-11-01 00:00:00

abstract：:While there have been more and more studies concerning mitogen-activated protein kinases (MAPKs) signaling pathways, which control many cellular complex programmes, such as cell proliferation, differentiation, cell death and embryogenesis. However, few studies are carried out about expression and activation of classic...

journal_title：Molecular biology reports

authors： Zheng ST,Huo Q,Tuerxun A,Ma WJ,Lv GD,Huang CG,Liu Q,Wang X,Lin RY,Sheyhidin I,Lu XM

更新日期：2011-02-01 00:00:00

abstract：:The purpose of this study was to investigate the efficacy of Endostar combined with chemotherapy on human esophageal squamous cell carcinoma Eca-109 in mice. The tumor xenograft models were established and randomly assigned to 4 groups: control group, Endostar group (1.5 mg/kg day, once daily for 3 weeks), chemotherap...

journal_title：Molecular biology reports

authors： Chang L,Guo F,Lv Y,Wang Y,Huo B,Wang L,Liu W

更新日期：2013-01-01 00:00:00

abstract：:Mitochondrial disorders are a frequent cause of neurological disability affecting children and adults. Traditionally, molecular diagnosis of mitochondrial diseases was mostly accomplished by the use of Sanger sequencing and PCR-RFLP. However, there are particular drawbacks associated with the use of these methods. Rec...

journal_title：Molecular biology reports

authors： Kauffman MA,Gonzlez-Morón D,Consalvo D,Westergaard G,Vazquez M,Mancini E,Taratuto AL,Rey R,Kochen S

更新日期：2012-06-01 00:00:00

abstract：:Circadian rhythms are endogenous and self-sustained oscillations of multiple biological processes with approximately 24-h rhythmicity. Circadian genes and their protein products constitute the molecular components of the circadian oscillator that form positive/negative feedback loops and generate circadian rhythms. Th...

journal_title：Molecular biology reports

authors： Rana S,Munawar M,Shahid A,Malik M,Ullah H,Fatima W,Mohsin S,Mahmood S

更新日期：2014-01-01 00:00:00

abstract：:Membrane-bound Δ9 desaturase perform oxygenated desaturation reactions to insert the first double bonds within fatty acyl chains between C9 and C10 positions of most saturated substrates. Arthrospira platensis, a blue green microalga, is an important source of polyunsaturated fatty acids (PUFA) such as oleic, linoleic...

journal_title：Molecular biology reports

authors： Ben Amor F,Ben Hlima H,Abdelkafi S,Fendri I

更新日期：2018-12-01 00:00:00

abstract：:Maize (Zea mays L.) is an important model plant with an important role in agriculture and national economies all over the world. The optimum growth temperature of maize is between 25 and 28 °C. At temperatures below 12 °C, maize is vulnerable to damage by chilling stress. MYB transcription factors play important roles...

journal_title：Molecular biology reports

authors： Li M,Lin L,Zhang Y,Sui N

更新日期：2019-08-01 00:00:00

abstract：:The Phytophthora genus is composed, mainly, of plant pathogens. This genus belongs to the Oomycete class, also known as "pseudo-fungi", within the Chromista Kingdom. Phytophthora spp. is highlighted due to the significant plant diseases that they cause, which represents some of the most economically and cultural losse...

journal_title：Molecular biology reports

authors： de Andrade Lourenço D,Branco I,Choupina A

更新日期：2020-11-01 00:00:00

abstract：:Lipoprotein-associated phospholipase A2 (LP-PLA2) may play an important role in the pathophysiology of coronary heart disease (CHD). The polymorphism of LP-PLA2 gene caused LP-PLA2 enzyme activity depressing or lost. But there is not a definite conclusion for the association of between the LP-PLA2 gene polymorphism an...

journal_title：Molecular biology reports

authors： Zheng GH,Chen HY,Xiong SQ,Chu JF

更新日期：2011-08-01 00:00:00