Development of new antibiotics: taking off finally?

abstract：:After the health catastrophe resulting from the widespread use of asbestos which was once hailed as a new miracle material, the increasing use of carbon nanotubes (CNTs) has spawned major concern due to their similarities in terms of size, shape and poor solubility. Assessment of genotoxicity has shown that CNTs can d...

journal_title：Swiss medical weekly

authors： van Berlo D,Clift MJ,Albrecht C,Schins RP

更新日期：2012-11-05 00:00:00

abstract：:Cells reside in mechanically rich and dynamic microenvironments, and the complex interplay between mechanics and biology is widely acknowledged. Recent research has yielded insights linking the mechanobiology of cells, human physiology, and pathophysiology. In particular, we have learned of the cell's astounding abili...

journal_title：Swiss medical weekly

authors： Steward RL Jr,Rosner SR,Zhou EH,Fredberg JJ

更新日期：2013-03-14 00:00:00

abstract：PURPOSE:There is increasing pressure on general practitioners (GPs) to identify patients with abdominal obesity in order to reduce the life-threatening consequences of this condition in the population. We aimed to confirm previous findings on the inaccuracy of anthropometric measurements performed by GPs in an academic...

journal_title：Swiss medical weekly

authors： Sebo P,Haller D,Pechère-Bertschi A,Bovier P,Herrmann F

更新日期：2015-02-21 00:00:00

abstract：BACKGROUND:The precision of symptom assessment and documentation in daily routine is unknown. Differences in hip studies have been observed between the charts and the patient questionnaires. This was the reason to perform this study and to compare the charts and the patient questionnaires. METHODS:This was a retrospec...

journal_title：Swiss medical weekly

authors： Huber JF,Dabis E,Huesler J,Ruflin GB

更新日期：2009-10-17 00:00:00

abstract：:The ex utero intrapartum treatment (EXIT) procedure is designed to guarantee sufficient oxygenation for a foetus at risk of airway obstruction. This is achieved by improving lung ventilation, usually by establishing an airway during caesarean delivery whilst preserving the foetal-placental circulation temporarily. Ind...

journal_title：Swiss medical weekly

authors： Kern C,Ange M,Morales,Peiry B,Pfister RE

更新日期：2007-05-19 00:00:00

abstract：OBJECTIVE:To examine the demographics, evolution and outcome of patients suffering from malignancies admitted to a medical intensive care unit. PATIENTS AND METHODS:Single centre retrospective cohort study of patients with malignancies. Data on demographics, diagnosis laboratory tests, provided therapy and outcome wer...

journal_title：Swiss medical weekly

authors： Unseld S,Schuepbach RA,Maggiorini M

更新日期：2013-03-26 00:00:00

abstract：QUESTIONS UNDER STUDY:Teenage and young adult (TYA) cancer patients are faced with the diagnosis during a challenging period of psychosocial development that may affect social outcomes in the long term. Therefore, we aimed to: (1) determine differences in social outcomes between long-term TYA cancer survivors and healt...

journal_title：Swiss medical weekly

authors： Mader L,Vetsch J,Christen S,Baenziger J,Roser K,Dehler S,Michel G

更新日期：2017-03-07 00:00:00

abstract：QUESTION UNDER STUDY:Domestic accidents are an important problem in paediatric medicine. This study was designed to gain a better understanding of burn mechanisms and target prevention. METHODS:Children treated for burn lesions in the Department of Paediatric Surgery between August 2004 and August 2005 were included i...

journal_title：Swiss medical weekly

authors： Natterer J,de Buys Roessingh A,Reinberg O,Hohlfeld J

更新日期：2009-09-19 00:00:00

abstract：OBJECTIVE:An increasing number of patients with asthma are attracted by complementary and alternative medicine (CAM). Therefore, it is of importance that scientific evidence about the efficacy of this type of therapy is regarded. METHOD:We searched the electronic databases Medline, Embase and the Cochrane Library for ...

journal_title：Swiss medical weekly

authors： Steurer-Stey C,Russi EW,Steurer J

更新日期：2002-06-29 00:00:00

abstract：:The United Nations General Assembly has convened a Summit on non-communicable diseases (NCDs), an historic moment in the global combat of these disorders. Lifestyles in increasingly urban and globalised environments have led to a steep surge in NCD incidence in low and middle income countries, where two thirds of all ...

journal_title：Swiss medical weekly

authors： Probst-Hensch N,Tanner M,Kessler C,Burri C,Künzli N

更新日期：2011-09-07 00:00:00

abstract：INTRODUCTION:Effort-reward imbalance (ERI) and work-life imbalance (WLI) are recognised risk factors for work stress and burnout but have not been investigated conjointly so far and compared with each other in this regard. The present cross-sectional study provides initial evidence by studying associations of ERI and W...

journal_title：Swiss medical weekly

authors： Hämmig O,Brauchli R,Bauer GF

更新日期：2012-05-31 00:00:00

abstract：:Giant cell arteritis (GCA) is the most common of the vasculitis syndromes and, being a disease of the elderly, its incidence is increasing with the general ageing of the population. GCA is most feared for its early complications, namely blindness and stroke, resulting from inflammation and subsequent occlusion of ocul...

journal_title：Swiss medical weekly

authors： Kesten F,Aschwanden M,Gubser P,Glatz K,Daikeler T,Hess C

更新日期：2011-09-28 00:00:00

abstract：:Patients with chronic heart failure who are not eligible for heart transplant and whose life expectancy depends mainly on the heart disease may benefit from mechanical circulatory support. Mechanical circulatory support restores adequate cardiac output and organ perfusion and eventually improves patients' clinical con...

journal_title：Swiss medical weekly

authors： Tozzi P,Hullin R

更新日期：2016-03-05 00:00:00

abstract：QUESTIONS UNDER STUDY/PRINCIPLES:Although probe-based confocal laser endomicroscopy (pCLE) is on the edge of entering daily practice in gastroenterological endoscopy, findings in the field of respiratory medicine are only rarely reported, keeping pCLE during flexible bronchoscopy as a mere preclinical research tool. Si...

journal_title：Swiss medical weekly

authors： Yserbyt J,Dooms C,Ninane V,Decramer M,Verleden G

更新日期：2013-03-26 00:00:00

abstract：QUESTIONS UNDER STUDY/PRINCIPLES:A retrospective assessment of long-term results on a single centre, single author experience in treating prostate cancer with high dose curative radiotherapy (RT) with or without androgen deprivation (AD). METHODS:Between 1991 and 2004, 408 patients with clinically localised prostate c...

journal_title：Swiss medical weekly

authors： Miralbell R,Pampallona S,Rouzaud M,Pugliesi A,Weber D,Ares C

更新日期：2009-09-05 00:00:00

abstract：:Although progress has been made in the management of acute leukaemias, most patients who fail to respond to front-line therapies with cytostatic agents and stem cell transplantation, or who relapse after an initial response die from progressive disease. Novel treatment modalities exploiting donor-derived natural kille...

journal_title：Swiss medical weekly

authors： Wodnar-Filipowicz A,Kalberer CP

更新日期：2006-06-10 00:00:00

abstract：OBJECTIVE:Regular checking of the fitness to drive of elderly car-license holders is required in some countries, and this will become increasingly important as more countries face aging populations. The present study investigated whether the analysis of saccadic eye movements could be used as a screening method for the...

journal_title：Swiss medical weekly

authors： Schmitt KU,Seeger R,Fischer H,Lanz C,Muser M,Walz F,Schwarz U

更新日期：2015-02-09 00:00:00

abstract：:Kras, a small intracellular GTPase, is a central intermediary of the epidermal growth factor receptor (EGFR) and other tyrosine kinase receptor pathways. Increased EGFR and Kras signalling is involved in colorectal carcinogenesis and tumour progression. Mutations of Kras result in the loss of its GTPase activity and t...

journal_title：Swiss medical weekly

authors： Wicki A,Herrmann R,Christofori G

更新日期：2010-11-19 00:00:00

abstract：BACKGROUND:Renal replacement therapy for paediatric end-stage renal disease (ESRD) has developed steadily since its introduction five decades ago. Continuous and long-term analysis of patient outcomes is essential for quality control. METHODS:The Swiss Paediatric Renal Registry, founded in 1970, includes patients diag...

journal_title：Swiss medical weekly

authors： Maurer E,Neuhaus TJ,Weitz M,Kuehni CE,Laube GF

更新日期：2020-07-27 00:00:00

abstract：:The current situation of the biomedical sciences is critically discussed. It can be summarized as follows: 1. We have to acknowledge the presence of a serious credibility problem, which might undermine the foundations of medical science. ("Sliding on a slippery slope") 2. Multiple forces going beyond simple conflicts ...

journal_title：Swiss medical weekly

authors： Obrist R

更新日期：2015-03-13 00:00:00

abstract：:Depending on the populations studied and the definitions applied, the prevalence of treatment-resistant hypertension varies from 10% to 15%, but is higher in conditions associated with increased sympathetic drive, such as obesity, obstructive sleep apnoea, diabetes or renal dysfunction. The Symplicity studies recently...

journal_title：Swiss medical weekly

authors： Gu YM,Asayama K,Liu YP,Staessen JA

更新日期：2012-07-17 00:00:00

abstract：AIM:To test the hypothesis that rationing of medical management mainly based on age exists in our health care system today. METHODS:We studied 303 consecutive patients hospitalised for acute coronary syndrome (ACS) and 163 consecutive patients hospitalised with congestive heart failure (CHF). They were divided into tw...

journal_title：Swiss medical weekly

authors： Jenni D,Osterwalder R,Osswald S,Buser P,Pfisterer M

更新日期：2001-11-10 00:00:00

abstract：BACKGROUND:Thyroid hemiagenesis (TH) is a rare congenital abnormality of the thyroid gland, characterised by the absence of one lobe. The true prevalence of this congenital abnormality is not known because the absence of one thyroid lobe usually does not cause clinical symptoms by itself. This study aims to identify th...

journal_title：Swiss medical weekly

authors： Berker D,Ozuguz U,Isik S,Aydin Y,Ates Tutuncu Y,Akbaba G,Guler S

更新日期：2010-02-20 00:00:00

abstract：BACKGROUND:Many antimicrobial stewardship programmes (ASPs) target the intensive care unit owing to high antimicrobial utilisation. In this review, we summarise and assess the quality of evidence supporting the implementation of various ASP strategies in the intensive care unit setting with a focus on publications betw...

journal_title：Swiss medical weekly

authors： Mertz D,Brooks A,Irfan N,Sung M

更新日期：2015-12-21 00:00:00

abstract：QUESTIONS UNDER STUDY:To evaluate the diagnostic value of serum Cystatin C and urine neutrophil gelatinase-associated lipocalin (NGAL) for the detection of acute kidney injury in patients undergoing congenital heart surgery. METHODS:Serial samples of serum Cystatin C and urine NGAL were collected from 139 consecutive ...

journal_title：Swiss medical weekly

authors： Seitz S,Rauh M,Gloeckler M,Cesnjevar R,Dittrich S,Koch AM

更新日期：2013-01-17 00:00:00

abstract：:Lung transplantation has now been performed for more than 30 years in patients with end-stage chronic obstructive pulmonary disease (COPD). This disease is the major indication for lung transplantation, involving more than one third of the procedures worldwide. Although lung transplantation in COPD patients has clearl...

journal_title：Swiss medical weekly

authors： Lahzami S,Aubert JD

更新日期：2009-01-10 00:00:00

abstract：INTRODUCTION:Graft rejection and infection remain major morbidities following orthotopic liver transplantation (OLT). Rejection treatment may be associated with an increased rate of infectious complications. The aim of this study was to determine the relationship between rejection, rejection therapy and the risk of ass...

journal_title：Swiss medical weekly

authors： Garbino J,Romand JA,Pittet D,Giostra E,Mentha G,Suter P

更新日期：2005-10-01 00:00:00

abstract：:The atherogenic lipoprotein phenotype is characterised by a moderate increase in plasma triglycerides, a decrease in high density lipoprotein cholesterol and the prevalence of smaller denser low density lipoprotein particles. The prevalence of this partially inheritable phenotype is approximately 30% and is a feature ...

journal_title：Swiss medical weekly

authors： Berneis K,Rizzo M

更新日期：2004-12-18 00:00:00

abstract：BACKGROUND:Hypoxia-inducible factor-1α (HIF-1α) plays an important role in tumour progression and metastasis through activation of many target genes that are especially involved in pivotal aspects of cancer biology. However, the prognostic role of HIF-1α has been controversial in primary patients with lung cancer. This...

journal_title：Swiss medical weekly

authors： Ren W,Mi D,Yang K,Cao N,Tian J,Li Z,Ma B

更新日期：2013-09-06 00:00:00

abstract：QUESTIONS UNDER STUDY:Postmenopausal women are more likely to develop coronary artery disease than premenopausal women of the same age. Postmenopausal oral oestrogen therapy is associated with increased levels of high-density lipoprotein (HDL) cholesterol and decreased levels of lowdensity lipoprotein (LDL) cholesterol...

journal_title：Swiss medical weekly

authors： Delibasi T,Kockar C,Celik A,Kockar O

更新日期：2006-08-05 00:00:00