Antioxidant effects of hormone replacement therapy in postmenopausal women.

Abstract:

QUESTIONS UNDER STUDY:Postmenopausal women are more likely to develop coronary artery disease than premenopausal women of the same age. Postmenopausal oral oestrogen therapy is associated with increased levels of high-density lipoprotein (HDL) cholesterol and decreased levels of lowdensity lipoprotein (LDL) cholesterol. In this study we investigated the direct contribution of hormone replacement therapy on total antioxidant capacity rather than its effects on the serum lipid profile. METHODS:At the time of enrolment and after the drug delivery plasma total cholesterol, triglycerides (TG), HDL, LDL, uric acid, total bilirubin, albumin, oestradiol levels and total antioxidant capacity of plasma were assessed. RESULTS:Levels of plasma TG and total antioxidant capacity were significantly increased in the study group. CONCLUSIONS:Our results suggest that oestrogen has an antioxidant effect following 3 months of hormone replacement therapy. Progesterone in combination with oestrogen does not have this effect. Also plasma TG levels increased in those patients receiving HRT after 3 months.

journal_name

Swiss Med Wkly

journal_title

Swiss medical weekly

authors

Delibasi T,Kockar C,Celik A,Kockar O

doi

2006/31/smw-11390

subject

Has Abstract

pub_date

2006-08-05 00:00:00

pages

510-4

issue

31-32

eissn

1424-7860

issn

1424-3997

pii

smw-11390

journal_volume

136

pub_type

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