The impact of clinical trial units on the value of clinical research in Switzerland.

abstract：:Since 2010, awareness of the global threat caused by antimicrobial resistance (AMR) has risen considerably and multiple policy and research initiatives have been implemented. Research and development (R&D) of much-needed new antibiotics active against multiresistant pathogens is a key component of all programmes aimin...

journal_title：Swiss medical weekly

authors： Bettiol E,Harbarth S

更新日期：2015-07-31 00:00:00

abstract：BACKGROUND:B-type natriuretic peptide (BNP) has been proven to be a biochemical marker of severity of congestive heart failure. We are aware of only few papers reporting the association of BNP elevation and pulmonary hypertension (primary, thromboembolic, or as a consequence of chronic obstructive pulmonary disease). L...

journal_title：Swiss medical weekly

authors： Maeder M,Ammann P,Rickli H,Diethelm M

更新日期：2003-09-26 00:00:00

abstract：QUESTION UNDER STUDY:To evaluate the situation of Female Genital Mutilation (FGM) in Switzerland. METHODS:Through a questionnaire, Swiss gynaecologists were asked if they have been confronted to FGMs, if they have been asked to perform infibulations and FGMs. The health representatives (Kantonsärzte/médecins cantonaux...

journal_title：Swiss medical weekly

authors： Jäger F,Schulze S,Hohlfeld P

更新日期：2002-05-18 00:00:00

abstract：:The atherogenic lipoprotein phenotype is characterised by a moderate increase in plasma triglycerides, a decrease in high density lipoprotein cholesterol and the prevalence of smaller denser low density lipoprotein particles. The prevalence of this partially inheritable phenotype is approximately 30% and is a feature ...

journal_title：Swiss medical weekly

authors： Berneis K,Rizzo M

更新日期：2004-12-18 00:00:00

abstract：OBJECTIVE:Coronary artery bypass grafting (CABG) remains the gold standard for complex revascularisation in multivessel disease. The concept of the minimally invasive extracorporeal circulation circuit (MiECC) was introduced to minimise pathophysiological side effects of conventional extracorporeal circulation. This st...

journal_title：Swiss medical weekly

authors： Winkler B,Heinisch PP,Zuk G,Zuk K,Gahl B,Jenni HJ,Kadner A,Huber C,Carrel T

更新日期：2017-07-10 00:00:00

abstract：OBJECTIVES:Epidemological studies suggest that farmers are at an increased risk for chronic obstructive pulmonary disease because of exposure to organic dust. We assessed the proportion of farmers among patients with end stage lung disease and we measured the seasonal exposure of dairy farmers to organic dust in a rura...

journal_title：Swiss medical weekly

authors： Cathomas RL,Brüesch H,Fehr R,Reinhart WH,Kuhn M

更新日期：2002-04-06 00:00:00

abstract：BACKGROUND AND AIM:Perinatal and infant mortality rates are considered key indicators of medical care. The aim of this investigation was to examine how representative and reliable the official national figures of Switzerland are by comparing them with the data in local birth registers. METHODS:124 of 156 maternity hos...

journal_title：Swiss medical weekly

authors： Müller M,Drack G,Schindler C,Bucher HU

更新日期：2005-07-23 00:00:00

abstract：OBJECTIVE:To measure medical care and pharmaceutical drug use among Swiss primary care physicians and its determinants. DESIGN:Cross-sectional mailed survey. SETTING:1784 randomly selected Swiss primary care physicians, including general practitioners, internists and paediatricians. RESULTS:Twenty one percent (95% C...

journal_title：Swiss medical weekly

authors： Schneider M,Bouvier Gallacchi M,Goehring C,Künzi B,Bovier PA

更新日期：2007-02-24 00:00:00

abstract：STUDY OBJECTIVES:we performed an open-label national study to evaluate the effects of Bosentan on haemodynamics, exercise capacity, quality of life, safety and tolerability in patients with chronic thromboembolic pulmonary hypertension (CTEPH). PATIENTS AND METHODS:fifteen patients with CTEPH not eligible or waiting f...

journal_title：Swiss medical weekly

authors： Ulrich S,Speich R,Domenighetti G,Geiser T,Aubert JD,Rochat T,Huber L,Treder U,Fischler M

更新日期：2007-10-20 00:00:00

abstract：BACKGROUND:Preventive treatment may avoid future cases of tuberculosis among asylum seekers. The effectiveness of preventive treatment depends in large part on treatment completion. METHODS:In a prospective cohort study, asylum seekers of two of the Swiss Canton Vaud migration centres were screened with the Interferon...

journal_title：Swiss medical weekly

authors： Sarivalasis A,Bodenmann P,Langenskiold E,Lutchmaya-Flick C,Daher O,Zellweger JP

更新日期：2013-09-06 00:00:00

abstract：OBJECTIVE:To examine the demographics, evolution and outcome of patients suffering from malignancies admitted to a medical intensive care unit. PATIENTS AND METHODS:Single centre retrospective cohort study of patients with malignancies. Data on demographics, diagnosis laboratory tests, provided therapy and outcome wer...

journal_title：Swiss medical weekly

authors： Unseld S,Schuepbach RA,Maggiorini M

更新日期：2013-03-26 00:00:00

abstract：INTRODUCTION:In general practice, the diagnosis of dementia is often delayed. Therefore, the Swiss National Dementia Strategy 2014 concluded that action was needed to improve patient care. Little is known about GPs’ confidence in and approach to the diagnosis, disclosure and post-diagnostic management of individu...

journal_title：Swiss medical weekly

authors： Giezendanner S,Monsch AU,Kressig RW,Mueller Y,Streit S,Essig S,Zeller A,Bally K

更新日期：2018-12-21 00:00:00

abstract：:PRINCIPLES: Chronic obstructive pulmonary disease (COPD) is a major burden on patients and healthcare systems. Diagnosis and the management of COPD are often administered by general practitioners (GPs). This analysis investigated the adherence of GPs in Switzerland to the Global Initiative for Chronic Obstructive Lung...

journal_title：Swiss medical weekly

authors： Jochmann A,Neubauer F,Miedinger D,Schafroth S,Tamm M,Leuppi JD

更新日期：2010-08-09 00:00:00

abstract：QUESTIONS UNDER STUDY:In HIV-infected patients, comprehension of medication instructions is an essential condition for adherence to Highly Active Antiretroviral Therapy (HAART). In this study, we used a self-reported questionnaire to know which sources of medication information HIV-infected patients used and their impa...

journal_title：Swiss medical weekly

authors： Korb-Savoldelli V,Gillaizeau F,Caruba T,Tauckoor A,Prognon P,Durieux P,Sabatier B

更新日期：2012-07-26 00:00:00

abstract：:Prior to the introduction of chemotherapy, tuberculosis management relied upon aerotherapy, heliotherapy and good nutrition. This "treatment", exemplified by the regimen applied in Swiss and other European mountain resorts, is described by Thomas Mann in the book "The Magic Mountain". Tuberculosis chemotherapy began i...

journal_title：Swiss medical weekly

authors： Diacon AH,von Groote-Bidlingmaier F,Donald PR

更新日期：2012-08-22 00:00:00

abstract：OBJECTIVES:To compare the long-term effects of comprehensive outpatient versus inpatient rehabilitation with respect to morbidity and mortality, as well as to changes in physical performance and physical activity. DESIGN:A total of 163 consecutive patients were enrolled for comprehensive cardiac rehabilitation (CCR) f...

journal_title：Swiss medical weekly

authors： Steinacker JM,Liu Y,Muche R,Koenig W,Hahmann H,Imhof A,Kropf C,Brandstetter S,Schweikert B,Leidl R,Schiefer DH

更新日期：2011-01-06 00:00:00

abstract：:Congenital tuberculosis was first suspected in a premature infant with patent ductus arteriosus (PDA), progressive respiratory distress and septic shock, when an enlarged mediastinal lymph node was noted intraoperatively at the time of PDA ligature. Culture revealed Mycobacterium tuberculosis. The asymptomatic mother ...

journal_title：Swiss medical weekly

authors： Stähelin-Massik J,Carrel T,Duppenthaler A,Zeilinger G,Gnehm HE

更新日期：2002-11-23 00:00:00

abstract：:HMG-CoA reductase inhibitors, or statins, are lipid-lowering agents that have been shown to effectively decrease severe rejection periods and development of transplant coronary artery disease after heart transplantation. Precise regulation of major histocompatibility complex class II (MHC class II) gene expression pla...

journal_title：Swiss medical weekly

authors： Kwak B,Mulhaupt F,Veillard N,Pelli G,Mach F

更新日期：2001-01-27 00:00:00

abstract：PRINCIPLES:Since the recommendation that infants sleep in the supine position, there has been an increase in cases of posterior positional plagiocephaly. Even though this condition is a purely cosmetic problem, if it is severe it may affect the child psychologically. Positioning may help in mild or moderate cases, but ...

journal_title：Swiss medical weekly

authors： de Ribaupierre S,Vernet O,Rilliet B,Cavin B,Kalina D,Leyvraz P-

更新日期：2007-06-30 00:00:00

abstract：OBJECTIVE:To assess outcomes 24 months after treatment start for multidrug-resistant tuberculosis (MDR-TB). METHODS:Cohort study of all culture-positive MDR-TB cases notified in Switzerland from 01/2003 to 07/2010. RESULTS:Fifty-one cases were observed, with a median age of 26 years (range 2-56). Twenty-seven were ma...

journal_title：Swiss medical weekly

authors： Helbling P,Altpeter E,Egger JM,Zellweger JP

更新日期：2014-12-04 00:00:00

abstract：BACKGROUND:Campylobacteriosis and salmonellosis are important foodborne diseases in Europe, including in Switzerland. In 2014, notification rates for Switzerland were 92.9 per 100 000 population for campylobacteriosis and 15.2 per 100 000 population for salmonellosis. These notification rates originate from laboratory-...

journal_title：Swiss medical weekly

authors： Bless PJ,Schmutz C,Sartori K,Mäusezahl D

更新日期：2017-12-27 00:00:00

abstract：OBJECTIVE:To assess the presence of Mycoplasma pneumoniae-associated encephalitis in children in Switzerland and its likely pathogenesis. METHODS:M. pneumoniae-associated encephalitis cases seen at a single-centre during 2010-2013 were reviewed, and the Swiss Paediatric Surveillance Unit (SPSU) prospectively conducted...

journal_title：Swiss medical weekly

authors： Meyer Sauteur PM,Moeller A,Relly C,Berger C,Plecko B,Nadal D,Swiss Pediatric Surveillance Unit (SPSU).

更新日期：2016-01-11 00:00:00

abstract：BACKGROUND:On 1 January 2012 Swiss Diagnosis Related Groups (DRG), a new uniform payment system for in-patients was introduced in Switzerland with the intention to replace a "cost-based" with a "case-based" reimbursement system to increase efficiency. With the introduction of the new payment system we aim to answer que...

journal_title：Swiss medical weekly

authors： Thommen D,Weissenberger N,Schuetz P,Mueller B,Reemts C,Holler T,Schifferli JA,Gerber M,Hug BL

更新日期：2014-06-25 00:00:00

abstract：QUESTION UNDER STUDY:Purpose was to validate accuracy and reliability of automated oscillometric ankle-brachial (ABI) measurement prospectively against the current gold standard of Doppler-assisted ABI determination. METHODS:Oscillometric ABI was measured in 50 consecutive patients with peripheral arterial disease (n ...

journal_title：Swiss medical weekly

authors： Diehm N,Dick F,Czuprin C,Lawall H,Baumgartner I,Diehm C

更新日期：2009-06-27 00:00:00

abstract：BACKGROUND:Endoscopic retrograde biliary drainage (ERBD) using a plastic stent is suggested to be as effective as endoscopic nasobiliary drainage (ENBD) with a nasobiliary catheter for temporary biliary drainage in acute obstructive cholangitis. However, there are few studies that have compared the two methods. We ther...

journal_title：Swiss medical weekly

authors： Zhang RL,Cheng L,Cai XB,Zhao H,Zhu F,Wan XJ

更新日期：2013-07-07 00:00:00

abstract：QUESTIONS UNDER STUDY:Teenage and young adult (TYA) cancer patients are faced with the diagnosis during a challenging period of psychosocial development that may affect social outcomes in the long term. Therefore, we aimed to: (1) determine differences in social outcomes between long-term TYA cancer survivors and healt...

journal_title：Swiss medical weekly

authors： Mader L,Vetsch J,Christen S,Baenziger J,Roser K,Dehler S,Michel G

更新日期：2017-03-07 00:00:00

abstract：AIMS OF THE STUDY:Premature discontinuation occurs in about 25% of randomised clinical trials in Switzerland; it mainly affects investigator-initiated trials and is mostly due to problems with recruitment of patients. The aim of this study was to qualitatively investigate reasons for trial discontinuation due to poor p...

journal_title：Swiss medical weekly

authors： Briel M,Elger B,von Elm E,Satalkar P

更新日期：2017-11-16 00:00:00

abstract：:Multicentric carpotarsal osteolysis (MCTO) is an autosomal dominant disease of the skeleton characterised by progressive destruction of carpal and tarsal bones. Recently, it has been demonstrated that this disease is caused by heterozygous mutations in the gene for the transcriptional repressor MAFB. We analysed genom...

journal_title：Swiss medical weekly

authors： Zhuang L,Adler S,Aeberli D,Villiger PM,Trueb B

更新日期：2017-10-27 00:00:00

abstract：BACKGROUND:Many antimicrobial stewardship programmes (ASPs) target the intensive care unit owing to high antimicrobial utilisation. In this review, we summarise and assess the quality of evidence supporting the implementation of various ASP strategies in the intensive care unit setting with a focus on publications betw...

journal_title：Swiss medical weekly

authors： Mertz D,Brooks A,Irfan N,Sung M

更新日期：2015-12-21 00:00:00

abstract：:The awareness of Cheyne-Stokes respiration (CSR) and of the co-existence of the obstructive sleep apnoea syndrome and central breathing disturbances has rapidly grown in recent years. CSR is defined by a waxing and waning pattern of the breathing amplitude. Sleep related breathing disorders in patients with heart fail...

journal_title：Swiss medical weekly

authors： Randerath WJ

更新日期：2009-03-07 00:00:00