Abstract:
BACKGROUND:Many antimicrobial stewardship programmes (ASPs) target the intensive care unit owing to high antimicrobial utilisation. In this review, we summarise and assess the quality of evidence supporting the implementation of various ASP strategies in the intensive care unit setting with a focus on publications between 2010 and 2015. METHODS:We searched Medline up to April 2015 and screened publications of interest for additional relevant articles. We grouped the strategies into four categories: audit and feedback, formulary restrictions, guidelines/clinical pathways, and procalcitonin. We used GRADE terminology to describe the quality of evidence. RESULTS AND CONCLUSIONS:We identified several studies reporting optimisation and reduction of antibiotic utilisation as well as cost reduction in all four strategies. Randomised controlled trials reviewing the role of procalcitonin demonstrate a moderate level of evidence. Given the lack of randomised controlled trials to support the role of guidelines, formulary restrictions, and audit and feedback, the level of evidence supporting these strategies is low. Importantly, there is no convincing evidence to support the main goal of ASP, namely to improve patient outcomes. Larger, rigorous long-term studies using a cluster randomised controlled trial or at least a controlled quasi-experimental design with time series are required to assess the impact of ASP on patient-important outcomes and on the emergence of resistance in the intensive care unit setting.
journal_name
Swiss Med Wklyjournal_title
Swiss medical weeklyauthors
Mertz D,Brooks A,Irfan N,Sung Mdoi
10.4414/smw.2015.14220subject
Has Abstractpub_date
2015-12-21 00:00:00pages
w14220eissn
1424-7860issn
1424-3997pii
smw-14220journal_volume
145pub_type
杂志文章,评审abstract::Prior to the introduction of chemotherapy, tuberculosis management relied upon aerotherapy, heliotherapy and good nutrition. This "treatment", exemplified by the regimen applied in Swiss and other European mountain resorts, is described by Thomas Mann in the book "The Magic Mountain". Tuberculosis chemotherapy began i...
journal_title:Swiss medical weekly
pub_type: 历史文章,杂志文章,评审
doi:10.4414/smw.2012.13665
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abstract::This article discusses communication challenges in end-of-life decision making and outlines strategies from an area of growing interest and research. ...
journal_title:Swiss medical weekly
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2004/25/smw-10322
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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