Abstract:
:The anti-inflammatory genes, haem oxygenase 1 (HO-1, HMOX1) rs2071746 (unrestricted model: p = 9.07 × 10-4; recessive model: p = 4.99 × 10-4; multiplicative model: p = 0.0009; and additive model: p = 1.87 × 10-4) and interleukin-10 (IL-10) rs1800872 (dominant model: p = 0.0277) have been associated with paediatric inflammatory bowel disease. The present family-based case-trio study (n = 52) examined HO-1 gene expression in the presence of proinflammatory lipopolysaccharide and tumour necrosis factor-alpha in four B lymphocyte cell lines established from children with inflammatory bowel disease and demonstrated that mutations in IL-10 and IL-10 receptor B reduced HO-1 messenger RNA expression. This observation supports our hypothesis that HO-1 is regulated by the IL-10/STAT3 pathway and that both genes (IL10 and STAT3) could be involved in the pathogenesis of inflammatory bowel disease. We also compared HO-1 expression in diseased intestinal tissues with adjacent normal tissues from adults with inflammatory bowel disease. Of the 17 Crohn's disease patients, HO-1 expression in diseased tissues was downregulated in 9 patients (53%) and of the 10 ulcerative colitis patients HO-1 was downregulated in 7 patients (70%), compared with adjacent normal tissues. The downregulation of HO-1 gene expression may lower anti-inflammatory effects and worsen tissue injury in affected areas by inflammatory bowel disease.
journal_name
Swiss Med Wklyjournal_title
Swiss medical weeklyauthors
Lin Z,Hao H,Hegarty JP,Lin TR,Wang Y,Harris LR,Xu HN,Wu R,Thomas NJ,Floros Jdoi
10.4414/smw.2017.14456subject
Has Abstractpub_date
2017-08-02 00:00:00pages
w14456eissn
1424-7860issn
1424-3997pii
smw-14456journal_volume
147pub_type
杂志文章abstract::The ex utero intrapartum treatment (EXIT) procedure is designed to guarantee sufficient oxygenation for a foetus at risk of airway obstruction. This is achieved by improving lung ventilation, usually by establishing an airway during caesarean delivery whilst preserving the foetal-placental circulation temporarily. Ind...
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journal_title:Swiss medical weekly
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doi:smw-12605
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doi:2003/37/smw-10367
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doi:2006/31/smw-11390
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pub_type: 杂志文章
doi:2004/33/smw-10599
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doi:/aop/smw-aop12294
更新日期:2008-11-15 00:00:00
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