Intensity of cytosol expression of 8-OHdG in normal renal tubules is associated with the severity of renal fibrosis.

abstract：BACKGROUND:Introduction of potent antiretroviral combination therapy (ART) has reduced overall morbidity and mortality amongst HIV-infected adults. Some prophylactic regimes against opportunistic infections can be discontinued in patients under successful ART. QUESTIONS UNDER STUDY:(1) The influence of the availabilit...

journal_title：Swiss medical weekly

authors： Rossi M,Flepp M,Telenti A,Schiffer V,Egloff N,Bucher H,Vernazza P,Bernasconi E,Weber R,Rickenbach M,Furrer H,Swiss HIV Cohort Study.

更新日期：2001-08-11 00:00:00

abstract：QUESTIONS UNDER STUDY:In Switzerland, skin cancer is one of the most prevalent neoplasms. General practitioners (GPs) are often faced with suspicious skin lesions in their patients. The aim of our study was to assess GPs' competence to diagnose skin cancer and to examine whether this can be improved by a one-day dermat...

journal_title：Swiss medical weekly

authors： Badertscher N,Braun RP,Held U,Kofmehl R,Senn O,Hofbauer GF,Rossi PO,Wensing M,Rosemann T,Tandjung R

更新日期：2013-07-29 00:00:00

abstract：PRINCIPLES:Data on associations between physical activity and gastroesophageal reflux disease (GERD) have been inconsistent. Although experimental and clinical studies prove that exercise increases gastroesophageal reflux, epidemiological observations on the relationship between GERD and everyday physical effort delive...

journal_title：Swiss medical weekly

authors： Jóźków P,Waśko-Czopnik D,Dunajska K,Medraś M,Paradowski L

更新日期：2007-08-25 00:00:00

abstract：:Each year, over 5 million people die worldwide from stroke, and at least every sixth patient who survives will experience another stroke within five years [1]. We are therefore eager to advance early and rapid diagnosis, prognosis and optimal risk stratification, as well as secondary prevention. In this context, blood...

journal_title：Swiss medical weekly

authors： Sonderer J,Katan Kahles M

更新日期：2015-05-29 00:00:00

abstract：BACKGROUND:Epidemiological studies focusing on first-ever seizures have been carried out mainly on community based populations. However, since hospital populations may display varying clinical features, we prospectively analysed patients with first-ever seizure in a hospital based community to evaluate prognosis and th...

journal_title：Swiss medical weekly

authors： Kawkabani A,Rossetti AO,Despland PA

更新日期：2004-10-02 00:00:00

abstract：BACKGROUND:In Switzerland, intravenous drug use accounts for the majority of hepatitis C virus (HCV) infections. Early HCV treatment prevents further transmissions and reduces morbidity and mortality due to decompensated liver cirrhosis and hepatocellular carcinoma. Nevertheless, patients in drug substitution programme...

journal_title：Swiss medical weekly

authors： Bregenzer A,Conen A,Knuchel J,Friedl A,Eigenmann F,Näf M,Ackle P,Roth M,Fux CA

更新日期：2017-11-20 00:00:00

abstract：PRINCIPLES:Analysis of the spatial distribution of mortality data is important for identification of high-risk areas, which in turn might guide prevention, and modify behaviour and health resources allocation. This study aimed to update the Swiss mortality atlas by analysing recent data using Bayesian statistical metho...

journal_title：Swiss medical weekly

authors： Chammartin F,Probst-Hensch N,Utzinger J,Vounatsou P

更新日期：2016-02-22 00:00:00

abstract：PRINCIPLES:A decrease in plasma lipids occurs during severe sepsis and has prognostic implications in critical illness. Whether lipids have prognostic implications or could help to differentiate community-acquired pneumonia from other lower respiratory tract infections remains unknown. METHODS:We analysed data from pa...

journal_title：Swiss medical weekly

authors： Gruber M,Christ-Crain M,Stolz D,Keller U,Müller C,Bingisser R,Tamm M,Mueller B,Schuetz P

更新日期：2009-03-21 00:00:00

abstract：OBJECTIVE:An increasing number of patients with asthma are attracted by complementary and alternative medicine (CAM). Therefore, it is of importance that scientific evidence about the efficacy of this type of therapy is regarded. METHOD:We searched the electronic databases Medline, Embase and the Cochrane Library for ...

journal_title：Swiss medical weekly

authors： Steurer-Stey C,Russi EW,Steurer J

更新日期：2002-06-29 00:00:00

abstract：PRINCIPLES:Current evidence indicates that chronic kidney disease (CKD) can be detected by simple laboratory tests. This study aimed to evaluate the cost-effectiveness of microalbuminuria screening and subsequent treatment in different populations. METHODS:Cost-effectiveness of microalbuminuria screening in a cohort o...

journal_title：Swiss medical weekly

authors： Kessler R,Keusch G,Szucs TD,Wittenborn JS,Hoerger TJ,Brügger U,Wieser S

更新日期：2012-02-03 00:00:00

abstract：OBJECTIVES:Body temperature (BT) was shown to have impact on outcome in several medical conditions. This study investigated the prognostic impact of BT in patients with acute heart failure (HF). DESIGN AND PATIENTS:The B-type natriuretic peptide for Acute Shortness of breath EvaLuation (BASEL) study prospectively enro...

journal_title：Swiss medical weekly

authors： Klima T,Schindler C,Christ M,Rosser A,Breidthardt T,Hochholzer W,Laule K,Mueller C

更新日期：2008-05-31 00:00:00

abstract：QUESTION UNDER STUDY:To evaluate the situation of Female Genital Mutilation (FGM) in Switzerland. METHODS:Through a questionnaire, Swiss gynaecologists were asked if they have been confronted to FGMs, if they have been asked to perform infibulations and FGMs. The health representatives (Kantonsärzte/médecins cantonaux...

journal_title：Swiss medical weekly

authors： Jäger F,Schulze S,Hohlfeld P

更新日期：2002-05-18 00:00:00

abstract：BACKGROUND:General practitioners (GPs) use diagnostic tests to help distinguish between viral and bacterial acute respiratory tract infections (ARTI). We investigated the prevalence of these tests, and how tests are associated with diagnosis, treatment and patient satisfaction. METHODS:As part of a clinical trial, 45 ...

journal_title：Swiss medical weekly

authors： Briel M,Young J,Tschudi P,Hersberger KE,Hugenschmidt C,Langewitz W,Bucher HC

更新日期：2006-04-15 00:00:00

abstract：BACKGROUND:With the increase of the organ shortage, several authors assume that financial incentives would improve organ donation rates and fill the unbalance between the demand and the organs available for transplant medicine. This line of argument has been criticised with people arguing that an exchange of money for ...

journal_title：Swiss medical weekly

authors： Bosisio F,Santiago M,Benaroyo L

更新日期：2011-12-09 00:00:00

abstract：:Perinatal care of pregnant women at high risk for preterm delivery and of preterm infants born at the limit of viability (22-26 completed weeks of gestation) requires a multidisciplinary approach by an experienced perinatal team. Limited precision in the determination of both gestational age and foetal weight, as well...

journal_title：Swiss medical weekly

authors： Berger TM,Bernet V,El Alama S,Fauchère JC,Hösli I,Irion O,Kind C,Latal B,Nelle M,Pfister RE,Surbek D,Truttmann AC,Wisser J,Zimmermann R

更新日期：2011-10-18 00:00:00

abstract：:Metallothioneins (MTs) are a family of small proteins containing 61-68 amino acids with an unusually high concentration of cysteine. MT-1, the most functional and active MT in humans, has the ability to react with and enhance the detoxification of a number of metals including zinc, mercury, copper and cadmium. MT dysf...

journal_title：Swiss medical weekly

authors： Russo AF

更新日期：2008-02-09 00:00:00

abstract：:In his 1966 monograph "Charcot joints", Sidney N. Eichenholtz (1909-2000) described "three well defined stages … in the course and development of a Charcot joint", based on plain X-rays of 68 patients. Since then, medical imaging has advanced very much: computed tomography and magnetic resonance imaging (MRI) scans ex...

journal_title：Swiss medical weekly

authors： Chantelau EA,Grützner G

更新日期：2014-04-24 00:00:00

abstract：QUESTIONS UNDER STUDY:This study aims at estimating the costs of disorders of the brain in Switzerland based on the published epidemiological and economic evidence. METHODS:the data presented for Switzerland are derived from the "cost of disorders of the brain in Europe" study of the European Brain Counsil (EBC). Avai...

journal_title：Swiss medical weekly

authors： Jäger M,Sobocki P,Rössler W

更新日期：2008-01-12 00:00:00

abstract：BACKGROUND:Renal replacement therapy for paediatric end-stage renal disease (ESRD) has developed steadily since its introduction five decades ago. Continuous and long-term analysis of patient outcomes is essential for quality control. METHODS:The Swiss Paediatric Renal Registry, founded in 1970, includes patients diag...

journal_title：Swiss medical weekly

authors： Maurer E,Neuhaus TJ,Weitz M,Kuehni CE,Laube GF

更新日期：2020-07-27 00:00:00

abstract：BACKGROUND:Although most experts recommend empirical antibiotic treatment, covering also atypical bacteria, for patients admitted to an intensive care unit (ICU), the data are not clear for patients admitted to a general ward. European guidelines recommend starting empirical treatment with a beta-lactam antibiotic with...

journal_title：Swiss medical weekly

authors： Piso RJ,Arnold C,Bassetti S

更新日期：2013-09-19 00:00:00

abstract：BACKGROUND:The pathogenesis of elevated blood pressure and other cardiovascular risk factors in the population and their progression over time is still incompletely understood, especially in young and healthy adults. METHODS:The genetic and phenotypic determinants of blood pressure and other cardiovascular risk factor...

journal_title：Swiss medical weekly

authors： Conen D,Schön T,Aeschbacher S,Paré G,Frehner W,Risch M,Risch L

更新日期：2013-01-08 00:00:00

abstract：:With regard to HCV elimination in opioid agonist therapy patients by 2030, case finding and regular screening for new and re-infections remain a challenge, especially for non-cohort patients in a decentralised setting. Documentation of the HCV sero- and RNA status of each opioid agonist therapy  patient by the ca...

journal_title：Swiss medical weekly

authors： Schürch S,Fux CA,Dehler S,Conen A,Knuchel J,Friedl A,Eigenmann F,Roser P,Ackle P,Bregenzer A

更新日期：2020-08-06 00:00:00

abstract：QUESTIONS UNDER STUDY:Postmenopausal women are more likely to develop coronary artery disease than premenopausal women of the same age. Postmenopausal oral oestrogen therapy is associated with increased levels of high-density lipoprotein (HDL) cholesterol and decreased levels of lowdensity lipoprotein (LDL) cholesterol...

journal_title：Swiss medical weekly

authors： Delibasi T,Kockar C,Celik A,Kockar O

更新日期：2006-08-05 00:00:00

abstract：OBJECTIVE:To measure medical care and pharmaceutical drug use among Swiss primary care physicians and its determinants. DESIGN:Cross-sectional mailed survey. SETTING:1784 randomly selected Swiss primary care physicians, including general practitioners, internists and paediatricians. RESULTS:Twenty one percent (95% C...

journal_title：Swiss medical weekly

authors： Schneider M,Bouvier Gallacchi M,Goehring C,Künzi B,Bovier PA

更新日期：2007-02-24 00:00:00

abstract：PURPOSE:To study the association between maternal smoking during pregnancy and low birth weight (LBW), small-for-gestational-age birth weight (SGA) and preterm birth, and to quantify the population-attributable fractions for these outcomes in Switzerland. METHODS:Data were gathered for all births in the Canton of Vaud...

journal_title：Swiss medical weekly

authors： Chiolero A,Bovet P,Paccaud F

更新日期：2005-09-03 00:00:00

abstract：BACKGROUND:Sarcoidosis is a disorder of unknown aetiology. Most patients have steroid-responsive disease, but side effects and steroid resistance may necessitate alternative treatments. Endothelin has in-vitro fibrogenic activity and the endothelin system is activated in sarcoidosis. OBJECTIVES:We studied the efficacy...

journal_title：Swiss medical weekly

authors： Hostettler K,Baty F,Kleiner R,Junker L,Tamm M,Brutsche M

更新日期：2018-10-28 00:00:00

abstract：BACKGROUND:In 2005, findings of the first "cost of disorders of the brain in Europe" study of the European Brain Council (EBC) showed that these costs cause a substantial economic burden to the Swiss society. In 2010 an improved update with a broader range of disorders has been analysed. This report shows the new findi...

journal_title：Swiss medical weekly

authors： Maercker A,Perkonigg A,Preisig M,Schaller K,Weller M,Cost of Disorders of the Brain in Europe Study Group.

更新日期：2013-01-07 00:00:00

abstract：BACKGROUND:B-type natriuretic peptide (BNP) has been proven to be a biochemical marker of severity of congestive heart failure. We are aware of only few papers reporting the association of BNP elevation and pulmonary hypertension (primary, thromboembolic, or as a consequence of chronic obstructive pulmonary disease). L...

journal_title：Swiss medical weekly

authors： Maeder M,Ammann P,Rickli H,Diethelm M

更新日期：2003-09-26 00:00:00

abstract：QUESTIONS UNDER STUDY:To evaluate the diagnostic value of serum Cystatin C and urine neutrophil gelatinase-associated lipocalin (NGAL) for the detection of acute kidney injury in patients undergoing congenital heart surgery. METHODS:Serial samples of serum Cystatin C and urine NGAL were collected from 139 consecutive ...

journal_title：Swiss medical weekly

authors： Seitz S,Rauh M,Gloeckler M,Cesnjevar R,Dittrich S,Koch AM

更新日期：2013-01-17 00:00:00

abstract：:Osteoporosis is complicated by the occurrence of fragility fractures. Over past years, various treatment options have become available, mostly potent antiresorptive agents such as bisphosphonates and denosumab. However, antiresorptive therapy cannot fully and rapidly restore bone mass and structure that has been lost ...

journal_title：Swiss medical weekly

authors： Meier C,Lamy O,Krieg MA,Mellinghoff HU,Felder M,Ferrari S,Rizzoli R

更新日期：2014-06-04 00:00:00