Anti-metallothionein IgG and levels of metallothionein in autistic families.

Abstract:

:Metallothioneins (MTs) are a family of small proteins containing 61-68 amino acids with an unusually high concentration of cysteine. MT-1, the most functional and active MT in humans, has the ability to react with and enhance the detoxification of a number of metals including zinc, mercury, copper and cadmium. MT dysfunction may result, then, in many of the aetiological syndromes observed in autistic children, such as the leaky gut. It has been proposed that allergic autoimmune reactions occurring after exposure to heavy metals, may contribute to some symptoms associated with autism. Therefore abnormalities in MT concentration and/or structure, as well as the presence of anti-MT antibodies, may be associated with autism. We used direct ELISAs to quantitate the concentration of serum anti-metallothionein IgG in 66 individuals (parents and children) from 14 families with autistic children, as well as 11 controls from families with no history of autism. We measured the concentration of serum metallothionein in 39 of the above family members from 8 families. Our results indicate that a significantly high number (23 of 66) of autistic family members had high levels of anti-metallothionein IgG, when compared to controls (1 ) and the production of these antibodies correlated with levels of metallothionein, suggesting that the production of these antibodies is inherited. However, the presence of these antibodies does not correlate with autism, types of autism, including regression, or demographics such as allergies, respiratory problems or GI disease. This suggests that the presence of anti-metallothionein antibodies is not causative to autism and may be the result of other immunological pathology seen in many autistics.

journal_name

Swiss Med Wkly

journal_title

Swiss medical weekly

authors

Russo AF

subject

Has Abstract

pub_date

2008-02-09 00:00:00

pages

70-7

issue

5-6

eissn

1424-7860

issn

1424-3997

journal_volume

138

pub_type

杂志文章
  • Cerebral vasculitis complicating postoperative meningitis: the role of steroids revisited.

    abstract::Meningitis due to Streptococcus pneumoniae is a rare complication of trans-sphenoidal surgery. We present the case of a patient who developed pneumococcal meningitis with associated bacteraemia after elective endoscopic trans-sphenoidal resection of a pituitary macro-adenoma. After initial treatment with ceftriaxone a...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2012.13697

    authors: Darling KE,Niederhauser J,Bervini D,Giulieri S,Daniel RT,Bille J,Erard V

    更新日期:2012-10-29 00:00:00

  • Stent placement in the endovascular treatment of intracranial aneurysms.

    abstract:OBJECTIVE:To analyze the immediate and midterm angiographic and clinical results of stent placement in the endovascular treatment of intracranial cerebral aneurysms. METHODS:Out of 330 cerebral aneurysms treated by endovascular approach in our neurovascular centre, stents have been used in 18 patients. Twelve aneurysm...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:2008/43/smw-12396

    authors: Mordasini P,Walser A,Gralla J,Wiest R,Ozdoba C,Reinert M,Schroth G

    更新日期:2008-11-01 00:00:00

  • Diagnosis of mild bleeding disorders.

    abstract::The precise diagnosis of a severe haemorrhagic disorder is usually not too problematic. However, physicians are most often faced with individuals consulting for mild haemorrhagic symptoms, particularly occurring after a surgical intervention. The problem here is to evaluate whether this person really has a bleeding di...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:smw-12476

    authors: de Moerloose P,Levrat E,Fontana P,Boehlen F

    更新日期:2009-06-13 00:00:00

  • Intensive care without walls - introduction of a Medical Emergency Team system in a Swiss tertiary care centre.

    abstract:QUESTIONS UNDER STUDY:To improve the response of deteriorating patients during their hospital stay, the University Hospital Bern has introduced a Medical Emergency Team (MET). Aim of this retrospective cohort study is to review the preceding factors, patient characteristics, process parameters and their correlation to ...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2014.14027

    authors: Etter R,Takala J,Merz TM

    更新日期:2014-10-08 00:00:00

  • Arrhythmias in patients with surgically treated atrial septal defects.

    abstract::Atrial arrhythmias complicate the clinical course of adult patients with an atrial septal defect. Atrial flutter is more prevalent in younger patients, and frequently regresses after surgical defect closure. Atrial fibrillation however, which results from a chronic underlying disease, rarely reverts to sinus rhythm af...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:2005/11/smw-10926

    authors: Berger F,Vogel M,Kretschmar O,Dave H,Prêtre R,Dodge-Khatami A

    更新日期:2005-03-19 00:00:00

  • Planning ahead with dementia: what role can advance care planning play? A review on opportunities and challenges.

    abstract::Advance directives emerged in the 1960s with the goal of empowering people to exert control over their future medical decisions. However, it has become apparent, over recent years, that advance directives do not sufficiently capture the temporal and relational aspects of planning treatment and care. Advance care plann...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:10.4414/smw.2018.14706

    authors: Bosisio F,Jox RJ,Jones L,Rubli Truchard E

    更新日期:2018-12-30 00:00:00

  • Head-to-head comparison of length of stay, patients' outcome and satisfaction in Switzerland before and after SwissDRG-Implementation in 2012 in 2012: an observational study in two tertiary university centers.

    abstract:BACKGROUND:On 1 January 2012 Swiss Diagnosis Related Groups (DRG), a new uniform payment system for in-patients was introduced in Switzerland with the intention to replace a "cost-based" with a "case-based" reimbursement system to increase efficiency. With the introduction of the new payment system we aim to answer que...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2014.13972

    authors: Thommen D,Weissenberger N,Schuetz P,Mueller B,Reemts C,Holler T,Schifferli JA,Gerber M,Hug BL

    更新日期:2014-06-25 00:00:00

  • Ultrasonographic assessment of the morphological characteristics of the carotid plaque.

    abstract::Apart from the degree of stenosis, plaque morphology has emerged in recent years as an important contributory factor in stroke risk. Ultrasound studies have shown that hypo- or anechogenic plaques carry a higher risk of cerebrovascular events than echogenic ones. Similarly, heterogeneous plaques presenting a complex p...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:2005/43/smw-11038

    authors: Sztajzel R

    更新日期:2005-10-29 00:00:00

  • Systematic review of pneumothoraces after endoscopic retrograde cholangiopancreatography.

    abstract:AIMS OF THE STUDY:Pneumothoraces after endoscopic retrograde cholangiopancreatography (ERCP) are an uncommon but potentially lethal complication. Little evidence is available on their epidemiology, diagnosis and therapy. We aimed to evaluate current practices and provide recommendations. METHOD:We systematically revie...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2020.20199

    authors: Lehmann V,Keller W,Egger B

    更新日期:2020-04-03 00:00:00

  • Education, employment and marriage in long-term survivors of teenage and young adult cancer compared with healthy controls.

    abstract:QUESTIONS UNDER STUDY:Teenage and young adult (TYA) cancer patients are faced with the diagnosis during a challenging period of psychosocial development that may affect social outcomes in the long term. Therefore, we aimed to: (1) determine differences in social outcomes between long-term TYA cancer survivors and healt...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2017.14419

    authors: Mader L,Vetsch J,Christen S,Baenziger J,Roser K,Dehler S,Michel G

    更新日期:2017-03-07 00:00:00

  • Can geriatric approaches support the care of old patients in emergency departments? A review from a Swiss ED.

    abstract::In the coming decades, old patients will account for an increasing proportion of emergency department (ED) visits. During or after their stay in the ED, they more frequently suffer adverse outcomes than younger patients. There is evidence that specific age-centred approaches improve the outcomes. We therefore reviewed...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:10.4414/smw.2014.14040

    authors: Schoenenberger AW,Exadaktylos AK

    更新日期:2014-12-04 00:00:00

  • Health economic modelling of the cost-effectiveness of microalbuminuria screening in Switzerland.

    abstract:PRINCIPLES:Current evidence indicates that chronic kidney disease (CKD) can be detected by simple laboratory tests. This study aimed to evaluate the cost-effectiveness of microalbuminuria screening and subsequent treatment in different populations. METHODS:Cost-effectiveness of microalbuminuria screening in a cohort o...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2012.13508

    authors: Kessler R,Keusch G,Szucs TD,Wittenborn JS,Hoerger TJ,Brügger U,Wieser S

    更新日期:2012-02-03 00:00:00

  • Mycobacterium bohemicum--a cause of paediatric cervical lymphadenitis.

    abstract::We report on two toddlers suffering from Mycobacterium bohemicum lymphadenitis. Acid-fast bacilli were cultured from submandibular lymph nodes and identified by molecular methods as Mycobacterium bohemicum. Surgical treatment was successful and complemented by oral treatment with clarithromycin and rifampicin. ...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:2004/15/smw-10558

    authors: Schulzke S,Adler H,Bär G,Heininger U,Hammer J

    更新日期:2004-04-17 00:00:00

  • Injuries in agriculture--injury severity and mortality.

    abstract:PRINCIPALS:Accidents in agriculture are a problem of global importance. The hazards of working in agriculture are manifold (machines, animals, heights). We therefore assessed injury severity and mortality from accidents in farming. METHODS:We retrospectively analysed all farming accidents treated over a 12-year period...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2013.13846

    authors: Pfortmueller CA,Kradolfer D,Kunz M,Lehmann B,Lindner G,Exadaktylos A

    更新日期:2013-08-27 00:00:00

  • Dementia with lewy bodies--diagnosis and treatment.

    abstract::Dementia with Lewy bodies (DLB) accounts for 15-20% of all autopsy confirmed dementias in old age. Characteristic histopathological changes are intracellular Lewy bodies and Lewy neurites, with abundant senile plaques but sparse neurofibrillary tangles. Core clinical features are fluctuating cognitive impairment, pers...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:2003/09/smw-10028

    authors: Mosimann UP,McKeith IG

    更新日期:2003-03-08 00:00:00

  • Flattening the curve in 52 days: characterisation of the COVID-19 pandemic in the Principality of Liechtenstein - an observational study.

    abstract:BACKGROUND:The principality of Liechtenstein had its first COVID-19 case at the beginning of March 2020. After exponential growth, the pandemic’s first wave was contained, with the last case being diagnosed 52 days after the initial occurrence. AIM:To characterise the COVID-19 pandemic in Liechtenstein. METHODS...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2020.20361

    authors: Thiel SL,Weber MC,Risch L,Wohlwend N,Lung T,Hillmann D,Ritzler M,Risch M,Kohler P,Vernazza P,Kahlert CR,Fleisch F,Cusini A,Karajan TV,Copeland S,Paprotny M

    更新日期:2020-10-16 00:00:00

  • Molecular determinants for amyloid fibril formation: lessons from lung surfactant protein C.

    abstract::Amyloid fibrils are polymers composed of proteins in beta-sheet conformation, which are found in at least 20 diseases for which no cure is available. These diseases include Alzheimer's disease and spongiform encephalopathies, in which the amyloid beta-peptide and the prion protein (PrP), respectively, form amyloid. Al...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:2003/19/smw-09987

    authors: Johansson J

    更新日期:2003-05-17 00:00:00

  • Evidence for prevention and screening: recommendations in adults.

    abstract::A growing body of evidence supports preventive interventions in asymptomatic adults. Primary prevention, which includes counselling (in particular for smoking cessation) and review of immunisation status, has been shown to be more cost-effective than secondary prevention. Evidence supports screening for hypertension, ...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:2002/27/smw-09920

    authors: Hengstler P,Battegay E,Cornuz J,Bucher H,Battegay M

    更新日期:2002-07-13 00:00:00

  • The effect of intra-articular injection of Diprospan at the knee joint on the hypothalamic-pituitary-adrenal axis.

    abstract:QUESTIONS UNDER STUDY:In this work we wanted to evaluate the effect of intra-articular injection (IAI) at the knee joint of 1 ml of Diprospan on the hypothalamic-pituitary-adrenal (HPA) axis. METHODS:Consecutive patients attending the rheumatology or orthopaedic clinic with osteoarthritic knee pain not responding sati...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2015.14134

    authors: Habib G,Zahran R,Najjar R,Badarny S,Jabbour A,Artul S,Hakim G,Jabaly-Habib H

    更新日期:2015-05-21 00:00:00

  • 31 years of lung cancer in the canton of Zurich, Switzerland: incidence trends by sex, histology and laterality.

    abstract:QUESTIONS UNDER STUDY:Lung cancer belongs to the most common cancers in Switzerland. We examined trends in lung cancer incidence, with focus on sex, histology and laterality, in the Canton of Zurich since 1980. MATERIAL AND METHODS:Registry data consisting of 16 798 lung cancer cases from 1980 to 2010 were analysed. C...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2016.14327

    authors: Oberli LS,Valeri F,Korol D,Rohrmann S,Dehler S

    更新日期:2016-07-11 00:00:00

  • Gender and the relationship between traumatic childhood experiences and pain in adulthood.

    abstract:OBJECTIVES AND METHODS:Gender differences regarding 17 childhood experiences, thought to have traumatising potential (Traumatic Childhood Experiences = TCE), and pain behaviour in adulthood were assessed using a self-administered, anonymously filled-out questionnaire. Patients were consecutively accrued in the offices ...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:2006/39/smw-11357

    authors: Unternährer I,Minder CE,Adler RH

    更新日期:2006-09-30 00:00:00

  • TNF-alpha blockers in inflammatory bowel diseases: practical consensus recommendations and a user's guide.

    abstract::More than seventy years after their initial characterisation, the aetiology of inflammatory bowel diseases remains elusive. A recent review evaluating the incidence trends of the last 25 years concluded that an increasing incidence has been observed almost worldwide. A north-south gradient is still found in Europe. Ge...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:smw-12549

    authors: Pache I,Rogler G,Felley C

    更新日期:2009-05-16 00:00:00

  • Preventing HIV transmission through blockade of CCR5: rationale, progress and perspectives.

    abstract::Of the two million people estimated to be newly infected with human immunodeficiency virus (HIV) every year, 95% live in poorer regions of the world where effective HIV treatment is not universally available. Strategies to reduce the spread of HIV infection, which predominantly occurs via sexual contact, are urgently ...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2018.14580

    authors: Hartley O,Martins E,Scurci I

    更新日期:2018-01-26 00:00:00

  • High rate of completion of preventive therapy for latent tuberculosis infection among asylum seekers in a Swiss Canton.

    abstract:BACKGROUND:Preventive treatment may avoid future cases of tuberculosis among asylum seekers. The effectiveness of preventive treatment depends in large part on treatment completion. METHODS:In a prospective cohort study, asylum seekers of two of the Swiss Canton Vaud migration centres were screened with the Interferon...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2013.13860

    authors: Sarivalasis A,Bodenmann P,Langenskiold E,Lutchmaya-Flick C,Daher O,Zellweger JP

    更新日期:2013-09-06 00:00:00

  • Gestational age-adapted oxygen saturation targeting and outcome of extremely low gestational age neonates (ELGANs).

    abstract:QUESTIONS UNDER STUDY:Optimal oxygen saturation (SpO2) targets for extremely low gestational age neonates (ELGANs, gestational age [GA] <28 weeks) are unknown. Conflicting results from five recently published multicentre trials, which randomised ELGANs to high (91 to 95%) or low (85 to 89%) SpO2 targets from birth up t...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2015.14197

    authors: Hergenhan A,Steurer M,Berger TM

    更新日期:2015-11-02 00:00:00

  • Procalcitonin: how a hormone became a marker and mediator of sepsis.

    abstract::Calcitonin was discovered in the early 1960s [1], at which time it was assumed to be a single hormone with a yet-to-be-determined role in human physiology. Since then it has been found to be only one entity among a large array of related circulating peptides, at least one of which has a pivotal role in the host respon...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:2001/41/smw-09751

    authors: Müller B,Becker KL

    更新日期:2001-10-20 00:00:00

  • Endoscopy teams' judgment of discomfort among patients undergoing colonoscopy: "How bad was it really?".

    abstract:QUESTIONS UNDER STUDY / PRINCIPLES:Colonoscopies are complex procedures that depend greatly on the patient's cooperation and on the correct judgment of a tolerable amount of discomfort by the endoscopy team, even in sedated patients. Little is known regarding the accuracy of the patient comfort level assessments made b...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2012.13726

    authors: Heuss LT,Sughanda SP,Degen LP

    更新日期:2012-11-05 00:00:00

  • A report of ten patients with thyroid hemiagenesis: ultrasound screening in patients with thyroid disease.

    abstract:BACKGROUND:Thyroid hemiagenesis (TH) is a rare congenital abnormality of the thyroid gland, characterised by the absence of one lobe. The true prevalence of this congenital abnormality is not known because the absence of one thyroid lobe usually does not cause clinical symptoms by itself. This study aims to identify th...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:smw-12956

    authors: Berker D,Ozuguz U,Isik S,Aydin Y,Ates Tutuncu Y,Akbaba G,Guler S

    更新日期:2010-02-20 00:00:00

  • Lung transplantation for COPD - evidence-based?

    abstract::Lung transplantation has now been performed for more than 30 years in patients with end-stage chronic obstructive pulmonary disease (COPD). This disease is the major indication for lung transplantation, involving more than one third of the procedures worldwide. Although lung transplantation in COPD patients has clearl...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:smw-12377

    authors: Lahzami S,Aubert JD

    更新日期:2009-01-10 00:00:00

  • Screening for delirium with the Intensive Care Delirium Screening Checklist (ICDSC): a re-evaluation of the threshold for delirium.

    abstract:BACKGROUND:With its high incidence and subsequent adverse consequences in the intensive care setting, several instruments have been developed to screen for and detect delirium. One of the more commonly used is the Intensive Care Delirium Screening Checklist (ICDSC); however, the optimal cut-off score indicating deliriu...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2018.14597

    authors: Boettger S,Garcia Nuñez D,Meyer R,Richter A,Rudiger A,Schubert M,Jenewein J

    更新日期:2018-03-14 00:00:00