Molecular determinants for amyloid fibril formation: lessons from lung surfactant protein C.

Abstract:

:Amyloid fibrils are polymers composed of proteins in beta-sheet conformation, which are found in at least 20 diseases for which no cure is available. These diseases include Alzheimer's disease and spongiform encephalopathies, in which the amyloid beta-peptide and the prion protein (PrP), respectively, form amyloid. All fibrils are morphologically very similar although the native structures of the corresponding proteins are widely different. Proteins that are not known to form fibrils in vivo can do so under conditions where unfolding intermediates are well populated. This indicates that fibril formation can arise from most, if not all, polypeptide chains under certain conditions, and that nature has found ways to avoid fibrillogenic protein conformations. In support of this, it was recently found that unpaired beta-strands present in native proteins are prevented from forming intermolecular beta-sheets, by strategic placement of prolines and charged residues for example. Structural studies of the lung surfactant-associated protein C (SP-C) have revealed determinants for amyloid fibril formation. The poly-valine alpha-helix of SP-C spontaneously converts to beta-sheet aggregates in vitro and SP-C amyloid fibrils are found in pulmonary alveolar proteinosis. A beta, PrP, and SP-C harbour an alpha-helix which is strongly predicted to form a beta-strand, and in all cases investigated so far such alpha-helix/beta-sheet discordance correlates with the ability to form beta-sheet aggregates and fibrils.

journal_name

Swiss Med Wkly

journal_title

Swiss medical weekly

authors

Johansson J

doi

2003/19/smw-09987

keywords:

subject

Has Abstract

pub_date

2003-05-17 00:00:00

pages

275-82

issue

19-20

eissn

1424-7860

issn

1424-3997

pii

smw-09987

journal_volume

133

pub_type

杂志文章,评审
  • Vulnerability to relapse under stress: insights from affective neuroscience.

    abstract::In this review article, we aim at analysing the role of stress in addiction and relapse. In order to do so, we first offer a summary of the findings from affective neuroscience trying to understand compulsive reward-seeking behaviours. These behaviours are characterised by an imbalance between the considerable amount ...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:10.4414/smw.2019.20151

    authors: Pool ER,Sander D

    更新日期:2019-11-29 00:00:00

  • Arrhythmias in patients with surgically treated atrial septal defects.

    abstract::Atrial arrhythmias complicate the clinical course of adult patients with an atrial septal defect. Atrial flutter is more prevalent in younger patients, and frequently regresses after surgical defect closure. Atrial fibrillation however, which results from a chronic underlying disease, rarely reverts to sinus rhythm af...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:2005/11/smw-10926

    authors: Berger F,Vogel M,Kretschmar O,Dave H,Prêtre R,Dodge-Khatami A

    更新日期:2005-03-19 00:00:00

  • Contraception and sexuality after termination of pregnancy: a comparison between Lugano and Geneva.

    abstract:OBJECTIVE:To evaluate the impact of a voluntary termination of pregnancy (TOP) on contraceptive practice and sexual well-being in women. STUDY DESIGN AND METHODS:Comparative evaluation of a retrospective study conducted in Lugano in 1995 with 85 women interviewed 3-6 months post-TOP, and a prospective study carried ou...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:2001/35/smw-09768

    authors: Bianchi-Demicheli F,Perrin E,Lüdicke F,Campana A

    更新日期:2001-09-08 00:00:00

  • Fibroblasts as therapeutic targets in rheumatoid arthritis and cancer.

    abstract::Rheumatoid arthritis is a common chronic inflammatory disease that causes progressive synovial inflammation resulting in irreversible joint destruction, chronic disability and premature mortality. Although it is recognised that in rheumatoid arthritis, inflammation and its persistence result from complex interactions ...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:10.4414/smw.2012.13529

    authors: Juarez M,Filer A,Buckley CD

    更新日期:2012-02-24 00:00:00

  • Satisfaction of patients on chronic haemodialysis and peritoneal dialysis.

    abstract:BACKGROUND:In contrast to quality of life, patient satisfaction on chronic haemodialysis (HD) and peritoneal dialysis (PD) has only rarely been studied. PATIENTS AND METHODS:All chronic HD and PD patients of the 19 centres located in western Switzerland were asked to complete a specific questionnaire, assessing dialys...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,多中心研究

    doi:2006/13/smw-11180

    authors: Wasserfallen JB,Moinat M,Halabi G,Saudan P,Perneger T,Feldman HI,Martin PY,Wauters JP

    更新日期:2006-04-01 00:00:00

  • A new sexually transmitted infection (STI) in Geneva? Ciprofloxacin-resistant Neisseria gonorrhoeae, 2002-2005.

    abstract:PRINCIPLES:Neisseria gonorrhoeae (NG) resistant to ciprofloxacin (CR) was documented for the first time in Geneva in 2002 and increased from 7% that year to 47% in 2005. We describe NG cases during this period and compare characteristics of CR and ciprofloxacin susceptible (CS) cases. METHOD:Geneva microbiological lab...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:2008/15/smw-12029

    authors: Le Lin B,Pastore R,Liassine N,Aramburu C,Sudre P

    更新日期:2008-04-19 00:00:00

  • Device-less patent foramen ovale closure by radiofrequency thermal energy.

    abstract:UNLABELLED:The goal of this study was to assess the feasibility, safety and success of a system which uses radiofrequency energy (RFE) rather than a device for percutaneous closure of patent foramen ovale (PFO). METHODS:Sixteen patients (10 men, 6 women, mean age 50 years) were included in the study. All of them had a...

    journal_title:Swiss medical weekly

    pub_type: 临床试验,杂志文章

    doi:2008/07/smw-12182

    authors: Walpoth NB,Habermacher K,Moarof I,Watson S,Wahl A,Windecker S,Schönenberger C,Meier B

    更新日期:2008-02-23 00:00:00

  • A stepwise drug treatment algorithm to obtain complete remission in depression: a Geneva study.

    abstract:QUESTIONS UNDER STUDY/PRINCIPLES:We describe the proportion of severely depressed outpatients reaching complete remission at the different stages of a drug treatment algorithm. We compare several treatment options for SSRI (selective serotonin reuptake inhibitor) non-responders and test the feasibility of the algorithm...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:2006/05/smw-11267

    authors: Bondolfi G,Aubry JM,Golaz J,Gex-Fabry M,Gervasoni N,Bertschy G

    更新日期:2006-02-04 00:00:00

  • Symptom assessment in lumbar stenosis/spondylolysis - patient questionnaire versus physician chart.

    abstract:BACKGROUND:The precision of symptom assessment and documentation in daily routine is unknown. Differences in hip studies have been observed between the charts and the patient questionnaires. This was the reason to perform this study and to compare the charts and the patient questionnaires. METHODS:This was a retrospec...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:smw-12581

    authors: Huber JF,Dabis E,Huesler J,Ruflin GB

    更新日期:2009-10-17 00:00:00

  • Diagnosis of mild bleeding disorders.

    abstract::The precise diagnosis of a severe haemorrhagic disorder is usually not too problematic. However, physicians are most often faced with individuals consulting for mild haemorrhagic symptoms, particularly occurring after a surgical intervention. The problem here is to evaluate whether this person really has a bleeding di...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:smw-12476

    authors: de Moerloose P,Levrat E,Fontana P,Boehlen F

    更新日期:2009-06-13 00:00:00

  • LDL size: does it matter?

    abstract::The atherogenic lipoprotein phenotype is characterised by a moderate increase in plasma triglycerides, a decrease in high density lipoprotein cholesterol and the prevalence of smaller denser low density lipoprotein particles. The prevalence of this partially inheritable phenotype is approximately 30% and is a feature ...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:2004/49/smw-10813

    authors: Berneis K,Rizzo M

    更新日期:2004-12-18 00:00:00

  • Termination of pregnancy in a border region between Switzerland and Italy (2008-2015).

    abstract::In Switzerland, voluntary termination of pregnancy (VTP) can be performed in all public and private hospitals with an obstetrics/gynaecology department. For various reasons, many Italian women use the Swiss healthcare system, in particular in Canton Ticino, a border region adjacent to Italy in the southern part of Swi...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2018.14636

    authors: Reinholz D,Casati S,Beretta O,Merlani G

    更新日期:2018-07-09 00:00:00

  • Proteostasis: bad news and good news from the endoplasmic reticulum.

    abstract::The endoplasmic reticulum (ER) is an intracellular compartment dedicated to the synthesis and maturation of secretory and membrane proteins, totalling about 30% of the total eukaryotic cells proteome. The capacity to produce correctly folded polypeptides and to transport them to their correct intra- or extracellular d...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:10.4414/smw.2014.14001

    authors: Noack J,Brambilla Pisoni G,Molinari M

    更新日期:2014-08-21 00:00:00

  • Antifungal chemotherapy: advances and perspectives.

    abstract::Invasive fungal infections have emerged as important causes of morbidity and mortality in immunocompromised patients. In response to this challenge, the field of antifungal chemotherapy has considerably expanded. Fluconazole and itraconazole, introduced in the late 1980s, were the first durably useful alternatives to ...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:2002/23/smw-09729

    authors: Groll AH,Walsh TJ

    更新日期:2002-06-15 00:00:00

  • Education, employment and marriage in long-term survivors of teenage and young adult cancer compared with healthy controls.

    abstract:QUESTIONS UNDER STUDY:Teenage and young adult (TYA) cancer patients are faced with the diagnosis during a challenging period of psychosocial development that may affect social outcomes in the long term. Therefore, we aimed to: (1) determine differences in social outcomes between long-term TYA cancer survivors and healt...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2017.14419

    authors: Mader L,Vetsch J,Christen S,Baenziger J,Roser K,Dehler S,Michel G

    更新日期:2017-03-07 00:00:00

  • Comparison of the safety and effectiveness of endoscopic biliary decompression by nasobiliary catheter and plastic stent placement in acute obstructive cholangitis.

    abstract:BACKGROUND:Endoscopic retrograde biliary drainage (ERBD) using a plastic stent is suggested to be as effective as endoscopic nasobiliary drainage (ENBD) with a nasobiliary catheter for temporary biliary drainage in acute obstructive cholangitis. However, there are few studies that have compared the two methods. We ther...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,随机对照试验

    doi:10.4414/smw.2013.13823

    authors: Zhang RL,Cheng L,Cai XB,Zhao H,Zhu F,Wan XJ

    更新日期:2013-07-07 00:00:00

  • Fast tracking in liver transplantation. Immediate postoperative tracheal extubation: feasibility and clinical impact.

    abstract::Increased survival rates after orthotopic liver transplantation (OLT) in patients with end-stage liver disease have become possible due to an advanced understanding of the pathophysiology of liver disease, the establishment of multiorgan procurement and preservation techniques, and the development of safer and more po...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:2007/13/smw-11681

    authors: Glanemann M,Busch T,Neuhaus P,Kaisers U

    更新日期:2007-04-07 00:00:00

  • Hepatitis delta in Switzerland: a silent epidemic.

    abstract:OBJECTIVES:The sero-prevalence of co-infection with the hepatitis B virus (HBV) and the hepatitis D virus (HDV) is well known in many European countries, starting from 6.8% in Germany to more than 27% in some Turkish areas. To gain a better description of this infection in Switzerland, and to characterise those affecte...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2011.13176

    authors: Genné D,Rossi I

    更新日期:2011-03-18 00:00:00

  • Giant cell arteritis--a changing entity.

    abstract::Giant cell arteritis (GCA) is the most common of the vasculitis syndromes and, being a disease of the elderly, its incidence is increasing with the general ageing of the population. GCA is most feared for its early complications, namely blindness and stroke, resulting from inflammation and subsequent occlusion of ocul...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:10.4414/smw.2011.13272

    authors: Kesten F,Aschwanden M,Gubser P,Glatz K,Daikeler T,Hess C

    更新日期:2011-09-28 00:00:00

  • Heart failure clinic in a community hospital improves outcome in heart failure patients.

    abstract:PRINCIPLES:Heart failure is associated with a grim prognosis. Disease management programmes can improve prognosis in heart failure patients but the applicability to the general population remains limited. We aimed to compare the outcome, pharmacological therapy, and quality of life in unselected heart failure patients ...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:2006/17/smw-11274

    authors: Lainscak M,Keber I

    更新日期:2006-04-29 00:00:00

  • Transition to postgraduate practice: perceptions of preparedness and experience of the daily work of junior residents.

    abstract:BACKGROUND:The transition from undergraduate to postgraduate training is a crucial career step for physicians. Several international studies have shown that graduates feel insufficiently prepared to perform various aspects of clinical practice. The publication of a national framework for undergraduate medical education...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2020.20370

    authors: Monti M,Brunet L,Michaud PA

    更新日期:2020-11-24 00:00:00

  • Treatment outcomes of multidrug-resistant tuberculosis in Switzerland.

    abstract:OBJECTIVE:To assess outcomes 24 months after treatment start for multidrug-resistant tuberculosis (MDR-TB). METHODS:Cohort study of all culture-positive MDR-TB cases notified in Switzerland from 01/2003 to 07/2010. RESULTS:Fifty-one cases were observed, with a median age of 26 years (range 2-56). Twenty-seven were ma...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2014.14053

    authors: Helbling P,Altpeter E,Egger JM,Zellweger JP

    更新日期:2014-12-04 00:00:00

  • Social, cultural and experiential patterning of attitudes and behaviour towards assisted suicide in Switzerland: evidence from a national population-based study.

    abstract::Switzerland has the longest history of the legal practice of non-physician assisted suicide of any country. Assisted suicide is not very tightly regulated in Switzerland, and almost all assisted suicides are supported by a right-to-die organisation. Our study investigates older adults’ attitudes and behaviour to...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2020.20275

    authors: Vilpert S,Bolliger E,Borrat-Besson C,Borasio GD,Maurer J

    更新日期:2020-07-01 00:00:00

  • Individualised nutritional support in medical inpatients - a practical guideline.

    abstract::Malnutrition has been defined as a “state resulting from lack of uptake or intake of nutrition, leading to altered body composition and body cell mass, as well as to diminished physical and mental function and impaired clinical outcome from disease.” Particularly for the multimorbid medical inpatient, ther...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2020.20204

    authors: Baumgartner A,Kägi-Braun N,Tribolet P,Gomes F,Stanga Z,Schuetz P

    更新日期:2020-04-15 00:00:00

  • Carbon nanotubes: an insight into the mechanisms of their potential genotoxicity.

    abstract::After the health catastrophe resulting from the widespread use of asbestos which was once hailed as a new miracle material, the increasing use of carbon nanotubes (CNTs) has spawned major concern due to their similarities in terms of size, shape and poor solubility. Assessment of genotoxicity has shown that CNTs can d...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:10.4414/smw.2012.13698

    authors: van Berlo D,Clift MJ,Albrecht C,Schins RP

    更新日期:2012-11-05 00:00:00

  • Cessation of extracorporeal photopheresis in chronic lung allograft dysfunction: effects on clinical outcome in adults.

    abstract:BACKGROUND:Extracorporeal photopheresis (ECP) has been reported to be safe and the ultimate treatment option in lung transplant recipients with chronic lung allograft dysfunction (CLAD), the main overall cause of mortality in lung transplant recipients. However, ECP is not reimbursed in selected health jurisdictions, a...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2017.14429

    authors: Robinson CA,Huber L,Murer C,Schuurmans M,Kohler M,Hofbauer G,Benden C

    更新日期:2017-03-13 00:00:00

  • External radiotherapy for prostate cancer with or without androgen deprivation: Geneva, 1991 to 2004.

    abstract:QUESTIONS UNDER STUDY/PRINCIPLES:A retrospective assessment of long-term results on a single centre, single author experience in treating prostate cancer with high dose curative radiotherapy (RT) with or without androgen deprivation (AD). METHODS:Between 1991 and 2004, 408 patients with clinically localised prostate c...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:smw-12604

    authors: Miralbell R,Pampallona S,Rouzaud M,Pugliesi A,Weber D,Ares C

    更新日期:2009-09-05 00:00:00

  • Therapeutical options for the treatment of Cheyne-Stokes respiration.

    abstract::The awareness of Cheyne-Stokes respiration (CSR) and of the co-existence of the obstructive sleep apnoea syndrome and central breathing disturbances has rapidly grown in recent years. CSR is defined by a waxing and waning pattern of the breathing amplitude. Sleep related breathing disorders in patients with heart fail...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:smw-12425

    authors: Randerath WJ

    更新日期:2009-03-07 00:00:00

  • Aortic valve replacement using autologous pericardium: single centre experience with the Ozaki technique.

    abstract:OBJECTIVE:To assess the clinical implementation and report preliminary results of a novel technique called the Ozaki procedure for stentless aortic valve replacement through reconstruction of the valve leaflets from autologous pericardium. METHOD:Between September 2015 and May 2017 30 patients (20 males, mean ± standa...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2018.14591

    authors: Reuthebuch O,Koechlin L,Schurr U,Grapow M,Fassl J,Eckstein FS

    更新日期:2018-02-09 00:00:00

  • A 10-year observational study of Streptococcus dysgalactiae bacteraemia in adults: frequent occurrence among female intravenous drug users.

    abstract::Beta-haemolytic streptococci of groups C and G have become increasingly recognized as causes of invasive human infections. We reviewed clinical and molecular characteristics of Streptococcus dysgalactiae isolates that caused bacteraemia in adults from 2006 to 2015. Among 67 episodes, skin and soft-tissue infections (4...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2017.14469

    authors: Ruppen C,Rasmussen M,Casanova C,Sendi P

    更新日期:2017-07-24 00:00:00