Abstract:
OBJECTIVE:To assess outcomes 24 months after treatment start for multidrug-resistant tuberculosis (MDR-TB). METHODS:Cohort study of all culture-positive MDR-TB cases notified in Switzerland from 01/2003 to 07/2010. RESULTS:Fifty-one cases were observed, with a median age of 26 years (range 2-56). Twenty-seven were male, five of Swiss origin, 46 of foreign origin (Asia 18, Africa 13, former Soviet Union 8), including 21 asylum seekers and refugees. Twelve had received a previous treatment for TB and 24 had not (15 unknown). Forty-four cases were pulmonary of which 25 were known to be sputum smear positive. All but two strains showed additional resistances: 29 to ethambutol, 27 to pyrazinamide, 6 to a fluoroquinolone, 5 to amikacin. None was resistant to both of the latter two classes. Molecular analyses showed three pairs of identical strains. Fluoroquinolones were used in 48 patients and second-line injectable drugs in 37. The median duration of MDR treatment was 18 months (range 1-26). The outcome after 24 months was successful in 39 (76%) and unsatisfactory in 12 (24%) patients: two deaths from TB; two treatments terminated owing to side effects of drugs and one owing to pregnancy; four defaults from treatment at months 0, 4, 8, and 21; two transfers abroad with unknown outcome; one outcome unknown. There was no significant association of unfavourable outcomes with age, sex, origin, previous treatment, treatment delay, resistance pattern, and classes of drugs used. CONCLUSIONS:MDR-TB in Switzerland occurs mostly in persons of foreign origin. Results of decentralised treatments were satisfactory.
journal_name
Swiss Med Wklyjournal_title
Swiss medical weeklyauthors
Helbling P,Altpeter E,Egger JM,Zellweger JPdoi
10.4414/smw.2014.14053subject
Has Abstractpub_date
2014-12-04 00:00:00pages
w14053eissn
1424-7860issn
1424-3997pii
smw-14053journal_volume
144pub_type
杂志文章abstract::Patients with a solid organ transplant have increased in numbers and in individual survival in Switzerland over the last decades. As a consequence of long-term immunosuppression, skin cancer in solid organ recipients (SOTRs) has been recognized as an important problem. Screening and education of potential SOTRs about ...
journal_title:Swiss medical weekly
pub_type: 杂志文章,实务指引
doi:smw-12725
更新日期:2009-07-25 00:00:00
abstract:QUESTIONS UNDER STUDY:Suicidal behaviour is a major source of burden of disease. While most studies focus on cost associated with completed suicides, data on costs of, non-lethal, suicide attempts are lacking. The aim of this study was to assess direct annual cost of suicide attempts in Basel in 2003 from a health serv...
journal_title:Swiss medical weekly
pub_type: 杂志文章,多中心研究
doi:10.4414/smw.2012.13648
更新日期:2012-07-23 00:00:00
abstract:AIMS:In comparison with other central European countries, Switzerland has a high prevalence of gun ownership and a high rate of suicide by shooting. After the Army XXI reform in 2003, which reduced personnel from about 400,000 to approximately 200,000, a decline in suicides by firearms and a decline in the total number...
journal_title:Swiss medical weekly
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doi:10.4414/smw.2018.14646
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2014.14001
更新日期:2014-08-21 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2015.14138
更新日期:2015-05-29 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2013.13754
更新日期:2013-01-24 00:00:00
abstract:OBJECTIVES:To determine 1) rates of needlestick and sharps injuries (NSSIs) not reported to occupational health services, 2) reasons for underreporting and 3) awareness of reporting procedures in a Swiss university hospital. MATERIALS AND METHODS:We surveyed 6,367 employees having close clinical contact with patients ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2012.13523
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20379
更新日期:2020-12-05 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2019.20151
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pub_type: 杂志文章
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更新日期:2020-11-24 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2016.14267
更新日期:2016-03-05 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2015.14103
更新日期:2015-02-06 00:00:00
abstract::Malnutrition has been defined as a “state resulting from lack of uptake or intake of nutrition, leading to altered body composition and body cell mass, as well as to diminished physical and mental function and impaired clinical outcome from disease.” Particularly for the multimorbid medical inpatient, ther...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20204
更新日期:2020-04-15 00:00:00
abstract::Isolated left ventricular hypertrophy, in the absence of hypertension or aortic stenosis, is commonly attributed to hypertrophic cardiomyopathy (HCM). According to the clinical setting, however, other differential diagnoses should be considered. The diagnosis of cardiac amyloidosis may be very challenging especially w...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2004/19/smw-10584
更新日期:2004-05-15 00:00:00
abstract::Cells reside in mechanically rich and dynamic microenvironments, and the complex interplay between mechanics and biology is widely acknowledged. Recent research has yielded insights linking the mechanobiology of cells, human physiology, and pathophysiology. In particular, we have learned of the cell's astounding abili...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2013.13766
更新日期:2013-03-14 00:00:00
abstract:QUESTIONS UNDER STUDY:Some evidence suggests that a loud voice is a core characteristic of medical professionals. It is unknown whether medical students talk louder than their non-medical peers and, if so, whether they commence their studies with a loud voice, representing a characteristic of admission, or whether soun...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2012.13534
更新日期:2012-03-09 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20361
更新日期:2020-10-16 00:00:00
abstract::Sequencing the human genome was the big challenge of the last decade. Ten years later, the large amount of DNA sequences accumulated in our databases allows us to look at genome variations between humans. The level of complexity of these variations is much higher than previously expected. It goes from changes in the n...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2011.13321
更新日期:2011-12-19 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2017.14469
更新日期:2017-07-24 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:smw-11284
更新日期:2009-08-08 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,meta分析,评审
doi:10.4414/smw.2013.13855
更新日期:2013-09-06 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2003/21/smw-10230
更新日期:2003-05-31 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20388
更新日期:2020-12-14 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2018.14597
更新日期:2018-03-14 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20176
更新日期:2020-01-15 00:00:00
abstract:BACKGROUND:Glomerulonephritis is a rare yet serious group of diseases with a high risk of progression to end-stage renal disease. For optimal healthcare planning, detailed epidemiological and demographic data are essential. Despite their clinical relevance, these data are largely lacking in Switzerland. OBJECTIVE:The ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20353
更新日期:2020-10-06 00:00:00
abstract::We report on two toddlers suffering from Mycobacterium bohemicum lymphadenitis. Acid-fast bacilli were cultured from submandibular lymph nodes and identified by molecular methods as Mycobacterium bohemicum. Surgical treatment was successful and complemented by oral treatment with clarithromycin and rifampicin. ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2004/15/smw-10558
更新日期:2004-04-17 00:00:00
abstract::Although progress has been made in the management of acute leukaemias, most patients who fail to respond to front-line therapies with cytostatic agents and stem cell transplantation, or who relapse after an initial response die from progressive disease. Novel treatment modalities exploiting donor-derived natural kille...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:
更新日期:2006-06-10 00:00:00
abstract:OBJECTIVE:To measure medical care and pharmaceutical drug use among Swiss primary care physicians and its determinants. DESIGN:Cross-sectional mailed survey. SETTING:1784 randomly selected Swiss primary care physicians, including general practitioners, internists and paediatricians. RESULTS:Twenty one percent (95% C...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2007/07/smw-11606
更新日期:2007-02-24 00:00:00
abstract:BACKGROUND:Campylobacteriosis and salmonellosis are important foodborne diseases in Europe, including in Switzerland. In 2014, notification rates for Switzerland were 92.9 per 100 000 population for campylobacteriosis and 15.2 per 100 000 population for salmonellosis. These notification rates originate from laboratory-...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2017.14569
更新日期:2017-12-27 00:00:00