The role of rituximab in the treatment of ANCA-associated vasculitides (AAV).

Abstract:

:The antineutrophil cytoplasmic antibody (ANCA) associated vasculitides (AAV) are a group of primary vasculitides that affect predominantly small- to medium-sized blood vessels. AAV include granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA). Disease severity is dictated by the location and extent of the blood vessels affected. If left untreated, systemic forms of AAV are often fatal. The advent of immunosuppressive therapy (cyclophosphamide plus glucocorticoids) has revolutionised the prognosis for patients with AAV, transforming the course of the disease from fatal to one that can be managed, though not without significant treatment-related toxicity. Recently, the monoclonal antibody rituximab was approved for the treatment of GPA and MPA, providing the first major alternative to cyclophosphamide for induction therapy of AAV. This review explores the emerging role of rituximab in the management of this complex disorder.

journal_name

Swiss Med Wkly

journal_title

Swiss medical weekly

authors

Daikeler T,Kistler AD,Martin PY,Vogt B,Huynh-Do U

doi

10.4414/smw.2015.14103

subject

Has Abstract

pub_date

2015-02-06 00:00:00

pages

w14103

eissn

1424-7860

issn

1424-3997

pii

smw-14103

journal_volume

145

pub_type

杂志文章,评审
  • Is the Eichenholtz classification still valid for the diabetic Charcot foot?

    abstract::In his 1966 monograph "Charcot joints", Sidney N. Eichenholtz (1909-2000) described "three well defined stages … in the course and development of a Charcot joint", based on plain X-rays of 68 patients. Since then, medical imaging has advanced very much: computed tomography and magnetic resonance imaging (MRI) scans ex...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:10.4414/smw.2014.13948

    authors: Chantelau EA,Grützner G

    更新日期:2014-04-24 00:00:00

  • How patients with insulin-treated type 1 and type 2 diabetes view their own and their physician's treatment goals.

    abstract:OBJECTIVES:To investigate the subjective treatment goals of insulin-treated diabetic patients. METHODS:297 type 1 and 205 type 2 diabetic patients, representative of the North-western Swiss population, filled out a self report questionnaire focusing on their own treatment goals using standardized measures wherever ava...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:2006/35/smw-11502

    authors: Puder JJ,Endrass J,Moriconi N,Keller U

    更新日期:2006-09-02 00:00:00

  • Cost of disorders of the brain in Switzerland with a focus on mental disorders.

    abstract:QUESTIONS UNDER STUDY:This study aims at estimating the costs of disorders of the brain in Switzerland based on the published epidemiological and economic evidence. METHODS:the data presented for Switzerland are derived from the "cost of disorders of the brain in Europe" study of the European Brain Counsil (EBC). Avai...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:2008/01/smw-11910

    authors: Jäger M,Sobocki P,Rössler W

    更新日期:2008-01-12 00:00:00

  • The economic and public health impact of influenza vaccinations: contributions of Swiss pharmacies in the 2016/17 and 2017/18 influenza seasons and implications for vaccination policy

    abstract:AIMS OF THE STUDY:Healthy adults have had the option to receive prescriptionless vaccination against influenza in pharmacies of several Swiss cantons since the 2015/16 influenza season. We aimed to assess in a cost-benefit analysis the resulting net benefits for the Swiss economy and public health, and the benefits tha...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2019.20161

    authors: Brunner I,Schmedders K,Wolfensberger A,Schreiber PW,Kuster SP

    更新日期:2019-12-17 00:00:00

  • Hepatitis delta in Switzerland: a silent epidemic.

    abstract:OBJECTIVES:The sero-prevalence of co-infection with the hepatitis B virus (HBV) and the hepatitis D virus (HDV) is well known in many European countries, starting from 6.8% in Germany to more than 27% in some Turkish areas. To gain a better description of this infection in Switzerland, and to characterise those affecte...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2011.13176

    authors: Genné D,Rossi I

    更新日期:2011-03-18 00:00:00

  • Prospective study of accidental carbon monoxide poisoning in 38 Swiss soldiers.

    abstract:BACKGROUND:Carbon monoxide (CO) poisoning is associated with a wide range of non-specific symptoms, whose time course and prognostic significance are ill defined. METHODS:We observed a large CO poisoning in a homogenous cohort of 38 male recruits and compared their symptoms with those of 46 unexposed controls from the...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:2005/27/smw-11149

    authors: Henz S,Maeder M

    更新日期:2005-07-09 00:00:00

  • Vulnerability to relapse under stress: insights from affective neuroscience.

    abstract::In this review article, we aim at analysing the role of stress in addiction and relapse. In order to do so, we first offer a summary of the findings from affective neuroscience trying to understand compulsive reward-seeking behaviours. These behaviours are characterised by an imbalance between the considerable amount ...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:10.4414/smw.2019.20151

    authors: Pool ER,Sander D

    更新日期:2019-11-29 00:00:00

  • Kerley B lines in the lung apex - a distinct CT sign for pulmonary congestion.

    abstract:AIMS OF THE STUDY:The purpose of this study was to establish a new computed tomography (CT) sign for pulmonary congestion (Kerley B lines in the lung apex in patients with cardiac or renal insufficiency) and to find the best signs to differentiate between pulmonary congestion and interstitial lung disease (ILD). METHO...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2019.20119

    authors: Loebelenz LI,Ebner L,Obmann VC,Huber AT,Christe A

    更新日期:2019-09-02 00:00:00

  • The impact of clinical trial units on the value of clinical research in Switzerland.

    abstract::A prominent 2014 series by The Lancet on "Increasing value, reducing waste in biomedical research" provided recommendations on how to optimise precious resources, including in clinical research. Despite being ideally placed to lead the movement in patient-oriented clinical research, academia struggles to take correspo...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:10.4414/smw.2018.14615

    authors: von Niederhäusern B,Magnin A,Pauli-Magnus C

    更新日期:2018-04-26 00:00:00

  • Medical care of type 2 diabetes mellitus in light of international and national recommendations: a retrospective analysis.

    abstract:QUESTION UNDER STUDY:Type 2 diabetes mellitus (T2Dm) is a chronic disease with great economic impact. In 2009, the Swiss Society for Endocrinology and Diabetes (SSED) published recommendations for treatment of T2Dm. In Switzerland, few data are currently available on metabolic control and physician compliance with trea...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2013.13871

    authors: Burgmann K,Fatio S,Jordi B,Rutishauser J

    更新日期:2013-10-25 00:00:00

  • Additional malignancies in patients with neuroendocrine tumours: analysis of the SwissNET registry.

    abstract:PRINCIPLES:Neuroendocrine neoplasms (NENs) are believed to be associated with an increased risk for additional malignancies (AMs). We aimed to (1) assess the occurrence of AM in NEN patients (2) investigate the characteristics and temporal relationship of NEN patients with and without AM. METHODS:The SwissNET registry...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2016.14362

    authors: Kollár A,Blank A,Perren A,Bütikofer L,Stettler C,Christ E

    更新日期:2016-11-12 00:00:00

  • Injury and repeated injury - what is the link with acute consumption, binge drinking and chronic heavy alcohol use?

    abstract:OBJECTIVES:First, to test whether current injury is more closely related to acute intake than to usual consumption patterns, and second, to test whether repeated injury is more closely related to general consumption patterns than to acute intake. METHODS:Screening of alcohol consumption of 7,872 patients enrolling bet...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:2007/45/smw-11697

    authors: Gmel G,Givel JC,Yersin B,Daeppen JB

    更新日期:2007-11-17 00:00:00

  • Optimal reperfusion in ST-elevation myocardial infarction--the role of the coronary microcirculation.

    abstract::Coronary microcirculation plays a crucial role for the outcomes of patients with STEMI. Although PPCI improves outcomes compared to thrombolysis, a substantial amount of STEMI patients do not achieve optimal myocardial reperfusion. Angiographic methods for assessment of reperfusion like TIMI Flow and MBG are easy to u...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:10.4414/smw.2011.13313

    authors: Cuculi F,De Caterina AR,Kharbanda RK,Banning AP

    更新日期:2011-12-09 00:00:00

  • Insufficient recruitment and premature discontinuation of clinical trials in Switzerland: qualitative study with trialists and other stakeholders.

    abstract:AIMS OF THE STUDY:Premature discontinuation occurs in about 25% of randomised clinical trials in Switzerland; it mainly affects investigator-initiated trials and is mostly due to problems with recruitment of patients. The aim of this study was to qualitatively investigate reasons for trial discontinuation due to poor p...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2017.14556

    authors: Briel M,Elger B,von Elm E,Satalkar P

    更新日期:2017-11-16 00:00:00

  • A new sexually transmitted infection (STI) in Geneva? Ciprofloxacin-resistant Neisseria gonorrhoeae, 2002-2005.

    abstract:PRINCIPLES:Neisseria gonorrhoeae (NG) resistant to ciprofloxacin (CR) was documented for the first time in Geneva in 2002 and increased from 7% that year to 47% in 2005. We describe NG cases during this period and compare characteristics of CR and ciprofloxacin susceptible (CS) cases. METHOD:Geneva microbiological lab...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:2008/15/smw-12029

    authors: Le Lin B,Pastore R,Liassine N,Aramburu C,Sudre P

    更新日期:2008-04-19 00:00:00

  • Gestational age-adapted oxygen saturation targeting and outcome of extremely low gestational age neonates (ELGANs).

    abstract:QUESTIONS UNDER STUDY:Optimal oxygen saturation (SpO2) targets for extremely low gestational age neonates (ELGANs, gestational age [GA] <28 weeks) are unknown. Conflicting results from five recently published multicentre trials, which randomised ELGANs to high (91 to 95%) or low (85 to 89%) SpO2 targets from birth up t...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2015.14197

    authors: Hergenhan A,Steurer M,Berger TM

    更新日期:2015-11-02 00:00:00

  • Sleep and wakefulness disturbances in Swiss pharmacy customers.

    abstract:BACKGROUND AND OBJECTIVE:Sleep disturbances are prevalent but often overlooked or underestimated. We suspected that sleep disorders might be particularly common among pharmacy customers, and that they could benefit from counselling. Therefore, we described the prevalence and severity of symptoms associated with sleep a...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:2006/09/smw-11265

    authors: Schwegler K,Klaghofer R,Nirkko AC,Mathis J,Hersberger KE,Bloch KE

    更新日期:2006-03-04 00:00:00

  • Mental disorders in the pediatric setting – results of a Swiss survey.

    abstract:THEORETICAL BACKGROUND:Mental disorders emerge in childhood and adolescence and are important risk factors for mental disorders in adolescence and adulthood. Since paediatricians are typically the first to see children with psychological problems, the aim of this study was to obtain a survey of mental disorders of chil...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2010.13092

    authors: In-Albon T,Zumsteg U,Müller D,Schneider S

    更新日期:2010-08-27 00:00:00

  • A randomised prospective study to evaluate a rapid HIV-antibody assay in the management of cases of percutaneous exposure amongst health care workers.

    abstract::A rapid start of post-exposure prophylaxis with an antiretroviral regime is recommended after percutaneous exposure to blood from an HIV-positive source. Since the HIV-antibody status of the source is usually not known at the time of injury, antiretroviral treatment is started pending the results of HIV testing of the...

    journal_title:Swiss medical weekly

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:2001/01/smw-05828

    authors: King AM,Osterwalder JJ,Vernazza PL

    更新日期:2001-01-12 00:00:00

  • Minimally invasive extracorporeal circulation: excellent outcome and life expectancy after coronary artery bypass grafting surgery.

    abstract:OBJECTIVE:Coronary artery bypass grafting (CABG) remains the gold standard for complex revascularisation in multivessel disease. The concept of the minimally invasive extracorporeal circulation circuit (MiECC) was introduced to minimise pathophysiological side effects of conventional extracorporeal circulation. This st...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2017.14474

    authors: Winkler B,Heinisch PP,Zuk G,Zuk K,Gahl B,Jenni HJ,Kadner A,Huber C,Carrel T

    更新日期:2017-07-10 00:00:00

  • Fibroblasts as therapeutic targets in rheumatoid arthritis and cancer.

    abstract::Rheumatoid arthritis is a common chronic inflammatory disease that causes progressive synovial inflammation resulting in irreversible joint destruction, chronic disability and premature mortality. Although it is recognised that in rheumatoid arthritis, inflammation and its persistence result from complex interactions ...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:10.4414/smw.2012.13529

    authors: Juarez M,Filer A,Buckley CD

    更新日期:2012-02-24 00:00:00

  • Is a change in vocal loudness a first step towards becoming a medical doctor?

    abstract:QUESTIONS UNDER STUDY:Some evidence suggests that a loud voice is a core characteristic of medical professionals. It is unknown whether medical students talk louder than their non-medical peers and, if so, whether they commence their studies with a loud voice, representing a characteristic of admission, or whether soun...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2012.13534

    authors: Kiese-Himmel C,Himmel W,Rodenstock M,Scherer M

    更新日期:2012-03-09 00:00:00

  • Severe injection site reactions after subcutaneous administration of Sayana©.

    abstract:PURPOSE:Sayana® was introduced as the first depot medroxyprogesterone acetate-containing contraceptive that is administered via subcutaneous injection. Within 10 months, the Regional Pharmacovigilance Centre (RPVC) Zurich received several anonymous reports of serious local reactions after Sayana® administration. In thi...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2017.14432

    authors: Jödicke AM,Dahmke H,Damke B,Schäublin M,Kullak-Ublick GA,Weiler S

    更新日期:2017-05-10 00:00:00

  • Heart failure clinic in a community hospital improves outcome in heart failure patients.

    abstract:PRINCIPLES:Heart failure is associated with a grim prognosis. Disease management programmes can improve prognosis in heart failure patients but the applicability to the general population remains limited. We aimed to compare the outcome, pharmacological therapy, and quality of life in unselected heart failure patients ...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:2006/17/smw-11274

    authors: Lainscak M,Keber I

    更新日期:2006-04-29 00:00:00

  • Aortic valve replacement using autologous pericardium: single centre experience with the Ozaki technique.

    abstract:OBJECTIVE:To assess the clinical implementation and report preliminary results of a novel technique called the Ozaki procedure for stentless aortic valve replacement through reconstruction of the valve leaflets from autologous pericardium. METHOD:Between September 2015 and May 2017 30 patients (20 males, mean ± standa...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2018.14591

    authors: Reuthebuch O,Koechlin L,Schurr U,Grapow M,Fassl J,Eckstein FS

    更新日期:2018-02-09 00:00:00

  • Social contexts of sports-practicing youths' hazardous drinking.

    abstract::Sports-practicing youths are at an elevated risk for alcohol use and misuse. Although much attention has recently been given to depicting subgroups facing the greatest threats, little evidence exists on the contexts in which their drinking takes place. Using data from a cross-sectional study on youth sports participat...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2012.13526

    authors: Bélanger RE,Ohl F,Berchtold A,Akre C,Suris JC

    更新日期:2012-02-17 00:00:00

  • Flattening the curve in 52 days: characterisation of the COVID-19 pandemic in the Principality of Liechtenstein - an observational study.

    abstract:BACKGROUND:The principality of Liechtenstein had its first COVID-19 case at the beginning of March 2020. After exponential growth, the pandemic’s first wave was contained, with the last case being diagnosed 52 days after the initial occurrence. AIM:To characterise the COVID-19 pandemic in Liechtenstein. METHODS...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2020.20361

    authors: Thiel SL,Weber MC,Risch L,Wohlwend N,Lung T,Hillmann D,Ritzler M,Risch M,Kohler P,Vernazza P,Kahlert CR,Fleisch F,Cusini A,Karajan TV,Copeland S,Paprotny M

    更新日期:2020-10-16 00:00:00

  • Survey of management of first-ever seizures in a hospital based community.

    abstract:BACKGROUND:Epidemiological studies focusing on first-ever seizures have been carried out mainly on community based populations. However, since hospital populations may display varying clinical features, we prospectively analysed patients with first-ever seizure in a hospital based community to evaluate prognosis and th...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:2004/39/smw-10738

    authors: Kawkabani A,Rossetti AO,Despland PA

    更新日期:2004-10-02 00:00:00

  • A 10-year observational study of Streptococcus dysgalactiae bacteraemia in adults: frequent occurrence among female intravenous drug users.

    abstract::Beta-haemolytic streptococci of groups C and G have become increasingly recognized as causes of invasive human infections. We reviewed clinical and molecular characteristics of Streptococcus dysgalactiae isolates that caused bacteraemia in adults from 2006 to 2015. Among 67 episodes, skin and soft-tissue infections (4...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2017.14469

    authors: Ruppen C,Rasmussen M,Casanova C,Sendi P

    更新日期:2017-07-24 00:00:00

  • Cardiac pre-competiton screening in Swiss athletes. Current situation in competitive athletes and short-time assessment of an exemplary local screening program.

    abstract:AIM OF THE STUDY:In Switzerland, screening concepts for the prevention of sports-associated sudden cardiac death are still insufficiently established in the large group of competitive athletes who are not integrated in an Olympic- or other high-level squad. The aim of the present study was to objectively determine the ...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2012.13575

    authors: Schmied C,Notz S,Cribari M,Gähwiler R,Keller DI,Lüscher TF

    更新日期:2012-05-31 00:00:00