Gestational age-adapted oxygen saturation targeting and outcome of extremely low gestational age neonates (ELGANs).


QUESTIONS UNDER STUDY:Optimal oxygen saturation (SpO2) targets for extremely low gestational age neonates (ELGANs, gestational age [GA] <28 weeks) are unknown. Conflicting results from five recently published multicentre trials, which randomised ELGANs to high (91 to 95%) or low (85 to 89%) SpO2 targets from birth up to a corrected GA of 36 weeks, prompted us to examine our experience with two different SpO2 policies. METHODS:We retrospectively compared outcomes of two cohorts of ELGANs which were exposed to two different SpO2 target policies adapted to the infants' corrected GA. Between 1 January 2000 and 30 June 2007, SpO2 targets were 85 to 95% at <30 weeks and 88 to 97% at ≥30 weeks (high SpO2 target cohort, n = 157). Between 1 July 2007 and 31 December 2011, SpO2 targets were lowered to 80 to 90% at <30 weeks, 85 to 95% between 30 and 34 weeks and finally 88 to 97% at ≥34 weeks (low SpO2 target cohort, n = 84). RESULTS:There were no statistically significant differences between the high and low SpO2 target cohorts in mortality rates (15.9 vs 17.9%, risk ratio [RR] 0.89; 95% confidence interval [CI] 0.50-1.60), incidences of severe retinopathy of prematurity (2.3 vs 0%, RR 3.68; 95% CI 0.19-70.3), or moderate/severe bronchopulmonary dysplasia (14.4 vs 21.1%, RR 0.68; 95% CI 0.37-1.26). CONCLUSIONS:Adapting SpO2 targets to the advancing corrected GA seems safe and is associated with low incidences of short-term complications. Mortality rates did not vary with the two different SpO2 target policies utilised and were comparable to those reported from recently published randomised controlled SpO2 target trials.


Swiss Med Wkly


Swiss medical weekly


Hergenhan A,Steurer M,Berger TM




Has Abstract


2015-11-02 00:00:00












  • Surgical management of vascular Ehlers-Danlos syndrome and its challenges: a case report.

    abstract:BACKGROUND:Ehlers-Danlos syndrome (EDS) is a heterogeneous group of rare inherited diseases involving connective tissue. Vascular EDS (vEDS) is associated with abnormal type III collagen, which is an essential component of skin, hollow organs and arterial walls, and causes potentially fatal visceral and arterial compli...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: da Rocha de Sousa F,Colucci N,Dupuis A,Toso C,Buchs NC,Abbassi Z

    更新日期:2020-12-05 00:00:00

  • A new sexually transmitted infection (STI) in Geneva? Ciprofloxacin-resistant Neisseria gonorrhoeae, 2002-2005.

    abstract:PRINCIPLES:Neisseria gonorrhoeae (NG) resistant to ciprofloxacin (CR) was documented for the first time in Geneva in 2002 and increased from 7% that year to 47% in 2005. We describe NG cases during this period and compare characteristics of CR and ciprofloxacin susceptible (CS) cases. METHOD:Geneva microbiological lab...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Le Lin B,Pastore R,Liassine N,Aramburu C,Sudre P

    更新日期:2008-04-19 00:00:00

  • Information about medication in HIV-infected patients and its relation to adherence.

    abstract:QUESTIONS UNDER STUDY:In HIV-infected patients, comprehension of medication instructions is an essential condition for adherence to Highly Active Antiretroviral Therapy (HAART). In this study, we used a self-reported questionnaire to know which sources of medication information HIV-infected patients used and their impa...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Korb-Savoldelli V,Gillaizeau F,Caruba T,Tauckoor A,Prognon P,Durieux P,Sabatier B

    更新日期:2012-07-26 00:00:00

  • Hepatitis delta in Switzerland: a silent epidemic.

    abstract:OBJECTIVES:The sero-prevalence of co-infection with the hepatitis B virus (HBV) and the hepatitis D virus (HDV) is well known in many European countries, starting from 6.8% in Germany to more than 27% in some Turkish areas. To gain a better description of this infection in Switzerland, and to characterise those affecte...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Genné D,Rossi I

    更新日期:2011-03-18 00:00:00

  • Only conflicts of interest?

    abstract::The current situation of the biomedical sciences is critically discussed. It can be summarized as follows: 1. We have to acknowledge the presence of a serious credibility problem, which might undermine the foundations of medical science. ("Sliding on a slippery slope") 2. Multiple forces going beyond simple conflicts ...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审


    authors: Obrist R

    更新日期:2015-03-13 00:00:00

  • A randomised prospective study to evaluate a rapid HIV-antibody assay in the management of cases of percutaneous exposure amongst health care workers.

    abstract::A rapid start of post-exposure prophylaxis with an antiretroviral regime is recommended after percutaneous exposure to blood from an HIV-positive source. Since the HIV-antibody status of the source is usually not known at the time of injury, antiretroviral treatment is started pending the results of HIV testing of the...

    journal_title:Swiss medical weekly

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: King AM,Osterwalder JJ,Vernazza PL

    更新日期:2001-01-12 00:00:00

  • Clinical settings and specialties notifying cases of bacterial sexually transmitted infections in Switzerland: cross-sectional study.

    abstract:QUESTIONS UNDER STUDY:In the next Swiss National HIV and Sexually Transmitted Infection (STI) Strategy 2011-2017, STI control will be integrated with HIV prevention. Information is needed which will improve the targeting of professional education. The objective of this study was to describe the clinical specialities an...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Baillif A,Low N

    更新日期:2011-01-20 00:00:00

  • Ex utero intrapartum treatment (EXIT), a resuscitation option for intra-thoracic foetal pathologies.

    abstract::The ex utero intrapartum treatment (EXIT) procedure is designed to guarantee sufficient oxygenation for a foetus at risk of airway obstruction. This is achieved by improving lung ventilation, usually by establishing an airway during caesarean delivery whilst preserving the foetal-placental circulation temporarily. Ind...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审


    authors: Kern C,Ange M,Morales,Peiry B,Pfister RE

    更新日期:2007-05-19 00:00:00

  • Head-to-head comparison of length of stay, patients' outcome and satisfaction in Switzerland before and after SwissDRG-Implementation in 2012 in 2012: an observational study in two tertiary university centers.

    abstract:BACKGROUND:On 1 January 2012 Swiss Diagnosis Related Groups (DRG), a new uniform payment system for in-patients was introduced in Switzerland with the intention to replace a "cost-based" with a "case-based" reimbursement system to increase efficiency. With the introduction of the new payment system we aim to answer que...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Thommen D,Weissenberger N,Schuetz P,Mueller B,Reemts C,Holler T,Schifferli JA,Gerber M,Hug BL

    更新日期:2014-06-25 00:00:00

  • Describing adverse events in medical inpatients using the Global Trigger Tool.

    abstract:AIMS:The purpose of the study was to describe the type, prevalence, severity and preventability of adverse events (AEs) that affected hospitalised medical patients. We used the previously developed and validated Global Trigger Tool from the Institute for Healthcare Improvement. METHODS:Using an adapted version of the ...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Grossmann N,Gratwohl F,Musy SN,Nielen NM,Simon M,Donzé J

    更新日期:2019-11-10 00:00:00

  • Cystatin C and neutrophil gelatinase-associated lipocalin: biomarkers for acute kidney injury after congenital heart surgery.

    abstract:QUESTIONS UNDER STUDY:To evaluate the diagnostic value of serum Cystatin C and urine neutrophil gelatinase-associated lipocalin (NGAL) for the detection of acute kidney injury in patients undergoing congenital heart surgery. METHODS:Serial samples of serum Cystatin C and urine NGAL were collected from 139 consecutive ...

    journal_title:Swiss medical weekly

    pub_type: 临床试验,杂志文章


    authors: Seitz S,Rauh M,Gloeckler M,Cesnjevar R,Dittrich S,Koch AM

    更新日期:2013-01-17 00:00:00

  • Risk behaviours among native and immigrant youths in Switzerland: a cross-sectional study.

    abstract:QUESTION UNDER STUDY:Switzerland has been receiving migrants of various origins for more than 50 years. The adoption of risk-taking behaviours among migrant youths is unclear. Moreover, when studied, migrant youths are rarely analysed according to whether they are first or second generation, or just young people with m...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Campisi L,Berchtold A,Barrense-Dias Y,Akre C,Gehri M,Suris JC

    更新日期:2017-11-08 00:00:00

  • Low-molecular-weight heparin in patients with renal insufficiency.

    abstract:BACKGROUND:Low-molecular-weight heparins (LMWH) have been shown to be safer, more effective and more convenient than unfractionated heparin (UFH) in many clinical situations. However, their use is limited in patients with renal insufficiency (RI) due to bioaccumulation. METHOD:The literature is critically reviewed and...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审


    authors: Schmid P,Fischer AG,Wuillemin WA

    更新日期:2009-08-08 00:00:00

  • Function of natural killer cells in immune defence against human leukaemia.

    abstract::Although progress has been made in the management of acute leukaemias, most patients who fail to respond to front-line therapies with cytostatic agents and stem cell transplantation, or who relapse after an initial response die from progressive disease. Novel treatment modalities exploiting donor-derived natural kille...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审


    authors: Wodnar-Filipowicz A,Kalberer CP

    更新日期:2006-06-10 00:00:00

  • Transition to postgraduate practice: perceptions of preparedness and experience of the daily work of junior residents.

    abstract:BACKGROUND:The transition from undergraduate to postgraduate training is a crucial career step for physicians. Several international studies have shown that graduates feel insufficiently prepared to perform various aspects of clinical practice. The publication of a national framework for undergraduate medical education...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Monti M,Brunet L,Michaud PA

    更新日期:2020-11-24 00:00:00

  • Effort-reward and work-life imbalance, general stress and burnout among employees of a large public hospital in Switzerland.

    abstract:INTRODUCTION:Effort-reward imbalance (ERI) and work-life imbalance (WLI) are recognised risk factors for work stress and burnout but have not been investigated conjointly so far and compared with each other in this regard. The present cross-sectional study provides initial evidence by studying associations of ERI and W...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Hämmig O,Brauchli R,Bauer GF

    更新日期:2012-05-31 00:00:00

  • Cessation of extracorporeal photopheresis in chronic lung allograft dysfunction: effects on clinical outcome in adults.

    abstract:BACKGROUND:Extracorporeal photopheresis (ECP) has been reported to be safe and the ultimate treatment option in lung transplant recipients with chronic lung allograft dysfunction (CLAD), the main overall cause of mortality in lung transplant recipients. However, ECP is not reimbursed in selected health jurisdictions, a...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Robinson CA,Huber L,Murer C,Schuurmans M,Kohler M,Hofbauer G,Benden C

    更新日期:2017-03-13 00:00:00

  • Outpatient treatment of pulmonary embolism.

    abstract::Pulmonary embolism (PE) is traditionally treated in hospital. Growing evidence from non randomized prospective studies suggests that a substantial proportion of patients with non-massive PE might be safely treated in the outpatient setting using low molecular weight heparins. Based on this evidence, professional socie...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审


    authors: Aujesky D,Mazzolai L,Hugli O,Perrier A

    更新日期:2009-11-28 00:00:00

  • Optimal reperfusion in ST-elevation myocardial infarction--the role of the coronary microcirculation.

    abstract::Coronary microcirculation plays a crucial role for the outcomes of patients with STEMI. Although PPCI improves outcomes compared to thrombolysis, a substantial amount of STEMI patients do not achieve optimal myocardial reperfusion. Angiographic methods for assessment of reperfusion like TIMI Flow and MBG are easy to u...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审


    authors: Cuculi F,De Caterina AR,Kharbanda RK,Banning AP

    更新日期:2011-12-09 00:00:00

  • Systematic review of pneumothoraces after endoscopic retrograde cholangiopancreatography.

    abstract:AIMS OF THE STUDY:Pneumothoraces after endoscopic retrograde cholangiopancreatography (ERCP) are an uncommon but potentially lethal complication. Little evidence is available on their epidemiology, diagnosis and therapy. We aimed to evaluate current practices and provide recommendations. METHOD:We systematically revie...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Lehmann V,Keller W,Egger B

    更新日期:2020-04-03 00:00:00

  • Tobacco and alcohol during pregnancy: prevalence and determinants in Geneva in 2008.

    abstract:OBJECTIVES:To describe alcohol and tobacco consumption during pregnancy in women giving birth in a public hospital in Geneva, to evaluate risk factors related to these consumptions and to explore the influence of close relatives on the consumption habits of pregnant women. METHODS:A cross-sectional questionnaire surve...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Dupraz J,Graff V,Barasche J,Etter JF,Boulvain M

    更新日期:2013-05-25 00:00:00

  • Molecular determinants for amyloid fibril formation: lessons from lung surfactant protein C.

    abstract::Amyloid fibrils are polymers composed of proteins in beta-sheet conformation, which are found in at least 20 diseases for which no cure is available. These diseases include Alzheimer's disease and spongiform encephalopathies, in which the amyloid beta-peptide and the prion protein (PrP), respectively, form amyloid. Al...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审


    authors: Johansson J

    更新日期:2003-05-17 00:00:00

  • Recommendations for the treatment of hypertension in the elderly and very elderly--a scotoma within international guidelines.

    abstract::The recommendations of international scientific societies for the treatment of hypertension in the geriatric population are different. Lack of outcome trials, non-standardised terminology as well as differing levels of evidence contribute to the inconsistencies in the guidelines. This review article compares six inter...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审


    authors: Schäfer HH,De Villiers JN,Sudano I,Dischinger S,Theus GR,Zilla P,Dieterle T

    更新日期:2012-05-09 00:00:00

  • The predictive validity of the aptitude test for the performance of students starting a medical curriculum.

    abstract:INTRODUCTION:Selection of medical students varies between German- and French-speaking Swiss faculties. Geneva introduced an aptitude test in 2010, aimed at helping decision making among students. The test was compulsory: it had to be taken by those who intended to register for medical studies. But it was not selective:...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Cerutti B,Bernheim L,van Gessel E

    更新日期:2013-09-19 00:00:00

  • Arrhythmias in patients with surgically treated atrial septal defects.

    abstract::Atrial arrhythmias complicate the clinical course of adult patients with an atrial septal defect. Atrial flutter is more prevalent in younger patients, and frequently regresses after surgical defect closure. Atrial fibrillation however, which results from a chronic underlying disease, rarely reverts to sinus rhythm af...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审


    authors: Berger F,Vogel M,Kretschmar O,Dave H,Prêtre R,Dodge-Khatami A

    更新日期:2005-03-19 00:00:00

  • Long term effects of comprehensive cardiac rehabilitation in an inpatient and outpatient setting.

    abstract:OBJECTIVES:To compare the long-term effects of comprehensive outpatient versus inpatient rehabilitation with respect to morbidity and mortality, as well as to changes in physical performance and physical activity. DESIGN:A total of 163 consecutive patients were enrolled for comprehensive cardiac rehabilitation (CCR) f...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Steinacker JM,Liu Y,Muche R,Koenig W,Hahmann H,Imhof A,Kropf C,Brandstetter S,Schweikert B,Leidl R,Schiefer DH

    更新日期:2011-01-06 00:00:00

  • Ovarian cancer in Switzerland: incidence and treatment according to hospital registry data.

    abstract:OBJECTIVE:The methods used to diagnose and classify ovarian cancer have changed over the past decade. We used hospital registry data to assess the incidence, treatment durations and hospital costs of ovarian cancer in Switzerland. METHODS:We carried out a retrospective analysis of a hospital registry covering all inpa...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Wieser S,Schmidt M,Kind AB,Heinzelmann-Schwarz VA

    更新日期:2018-07-29 00:00:00

  • Screening strategy for Chagas disease in a non-endemic country (Switzerland): a prospective evaluation.

    abstract::The WHO recommends screening of Latin American migrants for Chagas disease to reduce morbidity and mortality and increase the likelihood of eradicating the disease. The objective was to assess the feasibility and acceptability of a screening strategy in one Swiss canton. From February 2011 to September 2012, people at...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Da Costa-Demaurex C,Cárdenas MT,Aparicio H,Bodenmann P,Genton B,D'Acremont V

    更新日期:2019-04-04 00:00:00

  • Patients' understanding of blood tests and attitudes to HIV screening in the emergency department of a Swiss teaching hospital: a cross-sectional observational study.

    abstract:BACKGROUND:In Switzerland, patients may undergo "blood tests" without being informed what these are screening for. Inadequate doctor-patient communication may result in patient misunderstanding. We examined what patients in the emergency department (ED) believed they had been screened for and explored their attitudes t...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Favre-Bulle T,Baudat D,Darling KE,Mamin R,Peters S,Cavassini M,Hugli O

    更新日期:2015-12-04 00:00:00

  • Epidemiology and pathophysiology of obesity as cause of cancer.

    abstract::According to World Health Organisation estimates 1.1 billion people were overweight or obese worldwide in the year 2000 with the prevalence rapidly increasing. Compelling evidence suggests that excess body weight is a risk factor for several cancer types including cancer of the colon, breast, endometrium, kidney, oeso...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审


    authors: Ceschi M,Gutzwiller F,Moch H,Eichholzer M,Probst-Hensch NM

    更新日期:2007-01-27 00:00:00