Abstract:
QUESTIONS UNDER STUDY:Optimal oxygen saturation (SpO2) targets for extremely low gestational age neonates (ELGANs, gestational age [GA] <28 weeks) are unknown. Conflicting results from five recently published multicentre trials, which randomised ELGANs to high (91 to 95%) or low (85 to 89%) SpO2 targets from birth up to a corrected GA of 36 weeks, prompted us to examine our experience with two different SpO2 policies. METHODS:We retrospectively compared outcomes of two cohorts of ELGANs which were exposed to two different SpO2 target policies adapted to the infants' corrected GA. Between 1 January 2000 and 30 June 2007, SpO2 targets were 85 to 95% at <30 weeks and 88 to 97% at ≥30 weeks (high SpO2 target cohort, n = 157). Between 1 July 2007 and 31 December 2011, SpO2 targets were lowered to 80 to 90% at <30 weeks, 85 to 95% between 30 and 34 weeks and finally 88 to 97% at ≥34 weeks (low SpO2 target cohort, n = 84). RESULTS:There were no statistically significant differences between the high and low SpO2 target cohorts in mortality rates (15.9 vs 17.9%, risk ratio [RR] 0.89; 95% confidence interval [CI] 0.50-1.60), incidences of severe retinopathy of prematurity (2.3 vs 0%, RR 3.68; 95% CI 0.19-70.3), or moderate/severe bronchopulmonary dysplasia (14.4 vs 21.1%, RR 0.68; 95% CI 0.37-1.26). CONCLUSIONS:Adapting SpO2 targets to the advancing corrected GA seems safe and is associated with low incidences of short-term complications. Mortality rates did not vary with the two different SpO2 target policies utilised and were comparable to those reported from recently published randomised controlled SpO2 target trials.
journal_name
Swiss Med Wklyjournal_title
Swiss medical weeklyauthors
Hergenhan A,Steurer M,Berger TMdoi
10.4414/smw.2015.14197subject
Has Abstractpub_date
2015-11-02 00:00:00pages
w14197eissn
1424-7860issn
1424-3997pii
smw-14197journal_volume
145pub_type
杂志文章abstract::A rapid start of post-exposure prophylaxis with an antiretroviral regime is recommended after percutaneous exposure to blood from an HIV-positive source. Since the HIV-antibody status of the source is usually not known at the time of injury, antiretroviral treatment is started pending the results of HIV testing of the...
journal_title:Swiss medical weekly
pub_type: 临床试验,杂志文章,随机对照试验
doi:2001/01/smw-05828
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abstract:AIMS OF THE STUDY:The purpose of this study was to establish a new computed tomography (CT) sign for pulmonary congestion (Kerley B lines in the lung apex in patients with cardiac or renal insufficiency) and to find the best signs to differentiate between pulmonary congestion and interstitial lung disease (ILD). METHO...
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2011.13321
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pub_type: 杂志文章
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journal_title:Swiss medical weekly
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2003/01/smw-10093
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:2008/43/smw-12396
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,评审
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journal_title:Swiss medical weekly
pub_type: 临床试验,杂志文章
doi:10.4414/smw.2013.13744
更新日期:2013-01-17 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
doi:10.4414/smw.2013.13764
更新日期:2013-03-26 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2011-01-17 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2001/43/smw-09823
更新日期:2001-11-10 00:00:00
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pub_type: 杂志文章
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doi:smw-12756
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pub_type: 历史文章,杂志文章,评审
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pub_type: 杂志文章,多中心研究
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更新日期:2012-07-23 00:00:00
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doi:smw-12494
更新日期:2009-03-21 00:00:00
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pub_type: 杂志文章
doi:10.4414/smw.2011.13223
更新日期:2011-08-26 00:00:00
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pub_type: 杂志文章
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更新日期:2006-09-02 00:00:00
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pub_type: 杂志文章
doi:2006/17/smw-11274
更新日期:2006-04-29 00:00:00
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pub_type: 历史文章,杂志文章,评审
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pub_type: 杂志文章,评审
doi:10.4414/smw.2012.13673
更新日期:2012-09-20 00:00:00