Proteostasis: bad news and good news from the endoplasmic reticulum.

abstract：:Understanding how best to manage the complex healthcare needs of hospitalised, mostly multimorbid medical patients is an international priority. Healthcare should be effective, safe and provide high quality at a reasonable cost. However, basic logistic and organisational issues of medical ward-based care have received...

journal_title：Swiss medical weekly

authors： Kutz A,Ebrahimi F,Struja T,Greenwald J,Schuetz P,Mueller B

更新日期：2017-10-22 00:00:00

abstract：STUDY OBJECTIVES:we performed an open-label national study to evaluate the effects of Bosentan on haemodynamics, exercise capacity, quality of life, safety and tolerability in patients with chronic thromboembolic pulmonary hypertension (CTEPH). PATIENTS AND METHODS:fifteen patients with CTEPH not eligible or waiting f...

journal_title：Swiss medical weekly

authors： Ulrich S,Speich R,Domenighetti G,Geiser T,Aubert JD,Rochat T,Huber L,Treder U,Fischler M

更新日期：2007-10-20 00:00:00

abstract：QUESTION UNDER STUDY:To investigate the change over time in the number of ED admissions with positive blood alcohol concentration (BAC) and to evaluate predictors of BAC level. METHODS:We conducted a single site retrospective study at the ED of a tertiary referral hospital (western part of Switzerland) and obtained al...

journal_title：Swiss medical weekly

authors： Bertholet N,Adam A,Faouzi M,Boulat O,Yersin B,Daeppen JB,Clerc D

更新日期：2014-08-07 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic and usually progressive lung disorder of unknown aetiology. Conventional management of patients with IPF has been primarily based on the concept that suppressing inflammation would prevent progression to fibrosis. Although the pathogenesis is incompletely understood, it...

journal_title：Swiss medical weekly

authors： Geiser T

更新日期：2003-07-26 00:00:00

abstract：BACKGROUND:In Switzerland, patients may undergo "blood tests" without being informed what these are screening for. Inadequate doctor-patient communication may result in patient misunderstanding. We examined what patients in the emergency department (ED) believed they had been screened for and explored their attitudes t...

journal_title：Swiss medical weekly

authors： Favre-Bulle T,Baudat D,Darling KE,Mamin R,Peters S,Cavassini M,Hugli O

更新日期：2015-12-04 00:00:00

abstract：:The awareness of Cheyne-Stokes respiration (CSR) and of the co-existence of the obstructive sleep apnoea syndrome and central breathing disturbances has rapidly grown in recent years. CSR is defined by a waxing and waning pattern of the breathing amplitude. Sleep related breathing disorders in patients with heart fail...

journal_title：Swiss medical weekly

authors： Randerath WJ

更新日期：2009-03-07 00:00:00

abstract：OBJECTIVE:To assess the clinical implementation and report preliminary results of a novel technique called the Ozaki procedure for stentless aortic valve replacement through reconstruction of the valve leaflets from autologous pericardium. METHOD:Between September 2015 and May 2017 30 patients (20 males, mean ± standa...

journal_title：Swiss medical weekly

authors： Reuthebuch O,Koechlin L,Schurr U,Grapow M,Fassl J,Eckstein FS

更新日期：2018-02-09 00:00:00

abstract：:Each year, over 5 million people die worldwide from stroke, and at least every sixth patient who survives will experience another stroke within five years [1]. We are therefore eager to advance early and rapid diagnosis, prognosis and optimal risk stratification, as well as secondary prevention. In this context, blood...

journal_title：Swiss medical weekly

authors： Sonderer J,Katan Kahles M

更新日期：2015-05-29 00:00:00

abstract：:Better recipient selection, sophisticated postoperative surveillance and new immunosuppressive and anti-infective regimens can improve the results of lung transplantation. We compared the results of lung transplants performed between 1992 and 1996 (early period; 47) and between 1997 and 2000 (recent period; 46) in a c...

journal_title：Swiss medical weekly

authors： Speich R,Boehler A,Zalunardo MP,Stocker R,Russi EW,Weder W

更新日期：2001-05-05 00:00:00

abstract：BACKGROUND:Introduction of potent antiretroviral combination therapy (ART) has reduced overall morbidity and mortality amongst HIV-infected adults. Some prophylactic regimes against opportunistic infections can be discontinued in patients under successful ART. QUESTIONS UNDER STUDY:(1) The influence of the availabilit...

journal_title：Swiss medical weekly

authors： Rossi M,Flepp M,Telenti A,Schiffer V,Egloff N,Bucher H,Vernazza P,Bernasconi E,Weber R,Rickenbach M,Furrer H,Swiss HIV Cohort Study.

更新日期：2001-08-11 00:00:00

abstract：BACKGROUND:since 1999 data from pulmonary hypertension (PH) patients from all PH centres in Switzerland were prospectively collected. We analyse the epidemiological aspects of these data. METHODS:PH was defined as a mean pulmonary artery pressure of >25 mm Hg at rest or >30 mm Hg during exercise. Patients with pulmona...

journal_title：Swiss medical weekly

authors： Tueller C,Stricker H,Soccal P,Tamm M,Aubert JD,Maggiorini M,Zwahlen M,Nicod L,Swiss Society for Pulmonary Hypertension.

更新日期：2008-06-28 00:00:00

abstract：BACKGROUND:Glomerulonephritis is a rare yet serious group of diseases with a high risk of progression to end-stage renal disease. For optimal healthcare planning, detailed epidemiological and demographic data are essential. Despite their clinical relevance, these data are largely lacking in Switzerland. OBJECTIVE:The ...

journal_title：Swiss medical weekly

authors： Nanchen G,Schutzbach K,Rotman S,Winzeler R,Ambühl P,Halfon M,Pruijm M

更新日期：2020-10-06 00:00:00

abstract：OBJECTIVES:Epidemological studies suggest that farmers are at an increased risk for chronic obstructive pulmonary disease because of exposure to organic dust. We assessed the proportion of farmers among patients with end stage lung disease and we measured the seasonal exposure of dairy farmers to organic dust in a rura...

journal_title：Swiss medical weekly

authors： Cathomas RL,Brüesch H,Fehr R,Reinhart WH,Kuhn M

更新日期：2002-04-06 00:00:00

abstract：BACKGROUND:Several publications reported on the safety and efficacy of bortezomib, a novel first-in-class anti-cancer agent, in the treatment of relapsed/refractory multiple myeloma in controlled clinical trials. Complementary data on the experience with bortezomib in daily oncology practice are needed. We report on th...

journal_title：Swiss medical weekly

authors： Freimann H,Calderoni A,Cornu P,Olie R

更新日期：2007-06-02 00:00:00

abstract：BACKGROUND:A clinical research application must be submitted for approval by a competent ethics committee (EC) before a study can be executed. There is very limited information on how such submissions could be optimised, especially regarding research in children and adolescents, which requires particular caution and ag...

journal_title：Swiss medical weekly

authors： Bergstraesser E,Nadal D,Özgü H,Kleist P

更新日期：2020-06-19 00:00:00

abstract：:Sports-practicing youths are at an elevated risk for alcohol use and misuse. Although much attention has recently been given to depicting subgroups facing the greatest threats, little evidence exists on the contexts in which their drinking takes place. Using data from a cross-sectional study on youth sports participat...

journal_title：Swiss medical weekly

authors： Bélanger RE,Ohl F,Berchtold A,Akre C,Suris JC

更新日期：2012-02-17 00:00:00

abstract：BACKGROUND:B-type natriuretic peptide (BNP) has been proven to be a biochemical marker of severity of congestive heart failure. We are aware of only few papers reporting the association of BNP elevation and pulmonary hypertension (primary, thromboembolic, or as a consequence of chronic obstructive pulmonary disease). L...

journal_title：Swiss medical weekly

authors： Maeder M,Ammann P,Rickli H,Diethelm M

更新日期：2003-09-26 00:00:00

abstract：QUESTIONS UNDER STUDY:To evaluate the diagnostic value of serum Cystatin C and urine neutrophil gelatinase-associated lipocalin (NGAL) for the detection of acute kidney injury in patients undergoing congenital heart surgery. METHODS:Serial samples of serum Cystatin C and urine NGAL were collected from 139 consecutive ...

journal_title：Swiss medical weekly

authors： Seitz S,Rauh M,Gloeckler M,Cesnjevar R,Dittrich S,Koch AM

更新日期：2013-01-17 00:00:00

abstract：OBJECTIVE:The methods used to diagnose and classify ovarian cancer have changed over the past decade. We used hospital registry data to assess the incidence, treatment durations and hospital costs of ovarian cancer in Switzerland. METHODS:We carried out a retrospective analysis of a hospital registry covering all inpa...

journal_title：Swiss medical weekly

authors： Wieser S,Schmidt M,Kind AB,Heinzelmann-Schwarz VA

更新日期：2018-07-29 00:00:00

abstract：:We present the case of an oncology patient admitted to our hospital during the current COVID-19 pandemic with clinical and radiological features strongly suggestive of interstitial pneumonia. Multiple laboratory tests were negative for SARS-CoV-2 (polymerase chain reaction testing of nasopharyngeal swabs, and of induc...

journal_title：Swiss medical weekly

authors： Rigamonti E,Salera D,Gheorghiu AC,Fratila C,Gianella P

更新日期：2020-07-11 00:00:00

abstract：BACKGROUND:To compare the efficacy of two different regimens in treatment of brucellosis. METHODS:This randomised clinical trial study was conducted on 280 patients with brucellosis in Babol, Iran, from April 1999 to January 2002. One of the following two regimens was randomly prescribed for two months: co-trimoxazole...

journal_title：Swiss medical weekly

authors： Roushan MR,Gangi SM,Ahmadi SA

更新日期：2004-09-18 00:00:00

abstract：INTRODUCTION:It has been proposed that reactive oxygen species play a role in renal fibrosis. 8-OHdG, a metabolite of oxidative damage to leukocyte DNA, has been identified as a marker of oxidative stress in patients with chronic renal failure. MATERIALS AND METHODS:Seventy-four patients following nephrectomy were ret...

journal_title：Swiss medical weekly

authors： Tsai JP,Liou JH,Yeh KT,Tai HC,Cheng YW,Chang HR

更新日期：2011-10-12 00:00:00

abstract：OBJECTIVES:Several studies have reported prolonged QTc intervals in patients under methadone maintenance treatment, including development of torsade-de-pointes arrhythmia and death. It is still not clear why some patients develop critical QTc extensions while others do not. METHODS:ECG findings in a convenience sample...

journal_title：Swiss medical weekly

authors： Gholami N,Boesch L,Falcato L,Stohler R,Bruggmann P

更新日期：2013-09-06 00:00:00

abstract：OBJECTIVES:To investigate the subjective treatment goals of insulin-treated diabetic patients. METHODS:297 type 1 and 205 type 2 diabetic patients, representative of the North-western Swiss population, filled out a self report questionnaire focusing on their own treatment goals using standardized measures wherever ava...

journal_title：Swiss medical weekly

authors： Puder JJ,Endrass J,Moriconi N,Keller U

更新日期：2006-09-02 00:00:00

abstract：:In Switzerland, voluntary termination of pregnancy (VTP) can be performed in all public and private hospitals with an obstetrics/gynaecology department. For various reasons, many Italian women use the Swiss healthcare system, in particular in Canton Ticino, a border region adjacent to Italy in the southern part of Swi...

journal_title：Swiss medical weekly

authors： Reinholz D,Casati S,Beretta O,Merlani G

更新日期：2018-07-09 00:00:00

abstract：BACKGROUND:In recent years, several treatment modalities have proved to be effective in the treatment of neuroendocrine tumours (NETs). However, there is currently no consensus on the sequence in which these options are best used. METHODS:In this observational study, we analysed the treatment modalities and sequences ...

journal_title：Swiss medical weekly

authors： Kollar A,Bütikofer L,Ochsenbein A,Stettler C,Trepp R

更新日期：2020-01-15 00:00:00

abstract：QUESTIONS UNDER STUDY:Measuring the patient safety climate in the organisation of healthcare can help to identify problematic issues with a view to improving patient safety. We aimed (1) to describe the nurse-reported engagement in safety behaviours, (2) to describe the prevailing nurse-reported patient safety climate ...

journal_title：Swiss medical weekly

authors： Ausserhofer D,Schubert M,Engberg S,Blegen M,De G,Schwendimann R

更新日期：2012-01-20 00:00:00

abstract：:Although progress has been made in the management of acute leukaemias, most patients who fail to respond to front-line therapies with cytostatic agents and stem cell transplantation, or who relapse after an initial response die from progressive disease. Novel treatment modalities exploiting donor-derived natural kille...

journal_title：Swiss medical weekly

authors： Wodnar-Filipowicz A,Kalberer CP

更新日期：2006-06-10 00:00:00

abstract：PRINCIPLES:Since the recommendation that infants sleep in the supine position, there has been an increase in cases of posterior positional plagiocephaly. Even though this condition is a purely cosmetic problem, if it is severe it may affect the child psychologically. Positioning may help in mild or moderate cases, but ...

journal_title：Swiss medical weekly

authors： de Ribaupierre S,Vernet O,Rilliet B,Cavin B,Kalina D,Leyvraz P-

更新日期：2007-06-30 00:00:00

abstract：BACKGROUND:General practitioners (GPs) use diagnostic tests to help distinguish between viral and bacterial acute respiratory tract infections (ARTI). We investigated the prevalence of these tests, and how tests are associated with diagnosis, treatment and patient satisfaction. METHODS:As part of a clinical trial, 45 ...

journal_title：Swiss medical weekly

authors： Briel M,Young J,Tschudi P,Hersberger KE,Hugenschmidt C,Langewitz W,Bucher HC

更新日期：2006-04-15 00:00:00