QTc prolongation in methadone maintenance--the role of HCV infection.

Abstract:

OBJECTIVES:Several studies have reported prolonged QTc intervals in patients under methadone maintenance treatment, including development of torsade-de-pointes arrhythmia and death. It is still not clear why some patients develop critical QTc extensions while others do not. METHODS:ECG findings in a convenience sample of 210 methadone-maintained heroin-dependent patients, taking HCV-infection status and methadone dosage into account simultaneously by means of a multiple linear regression model with QTc-interval as the dependent variable. RESULTS:Prolonged QTc-time is associated with hepatitis C infections (p = 0.005) and higher doses of racemic methadone (p = 0.012). CONCLUSION:Infection with hepatitis C increases the likelihood of critical QTc prolongation in patients in methadone maintenance treatment.

journal_name

Swiss Med Wkly

journal_title

Swiss medical weekly

authors

Gholami N,Boesch L,Falcato L,Stohler R,Bruggmann P

doi

10.4414/smw.2013.13852

subject

Has Abstract

pub_date

2013-09-06 00:00:00

pages

w13852

eissn

1424-7860

issn

1424-3997

pii

smw-13852

journal_volume

143

pub_type

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