Abstract:
OBJECTIVES:Several studies have reported prolonged QTc intervals in patients under methadone maintenance treatment, including development of torsade-de-pointes arrhythmia and death. It is still not clear why some patients develop critical QTc extensions while others do not. METHODS:ECG findings in a convenience sample of 210 methadone-maintained heroin-dependent patients, taking HCV-infection status and methadone dosage into account simultaneously by means of a multiple linear regression model with QTc-interval as the dependent variable. RESULTS:Prolonged QTc-time is associated with hepatitis C infections (p = 0.005) and higher doses of racemic methadone (p = 0.012). CONCLUSION:Infection with hepatitis C increases the likelihood of critical QTc prolongation in patients in methadone maintenance treatment.
journal_name
Swiss Med Wklyjournal_title
Swiss medical weeklyauthors
Gholami N,Boesch L,Falcato L,Stohler R,Bruggmann Pdoi
10.4414/smw.2013.13852subject
Has Abstractpub_date
2013-09-06 00:00:00pages
w13852eissn
1424-7860issn
1424-3997pii
smw-13852journal_volume
143pub_type
杂志文章abstract:OBJECTIVE:To provide population-based, gestational age (GA) stratified incidence of mortality and morbidities. METHODS:Population-based prospective observational study of infants born between 23 0/7 and 31 6/7 weeks GA in the years 2000-2004 in all Swiss neonatal intensive care units. Outcomes measured were: mortality...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2011.13212
更新日期:2011-06-24 00:00:00
abstract:BACKGROUND:Evaluation of the current clinical treatment of psoriasis in Switzerland remains to be measured with the parameters cost-of-illness and quality of life. OBJECTIVE:To obtain data on out-of-pocket expenses, costs of outpatient/office-based care and inpatient care for psoriasis, and to extrapolate total costs ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:smw-12756
更新日期:2010-02-06 00:00:00
abstract:OBJECTIVES:To assess adherence to recommended standards of diabetes care by Swiss primary care physicians. METHODS:Medical files of community-based primary care physician were reviewed to assess adherence to recommended standards of diabetes care. These standards of care were based on a uniform set of definitions addr...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2007/11/smw-11592
更新日期:2007-03-24 00:00:00
abstract::In this review article, we aim at analysing the role of stress in addiction and relapse. In order to do so, we first offer a summary of the findings from affective neuroscience trying to understand compulsive reward-seeking behaviours. These behaviours are characterised by an imbalance between the considerable amount ...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2019.20151
更新日期:2019-11-29 00:00:00
abstract:BACKGROUND:Extracorporeal photopheresis (ECP) has been reported to be safe and the ultimate treatment option in lung transplant recipients with chronic lung allograft dysfunction (CLAD), the main overall cause of mortality in lung transplant recipients. However, ECP is not reimbursed in selected health jurisdictions, a...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2017.14429
更新日期:2017-03-13 00:00:00
abstract::The current situation of the biomedical sciences is critically discussed. It can be summarized as follows: 1. We have to acknowledge the presence of a serious credibility problem, which might undermine the foundations of medical science. ("Sliding on a slippery slope") 2. Multiple forces going beyond simple conflicts ...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2015.14120
更新日期:2015-03-13 00:00:00
abstract:BACKGROUND:To compare the efficacy of two different regimens in treatment of brucellosis. METHODS:This randomised clinical trial study was conducted on 280 patients with brucellosis in Babol, Iran, from April 1999 to January 2002. One of the following two regimens was randomly prescribed for two months: co-trimoxazole...
journal_title:Swiss medical weekly
pub_type: 临床试验,杂志文章,随机对照试验
doi:2004/37/smw-10665
更新日期:2004-09-18 00:00:00
abstract::We present the case of an oncology patient admitted to our hospital during the current COVID-19 pandemic with clinical and radiological features strongly suggestive of interstitial pneumonia. Multiple laboratory tests were negative for SARS-CoV-2 (polymerase chain reaction testing of nasopharyngeal swabs, and of induc...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20312
更新日期:2020-07-11 00:00:00
abstract:BACKGROUND:Many antimicrobial stewardship programmes (ASPs) target the intensive care unit owing to high antimicrobial utilisation. In this review, we summarise and assess the quality of evidence supporting the implementation of various ASP strategies in the intensive care unit setting with a focus on publications betw...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2015.14220
更新日期:2015-12-21 00:00:00
abstract::In Switzerland, voluntary termination of pregnancy (VTP) can be performed in all public and private hospitals with an obstetrics/gynaecology department. For various reasons, many Italian women use the Swiss healthcare system, in particular in Canton Ticino, a border region adjacent to Italy in the southern part of Swi...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2018.14636
更新日期:2018-07-09 00:00:00
abstract:BACKGROUND:On 1 January 2012 Swiss Diagnosis Related Groups (DRG), a new uniform payment system for in-patients was introduced in Switzerland with the intention to replace a "cost-based" with a "case-based" reimbursement system to increase efficiency. With the introduction of the new payment system we aim to answer que...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2014.13972
更新日期:2014-06-25 00:00:00
abstract:PRINCIPLES:We aimed to evaluate the efficacy of, and treatment satisfaction with, insulin glargine administered with SoloSTAR® or ClikSTAR® pens in patients with type 2 diabetes mellitus managed by primary care physicians in Switzerland. METHODS:A total of 327 patients with inadequately controlled type 2 diabetes were...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2015.14114
更新日期:2015-03-05 00:00:00
abstract:QUESTIONS UNDER STUDY:The unexpected death of a preterm infant is an extremely painful situation for parents. Despite a number of quantitative studies, little is known about parents' inner experience. The aim of this study was to gather more in-depth information about what preoccupies parents in this situation of suffe...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2007/27/smw-11868
更新日期:2007-07-14 00:00:00
abstract:QUESTIONS UNDER STUDY/PRINCIPLES:Although probe-based confocal laser endomicroscopy (pCLE) is on the edge of entering daily practice in gastroenterological endoscopy, findings in the field of respiratory medicine are only rarely reported, keeping pCLE during flexible bronchoscopy as a mere preclinical research tool. Si...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2013.13764
更新日期:2013-03-26 00:00:00
abstract:OBJECTIVE:To assess the clinical implementation and report preliminary results of a novel technique called the Ozaki procedure for stentless aortic valve replacement through reconstruction of the valve leaflets from autologous pericardium. METHOD:Between September 2015 and May 2017 30 patients (20 males, mean ± standa...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2018.14591
更新日期:2018-02-09 00:00:00
abstract::Invasive fungal infections have emerged as important causes of morbidity and mortality in immunocompromised patients. In response to this challenge, the field of antifungal chemotherapy has considerably expanded. Fluconazole and itraconazole, introduced in the late 1980s, were the first durably useful alternatives to ...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2002/23/smw-09729
更新日期:2002-06-15 00:00:00
abstract:BACKGROUND:B-type natriuretic peptide (BNP) has been proven to be a biochemical marker of severity of congestive heart failure. We are aware of only few papers reporting the association of BNP elevation and pulmonary hypertension (primary, thromboembolic, or as a consequence of chronic obstructive pulmonary disease). L...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2003/37/smw-10367
更新日期:2003-09-26 00:00:00
abstract::The WHO recommends screening of Latin American migrants for Chagas disease to reduce morbidity and mortality and increase the likelihood of eradicating the disease. The objective was to assess the feasibility and acceptability of a screening strategy in one Swiss canton. From February 2011 to September 2012, people at...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2019.20050
更新日期:2019-04-04 00:00:00
abstract::The differential diagnosis for children with diabetes includes a group of monogenic diabetic disorders known as maturity-onset diabetes of the young (MODY). So far, six underlying gene defects have been identified. The most common subtypes are caused by mutations in the genes encoding the transcription factor HNF-1a (...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2005/23/smw-11030
更新日期:2005-06-11 00:00:00
abstract::Since 1946 the development of fractionation and purification methods of human plasma led to biologic immunoglobulin for intravenous use (IVIG). In 1980 a child with refractory immune thrombocytopenia (ITP), bleeding and secondary hypogammaglobulinaemia due to long term immunosuppressive treatment got IVIG. His platele...
journal_title:Swiss medical weekly
pub_type: 历史文章,杂志文章,评审
doi:10.4414/smw.2012.13593
更新日期:2012-05-31 00:00:00
abstract:QUESTION UNDER STUDY:What are the trends in avoidable cancer mortality in Switzerland and neighbouring countries? METHODS:Mortality data and population estimates 1996-2010 were obtained from the Swiss Federal Statistical Office for Switzerland and the World Health Organization Mortality Database (http://www.who.int/he...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2015.14184
更新日期:2015-10-02 00:00:00
abstract::Increased survival rates after orthotopic liver transplantation (OLT) in patients with end-stage liver disease have become possible due to an advanced understanding of the pathophysiology of liver disease, the establishment of multiorgan procurement and preservation techniques, and the development of safer and more po...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2007/13/smw-11681
更新日期:2007-04-07 00:00:00
abstract:OBJECTIVES:To describe alcohol and tobacco consumption during pregnancy in women giving birth in a public hospital in Geneva, to evaluate risk factors related to these consumptions and to explore the influence of close relatives on the consumption habits of pregnant women. METHODS:A cross-sectional questionnaire surve...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2013.13795
更新日期:2013-05-25 00:00:00
abstract:BACKGROUND:Introduction of potent antiretroviral combination therapy (ART) has reduced overall morbidity and mortality amongst HIV-infected adults. Some prophylactic regimes against opportunistic infections can be discontinued in patients under successful ART. QUESTIONS UNDER STUDY:(1) The influence of the availabilit...
journal_title:Swiss medical weekly
pub_type: 杂志文章,多中心研究
doi:2001/31/smw-09728
更新日期:2001-08-11 00:00:00
abstract::Pulmonary arterial hypertension (PAH) is a vascular disease of unknown aetiology, characterised by an abnormal thickening of the arterial wall that is responsible for an increase in pulmonary vascular resistance. The haemodynamic consequence of PAH is an increased afterload for the right ventricle and, eventually, rig...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2016.14305
更新日期:2016-05-31 00:00:00
abstract:PURPOSE:Stress ulcer prophylaxis prescriptions might not be sufficiently challenged throughout a patient's stay in an intensive care unit (ICU) and might be erroneously maintained after ICU discharge. This study aimed to determine (1) stress ulcer prophylaxis adequacy in ICU and (2) the proportion of patients recei...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20322
更新日期:2020-08-24 00:00:00
abstract:BACKGROUND:With its high incidence and subsequent adverse consequences in the intensive care setting, several instruments have been developed to screen for and detect delirium. One of the more commonly used is the Intensive Care Delirium Screening Checklist (ICDSC); however, the optimal cut-off score indicating deliriu...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2018.14597
更新日期:2018-03-14 00:00:00
abstract:QUESTIONS UNDER STUDY:Deep brain stimulation (DBS) has become a standard therapy for some forms of severe movement disorders and is investigated for other neurological and psychiatric disorders, although many scientific, clinical and ethical issues are still open. We analyse how the Swiss DBS community addresses these ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2012.13570
更新日期:2012-04-05 00:00:00
abstract:QUESTIONS UNDER STUDY:This study aims at estimating the costs of disorders of the brain in Switzerland based on the published epidemiological and economic evidence. METHODS:the data presented for Switzerland are derived from the "cost of disorders of the brain in Europe" study of the European Brain Counsil (EBC). Avai...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2008/01/smw-11910
更新日期:2008-01-12 00:00:00
abstract:BACKGROUND:since 1999 data from pulmonary hypertension (PH) patients from all PH centres in Switzerland were prospectively collected. We analyse the epidemiological aspects of these data. METHODS:PH was defined as a mean pulmonary artery pressure of >25 mm Hg at rest or >30 mm Hg during exercise. Patients with pulmona...
journal_title:Swiss medical weekly
pub_type: 杂志文章,多中心研究
doi:2008/25/smw-11915
更新日期:2008-06-28 00:00:00