Abstract:
:Increased survival rates after orthotopic liver transplantation (OLT) in patients with end-stage liver disease have become possible due to an advanced understanding of the pathophysiology of liver disease, the establishment of multiorgan procurement and preservation techniques, and the development of safer and more potent immunosuppressive drugs. In addition, standardisation of surgical techniques and advances in anaesthetic management have contributed significantly to this development. The up-to-date concept of improving patient outcome following OLT includes a fast track approach in selected patient populations, which may shorten ICU and/or hospital stay and reduce costs. In particular, immediate postoperative extubation has been identified as an excellent tool to achieve both improved clinical results and a reduced drain on financial resources. Studies on fast tracking protocols have shown clearly that prolonged mechanical ventilation following surgery is no longer justified in the majority of patients. On current evidence at least 70-80% of transplant recipients can be extubated immediately following surgery. The incidence of reintubation is not increased hereafter when compared to patients extubated later. However, special attention should be focused on liver transplant recipients in poor clinical condition at the time of OLT, undergoing complicated surgery, or receiving liver grafts with severe preservation injury. These patients might not be eligible for fast tracking protocols and may be at increased risk of prolonged postoperative mechanical ventilation.
journal_name
Swiss Med Wklyjournal_title
Swiss medical weeklyauthors
Glanemann M,Busch T,Neuhaus P,Kaisers Udoi
2007/13/smw-11681subject
Has Abstractpub_date
2007-04-07 00:00:00pages
187-91issue
13-14eissn
1424-7860issn
1424-3997pii
smw-11681journal_volume
137pub_type
杂志文章,评审abstract:STUDY OBJECTIVES:we performed an open-label national study to evaluate the effects of Bosentan on haemodynamics, exercise capacity, quality of life, safety and tolerability in patients with chronic thromboembolic pulmonary hypertension (CTEPH). PATIENTS AND METHODS:fifteen patients with CTEPH not eligible or waiting f...
journal_title:Swiss medical weekly
pub_type: 临床试验,杂志文章
doi:2007/41/smw-11819
更新日期:2007-10-20 00:00:00
abstract:BACKGROUND:In contrast to quality of life, patient satisfaction on chronic haemodialysis (HD) and peritoneal dialysis (PD) has only rarely been studied. PATIENTS AND METHODS:All chronic HD and PD patients of the 19 centres located in western Switzerland were asked to complete a specific questionnaire, assessing dialys...
journal_title:Swiss medical weekly
pub_type: 杂志文章,多中心研究
doi:2006/13/smw-11180
更新日期:2006-04-01 00:00:00
abstract::Kras, a small intracellular GTPase, is a central intermediary of the epidermal growth factor receptor (EGFR) and other tyrosine kinase receptor pathways. Increased EGFR and Kras signalling is involved in colorectal carcinogenesis and tumour progression. Mutations of Kras result in the loss of its GTPase activity and t...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2010.13112
更新日期:2010-11-19 00:00:00
abstract:AIM:The levels of teamwork and clinician burnout in healthcare differ depending on demographic and unit characteristics. However, the impact of these characteristics varies between clinical settings. In addition, the impact of objectively measured workload in such settings is largely unknown. The aim of this study was ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2019.20033
更新日期:2019-03-24 00:00:00
abstract:PRINCIPLES:Neuroendocrine neoplasms (NENs) are believed to be associated with an increased risk for additional malignancies (AMs). We aimed to (1) assess the occurrence of AM in NEN patients (2) investigate the characteristics and temporal relationship of NEN patients with and without AM. METHODS:The SwissNET registry...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2016.14362
更新日期:2016-11-12 00:00:00
abstract:BACKGROUND:The precision of symptom assessment and documentation in daily routine is unknown. Differences in hip studies have been observed between the charts and the patient questionnaires. This was the reason to perform this study and to compare the charts and the patient questionnaires. METHODS:This was a retrospec...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:smw-12581
更新日期:2009-10-17 00:00:00
abstract:QUESTIONS UNDER STUDY:Optimal oxygen saturation (SpO2) targets for extremely low gestational age neonates (ELGANs, gestational age [GA] <28 weeks) are unknown. Conflicting results from five recently published multicentre trials, which randomised ELGANs to high (91 to 95%) or low (85 to 89%) SpO2 targets from birth up t...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2015.14197
更新日期:2015-11-02 00:00:00
abstract:OBJECTIVE:Regular checking of the fitness to drive of elderly car-license holders is required in some countries, and this will become increasingly important as more countries face aging populations. The present study investigated whether the analysis of saccadic eye movements could be used as a screening method for the...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2015.14098
更新日期:2015-02-09 00:00:00
abstract:QUESTION UNDER STUDY:The present study aimed to compare the prevalence of work-life conflicts and the health status of physicians, with a representative sample of university graduates as well as with a representative sample of the general Swiss working population. Furthermore, it aimed to analyse whether work-life conf...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2010.13063
更新日期:2010-07-11 00:00:00
abstract:THEORETICAL BACKGROUND:Mental disorders emerge in childhood and adolescence and are important risk factors for mental disorders in adolescence and adulthood. Since paediatricians are typically the first to see children with psychological problems, the aim of this study was to obtain a survey of mental disorders of chil...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2010.13092
更新日期:2010-08-27 00:00:00
abstract:AIMS:We aimed to identify familial hypercholesterolaemia mutation carriers among participants to the Lausanne Institutional Biobank (BIL). Our experimental workflow was designed as a proof-of-concept demonstration of the resources and services provided by our integrated institutional clinical research support platform....
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2016.14326
更新日期:2016-08-06 00:00:00
abstract::Rehabilitation can be referred to as a "black box" because little is known about what specific interventions comprise the rehabilitation process, including patients with spinal cord injury (SCI). Despite that rehabilitation professionals can "see" daily what rehabilitation looks like, the contribution of each interven...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2012.13673
更新日期:2012-09-20 00:00:00
abstract:QUESTIONS UNDER STUDY:Postmenopausal women are more likely to develop coronary artery disease than premenopausal women of the same age. Postmenopausal oral oestrogen therapy is associated with increased levels of high-density lipoprotein (HDL) cholesterol and decreased levels of lowdensity lipoprotein (LDL) cholesterol...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2006/31/smw-11390
更新日期:2006-08-05 00:00:00
abstract::Calcitonin was discovered in the early 1960s [1], at which time it was assumed to be a single hormone with a yet-to-be-determined role in human physiology. Since then it has been found to be only one entity among a large array of related circulating peptides, at least one of which has a pivotal role in the host respon...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2001/41/smw-09751
更新日期:2001-10-20 00:00:00
abstract:BACKGROUND:Ehlers-Danlos syndrome (EDS) is a heterogeneous group of rare inherited diseases involving connective tissue. Vascular EDS (vEDS) is associated with abnormal type III collagen, which is an essential component of skin, hollow organs and arterial walls, and causes potentially fatal visceral and arterial compli...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20379
更新日期:2020-12-05 00:00:00
abstract:OBJECTIVE:To evaluate the current prevalence of self-reported interpersonal violence amongst patients consulting at the emergency department (ED) of a university hospital and to describe the characteristics of the violence sustained. METHODS:Ours was a cross-sectional study using a modified version of the Partner Viol...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2019.20147
更新日期:2019-12-17 00:00:00
abstract:BACKGROUND:In recent years, several treatment modalities have proved to be effective in the treatment of neuroendocrine tumours (NETs). However, there is currently no consensus on the sequence in which these options are best used. METHODS:In this observational study, we analysed the treatment modalities and sequences ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20176
更新日期:2020-01-15 00:00:00
abstract:BACKGROUND:Endoscopic retrograde biliary drainage (ERBD) using a plastic stent is suggested to be as effective as endoscopic nasobiliary drainage (ENBD) with a nasobiliary catheter for temporary biliary drainage in acute obstructive cholangitis. However, there are few studies that have compared the two methods. We ther...
journal_title:Swiss medical weekly
pub_type: 杂志文章,随机对照试验
doi:10.4414/smw.2013.13823
更新日期:2013-07-07 00:00:00
abstract::The precise diagnosis of a severe haemorrhagic disorder is usually not too problematic. However, physicians are most often faced with individuals consulting for mild haemorrhagic symptoms, particularly occurring after a surgical intervention. The problem here is to evaluate whether this person really has a bleeding di...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:smw-12476
更新日期:2009-06-13 00:00:00
abstract::New oral anticoagulants used as single target inhibitors of coagulation enzymes have been developed and tested in extensive trial programmes. Results of most of these trials showed non-inferior and/or superior efficacy and safety compared to standard treatment with LMWH or VKA. These results led to registration of the...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2012.13684
更新日期:2012-10-01 00:00:00
abstract::Prior to the introduction of chemotherapy, tuberculosis management relied upon aerotherapy, heliotherapy and good nutrition. This "treatment", exemplified by the regimen applied in Swiss and other European mountain resorts, is described by Thomas Mann in the book "The Magic Mountain". Tuberculosis chemotherapy began i...
journal_title:Swiss medical weekly
pub_type: 历史文章,杂志文章,评审
doi:10.4414/smw.2012.13665
更新日期:2012-08-22 00:00:00
abstract:QUESTION UNDER STUDY:Domestic accidents are an important problem in paediatric medicine. This study was designed to gain a better understanding of burn mechanisms and target prevention. METHODS:Children treated for burn lesions in the Department of Paediatric Surgery between August 2004 and August 2005 were included i...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:smw-12605
更新日期:2009-09-19 00:00:00
abstract:BACKGROUND:Introduction of potent antiretroviral combination therapy (ART) has reduced overall morbidity and mortality amongst HIV-infected adults. Some prophylactic regimes against opportunistic infections can be discontinued in patients under successful ART. QUESTIONS UNDER STUDY:(1) The influence of the availabilit...
journal_title:Swiss medical weekly
pub_type: 杂志文章,多中心研究
doi:2001/31/smw-09728
更新日期:2001-08-11 00:00:00
abstract:AIMS OF THE STUDY:The purpose of this study was to establish a new computed tomography (CT) sign for pulmonary congestion (Kerley B lines in the lung apex in patients with cardiac or renal insufficiency) and to find the best signs to differentiate between pulmonary congestion and interstitial lung disease (ILD). METHO...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2019.20119
更新日期:2019-09-02 00:00:00
abstract:AIMS:This study evaluated the evolution of the prenatal diagnosis of congenital heart disease (CHD) between 2003 and 2008 and its repercussion for the CHD prevalence rate at birth in a well-defined population (Canton of Vaud, Switzerland). METHODS AND RESULTS:All 572 cases of CHD reported in the Eurocat Registry of Va...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2014.14068
更新日期:2014-12-04 00:00:00
abstract::In this review article, we aim at analysing the role of stress in addiction and relapse. In order to do so, we first offer a summary of the findings from affective neuroscience trying to understand compulsive reward-seeking behaviours. These behaviours are characterised by an imbalance between the considerable amount ...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2019.20151
更新日期:2019-11-29 00:00:00
abstract:OBJECTIVE:The methods used to diagnose and classify ovarian cancer have changed over the past decade. We used hospital registry data to assess the incidence, treatment durations and hospital costs of ovarian cancer in Switzerland. METHODS:We carried out a retrospective analysis of a hospital registry covering all inpa...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2018.14647
更新日期:2018-07-29 00:00:00
abstract:BACKGROUND:Sarcoidosis is a disorder of unknown aetiology. Most patients have steroid-responsive disease, but side effects and steroid resistance may necessitate alternative treatments. Endothelin has in-vitro fibrogenic activity and the endothelin system is activated in sarcoidosis. OBJECTIVES:We studied the efficacy...
journal_title:Swiss medical weekly
pub_type: 杂志文章,随机对照试验
doi:10.4414/smw.2018.14677
更新日期:2018-10-28 00:00:00
abstract:QUESTIONS UNDER STUDY:Monitoring of antimicrobial resistance is a key component of antibiotic stewardship programs. In 2007, a significantly higher resistance rate of Escherichia coli to ciprofloxacin was found at the Department of Urology, University Hospital Zurich, Switzerland, when compared to other hospital units....
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2010.13059
更新日期:2010-07-15 00:00:00
abstract:BACKGROUND:Renal replacement therapy for paediatric end-stage renal disease (ESRD) has developed steadily since its introduction five decades ago. Continuous and long-term analysis of patient outcomes is essential for quality control. METHODS:The Swiss Paediatric Renal Registry, founded in 1970, includes patients diag...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20300
更新日期:2020-07-27 00:00:00