Abstract:
QUESTIONS UNDER STUDY:Monitoring of antimicrobial resistance is a key component of antibiotic stewardship programs. In 2007, a significantly higher resistance rate of Escherichia coli to ciprofloxacin was found at the Department of Urology, University Hospital Zurich, Switzerland, when compared to other hospital units. Thus, we aimed to determine the risk factors for this increased fluoroquinolone resistance in outpatients and inpatients with urinary tract infection (UTI) or colonisation with E. coli. METHODS:We performed a cross sectional study including 275 patients of the Department of Urology in whom E. coli was isolated from urine or blood cultures between 01.01.2006 and 31.08.2007. Clinical data were collected from patients' records using a structured questionnaire. Multivariable analysis was performed for the detection of risk factors. RESULTS:Ciprofloxacin-resistant E. coli was detected in 22% of patients. Risk factors for ciprofloxacin-resistant E. coli included prior use of fluoroquinolones (odds ratio [OR] (95% confidence intervals): 2.24 (1.08-4.62), p = 0.030), prior urinary tract catheterisation (OR: 2.41 (1.02-5.67), p = 0.044) and recurrent UTIs (OR: 2.26 (1.07-4.78), p = 0.032). 60.8% of all prescriptions in urinary tract infections were for fluoroquinolones, and this antibiotic class was the empiric antibiotic regimen of choice in 72.5% of all acute, uncomplicated, urinary tract infections. CONCLUSIONS:The increasing prevalence of ciprofloxacin-resistant E. coli makes empiric therapy in UTIs with this agent questionable, especially in patients with one or several of the above mentioned risk factors. Due to the increasing resistance rate, continuous surveillance and susceptibility testing in individual patients, particularly with complicated UTIs, is indispensable for adequate therapy.
journal_name
Swiss Med Wklyjournal_title
Swiss medical weeklyauthors
Nicoletti J,Kuster SP,Sulser T,Zbinden R,Ruef C,Ledergerber B,Weber Rdoi
10.4414/smw.2010.13059subject
Has Abstractpub_date
2010-07-15 00:00:00pages
w13059eissn
1424-7860issn
1424-3997pii
smw-13059journal_volume
140pub_type
杂志文章abstract:OBJECTIVES:First, to test whether current injury is more closely related to acute intake than to usual consumption patterns, and second, to test whether repeated injury is more closely related to general consumption patterns than to acute intake. METHODS:Screening of alcohol consumption of 7,872 patients enrolling bet...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2007/45/smw-11697
更新日期:2007-11-17 00:00:00
abstract::Coronary microcirculation plays a crucial role for the outcomes of patients with STEMI. Although PPCI improves outcomes compared to thrombolysis, a substantial amount of STEMI patients do not achieve optimal myocardial reperfusion. Angiographic methods for assessment of reperfusion like TIMI Flow and MBG are easy to u...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2011.13313
更新日期:2011-12-09 00:00:00
abstract::Antiosteoporotic drugs are recommended in patients with fragility fractures and in patients considered to be at high fracture risk on the basis of clinical risk factors and/or low bone mineral density. As first-line treatment most patients are started with an antiresorptive treatment, i.e. drugs that inhibit osteoclas...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2017.14484
更新日期:2017-08-16 00:00:00
abstract::The differential diagnosis for children with diabetes includes a group of monogenic diabetic disorders known as maturity-onset diabetes of the young (MODY). So far, six underlying gene defects have been identified. The most common subtypes are caused by mutations in the genes encoding the transcription factor HNF-1a (...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2005/23/smw-11030
更新日期:2005-06-11 00:00:00
abstract:OBJECTIVES:Women are still underrepresented in the senior ranks of medical school faculties. Thus far information has been lacking on gendersensitive career paths for professorial and nonprofessorial staff of Swiss medical schools. The aim of this study was to survey faculty members of all Swiss medical schools on soci...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2003/21/smw-10230
更新日期:2003-05-31 00:00:00
abstract:BACKGROUND:Thyroid hemiagenesis (TH) is a rare congenital abnormality of the thyroid gland, characterised by the absence of one lobe. The true prevalence of this congenital abnormality is not known because the absence of one thyroid lobe usually does not cause clinical symptoms by itself. This study aims to identify th...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:smw-12956
更新日期:2010-02-20 00:00:00
abstract:OBJECTIVE:The first description of the simplified acute physiology score (SAPS) II dates back to 1993, but little is known about its accuracy in daily practice. Our purpose was to evaluate the accuracy of scoring and the factors that affect it in a nationwide survey. METHODS:Twenty clinical scenarios, covering a broad...
journal_title:Swiss medical weekly
pub_type: 杂志文章,随机对照试验
doi:10.4414/smw.2014.14090
更新日期:2014-12-23 00:00:00
abstract:PRINCIPLES:Heart failure is associated with a grim prognosis. Disease management programmes can improve prognosis in heart failure patients but the applicability to the general population remains limited. We aimed to compare the outcome, pharmacological therapy, and quality of life in unselected heart failure patients ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2006/17/smw-11274
更新日期:2006-04-29 00:00:00
abstract:INTRODUCTION:Acute bronchiolitis is the most common lower respiratory tract infection in the first year of life. Current expert opinion and scientific data suggest that pharmaceutical agents have little impact on the natural course of the disease. METHODS:Postal questionnaires were sent to all Swiss paediatricians to ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2003/01/smw-10093
更新日期:2003-01-11 00:00:00
abstract:BACKGROUND:Many antimicrobial stewardship programmes (ASPs) target the intensive care unit owing to high antimicrobial utilisation. In this review, we summarise and assess the quality of evidence supporting the implementation of various ASP strategies in the intensive care unit setting with a focus on publications betw...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2015.14220
更新日期:2015-12-21 00:00:00
abstract::Of the two million people estimated to be newly infected with human immunodeficiency virus (HIV) every year, 95% live in poorer regions of the world where effective HIV treatment is not universally available. Strategies to reduce the spread of HIV infection, which predominantly occurs via sexual contact, are urgently ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2018.14580
更新日期:2018-01-26 00:00:00
abstract::Increased survival rates after orthotopic liver transplantation (OLT) in patients with end-stage liver disease have become possible due to an advanced understanding of the pathophysiology of liver disease, the establishment of multiorgan procurement and preservation techniques, and the development of safer and more po...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2007/13/smw-11681
更新日期:2007-04-07 00:00:00
abstract:BACKGROUND:In Switzerland, intravenous drug use accounts for the majority of hepatitis C virus (HCV) infections. Early HCV treatment prevents further transmissions and reduces morbidity and mortality due to decompensated liver cirrhosis and hepatocellular carcinoma. Nevertheless, patients in drug substitution programme...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2017.14544
更新日期:2017-11-20 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Sleep disturbances are prevalent but often overlooked or underestimated. We suspected that sleep disorders might be particularly common among pharmacy customers, and that they could benefit from counselling. Therefore, we described the prevalence and severity of symptoms associated with sleep a...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2006/09/smw-11265
更新日期:2006-03-04 00:00:00
abstract:AIMS OF THE STUDY:The Cancer Registry Zurich, Zug, Schaffhausen and Schwyz is one of the oldest cancer registries in Switzerland, first registering tumours in 1980 for the canton of Zurich. The aim of this study was to analyse trends in incidence and mortality for the most common types of cancer in the canton of Zurich...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20388
更新日期:2020-12-14 00:00:00
abstract::A prominent 2014 series by The Lancet on "Increasing value, reducing waste in biomedical research" provided recommendations on how to optimise precious resources, including in clinical research. Despite being ideally placed to lead the movement in patient-oriented clinical research, academia struggles to take correspo...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2018.14615
更新日期:2018-04-26 00:00:00
abstract::HMG-CoA reductase inhibitors, or statins, are lipid-lowering agents that have been shown to effectively decrease severe rejection periods and development of transplant coronary artery disease after heart transplantation. Precise regulation of major histocompatibility complex class II (MHC class II) gene expression pla...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2001/03/smw-06144
更新日期:2001-01-27 00:00:00
abstract:QUESTIONS UNDER STUDY/PRINCIPLES:We describe the proportion of severely depressed outpatients reaching complete remission at the different stages of a drug treatment algorithm. We compare several treatment options for SSRI (selective serotonin reuptake inhibitor) non-responders and test the feasibility of the algorithm...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2006/05/smw-11267
更新日期:2006-02-04 00:00:00
abstract:BACKGROUND:In contrast to quality of life, patient satisfaction on chronic haemodialysis (HD) and peritoneal dialysis (PD) has only rarely been studied. PATIENTS AND METHODS:All chronic HD and PD patients of the 19 centres located in western Switzerland were asked to complete a specific questionnaire, assessing dialys...
journal_title:Swiss medical weekly
pub_type: 杂志文章,多中心研究
doi:2006/13/smw-11180
更新日期:2006-04-01 00:00:00
abstract:PURPOSE:Sayana® was introduced as the first depot medroxyprogesterone acetate-containing contraceptive that is administered via subcutaneous injection. Within 10 months, the Regional Pharmacovigilance Centre (RPVC) Zurich received several anonymous reports of serious local reactions after Sayana® administration. In thi...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2017.14432
更新日期:2017-05-10 00:00:00
abstract:BACKGROUND:Considerable criticism has lately been raised by the media regarding the quality of Swiss medical expertises. The present investigation was therefore undertaken to assess the professional quality of Swiss medical expertises. The study was part of a market analysis of medical expertises (MGS study). METHODS:...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2011.13173
更新日期:2011-03-04 00:00:00
abstract:BACKGROUND:Endoscopic retrograde biliary drainage (ERBD) using a plastic stent is suggested to be as effective as endoscopic nasobiliary drainage (ENBD) with a nasobiliary catheter for temporary biliary drainage in acute obstructive cholangitis. However, there are few studies that have compared the two methods. We ther...
journal_title:Swiss medical weekly
pub_type: 杂志文章,随机对照试验
doi:10.4414/smw.2013.13823
更新日期:2013-07-07 00:00:00
abstract::Coronavirus disease 2019 (COVID-19) is primarily a pulmonary disease, but also affects the cardiovascular system in multiple ways. In this review, we will summarise and put into perspective findings and debates relating to the diverse aspects of cardiovascular involvement of COVID-19. We will review evidence for the r...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2020.20417
更新日期:2020-12-31 00:00:00
abstract::Cells reside in mechanically rich and dynamic microenvironments, and the complex interplay between mechanics and biology is widely acknowledged. Recent research has yielded insights linking the mechanobiology of cells, human physiology, and pathophysiology. In particular, we have learned of the cell's astounding abili...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2013.13766
更新日期:2013-03-14 00:00:00
abstract:QUESTIONS UNDER STUDY/PRINCIPLES:Although probe-based confocal laser endomicroscopy (pCLE) is on the edge of entering daily practice in gastroenterological endoscopy, findings in the field of respiratory medicine are only rarely reported, keeping pCLE during flexible bronchoscopy as a mere preclinical research tool. Si...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2013.13764
更新日期:2013-03-26 00:00:00
abstract::Apart from the degree of stenosis, plaque morphology has emerged in recent years as an important contributory factor in stroke risk. Ultrasound studies have shown that hypo- or anechogenic plaques carry a higher risk of cerebrovascular events than echogenic ones. Similarly, heterogeneous plaques presenting a complex p...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2005/43/smw-11038
更新日期:2005-10-29 00:00:00
abstract:PRINCIPLES:Analysis of the spatial distribution of mortality data is important for identification of high-risk areas, which in turn might guide prevention, and modify behaviour and health resources allocation. This study aimed to update the Swiss mortality atlas by analysing recent data using Bayesian statistical metho...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2016.14280
更新日期:2016-02-22 00:00:00
abstract:OBJECTIVES:To determine 1) rates of needlestick and sharps injuries (NSSIs) not reported to occupational health services, 2) reasons for underreporting and 3) awareness of reporting procedures in a Swiss university hospital. MATERIALS AND METHODS:We surveyed 6,367 employees having close clinical contact with patients ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2012.13523
更新日期:2012-02-10 00:00:00
abstract::The anti-inflammatory genes, haem oxygenase 1 (HO-1, HMOX1) rs2071746 (unrestricted model: p = 9.07 × 10-4; recessive model: p = 4.99 × 10-4; multiplicative model: p = 0.0009; and additive model: p = 1.87 × 10-4) and interleukin-10 (IL-10) rs1800872 (dominant model: p = 0.0277) have been associated with paediatric inf...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2017.14456
更新日期:2017-08-02 00:00:00
abstract:AIM:The levels of teamwork and clinician burnout in healthcare differ depending on demographic and unit characteristics. However, the impact of these characteristics varies between clinical settings. In addition, the impact of objectively measured workload in such settings is largely unknown. The aim of this study was ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2019.20033
更新日期:2019-03-24 00:00:00