Abstract:
:Antiosteoporotic drugs are recommended in patients with fragility fractures and in patients considered to be at high fracture risk on the basis of clinical risk factors and/or low bone mineral density. As first-line treatment most patients are started with an antiresorptive treatment, i.e. drugs that inhibit osteoclast development and/or function (bisphosphonates, denosumab, oestrogens or selective oestrogen receptor modulators). In the balance between benefits and risks of antiresorptive treatment, uncertainties remain regarding the optimal treatment duration and the management of patients after drug discontinuation. Based on the available evidence, this position statement will focus on the long-term management of osteoporosis therapy, formulating decision criteria for clinical practice.
journal_name
Swiss Med Wklyjournal_title
Swiss medical weeklyauthors
Meier C,Uebelhart B,Aubry-Rozier B,Birkhäuser M,Bischoff-Ferrari HA,Frey D,Kressig RW,Lamy O,Lippuner K,Stute P,Suhm N,Ferrari Sdoi
10.4414/smw.2017.14484subject
Has Abstractpub_date
2017-08-16 00:00:00pages
w14484eissn
1424-7860issn
1424-3997pii
smw-14484journal_volume
147pub_type
杂志文章abstract:PRINCIPLES:Analysis of the spatial distribution of mortality data is important for identification of high-risk areas, which in turn might guide prevention, and modify behaviour and health resources allocation. This study aimed to update the Swiss mortality atlas by analysing recent data using Bayesian statistical metho...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2016.14280
更新日期:2016-02-22 00:00:00
abstract::Amyloid fibrils are polymers composed of proteins in beta-sheet conformation, which are found in at least 20 diseases for which no cure is available. These diseases include Alzheimer's disease and spongiform encephalopathies, in which the amyloid beta-peptide and the prion protein (PrP), respectively, form amyloid. Al...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2003/19/smw-09987
更新日期:2003-05-17 00:00:00
abstract:INTRODUCTION:Selection of medical students varies between German- and French-speaking Swiss faculties. Geneva introduced an aptitude test in 2010, aimed at helping decision making among students. The test was compulsory: it had to be taken by those who intended to register for medical studies. But it was not selective:...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2013.13872
更新日期:2013-09-19 00:00:00
abstract:PRINCIPLES:Neisseria gonorrhoeae (NG) resistant to ciprofloxacin (CR) was documented for the first time in Geneva in 2002 and increased from 7% that year to 47% in 2005. We describe NG cases during this period and compare characteristics of CR and ciprofloxacin susceptible (CS) cases. METHOD:Geneva microbiological lab...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2008/15/smw-12029
更新日期:2008-04-19 00:00:00
abstract::In this review article, we aim at analysing the role of stress in addiction and relapse. In order to do so, we first offer a summary of the findings from affective neuroscience trying to understand compulsive reward-seeking behaviours. These behaviours are characterised by an imbalance between the considerable amount ...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2019.20151
更新日期:2019-11-29 00:00:00
abstract::The ex utero intrapartum treatment (EXIT) procedure is designed to guarantee sufficient oxygenation for a foetus at risk of airway obstruction. This is achieved by improving lung ventilation, usually by establishing an airway during caesarean delivery whilst preserving the foetal-placental circulation temporarily. Ind...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2007/19/smw-11526
更新日期:2007-05-19 00:00:00
abstract::The WHO recommends screening of Latin American migrants for Chagas disease to reduce morbidity and mortality and increase the likelihood of eradicating the disease. The objective was to assess the feasibility and acceptability of a screening strategy in one Swiss canton. From February 2011 to September 2012, people at...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2019.20050
更新日期:2019-04-04 00:00:00
abstract:OBJECTIVE:The methods used to diagnose and classify ovarian cancer have changed over the past decade. We used hospital registry data to assess the incidence, treatment durations and hospital costs of ovarian cancer in Switzerland. METHODS:We carried out a retrospective analysis of a hospital registry covering all inpa...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2018.14647
更新日期:2018-07-29 00:00:00
abstract::Isolated left ventricular hypertrophy, in the absence of hypertension or aortic stenosis, is commonly attributed to hypertrophic cardiomyopathy (HCM). According to the clinical setting, however, other differential diagnoses should be considered. The diagnosis of cardiac amyloidosis may be very challenging especially w...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2004/19/smw-10584
更新日期:2004-05-15 00:00:00
abstract:BACKGROUND:Sarcoidosis is a disorder of unknown aetiology. Most patients have steroid-responsive disease, but side effects and steroid resistance may necessitate alternative treatments. Endothelin has in-vitro fibrogenic activity and the endothelin system is activated in sarcoidosis. OBJECTIVES:We studied the efficacy...
journal_title:Swiss medical weekly
pub_type: 杂志文章,随机对照试验
doi:10.4414/smw.2018.14677
更新日期:2018-10-28 00:00:00
abstract:OBJECTIVE:To investigate whether olfactory performance decreases as a function of the number of pregnancies, previous research having indicated that olfactory function decreases in the course of pregnancy. METHODS:In a prospective study three groups of women were investigated (total n = 93), women who have given birth...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2008/31/smw-12200
更新日期:2008-08-09 00:00:00
abstract:BACKGROUND:Renal replacement therapy for paediatric end-stage renal disease (ESRD) has developed steadily since its introduction five decades ago. Continuous and long-term analysis of patient outcomes is essential for quality control. METHODS:The Swiss Paediatric Renal Registry, founded in 1970, includes patients diag...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20300
更新日期:2020-07-27 00:00:00
abstract::Invasive fungal infections have emerged as important causes of morbidity and mortality in immunocompromised patients. In response to this challenge, the field of antifungal chemotherapy has considerably expanded. Fluconazole and itraconazole, introduced in the late 1980s, were the first durably useful alternatives to ...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2002/23/smw-09729
更新日期:2002-06-15 00:00:00
abstract::Advance directives emerged in the 1960s with the goal of empowering people to exert control over their future medical decisions. However, it has become apparent, over recent years, that advance directives do not sufficiently capture the temporal and relational aspects of planning treatment and care. Advance care plann...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2018.14706
更新日期:2018-12-30 00:00:00
abstract::The anti-inflammatory genes, haem oxygenase 1 (HO-1, HMOX1) rs2071746 (unrestricted model: p = 9.07 × 10-4; recessive model: p = 4.99 × 10-4; multiplicative model: p = 0.0009; and additive model: p = 1.87 × 10-4) and interleukin-10 (IL-10) rs1800872 (dominant model: p = 0.0277) have been associated with paediatric inf...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2017.14456
更新日期:2017-08-02 00:00:00
abstract:QUESTIONS UNDER STUDY:Teenage and young adult (TYA) cancer patients are faced with the diagnosis during a challenging period of psychosocial development that may affect social outcomes in the long term. Therefore, we aimed to: (1) determine differences in social outcomes between long-term TYA cancer survivors and healt...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2017.14419
更新日期:2017-03-07 00:00:00
abstract::Cartilage hair hypoplasia (CHH) is a rare autosomal recessive ribosomopathy characterised by skeletal and integumentary system manifestations. It may also present with varied forms and intensities of haematopoietic and/or immune disorders. We report a 27-year-old female who presented a picture of combined immunodefici...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2018.14606
更新日期:2018-04-24 00:00:00
abstract:BACKGROUND:Several publications reported on the safety and efficacy of bortezomib, a novel first-in-class anti-cancer agent, in the treatment of relapsed/refractory multiple myeloma in controlled clinical trials. Complementary data on the experience with bortezomib in daily oncology practice are needed. We report on th...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2007/21/smw-11716
更新日期:2007-06-02 00:00:00
abstract::Congenital tuberculosis was first suspected in a premature infant with patent ductus arteriosus (PDA), progressive respiratory distress and septic shock, when an enlarged mediastinal lymph node was noted intraoperatively at the time of PDA ligature. Culture revealed Mycobacterium tuberculosis. The asymptomatic mother ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2002/41/smw-10101
更新日期:2002-11-23 00:00:00
abstract:QUESTIONS UNDER STUDY:Paraoxonase-1 (PON1) is an HDL-bound enzyme system which plays a key role in the protection of LDL and HDL from oxidation by hydrolysing activated phospholipids and lipid peroxide products. Oxidative stress has been involved in the pathogenesis of many complications of human pregnancy, including e...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:smw-12495
更新日期:2009-02-07 00:00:00
abstract:OBJECTIVES:To assess adherence to recommended standards of diabetes care by Swiss primary care physicians. METHODS:Medical files of community-based primary care physician were reviewed to assess adherence to recommended standards of diabetes care. These standards of care were based on a uniform set of definitions addr...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2007/11/smw-11592
更新日期:2007-03-24 00:00:00
abstract:BACKGROUND:In recent years, several treatment modalities have proved to be effective in the treatment of neuroendocrine tumours (NETs). However, there is currently no consensus on the sequence in which these options are best used. METHODS:In this observational study, we analysed the treatment modalities and sequences ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20176
更新日期:2020-01-15 00:00:00
abstract:BACKGROUND:Introduction of potent antiretroviral combination therapy (ART) has reduced overall morbidity and mortality amongst HIV-infected adults. Some prophylactic regimes against opportunistic infections can be discontinued in patients under successful ART. QUESTIONS UNDER STUDY:(1) The influence of the availabilit...
journal_title:Swiss medical weekly
pub_type: 杂志文章,多中心研究
doi:2001/31/smw-09728
更新日期:2001-08-11 00:00:00
abstract:AIMS OF THE STUDY:The Cancer Registry Zurich, Zug, Schaffhausen and Schwyz is one of the oldest cancer registries in Switzerland, first registering tumours in 1980 for the canton of Zurich. The aim of this study was to analyse trends in incidence and mortality for the most common types of cancer in the canton of Zurich...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20388
更新日期:2020-12-14 00:00:00
abstract::Pulmonary rehabilitation is a form of therapy for patients with chronic lung disease that is evidence based, which ameliorates performance and endurance of the patient and improves quality of life significantly. Pulmonary rehabilitation also diminishes the amount of hospitalisations and the duration of stay in hospita...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2005/05/smw-10718
更新日期:2005-02-05 00:00:00
abstract:QUESTION UNDER STUDY:Purpose was to validate accuracy and reliability of automated oscillometric ankle-brachial (ABI) measurement prospectively against the current gold standard of Doppler-assisted ABI determination. METHODS:Oscillometric ABI was measured in 50 consecutive patients with peripheral arterial disease (n ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:smw-12636
更新日期:2009-06-27 00:00:00
abstract:BACKGROUND:Epidemiological studies focusing on first-ever seizures have been carried out mainly on community based populations. However, since hospital populations may display varying clinical features, we prospectively analysed patients with first-ever seizure in a hospital based community to evaluate prognosis and th...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2004/39/smw-10738
更新日期:2004-10-02 00:00:00
abstract:BACKGROUND:The number of individuals with autoimmune inflammatory rheumatic diseases (AIIRDs) treated with immunosuppressive drugs is increasing steadily. The variety of immunosuppressive drugs and, in particular, biological therapies is also rising. The immunosuppressants, as well as the AIIRD itself, increase the ris...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2015.14159
更新日期:2015-07-28 00:00:00
abstract:QUESTIONS UNDER STUDY:Suicidal behaviour is a major source of burden of disease. While most studies focus on cost associated with completed suicides, data on costs of, non-lethal, suicide attempts are lacking. The aim of this study was to assess direct annual cost of suicide attempts in Basel in 2003 from a health serv...
journal_title:Swiss medical weekly
pub_type: 杂志文章,多中心研究
doi:10.4414/smw.2012.13648
更新日期:2012-07-23 00:00:00
abstract:BACKGROUND:The past 25 years have seen the increased use of minimally invasive surgery. The development of these techniques has impacted the domain of liver surgery. This study aimed to describe the safety, feasibility, benefits and results of laparoscopic liver resection in a single tertiary care centre. METHODS:We r...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2021.20391
更新日期:2021-01-20 00:00:00