Illuminating human health through cell mechanics.

Abstract:

:Cells reside in mechanically rich and dynamic microenvironments, and the complex interplay between mechanics and biology is widely acknowledged. Recent research has yielded insights linking the mechanobiology of cells, human physiology, and pathophysiology. In particular, we have learned of the cell's astounding ability to sense and respond to its mechanical microenvironment. This seemingly innate behaviour of the cell has driven efforts to characterise precisely the cellular behaviour from a mechanical viewpoint. Here we present an overview of technologies used to probe cell mechanical and material properties, how they have led to the discovery of seemingly strange cellular mechanical behaviours, and their influential role in health and disease, including asthma, cancer, and glaucoma. The properties reviewed here have implications in physiology and pathology and raise questions that will fuel research opportunities for years to come.

journal_name

Swiss Med Wkly

journal_title

Swiss medical weekly

authors

Steward RL Jr,Rosner SR,Zhou EH,Fredberg JJ

doi

10.4414/smw.2013.13766

subject

Has Abstract

pub_date

2013-03-14 00:00:00

pages

w13766

eissn

1424-7860

issn

1424-3997

pii

smw-13766

journal_volume

143

pub_type

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