Abstract:
:The current situation of the biomedical sciences is critically discussed. It can be summarized as follows: 1. We have to acknowledge the presence of a serious credibility problem, which might undermine the foundations of medical science. ("Sliding on a slippery slope") 2. Multiple forces going beyond simple conflicts of interest push medical science further down the slippery slope. ("Who is pushing?") 3. The public awareness of something seriously wrong with medical science is mounting on all levels of our multimedia society. ("Looking into the media mirror") 4. Technical corrective measures may be easily implemented, however, to change an expanding and "successful" science culture actually destroying it's own foundations will need a sustained effort by the medical and scientific community on all levels. ("Look away--or act?").
journal_name
Swiss Med Wklyjournal_title
Swiss medical weeklyauthors
Obrist Rdoi
10.4414/smw.2015.14120subject
Has Abstractpub_date
2015-03-13 00:00:00pages
w14120eissn
1424-7860issn
1424-3997pii
smw-14120journal_volume
145pub_type
杂志文章,评审abstract::Increased survival rates after orthotopic liver transplantation (OLT) in patients with end-stage liver disease have become possible due to an advanced understanding of the pathophysiology of liver disease, the establishment of multiorgan procurement and preservation techniques, and the development of safer and more po...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2007/13/smw-11681
更新日期:2007-04-07 00:00:00
abstract::Depending on the populations studied and the definitions applied, the prevalence of treatment-resistant hypertension varies from 10% to 15%, but is higher in conditions associated with increased sympathetic drive, such as obesity, obstructive sleep apnoea, diabetes or renal dysfunction. The Symplicity studies recently...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2012.13638
更新日期:2012-07-17 00:00:00
abstract::Current guidelines from the Swiss Association against Osteoporosis (SVGO) dating from 2015 recommend therapy for men and women at increased fracture risk, specifically those with a vertebral or hip fracture; those with bone mineral density T-score <−2.5 at spine or hip; and those with a high 10-year probability ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20352
更新日期:2020-09-29 00:00:00
abstract:QUESTIONS UNDER STUDY:In this work we wanted to evaluate the effect of intra-articular injection (IAI) at the knee joint of 1 ml of Diprospan on the hypothalamic-pituitary-adrenal (HPA) axis. METHODS:Consecutive patients attending the rheumatology or orthopaedic clinic with osteoarthritic knee pain not responding sati...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2015.14134
更新日期:2015-05-21 00:00:00
abstract::Pulmonary rehabilitation is a form of therapy for patients with chronic lung disease that is evidence based, which ameliorates performance and endurance of the patient and improves quality of life significantly. Pulmonary rehabilitation also diminishes the amount of hospitalisations and the duration of stay in hospita...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2005/05/smw-10718
更新日期:2005-02-05 00:00:00
abstract::Patients with a solid organ transplant have increased in numbers and in individual survival in Switzerland over the last decades. As a consequence of long-term immunosuppression, skin cancer in solid organ recipients (SOTRs) has been recognized as an important problem. Screening and education of potential SOTRs about ...
journal_title:Swiss medical weekly
pub_type: 杂志文章,实务指引
doi:smw-12725
更新日期:2009-07-25 00:00:00
abstract:OBJECTIVES:Body temperature (BT) was shown to have impact on outcome in several medical conditions. This study investigated the prognostic impact of BT in patients with acute heart failure (HF). DESIGN AND PATIENTS:The B-type natriuretic peptide for Acute Shortness of breath EvaLuation (BASEL) study prospectively enro...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2008/21/smw-12013
更新日期:2008-05-31 00:00:00
abstract::Congenital tuberculosis was first suspected in a premature infant with patent ductus arteriosus (PDA), progressive respiratory distress and septic shock, when an enlarged mediastinal lymph node was noted intraoperatively at the time of PDA ligature. Culture revealed Mycobacterium tuberculosis. The asymptomatic mother ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2002/41/smw-10101
更新日期:2002-11-23 00:00:00
abstract:BACKGROUND:Evaluation of the current clinical treatment of psoriasis in Switzerland remains to be measured with the parameters cost-of-illness and quality of life. OBJECTIVE:To obtain data on out-of-pocket expenses, costs of outpatient/office-based care and inpatient care for psoriasis, and to extrapolate total costs ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:smw-12756
更新日期:2010-02-06 00:00:00
abstract::Hepatitis C virus (HCV) infection is a leading cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma worldwide. While current therapeutic options for hepatitis C are limited, recent progress in the understanding of the biology of HCV led to the identification of novel targets for antiviral interven...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2001/21/smw-06097
更新日期:2001-06-02 00:00:00
abstract:BACKGROUND:Low-molecular-weight heparins (LMWH) have been shown to be safer, more effective and more convenient than unfractionated heparin (UFH) in many clinical situations. However, their use is limited in patients with renal insufficiency (RI) due to bioaccumulation. METHOD:The literature is critically reviewed and...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:smw-11284
更新日期:2009-08-08 00:00:00
abstract::Patients with chronic heart failure who are not eligible for heart transplant and whose life expectancy depends mainly on the heart disease may benefit from mechanical circulatory support. Mechanical circulatory support restores adequate cardiac output and organ perfusion and eventually improves patients' clinical con...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2016.14267
更新日期:2016-03-05 00:00:00
abstract:BACKGROUND:A clinical research application must be submitted for approval by a competent ethics committee (EC) before a study can be executed. There is very limited information on how such submissions could be optimised, especially regarding research in children and adolescents, which requires particular caution and ag...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20267
更新日期:2020-06-19 00:00:00
abstract:BACKGROUND:Up to 30% of patients with chronic obstructive pulmonary disease (COPD) simultaneously suffer from often-unrecognised chronic heart failure (HF). Their timely identification is challenging as both conditions share similar clinical presentations. OBJECTIVE:To assess the performance of BNP in detecting left v...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2011.13298
更新日期:2011-11-09 00:00:00
abstract:AIMS OF THE STUDY:Pneumothoraces after endoscopic retrograde cholangiopancreatography (ERCP) are an uncommon but potentially lethal complication. Little evidence is available on their epidemiology, diagnosis and therapy. We aimed to evaluate current practices and provide recommendations. METHOD:We systematically revie...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20199
更新日期:2020-04-03 00:00:00
abstract:OBJECTIVES:To compare the long-term effects of comprehensive outpatient versus inpatient rehabilitation with respect to morbidity and mortality, as well as to changes in physical performance and physical activity. DESIGN:A total of 163 consecutive patients were enrolled for comprehensive cardiac rehabilitation (CCR) f...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2010.13141
更新日期:2011-01-06 00:00:00
abstract:PURPOSE:Sayana® was introduced as the first depot medroxyprogesterone acetate-containing contraceptive that is administered via subcutaneous injection. Within 10 months, the Regional Pharmacovigilance Centre (RPVC) Zurich received several anonymous reports of serious local reactions after Sayana® administration. In thi...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2017.14432
更新日期:2017-05-10 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Sleep disturbances are prevalent but often overlooked or underestimated. We suspected that sleep disorders might be particularly common among pharmacy customers, and that they could benefit from counselling. Therefore, we described the prevalence and severity of symptoms associated with sleep a...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2006/09/smw-11265
更新日期:2006-03-04 00:00:00
abstract::The atherogenic lipoprotein phenotype is characterised by a moderate increase in plasma triglycerides, a decrease in high density lipoprotein cholesterol and the prevalence of smaller denser low density lipoprotein particles. The prevalence of this partially inheritable phenotype is approximately 30% and is a feature ...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2004/49/smw-10813
更新日期:2004-12-18 00:00:00
abstract::Cartilage hair hypoplasia (CHH) is a rare autosomal recessive ribosomopathy characterised by skeletal and integumentary system manifestations. It may also present with varied forms and intensities of haematopoietic and/or immune disorders. We report a 27-year-old female who presented a picture of combined immunodefici...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2018.14606
更新日期:2018-04-24 00:00:00
abstract:QUESTIONS UNDER STUDY:Lung cancer belongs to the most common cancers in Switzerland. We examined trends in lung cancer incidence, with focus on sex, histology and laterality, in the Canton of Zurich since 1980. MATERIAL AND METHODS:Registry data consisting of 16 798 lung cancer cases from 1980 to 2010 were analysed. C...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2016.14327
更新日期:2016-07-11 00:00:00
abstract::Antibiotics account for a substantial proportion of hospital drug expenditures and tend to be misused or overused, generating unnecessary costs and causing the emergence of resistant bacteria. Antibiotic use was evaluated in a one-day prevalence study performed on the surgical and medical wards of eight Swiss non-univ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2004/33/smw-10599
更新日期:2004-08-21 00:00:00
abstract:OBJECTIVE:The methods used to diagnose and classify ovarian cancer have changed over the past decade. We used hospital registry data to assess the incidence, treatment durations and hospital costs of ovarian cancer in Switzerland. METHODS:We carried out a retrospective analysis of a hospital registry covering all inpa...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2018.14647
更新日期:2018-07-29 00:00:00
abstract::Since 2010, awareness of the global threat caused by antimicrobial resistance (AMR) has risen considerably and multiple policy and research initiatives have been implemented. Research and development (R&D) of much-needed new antibiotics active against multiresistant pathogens is a key component of all programmes aimin...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2015.14167
更新日期:2015-07-31 00:00:00
abstract::Meningitis due to Streptococcus pneumoniae is a rare complication of trans-sphenoidal surgery. We present the case of a patient who developed pneumococcal meningitis with associated bacteraemia after elective endoscopic trans-sphenoidal resection of a pituitary macro-adenoma. After initial treatment with ceftriaxone a...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2012.13697
更新日期:2012-10-29 00:00:00
abstract:BACKGROUND:Campylobacteriosis and salmonellosis are important foodborne diseases in Europe, including in Switzerland. In 2014, notification rates for Switzerland were 92.9 per 100 000 population for campylobacteriosis and 15.2 per 100 000 population for salmonellosis. These notification rates originate from laboratory-...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2017.14569
更新日期:2017-12-27 00:00:00
abstract::In Switzerland, approximately 350,000 people aged 70 years or older own a valid driving license. By law, these drivers are medically assessed every other year, most commonly by their general practitioner, to exclude that a medical condition is interfering with their driving skills. A prerequisite for driving is the in...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2011.13136
更新日期:2011-01-17 00:00:00
abstract:PRINCIPLES:Neisseria gonorrhoeae (NG) resistant to ciprofloxacin (CR) was documented for the first time in Geneva in 2002 and increased from 7% that year to 47% in 2005. We describe NG cases during this period and compare characteristics of CR and ciprofloxacin susceptible (CS) cases. METHOD:Geneva microbiological lab...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2008/15/smw-12029
更新日期:2008-04-19 00:00:00
abstract:QUESTIONS UNDER STUDY/PRINCIPLES:A retrospective assessment of long-term results on a single centre, single author experience in treating prostate cancer with high dose curative radiotherapy (RT) with or without androgen deprivation (AD). METHODS:Between 1991 and 2004, 408 patients with clinically localised prostate c...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:smw-12604
更新日期:2009-09-05 00:00:00
abstract:QUESTIONS UNDER STUDY:In Switzerland, skin cancer is one of the most prevalent neoplasms. General practitioners (GPs) are often faced with suspicious skin lesions in their patients. The aim of our study was to assess GPs' competence to diagnose skin cancer and to examine whether this can be improved by a one-day dermat...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2013.13834
更新日期:2013-07-29 00:00:00