External radiotherapy for prostate cancer with or without androgen deprivation: Geneva, 1991 to 2004.

Abstract:

QUESTIONS UNDER STUDY/PRINCIPLES:A retrospective assessment of long-term results on a single centre, single author experience in treating prostate cancer with high dose curative radiotherapy (RT) with or without androgen deprivation (AD). METHODS:Between 1991 and 2004, 408 patients with clinically localised prostate cancer were treated with RT (+/-AD) at the University Hospital of Geneva. RT alone was delivered to 229 patients whereas AD associated to RT was given to 179 patients. The latter was most frequently delivered to those patients with worse prognostic factors at diagnosis (high PSA values, high Gleason scores, stage T3-T4; p <0.001). Patient's biochemical failure was established at the time of PSA progression above the post-treatment nadir value +2 ng/ml. Late urinary, rectal, and sexual side effects were assessed and scored according to the Radiotherapy Oncology Group grading system. RESULTS:Ten-year overall survival (OS) and cancer specific survival were 93% and 62% (p = 0.10), and 94% and 71% (p = 0.19) for patients treated with RT with and without AD respectively (p = 0.10). Ten-year biochemical disease-free survival (bDFS) was 61% and 50% for patients treated with RT with and without AD, respectively (p = 0.14). On Cox regression analysis, PSA at diagnosis and treatment modality correlated significantly with OS, whereas PSA at diagnosis, Gleason score, and treatment modality correlated significantly with bDFS. Mostly high-risk patients (PSA >20 ng/ml and/or Gleason 8-10) benefited from neo-adjuvant AD+RT compared to patients treated with RT alone (67% versus 32%, 5-year bDFS; p <0.001). The 5-year probability of moderate to severe late urinary and low-GI toxicities was 15% and 7% respectively. Regarding sexual toxicity, the 5-year risk of complete failure of erections after treatment was 57%. CONCLUSIONS:AD+RT significantly improved both 10-year OS and bDFS, especially in patients with high-risk disease at diagnosis. Patients treated with RT alone presented with continuous failures during the 10-year interval of observation, thus questioning the wisdom of proposing RT alone at doses below 74 Gy, especially for patients with long life expectancies.

journal_name

Swiss Med Wkly

journal_title

Swiss medical weekly

authors

Miralbell R,Pampallona S,Rouzaud M,Pugliesi A,Weber D,Ares C

doi

smw-12604

subject

Has Abstract

pub_date

2009-09-05 00:00:00

pages

511-7

issue

35-36

eissn

1424-7860

issn

1424-3997

pii

smw-12604

journal_volume

139

pub_type

杂志文章
  • Outpatient treatment of pulmonary embolism.

    abstract::Pulmonary embolism (PE) is traditionally treated in hospital. Growing evidence from non randomized prospective studies suggests that a substantial proportion of patients with non-massive PE might be safely treated in the outpatient setting using low molecular weight heparins. Based on this evidence, professional socie...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:smw-12661

    authors: Aujesky D,Mazzolai L,Hugli O,Perrier A

    更新日期:2009-11-28 00:00:00

  • Tolerance to celecoxib in patients with a history of adverse reactions to nonsteroidal anti-inflammatory drugs.

    abstract:BACKGROUND:Adverse reactions to nonsteroidal antiinflammatory drugs (NSAIDs) are frequently reported, particularly among asthmatic patients. To date, there is no causal treatment available apart from tolerance induction. Therefore, the search for safe alternative drugs is of pivotal importance in clinical practice. OB...

    journal_title:Swiss medical weekly

    pub_type: 临床试验,杂志文章

    doi:2006/43/smw-11358

    authors: Roll A,Wüthrich B,Schmid-Grendelmeier P,Hofbauer G,Ballmer-Weber BK

    更新日期:2006-10-28 00:00:00

  • Ultrasonographic assessment of the morphological characteristics of the carotid plaque.

    abstract::Apart from the degree of stenosis, plaque morphology has emerged in recent years as an important contributory factor in stroke risk. Ultrasound studies have shown that hypo- or anechogenic plaques carry a higher risk of cerebrovascular events than echogenic ones. Similarly, heterogeneous plaques presenting a complex p...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:2005/43/smw-11038

    authors: Sztajzel R

    更新日期:2005-10-29 00:00:00

  • Symptom assessment in lumbar stenosis/spondylolysis - patient questionnaire versus physician chart.

    abstract:BACKGROUND:The precision of symptom assessment and documentation in daily routine is unknown. Differences in hip studies have been observed between the charts and the patient questionnaires. This was the reason to perform this study and to compare the charts and the patient questionnaires. METHODS:This was a retrospec...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:smw-12581

    authors: Huber JF,Dabis E,Huesler J,Ruflin GB

    更新日期:2009-10-17 00:00:00

  • Aortic valve replacement using autologous pericardium: single centre experience with the Ozaki technique.

    abstract:OBJECTIVE:To assess the clinical implementation and report preliminary results of a novel technique called the Ozaki procedure for stentless aortic valve replacement through reconstruction of the valve leaflets from autologous pericardium. METHOD:Between September 2015 and May 2017 30 patients (20 males, mean ± standa...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2018.14591

    authors: Reuthebuch O,Koechlin L,Schurr U,Grapow M,Fassl J,Eckstein FS

    更新日期:2018-02-09 00:00:00

  • Surgical management of vascular Ehlers-Danlos syndrome and its challenges: a case report.

    abstract:BACKGROUND:Ehlers-Danlos syndrome (EDS) is a heterogeneous group of rare inherited diseases involving connective tissue. Vascular EDS (vEDS) is associated with abnormal type III collagen, which is an essential component of skin, hollow organs and arterial walls, and causes potentially fatal visceral and arterial compli...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2020.20379

    authors: da Rocha de Sousa F,Colucci N,Dupuis A,Toso C,Buchs NC,Abbassi Z

    更新日期:2020-12-05 00:00:00

  • Association between maternal smoking and low birth weight in Switzerland: the EDEN study.

    abstract:PURPOSE:To study the association between maternal smoking during pregnancy and low birth weight (LBW), small-for-gestational-age birth weight (SGA) and preterm birth, and to quantify the population-attributable fractions for these outcomes in Switzerland. METHODS:Data were gathered for all births in the Canton of Vaud...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:2005/35/smw-11122

    authors: Chiolero A,Bovet P,Paccaud F

    更新日期:2005-09-03 00:00:00

  • APOE epsilon status in Hungarian patients with primary progressive multiple sclerosis.

    abstract:PRINCIPLES:Apolipoprotein E (ApoE), an important glycoprotein in the transport, uptake and redistribution of cholesterol, is necessary in nerve tissue repair. The APOE gene (APOE) is involved in neurodegenerative diseases, the best-known association being that between the APOE ε4 allele and Alzheimer's disease. Multipl...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,多中心研究

    doi:10.4414/smw.2010.13119

    authors: Losonczi E,Bencsik K,Fricska Nagy Z,Honti V,Szalczer E,Rajda C,Illés Z,Mátyás K,Rózsa C,Csépány T,Füvesi J,Vécsei L

    更新日期:2010-11-26 00:00:00

  • Clinical settings and specialties notifying cases of bacterial sexually transmitted infections in Switzerland: cross-sectional study.

    abstract:QUESTIONS UNDER STUDY:In the next Swiss National HIV and Sexually Transmitted Infection (STI) Strategy 2011-2017, STI control will be integrated with HIV prevention. Information is needed which will improve the targeting of professional education. The objective of this study was to describe the clinical specialities an...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2011.13143

    authors: Baillif A,Low N

    更新日期:2011-01-20 00:00:00

  • Is the Eichenholtz classification still valid for the diabetic Charcot foot?

    abstract::In his 1966 monograph "Charcot joints", Sidney N. Eichenholtz (1909-2000) described "three well defined stages … in the course and development of a Charcot joint", based on plain X-rays of 68 patients. Since then, medical imaging has advanced very much: computed tomography and magnetic resonance imaging (MRI) scans ex...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:10.4414/smw.2014.13948

    authors: Chantelau EA,Grützner G

    更新日期:2014-04-24 00:00:00

  • Association of the haem oxygenase-1 gene with inflammatory bowel disease.

    abstract::The anti-inflammatory genes, haem oxygenase 1 (HO-1, HMOX1) rs2071746 (unrestricted model: p = 9.07 × 10-4; recessive model: p = 4.99 × 10-4; multiplicative model: p = 0.0009; and additive model: p = 1.87 × 10-4) and interleukin-10 (IL-10) rs1800872 (dominant model: p = 0.0277) have been associated with paediatric inf...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2017.14456

    authors: Lin Z,Hao H,Hegarty JP,Lin TR,Wang Y,Harris LR,Xu HN,Wu R,Thomas NJ,Floros J

    更新日期:2017-08-02 00:00:00

  • Contraception and sexuality after termination of pregnancy: a comparison between Lugano and Geneva.

    abstract:OBJECTIVE:To evaluate the impact of a voluntary termination of pregnancy (TOP) on contraceptive practice and sexual well-being in women. STUDY DESIGN AND METHODS:Comparative evaluation of a retrospective study conducted in Lugano in 1995 with 85 women interviewed 3-6 months post-TOP, and a prospective study carried ou...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:2001/35/smw-09768

    authors: Bianchi-Demicheli F,Perrin E,Lüdicke F,Campana A

    更新日期:2001-09-08 00:00:00

  • Management of hepatitis C in opioid agonist therapy patients of the Swiss canton Aargau within and outside the cohort study.

    abstract::With regard to HCV elimination in opioid agonist therapy patients by 2030, case finding and regular screening for new and re-infections remain a challenge, especially for non-cohort patients in a decentralised setting. Documentation of the HCV sero- and RNA status of each opioid agonist therapy  patient by the ca...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2020.20317

    authors: Schürch S,Fux CA,Dehler S,Conen A,Knuchel J,Friedl A,Eigenmann F,Roser P,Ackle P,Bregenzer A

    更新日期:2020-08-06 00:00:00

  • Tobacco and alcohol during pregnancy: prevalence and determinants in Geneva in 2008.

    abstract:OBJECTIVES:To describe alcohol and tobacco consumption during pregnancy in women giving birth in a public hospital in Geneva, to evaluate risk factors related to these consumptions and to explore the influence of close relatives on the consumption habits of pregnant women. METHODS:A cross-sectional questionnaire surve...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2013.13795

    authors: Dupraz J,Graff V,Barasche J,Etter JF,Boulvain M

    更新日期:2013-05-25 00:00:00

  • Health economic modelling of the cost-effectiveness of microalbuminuria screening in Switzerland.

    abstract:PRINCIPLES:Current evidence indicates that chronic kidney disease (CKD) can be detected by simple laboratory tests. This study aimed to evaluate the cost-effectiveness of microalbuminuria screening and subsequent treatment in different populations. METHODS:Cost-effectiveness of microalbuminuria screening in a cohort o...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2012.13508

    authors: Kessler R,Keusch G,Szucs TD,Wittenborn JS,Hoerger TJ,Brügger U,Wieser S

    更新日期:2012-02-03 00:00:00

  • Current status and future challenges of deep brain stimulation in Switzerland.

    abstract:QUESTIONS UNDER STUDY:Deep brain stimulation (DBS) has become a standard therapy for some forms of severe movement disorders and is investigated for other neurological and psychiatric disorders, although many scientific, clinical and ethical issues are still open. We analyse how the Swiss DBS community addresses these ...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2012.13570

    authors: Christen M,Müller S

    更新日期:2012-04-05 00:00:00

  • Left ventricular hypertrophy: diagnostics pitfalls.

    abstract::Isolated left ventricular hypertrophy, in the absence of hypertension or aortic stenosis, is commonly attributed to hypertrophic cardiomyopathy (HCM). According to the clinical setting, however, other differential diagnoses should be considered. The diagnosis of cardiac amyloidosis may be very challenging especially w...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:2004/19/smw-10584

    authors: Bonvini RF,Camenzind E

    更新日期:2004-05-15 00:00:00

  • Risk behaviours among native and immigrant youths in Switzerland: a cross-sectional study.

    abstract:QUESTION UNDER STUDY:Switzerland has been receiving migrants of various origins for more than 50 years. The adoption of risk-taking behaviours among migrant youths is unclear. Moreover, when studied, migrant youths are rarely analysed according to whether they are first or second generation, or just young people with m...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2017.14531

    authors: Campisi L,Berchtold A,Barrense-Dias Y,Akre C,Gehri M,Suris JC

    更新日期:2017-11-08 00:00:00

  • 37-year incidence and mortality time trends of common cancer types by sex, age, and stage in the canton of Zurich.

    abstract:AIMS OF THE STUDY:The Cancer Registry Zurich, Zug, Schaffhausen and Schwyz is one of the oldest cancer registries in Switzerland, first registering tumours in 1980 for the canton of Zurich. The aim of this study was to analyse trends in incidence and mortality for the most common types of cancer in the canton of Zurich...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2020.20388

    authors: Wanner M,Matthes KL,Karavasiloglou N,Limam M,Korol D,Rohrmann S

    更新日期:2020-12-14 00:00:00

  • Osteoarticular infections in young children: what has changed over the last years?

    abstract::Osteoarticular infections remain a significant cause of morbidity worldwide in young children. They can have a devastating impact with a high rate of serious and long-lasting sequelae, especially on remaining growth. Depending on the localisation of infection, they manifest as osteomyelitis, septic arthritis, a combin...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:10.4414/smw.2014.13971

    authors: Ceroni D,Kampouroglou G,Valaikaite R,Anderson della Llana R,Salvo D

    更新日期:2014-06-12 00:00:00

  • Cardiac pre-competiton screening in Swiss athletes. Current situation in competitive athletes and short-time assessment of an exemplary local screening program.

    abstract:AIM OF THE STUDY:In Switzerland, screening concepts for the prevention of sports-associated sudden cardiac death are still insufficiently established in the large group of competitive athletes who are not integrated in an Olympic- or other high-level squad. The aim of the present study was to objectively determine the ...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2012.13575

    authors: Schmied C,Notz S,Cribari M,Gähwiler R,Keller DI,Lüscher TF

    更新日期:2012-05-31 00:00:00

  • Survival from methicillin-sensitive Staphylococcus aureus bloodstream infections over 20 years: a cohort of 1328 patients.

    abstract:PURPOSE:Staphylococcus aureus bloodstream infections (SA BSI) are associated with substantial mortality. The rapid emergence of methicillin-resistant S. aureus (MRSA), known to be associated with worse outcome, may blur advances made regarding mortality attributed to SA BSI caused by methicillin-sensitive S. aureus (MS...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2017.14508

    authors: Wiggli BJ,Frei R,Laffer R,Tschudin Sutter S,Widmer AF

    更新日期:2017-09-30 00:00:00

  • Carbon nanotubes: an insight into the mechanisms of their potential genotoxicity.

    abstract::After the health catastrophe resulting from the widespread use of asbestos which was once hailed as a new miracle material, the increasing use of carbon nanotubes (CNTs) has spawned major concern due to their similarities in terms of size, shape and poor solubility. Assessment of genotoxicity has shown that CNTs can d...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:10.4414/smw.2012.13698

    authors: van Berlo D,Clift MJ,Albrecht C,Schins RP

    更新日期:2012-11-05 00:00:00

  • Personal use of medical care and drugs among Swiss primary care physicians.

    abstract:OBJECTIVE:To measure medical care and pharmaceutical drug use among Swiss primary care physicians and its determinants. DESIGN:Cross-sectional mailed survey. SETTING:1784 randomly selected Swiss primary care physicians, including general practitioners, internists and paediatricians. RESULTS:Twenty one percent (95% C...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:2007/07/smw-11606

    authors: Schneider M,Bouvier Gallacchi M,Goehring C,Künzi B,Bovier PA

    更新日期:2007-02-24 00:00:00

  • The economic and public health impact of influenza vaccinations: contributions of Swiss pharmacies in the 2016/17 and 2017/18 influenza seasons and implications for vaccination policy

    abstract:AIMS OF THE STUDY:Healthy adults have had the option to receive prescriptionless vaccination against influenza in pharmacies of several Swiss cantons since the 2015/16 influenza season. We aimed to assess in a cost-benefit analysis the resulting net benefits for the Swiss economy and public health, and the benefits tha...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2019.20161

    authors: Brunner I,Schmedders K,Wolfensberger A,Schreiber PW,Kuster SP

    更新日期:2019-12-17 00:00:00

  • Renal denervation: time to open Pandora's box.

    abstract::Depending on the populations studied and the definitions applied, the prevalence of treatment-resistant hypertension varies from 10% to 15%, but is higher in conditions associated with increased sympathetic drive, such as obesity, obstructive sleep apnoea, diabetes or renal dysfunction. The Symplicity studies recently...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审

    doi:10.4414/smw.2012.13638

    authors: Gu YM,Asayama K,Liu YP,Staessen JA

    更新日期:2012-07-17 00:00:00

  • Heart failure clinic in a community hospital improves outcome in heart failure patients.

    abstract:PRINCIPLES:Heart failure is associated with a grim prognosis. Disease management programmes can improve prognosis in heart failure patients but the applicability to the general population remains limited. We aimed to compare the outcome, pharmacological therapy, and quality of life in unselected heart failure patients ...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:2006/17/smw-11274

    authors: Lainscak M,Keber I

    更新日期:2006-04-29 00:00:00

  • SwissScoring--a nationwide survey of SAPS II assessing practices and its accuracy.

    abstract:OBJECTIVE:The first description of the simplified acute physiology score (SAPS) II dates back to 1993, but little is known about its accuracy in daily practice. Our purpose was to evaluate the accuracy of scoring and the factors that affect it in a nationwide survey. METHODS:Twenty clinical scenarios, covering a broad...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,随机对照试验

    doi:10.4414/smw.2014.14090

    authors: Previsdomini M,Cerutti B,Merlani P,Kaufmann M,van Gessel E,Rothen HU,Perren A

    更新日期:2014-12-23 00:00:00

  • Teamwork and clinician burnout in Swiss intensive care: the predictive role of workload, and demographic and unit characteristics.

    abstract:AIM:The levels of teamwork and clinician burnout in healthcare differ depending on demographic and unit characteristics. However, the impact of these characteristics varies between clinical settings. In addition, the impact of objectively measured workload in such settings is largely unknown. The aim of this study was ...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:10.4414/smw.2019.20033

    authors: Welp A,Rothen HU,Massarotto P,Manser T

    更新日期:2019-03-24 00:00:00

  • Sleep and wakefulness disturbances in Swiss pharmacy customers.

    abstract:BACKGROUND AND OBJECTIVE:Sleep disturbances are prevalent but often overlooked or underestimated. We suspected that sleep disorders might be particularly common among pharmacy customers, and that they could benefit from counselling. Therefore, we described the prevalence and severity of symptoms associated with sleep a...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章

    doi:2006/09/smw-11265

    authors: Schwegler K,Klaghofer R,Nirkko AC,Mathis J,Hersberger KE,Bloch KE

    更新日期:2006-03-04 00:00:00