Abstract:
:Patients with chronic heart failure who are not eligible for heart transplant and whose life expectancy depends mainly on the heart disease may benefit from mechanical circulatory support. Mechanical circulatory support restores adequate cardiac output and organ perfusion and eventually improves patients' clinical condition, quality of life and life expectancy. This treatment is called destination therapy (DT) and we estimate that in Switzerland more than 120 patients per year could benefit from it. In the last 10 years, design of the devices, implantation techniques and prognoses have changed dramatically. The key to successful therapy with a left ventricular assist device is appropriate patient selection, although we are still working on the definition of reliable inclusion and exclusion criteria and optimal timing for surgical implantation. Devices providing best long-term results are continuous flow, rotary or axial blood pumps implanted using minimally invasive techniques on a beating heart. These new devices (Thoratec HeartMate II and HeartWare HVAD) have only a single moving part, and have improved durability with virtually 10 years freedom from mechanical failure. In selected patients, the overall actuarial survival of DT patients is 75% at 1 year and 62% at 2 years, with a clear improvement in quality of life compared with medical management only. Complications include bleeding and infections; their overall incidence is significantly lower than with previous devices and their management is well defined. DT is evolving into an effective and reasonably cost-effective treatment option for a growing population of patients not eligible for heart transplant, showing encouraging survival rates at 2 years and providing clear improvement in quality of life. The future is bright for people suffering from chronic heart failure.
journal_name
Swiss Med Wklyjournal_title
Swiss medical weeklyauthors
Tozzi P,Hullin Rdoi
10.4414/smw.2016.14267subject
Has Abstractpub_date
2016-03-05 00:00:00pages
w14267eissn
1424-7860issn
1424-3997pii
smw-14267journal_volume
146pub_type
杂志文章,评审abstract:AIMS:In comparison with other central European countries, Switzerland has a high prevalence of gun ownership and a high rate of suicide by shooting. After the Army XXI reform in 2003, which reduced personnel from about 400,000 to approximately 200,000, a decline in suicides by firearms and a decline in the total number...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2018.14646
更新日期:2018-09-23 00:00:00
abstract::In the coming decades, old patients will account for an increasing proportion of emergency department (ED) visits. During or after their stay in the ED, they more frequently suffer adverse outcomes than younger patients. There is evidence that specific age-centred approaches improve the outcomes. We therefore reviewed...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2014.14040
更新日期:2014-12-04 00:00:00
abstract:BACKGROUND:In recent years, several treatment modalities have proved to be effective in the treatment of neuroendocrine tumours (NETs). However, there is currently no consensus on the sequence in which these options are best used. METHODS:In this observational study, we analysed the treatment modalities and sequences ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20176
更新日期:2020-01-15 00:00:00
abstract:QUESTIONS UNDER STUDY/PRINCIPLES:We describe the proportion of severely depressed outpatients reaching complete remission at the different stages of a drug treatment algorithm. We compare several treatment options for SSRI (selective serotonin reuptake inhibitor) non-responders and test the feasibility of the algorithm...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2006/05/smw-11267
更新日期:2006-02-04 00:00:00
abstract:: ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2011.13166
更新日期:2011-03-18 00:00:00
abstract::The ex utero intrapartum treatment (EXIT) procedure is designed to guarantee sufficient oxygenation for a foetus at risk of airway obstruction. This is achieved by improving lung ventilation, usually by establishing an airway during caesarean delivery whilst preserving the foetal-placental circulation temporarily. Ind...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2007/19/smw-11526
更新日期:2007-05-19 00:00:00
abstract:AIMS OF THE STUDY:Pneumothoraces after endoscopic retrograde cholangiopancreatography (ERCP) are an uncommon but potentially lethal complication. Little evidence is available on their epidemiology, diagnosis and therapy. We aimed to evaluate current practices and provide recommendations. METHOD:We systematically revie...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20199
更新日期:2020-04-03 00:00:00
abstract:BACKGROUND:The Swiss Monitoring of Potential Organ Donors (SwissPOD) was initiated to investigate the causes of the overall low organ donation rate in Switzerland. The objective of our study was an assessment of the donation after brain death (DBD) process in Swiss adult intensive care units (ICUs), and to provide an o...
journal_title:Swiss medical weekly
pub_type: 杂志文章,多中心研究
doi:10.4414/smw.2014.14045
更新日期:2014-10-23 00:00:00
abstract::Multicentric carpotarsal osteolysis (MCTO) is an autosomal dominant disease of the skeleton characterised by progressive destruction of carpal and tarsal bones. Recently, it has been demonstrated that this disease is caused by heterozygous mutations in the gene for the transcriptional repressor MAFB. We analysed genom...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2017.14529
更新日期:2017-10-27 00:00:00
abstract:BACKGROUND:The precision of symptom assessment and documentation in daily routine is unknown. Differences in hip studies have been observed between the charts and the patient questionnaires. This was the reason to perform this study and to compare the charts and the patient questionnaires. METHODS:This was a retrospec...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:smw-12581
更新日期:2009-10-17 00:00:00
abstract:OBJECTIVE:To provide population-based, gestational age (GA) stratified incidence of mortality and morbidities. METHODS:Population-based prospective observational study of infants born between 23 0/7 and 31 6/7 weeks GA in the years 2000-2004 in all Swiss neonatal intensive care units. Outcomes measured were: mortality...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2011.13212
更新日期:2011-06-24 00:00:00
abstract::Isolated left ventricular hypertrophy, in the absence of hypertension or aortic stenosis, is commonly attributed to hypertrophic cardiomyopathy (HCM). According to the clinical setting, however, other differential diagnoses should be considered. The diagnosis of cardiac amyloidosis may be very challenging especially w...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2004/19/smw-10584
更新日期:2004-05-15 00:00:00
abstract:BACKGROUND:Adverse reactions to nonsteroidal antiinflammatory drugs (NSAIDs) are frequently reported, particularly among asthmatic patients. To date, there is no causal treatment available apart from tolerance induction. Therefore, the search for safe alternative drugs is of pivotal importance in clinical practice. OB...
journal_title:Swiss medical weekly
pub_type: 临床试验,杂志文章
doi:2006/43/smw-11358
更新日期:2006-10-28 00:00:00
abstract::The United Nations General Assembly has convened a Summit on non-communicable diseases (NCDs), an historic moment in the global combat of these disorders. Lifestyles in increasingly urban and globalised environments have led to a steep surge in NCD incidence in low and middle income countries, where two thirds of all ...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2011.13266
更新日期:2011-09-07 00:00:00
abstract:OBJECTIVES:Tonsillectomy is one of the most frequently performed surgical procedures. Nevertheless there is less known about the impact of this procedure on Health-Related Quality of life (HRQOL). The two different most common used surgical techniques are "cold" (CT) and "hot" (HT) tonsillectomy. The aim of this study ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2007/31/smw-11735
更新日期:2007-08-11 00:00:00
abstract:BACKGROUND:Based on a reduction in morbidity and mortality, cardiac resynchronisation therapy (CRT) has evolved as a standard therapy for patients with advanced heart failure. OBJECTIVE:To provide insight into patient demographics, safety, echocardiographic remodelling and long-term follow-up of patients treated with ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2017.14425
更新日期:2017-04-18 00:00:00
abstract:BACKGROUND:Organs donated for transplantation remain a scarce resource in Switzerland. One of the reasons for this situation is the high percentage of patients or families who refuse to consent to donation. This study aimed to provide an overview of attitudes towards organ donation among Swiss residents, including any ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2017.14401
更新日期:2017-02-03 00:00:00
abstract:OBJECTIVE:To assess outcomes 24 months after treatment start for multidrug-resistant tuberculosis (MDR-TB). METHODS:Cohort study of all culture-positive MDR-TB cases notified in Switzerland from 01/2003 to 07/2010. RESULTS:Fifty-one cases were observed, with a median age of 26 years (range 2-56). Twenty-seven were ma...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2014.14053
更新日期:2014-12-04 00:00:00
abstract:PRINCIPLES:Data on associations between physical activity and gastroesophageal reflux disease (GERD) have been inconsistent. Although experimental and clinical studies prove that exercise increases gastroesophageal reflux, epidemiological observations on the relationship between GERD and everyday physical effort delive...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2007/33/smw-11887
更新日期:2007-08-25 00:00:00
abstract::In Switzerland, voluntary termination of pregnancy (VTP) can be performed in all public and private hospitals with an obstetrics/gynaecology department. For various reasons, many Italian women use the Swiss healthcare system, in particular in Canton Ticino, a border region adjacent to Italy in the southern part of Swi...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2018.14636
更新日期:2018-07-09 00:00:00
abstract:BACKGROUND:In Switzerland, patients may undergo "blood tests" without being informed what these are screening for. Inadequate doctor-patient communication may result in patient misunderstanding. We examined what patients in the emergency department (ED) believed they had been screened for and explored their attitudes t...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2015.14206
更新日期:2015-12-04 00:00:00
abstract:PURPOSE:There is increasing pressure on general practitioners (GPs) to identify patients with abdominal obesity in order to reduce the life-threatening consequences of this condition in the population. We aimed to confirm previous findings on the inaccuracy of anthropometric measurements performed by GPs in an academic...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2015.14115
更新日期:2015-02-21 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:smw-12549
更新日期:2009-05-16 00:00:00
abstract:QUESTIONS UNDER STUDY:The unexpected death of a preterm infant is an extremely painful situation for parents. Despite a number of quantitative studies, little is known about parents' inner experience. The aim of this study was to gather more in-depth information about what preoccupies parents in this situation of suffe...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2007/27/smw-11868
更新日期:2007-07-14 00:00:00
abstract:PRINCIPLES:A decrease in plasma lipids occurs during severe sepsis and has prognostic implications in critical illness. Whether lipids have prognostic implications or could help to differentiate community-acquired pneumonia from other lower respiratory tract infections remains unknown. METHODS:We analysed data from pa...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:smw-12494
更新日期:2009-03-21 00:00:00
abstract::Atrial arrhythmias complicate the clinical course of adult patients with an atrial septal defect. Atrial flutter is more prevalent in younger patients, and frequently regresses after surgical defect closure. Atrial fibrillation however, which results from a chronic underlying disease, rarely reverts to sinus rhythm af...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2005/11/smw-10926
更新日期:2005-03-19 00:00:00
abstract:BACKGROUND:General practitioners (GPs) use diagnostic tests to help distinguish between viral and bacterial acute respiratory tract infections (ARTI). We investigated the prevalence of these tests, and how tests are associated with diagnosis, treatment and patient satisfaction. METHODS:As part of a clinical trial, 45 ...
journal_title:Swiss medical weekly
pub_type: 杂志文章,随机对照试验
doi:2006/15/smw-11343
更新日期:2006-04-15 00:00:00
abstract:PRINCIPLES:Neisseria gonorrhoeae (NG) resistant to ciprofloxacin (CR) was documented for the first time in Geneva in 2002 and increased from 7% that year to 47% in 2005. We describe NG cases during this period and compare characteristics of CR and ciprofloxacin susceptible (CS) cases. METHOD:Geneva microbiological lab...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2008/15/smw-12029
更新日期:2008-04-19 00:00:00
abstract:QUESTIONS UNDER STUDY:Paraoxonase-1 (PON1) is an HDL-bound enzyme system which plays a key role in the protection of LDL and HDL from oxidation by hydrolysing activated phospholipids and lipid peroxide products. Oxidative stress has been involved in the pathogenesis of many complications of human pregnancy, including e...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:smw-12495
更新日期:2009-02-07 00:00:00
abstract:BACKGROUND:In 2005, findings of the first "cost of disorders of the brain in Europe" study of the European Brain Council (EBC) showed that these costs cause a substantial economic burden to the Swiss society. In 2010 an improved update with a broader range of disorders has been analysed. This report shows the new findi...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2013.13751
更新日期:2013-01-07 00:00:00