Cessation of extracorporeal photopheresis in chronic lung allograft dysfunction: effects on clinical outcome in adults.


BACKGROUND:Extracorporeal photopheresis (ECP) has been reported to be safe and the ultimate treatment option in lung transplant recipients with chronic lung allograft dysfunction (CLAD), the main overall cause of mortality in lung transplant recipients. However, ECP is not reimbursed in selected health jurisdictions, and reimbursement by health insurance providers is a major issue. In Switzerland, ECP is not recognised by the health authorities as a therapy option for CLAD; thus by the end of 2014, ECP had to be stopped in the majority of adult lung transplant recipients cared for at the University Hospital Zurich because of lack of continuous funding. OBJECTIVE:To describe the outcome of lung transplant recipients after forced cessation of ECP treatment. METHOD:We retrospectively analysed outcome of 12 lung transplant recipients undergoing ECP for different phenotypes of CLAD (bronchiolitis obliterans syndrome, restrictive allograft syndrome) at our centre followed-up for 12 months after forced cessation of ECP. RESULTS:Within the 12 months after treatment cessation, seven patients (58%) died with a median survival of 207 days (range 6-365 days). Lung function (FEV1, forced expiratory volume in 1 second) declined significantly 6 months after ECP cessation (p = 0.003). CONCLUSION:Our data support the role of ECP as valuable treatment option in lung transplant recipients with CLAD.


Swiss Med Wkly


Swiss medical weekly


Robinson CA,Huber L,Murer C,Schuurmans M,Kohler M,Hofbauer G,Benden C




Has Abstract


2017-03-13 00:00:00












  • A 10-year observational study of Streptococcus dysgalactiae bacteraemia in adults: frequent occurrence among female intravenous drug users.

    abstract::Beta-haemolytic streptococci of groups C and G have become increasingly recognized as causes of invasive human infections. We reviewed clinical and molecular characteristics of Streptococcus dysgalactiae isolates that caused bacteraemia in adults from 2006 to 2015. Among 67 episodes, skin and soft-tissue infections (4...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Ruppen C,Rasmussen M,Casanova C,Sendi P

    更新日期:2017-07-24 00:00:00

  • Injury and repeated injury - what is the link with acute consumption, binge drinking and chronic heavy alcohol use?

    abstract:OBJECTIVES:First, to test whether current injury is more closely related to acute intake than to usual consumption patterns, and second, to test whether repeated injury is more closely related to general consumption patterns than to acute intake. METHODS:Screening of alcohol consumption of 7,872 patients enrolling bet...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Gmel G,Givel JC,Yersin B,Daeppen JB

    更新日期:2007-11-17 00:00:00

  • Cognition and driving in older persons.

    abstract::In Switzerland, approximately 350,000 people aged 70 years or older own a valid driving license. By law, these drivers are medically assessed every other year, most commonly by their general practitioner, to exclude that a medical condition is interfering with their driving skills. A prerequisite for driving is the in...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审


    authors: Wagner JT,Müri RM,Nef T,Mosimann UP

    更新日期:2011-01-17 00:00:00

  • Complementary and alternative medicine in asthma: do they work?

    abstract:OBJECTIVE:An increasing number of patients with asthma are attracted by complementary and alternative medicine (CAM). Therefore, it is of importance that scientific evidence about the efficacy of this type of therapy is regarded. METHOD:We searched the electronic databases Medline, Embase and the Cochrane Library for ...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审


    authors: Steurer-Stey C,Russi EW,Steurer J

    更新日期:2002-06-29 00:00:00

  • Management of hepatitis C in opioid agonist therapy patients of the Swiss canton Aargau within and outside the cohort study.

    abstract::With regard to HCV elimination in opioid agonist therapy patients by 2030, case finding and regular screening for new and re-infections remain a challenge, especially for non-cohort patients in a decentralised setting. Documentation of the HCV sero- and RNA status of each opioid agonist therapy  patient by the ca...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Schürch S,Fux CA,Dehler S,Conen A,Knuchel J,Friedl A,Eigenmann F,Roser P,Ackle P,Bregenzer A

    更新日期:2020-08-06 00:00:00

  • Fibroblasts as therapeutic targets in rheumatoid arthritis and cancer.

    abstract::Rheumatoid arthritis is a common chronic inflammatory disease that causes progressive synovial inflammation resulting in irreversible joint destruction, chronic disability and premature mortality. Although it is recognised that in rheumatoid arthritis, inflammation and its persistence result from complex interactions ...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审


    authors: Juarez M,Filer A,Buckley CD

    更新日期:2012-02-24 00:00:00

  • Physical activity behaviour in patients with metabolic syndrome.

    abstract:STUDY/PRINCIPLES:Physical activity improves the clinical course of the metabolic syndrome and its risk factors. The aim of this study was to investigate the physical activity behaviour in patients with metabolic syndrome in regard to the recommendation of the Federal Offices of Public Health (BAG) and Sports (BASPO): "...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Murer M,Schmied C,Battegay E,Keller DI

    更新日期:2012-10-25 00:00:00

  • Admissions of patients with alcohol intoxication in the Emergency Department: a growing phenomenon.

    abstract:QUESTION UNDER STUDY:To investigate the change over time in the number of ED admissions with positive blood alcohol concentration (BAC) and to evaluate predictors of BAC level. METHODS:We conducted a single site retrospective study at the ED of a tertiary referral hospital (western part of Switzerland) and obtained al...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Bertholet N,Adam A,Faouzi M,Boulat O,Yersin B,Daeppen JB,Clerc D

    更新日期:2014-08-07 00:00:00

  • Aetiological blood biomarkers of ischaemic stroke.

    abstract::Each year, over 5 million people die worldwide from stroke, and at least every sixth patient who survives will experience another stroke within five years [1]. We are therefore eager to advance early and rapid diagnosis, prognosis and optimal risk stratification, as well as secondary prevention. In this context, blood...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审


    authors: Sonderer J,Katan Kahles M

    更新日期:2015-05-29 00:00:00

  • Posterior positional plagiocephaly treated with cranial remodeling orthosis.

    abstract:PRINCIPLES:Since the recommendation that infants sleep in the supine position, there has been an increase in cases of posterior positional plagiocephaly. Even though this condition is a purely cosmetic problem, if it is severe it may affect the child psychologically. Positioning may help in mild or moderate cases, but ...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: de Ribaupierre S,Vernet O,Rilliet B,Cavin B,Kalina D,Leyvraz P-

    更新日期:2007-06-30 00:00:00

  • Carbon nanotubes: an insight into the mechanisms of their potential genotoxicity.

    abstract::After the health catastrophe resulting from the widespread use of asbestos which was once hailed as a new miracle material, the increasing use of carbon nanotubes (CNTs) has spawned major concern due to their similarities in terms of size, shape and poor solubility. Assessment of genotoxicity has shown that CNTs can d...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审


    authors: van Berlo D,Clift MJ,Albrecht C,Schins RP

    更新日期:2012-11-05 00:00:00

  • Clinical and immune response to undiluted and diluted smallpox vaccine.

    abstract:QUESTION UNDER STUDY:To assess clinical reactions, immune responses and adverse events to undiluted, three- and sixfold diluted Lister strain vaccine stockpiled in Switzerland. METHODS:A prospective, triple-blinded, randomised, parallel group clinical trial was performed. RESULTS:From 2001 to 2007 104 persons with an...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,随机对照试验


    authors: Gassmann R,Engler OB,Steffen R,Alex M,Czerny CP,Mutsch M

    更新日期:2008-07-12 00:00:00

  • Systematic review of pneumothoraces after endoscopic retrograde cholangiopancreatography.

    abstract:AIMS OF THE STUDY:Pneumothoraces after endoscopic retrograde cholangiopancreatography (ERCP) are an uncommon but potentially lethal complication. Little evidence is available on their epidemiology, diagnosis and therapy. We aimed to evaluate current practices and provide recommendations. METHOD:We systematically revie...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Lehmann V,Keller W,Egger B

    更新日期:2020-04-03 00:00:00

  • Organic dust exposure in dairy farmers in an alpine region.

    abstract:OBJECTIVES:Epidemological studies suggest that farmers are at an increased risk for chronic obstructive pulmonary disease because of exposure to organic dust. We assessed the proportion of farmers among patients with end stage lung disease and we measured the seasonal exposure of dairy farmers to organic dust in a rura...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Cathomas RL,Brüesch H,Fehr R,Reinhart WH,Kuhn M

    更新日期:2002-04-06 00:00:00

  • Early diagnosis and management of dementia in general practice - how do Swiss GPs meet the challenge?

    abstract:INTRODUCTION:In general practice, the diagnosis of dementia is often delayed. Therefore, the Swiss National Dementia Strategy 2014 concluded that action was needed to improve patient care. Little is known about GPs’ confidence in and approach to the diagnosis, disclosure and post-diagnostic management of individu...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Giezendanner S,Monsch AU,Kressig RW,Mueller Y,Streit S,Essig S,Zeller A,Bally K

    更新日期:2018-12-21 00:00:00

  • Low-molecular-weight heparin in patients with renal insufficiency.

    abstract:BACKGROUND:Low-molecular-weight heparins (LMWH) have been shown to be safer, more effective and more convenient than unfractionated heparin (UFH) in many clinical situations. However, their use is limited in patients with renal insufficiency (RI) due to bioaccumulation. METHOD:The literature is critically reviewed and...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审


    authors: Schmid P,Fischer AG,Wuillemin WA

    更新日期:2009-08-08 00:00:00

  • Mechanical circulatory support for destination therapy.

    abstract::Patients with chronic heart failure who are not eligible for heart transplant and whose life expectancy depends mainly on the heart disease may benefit from mechanical circulatory support. Mechanical circulatory support restores adequate cardiac output and organ perfusion and eventually improves patients' clinical con...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审


    authors: Tozzi P,Hullin R

    更新日期:2016-03-05 00:00:00

  • Long term effects of comprehensive cardiac rehabilitation in an inpatient and outpatient setting.

    abstract:OBJECTIVES:To compare the long-term effects of comprehensive outpatient versus inpatient rehabilitation with respect to morbidity and mortality, as well as to changes in physical performance and physical activity. DESIGN:A total of 163 consecutive patients were enrolled for comprehensive cardiac rehabilitation (CCR) f...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Steinacker JM,Liu Y,Muche R,Koenig W,Hahmann H,Imhof A,Kropf C,Brandstetter S,Schweikert B,Leidl R,Schiefer DH

    更新日期:2011-01-06 00:00:00

  • Use of brain natriuretic peptide to detect previously unknown left ventricular dysfunction in patients with acute exacerbation of chronic obstructive pulmonary disease.

    abstract:BACKGROUND:Up to 30% of patients with chronic obstructive pulmonary disease (COPD) simultaneously suffer from often-unrecognised chronic heart failure (HF). Their timely identification is challenging as both conditions share similar clinical presentations. OBJECTIVE:To assess the performance of BNP in detecting left v...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Gariani K,Delabays A,Perneger TV,Agoritsas T

    更新日期:2011-11-09 00:00:00

  • Cost of disorders of the brain in Switzerland with a focus on mental disorders.

    abstract:QUESTIONS UNDER STUDY:This study aims at estimating the costs of disorders of the brain in Switzerland based on the published epidemiological and economic evidence. METHODS:the data presented for Switzerland are derived from the "cost of disorders of the brain in Europe" study of the European Brain Counsil (EBC). Avai...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Jäger M,Sobocki P,Rössler W

    更新日期:2008-01-12 00:00:00

  • Minimal residual disease monitoring: the new standard for treatment evaluation of haematological malignancies?

    abstract::Minimal residual disease (MRD) refers to the small number of malignant cells that remain after therapy when the patient is in remission and shows no symptoms or overt signs of disease. Current treatment protocols for haematological malignancies allow most patients to obtain some form of MRD state, but cure seldom foll...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审


    authors: Hauwel M,Matthes T

    更新日期:2014-01-22 00:00:00

  • Loss of a preterm infant: psychological aspects in parents.

    abstract:QUESTIONS UNDER STUDY:The unexpected death of a preterm infant is an extremely painful situation for parents. Despite a number of quantitative studies, little is known about parents' inner experience. The aim of this study was to gather more in-depth information about what preoccupies parents in this situation of suffe...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Glaser A,Bucher HU,Moergeli H,Fauchère JC,Buechi S

    更新日期:2007-07-14 00:00:00

  • Female genital mutilation in Switzerland: a survey among gynaecologists.

    abstract:QUESTION UNDER STUDY:To evaluate the situation of Female Genital Mutilation (FGM) in Switzerland. METHODS:Through a questionnaire, Swiss gynaecologists were asked if they have been confronted to FGMs, if they have been asked to perform infibulations and FGMs. The health representatives (Kantonsärzte/médecins cantonaux...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Jäger F,Schulze S,Hohlfeld P

    更新日期:2002-05-18 00:00:00

  • Clinical outcomes in patients with systemic lupus erythematosus treated with belimumab in clinical practice settings: a retrospective analysis of results from the OBSErve study in Switzerland.

    abstract:AIMS OF THE STUDY:To describe patterns of systemic lupus erythematosus (SLE) care and the clinical effectiveness of belimumab plus standard of care therapy in a real-world clinical setting in Switzerland. METHODS:This multicentre, observational, retrospective cohort study included adults with SLE who initiated belimum...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,多中心研究


    authors: von Kempis J,Duetsch S,Reuschling N,Villiger R,Villiger PM,Vallelian F,Schaer DJ,Mueller RB

    更新日期:2019-03-10 00:00:00

  • Pulmonary rehabilitation in Switzerland.

    abstract::Pulmonary rehabilitation is a form of therapy for patients with chronic lung disease that is evidence based, which ameliorates performance and endurance of the patient and improves quality of life significantly. Pulmonary rehabilitation also diminishes the amount of hospitalisations and the duration of stay in hospita...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审


    authors: Karrer W

    更新日期:2005-02-05 00:00:00

  • The costs of disorders of the brain in Switzerland: an update from the European Brain Council Study for 2010.

    abstract:BACKGROUND:In 2005, findings of the first "cost of disorders of the brain in Europe" study of the European Brain Council (EBC) showed that these costs cause a substantial economic burden to the Swiss society. In 2010 an improved update with a broader range of disorders has been analysed. This report shows the new findi...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Maercker A,Perkonigg A,Preisig M,Schaller K,Weller M,Cost of Disorders of the Brain in Europe Study Group.

    更新日期:2013-01-07 00:00:00

  • A stepwise drug treatment algorithm to obtain complete remission in depression: a Geneva study.

    abstract:QUESTIONS UNDER STUDY/PRINCIPLES:We describe the proportion of severely depressed outpatients reaching complete remission at the different stages of a drug treatment algorithm. We compare several treatment options for SSRI (selective serotonin reuptake inhibitor) non-responders and test the feasibility of the algorithm...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Bondolfi G,Aubry JM,Golaz J,Gex-Fabry M,Gervasoni N,Bertschy G

    更新日期:2006-02-04 00:00:00

  • Swiss Monitoring of Potential Organ Donors (SwissPOD): a prospective 12-month cohort study of all adult ICU deaths in Switzerland.

    abstract:BACKGROUND:The Swiss Monitoring of Potential Organ Donors (SwissPOD) was initiated to investigate the causes of the overall low organ donation rate in Switzerland. The objective of our study was an assessment of the donation after brain death (DBD) process in Swiss adult intensive care units (ICUs), and to provide an o...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,多中心研究


    authors: Weiss JH,Keel I,Immer FF,Wiegand J,Haberthür C,Comité National du Don d'Organes (CNDO).

    更新日期:2014-10-23 00:00:00

  • Ex utero intrapartum treatment (EXIT), a resuscitation option for intra-thoracic foetal pathologies.

    abstract::The ex utero intrapartum treatment (EXIT) procedure is designed to guarantee sufficient oxygenation for a foetus at risk of airway obstruction. This is achieved by improving lung ventilation, usually by establishing an airway during caesarean delivery whilst preserving the foetal-placental circulation temporarily. Ind...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章,评审


    authors: Kern C,Ange M,Morales,Peiry B,Pfister RE

    更新日期:2007-05-19 00:00:00

  • External radiotherapy for prostate cancer with or without androgen deprivation: Geneva, 1991 to 2004.

    abstract:QUESTIONS UNDER STUDY/PRINCIPLES:A retrospective assessment of long-term results on a single centre, single author experience in treating prostate cancer with high dose curative radiotherapy (RT) with or without androgen deprivation (AD). METHODS:Between 1991 and 2004, 408 patients with clinically localised prostate c...

    journal_title:Swiss medical weekly

    pub_type: 杂志文章


    authors: Miralbell R,Pampallona S,Rouzaud M,Pugliesi A,Weber D,Ares C

    更新日期:2009-09-05 00:00:00