Abstract:
BACKGROUND:Extracorporeal photopheresis (ECP) has been reported to be safe and the ultimate treatment option in lung transplant recipients with chronic lung allograft dysfunction (CLAD), the main overall cause of mortality in lung transplant recipients. However, ECP is not reimbursed in selected health jurisdictions, and reimbursement by health insurance providers is a major issue. In Switzerland, ECP is not recognised by the health authorities as a therapy option for CLAD; thus by the end of 2014, ECP had to be stopped in the majority of adult lung transplant recipients cared for at the University Hospital Zurich because of lack of continuous funding. OBJECTIVE:To describe the outcome of lung transplant recipients after forced cessation of ECP treatment. METHOD:We retrospectively analysed outcome of 12 lung transplant recipients undergoing ECP for different phenotypes of CLAD (bronchiolitis obliterans syndrome, restrictive allograft syndrome) at our centre followed-up for 12 months after forced cessation of ECP. RESULTS:Within the 12 months after treatment cessation, seven patients (58%) died with a median survival of 207 days (range 6-365 days). Lung function (FEV1, forced expiratory volume in 1 second) declined significantly 6 months after ECP cessation (p = 0.003). CONCLUSION:Our data support the role of ECP as valuable treatment option in lung transplant recipients with CLAD.
journal_name
Swiss Med Wklyjournal_title
Swiss medical weeklyauthors
Robinson CA,Huber L,Murer C,Schuurmans M,Kohler M,Hofbauer G,Benden Cdoi
10.4414/smw.2017.14429subject
Has Abstractpub_date
2017-03-13 00:00:00pages
w14429eissn
1424-7860issn
1424-3997pii
smw-14429journal_volume
147pub_type
杂志文章abstract::Beta-haemolytic streptococci of groups C and G have become increasingly recognized as causes of invasive human infections. We reviewed clinical and molecular characteristics of Streptococcus dysgalactiae isolates that caused bacteraemia in adults from 2006 to 2015. Among 67 episodes, skin and soft-tissue infections (4...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2017.14469
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2007/45/smw-11697
更新日期:2007-11-17 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2002/25/smw-09972
更新日期:2002-06-29 00:00:00
abstract::With regard to HCV elimination in opioid agonist therapy patients by 2030, case finding and regular screening for new and re-infections remain a challenge, especially for non-cohort patients in a decentralised setting. Documentation of the HCV sero- and RNA status of each opioid agonist therapy patient by the ca...
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2012.13529
更新日期:2012-02-24 00:00:00
abstract:STUDY/PRINCIPLES:Physical activity improves the clinical course of the metabolic syndrome and its risk factors. The aim of this study was to investigate the physical activity behaviour in patients with metabolic syndrome in regard to the recommendation of the Federal Offices of Public Health (BAG) and Sports (BASPO): "...
journal_title:Swiss medical weekly
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doi:10.4414/smw.2012.13691
更新日期:2012-10-25 00:00:00
abstract:QUESTION UNDER STUDY:To investigate the change over time in the number of ED admissions with positive blood alcohol concentration (BAC) and to evaluate predictors of BAC level. METHODS:We conducted a single site retrospective study at the ED of a tertiary referral hospital (western part of Switzerland) and obtained al...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2014.13982
更新日期:2014-08-07 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2015.14138
更新日期:2015-05-29 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2007/25/smw-11702
更新日期:2007-06-30 00:00:00
abstract::After the health catastrophe resulting from the widespread use of asbestos which was once hailed as a new miracle material, the increasing use of carbon nanotubes (CNTs) has spawned major concern due to their similarities in terms of size, shape and poor solubility. Assessment of genotoxicity has shown that CNTs can d...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2012.13698
更新日期:2012-11-05 00:00:00
abstract:QUESTION UNDER STUDY:To assess clinical reactions, immune responses and adverse events to undiluted, three- and sixfold diluted Lister strain vaccine stockpiled in Switzerland. METHODS:A prospective, triple-blinded, randomised, parallel group clinical trial was performed. RESULTS:From 2001 to 2007 104 persons with an...
journal_title:Swiss medical weekly
pub_type: 杂志文章,随机对照试验
doi:2008/27/smw-11966
更新日期:2008-07-12 00:00:00
abstract:AIMS OF THE STUDY:Pneumothoraces after endoscopic retrograde cholangiopancreatography (ERCP) are an uncommon but potentially lethal complication. Little evidence is available on their epidemiology, diagnosis and therapy. We aimed to evaluate current practices and provide recommendations. METHOD:We systematically revie...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20199
更新日期:2020-04-03 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2002/13/smw-09892
更新日期:2002-04-06 00:00:00
abstract:INTRODUCTION:In general practice, the diagnosis of dementia is often delayed. Therefore, the Swiss National Dementia Strategy 2014 concluded that action was needed to improve patient care. Little is known about GPs’ confidence in and approach to the diagnosis, disclosure and post-diagnostic management of individu...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2018.14695
更新日期:2018-12-21 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:smw-11284
更新日期:2009-08-08 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2016.14267
更新日期:2016-03-05 00:00:00
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pub_type: 杂志文章
doi:10.4414/smw.2010.13141
更新日期:2011-01-06 00:00:00
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pub_type: 杂志文章
doi:10.4414/smw.2011.13298
更新日期:2011-11-09 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2008/01/smw-11910
更新日期:2008-01-12 00:00:00
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更新日期:2014-01-22 00:00:00
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doi:2007/27/smw-11868
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doi:2002/19/smw-09912
更新日期:2002-05-18 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.4414/smw.2019.20022
更新日期:2019-03-10 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2005/05/smw-10718
更新日期:2005-02-05 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2013.13751
更新日期:2013-01-07 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2006/05/smw-11267
更新日期:2006-02-04 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,多中心研究
doi:10.4414/smw.2014.14045
更新日期:2014-10-23 00:00:00
abstract::The ex utero intrapartum treatment (EXIT) procedure is designed to guarantee sufficient oxygenation for a foetus at risk of airway obstruction. This is achieved by improving lung ventilation, usually by establishing an airway during caesarean delivery whilst preserving the foetal-placental circulation temporarily. Ind...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2007/19/smw-11526
更新日期:2007-05-19 00:00:00
abstract:QUESTIONS UNDER STUDY/PRINCIPLES:A retrospective assessment of long-term results on a single centre, single author experience in treating prostate cancer with high dose curative radiotherapy (RT) with or without androgen deprivation (AD). METHODS:Between 1991 and 2004, 408 patients with clinically localised prostate c...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:smw-12604
更新日期:2009-09-05 00:00:00