Abstract:
BACKGROUND:Extracorporeal photopheresis (ECP) has been reported to be safe and the ultimate treatment option in lung transplant recipients with chronic lung allograft dysfunction (CLAD), the main overall cause of mortality in lung transplant recipients. However, ECP is not reimbursed in selected health jurisdictions, and reimbursement by health insurance providers is a major issue. In Switzerland, ECP is not recognised by the health authorities as a therapy option for CLAD; thus by the end of 2014, ECP had to be stopped in the majority of adult lung transplant recipients cared for at the University Hospital Zurich because of lack of continuous funding. OBJECTIVE:To describe the outcome of lung transplant recipients after forced cessation of ECP treatment. METHOD:We retrospectively analysed outcome of 12 lung transplant recipients undergoing ECP for different phenotypes of CLAD (bronchiolitis obliterans syndrome, restrictive allograft syndrome) at our centre followed-up for 12 months after forced cessation of ECP. RESULTS:Within the 12 months after treatment cessation, seven patients (58%) died with a median survival of 207 days (range 6-365 days). Lung function (FEV1, forced expiratory volume in 1 second) declined significantly 6 months after ECP cessation (p = 0.003). CONCLUSION:Our data support the role of ECP as valuable treatment option in lung transplant recipients with CLAD.
journal_name
Swiss Med Wklyjournal_title
Swiss medical weeklyauthors
Robinson CA,Huber L,Murer C,Schuurmans M,Kohler M,Hofbauer G,Benden Cdoi
10.4414/smw.2017.14429subject
Has Abstractpub_date
2017-03-13 00:00:00pages
w14429eissn
1424-7860issn
1424-3997pii
smw-14429journal_volume
147pub_type
杂志文章abstract::Lung transplantation has now been performed for more than 30 years in patients with end-stage chronic obstructive pulmonary disease (COPD). This disease is the major indication for lung transplantation, involving more than one third of the procedures worldwide. Although lung transplantation in COPD patients has clearl...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:smw-12377
更新日期:2009-01-10 00:00:00
abstract::We present the case of an oncology patient admitted to our hospital during the current COVID-19 pandemic with clinical and radiological features strongly suggestive of interstitial pneumonia. Multiple laboratory tests were negative for SARS-CoV-2 (polymerase chain reaction testing of nasopharyngeal swabs, and of induc...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20312
更新日期:2020-07-11 00:00:00
abstract::Perinatal care of pregnant women at high risk for preterm delivery and of preterm infants born at the limit of viability (22-26 completed weeks of gestation) requires a multidisciplinary approach by an experienced perinatal team. Limited precision in the determination of both gestational age and foetal weight, as well...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2011.13280
更新日期:2011-10-18 00:00:00
abstract::In Switzerland, voluntary termination of pregnancy (VTP) can be performed in all public and private hospitals with an obstetrics/gynaecology department. For various reasons, many Italian women use the Swiss healthcare system, in particular in Canton Ticino, a border region adjacent to Italy in the southern part of Swi...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2018.14636
更新日期:2018-07-09 00:00:00
abstract:PRINCIPLES:Data on associations between physical activity and gastroesophageal reflux disease (GERD) have been inconsistent. Although experimental and clinical studies prove that exercise increases gastroesophageal reflux, epidemiological observations on the relationship between GERD and everyday physical effort delive...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2007/33/smw-11887
更新日期:2007-08-25 00:00:00
abstract::A nationwide survey was conducted in Switzerland to assess the quality level of osteoporosis management in patients aged 50 years or older presenting with a fragility fracture to the emergency ward of the participating hospitals. Eight centres recruited 4966 consecutive patients who presented with one or more fracture...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:/aop/smw-aop12294
更新日期:2008-11-15 00:00:00
abstract:QUESTION UNDER STUDY:Purpose was to validate accuracy and reliability of automated oscillometric ankle-brachial (ABI) measurement prospectively against the current gold standard of Doppler-assisted ABI determination. METHODS:Oscillometric ABI was measured in 50 consecutive patients with peripheral arterial disease (n ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:smw-12636
更新日期:2009-06-27 00:00:00
abstract::Osteoarticular infections remain a significant cause of morbidity worldwide in young children. They can have a devastating impact with a high rate of serious and long-lasting sequelae, especially on remaining growth. Depending on the localisation of infection, they manifest as osteomyelitis, septic arthritis, a combin...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2014.13971
更新日期:2014-06-12 00:00:00
abstract::Patients with chronic heart failure who are not eligible for heart transplant and whose life expectancy depends mainly on the heart disease may benefit from mechanical circulatory support. Mechanical circulatory support restores adequate cardiac output and organ perfusion and eventually improves patients' clinical con...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2016.14267
更新日期:2016-03-05 00:00:00
abstract::Metallothioneins (MTs) are a family of small proteins containing 61-68 amino acids with an unusually high concentration of cysteine. MT-1, the most functional and active MT in humans, has the ability to react with and enhance the detoxification of a number of metals including zinc, mercury, copper and cadmium. MT dysf...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:
更新日期:2008-02-09 00:00:00
abstract::Atrial arrhythmias complicate the clinical course of adult patients with an atrial septal defect. Atrial flutter is more prevalent in younger patients, and frequently regresses after surgical defect closure. Atrial fibrillation however, which results from a chronic underlying disease, rarely reverts to sinus rhythm af...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2005/11/smw-10926
更新日期:2005-03-19 00:00:00
abstract:BACKGROUND:In recent years, several treatment modalities have proved to be effective in the treatment of neuroendocrine tumours (NETs). However, there is currently no consensus on the sequence in which these options are best used. METHODS:In this observational study, we analysed the treatment modalities and sequences ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20176
更新日期:2020-01-15 00:00:00
abstract:OBJECTIVE:To assess the clinical implementation and report preliminary results of a novel technique called the Ozaki procedure for stentless aortic valve replacement through reconstruction of the valve leaflets from autologous pericardium. METHOD:Between September 2015 and May 2017 30 patients (20 males, mean ± standa...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2018.14591
更新日期:2018-02-09 00:00:00
abstract:BACKGROUND:Preventive treatment may avoid future cases of tuberculosis among asylum seekers. The effectiveness of preventive treatment depends in large part on treatment completion. METHODS:In a prospective cohort study, asylum seekers of two of the Swiss Canton Vaud migration centres were screened with the Interferon...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2013.13860
更新日期:2013-09-06 00:00:00
abstract:QUESTIONS UNDER STUDY:To improve the response of deteriorating patients during their hospital stay, the University Hospital Bern has introduced a Medical Emergency Team (MET). Aim of this retrospective cohort study is to review the preceding factors, patient characteristics, process parameters and their correlation to ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2014.14027
更新日期:2014-10-08 00:00:00
abstract:QUESTIONS UNDER STUDY/PRINCIPLES:Although probe-based confocal laser endomicroscopy (pCLE) is on the edge of entering daily practice in gastroenterological endoscopy, findings in the field of respiratory medicine are only rarely reported, keeping pCLE during flexible bronchoscopy as a mere preclinical research tool. Si...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2013.13764
更新日期:2013-03-26 00:00:00
abstract::The atherogenic lipoprotein phenotype is characterised by a moderate increase in plasma triglycerides, a decrease in high density lipoprotein cholesterol and the prevalence of smaller denser low density lipoprotein particles. The prevalence of this partially inheritable phenotype is approximately 30% and is a feature ...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2004/49/smw-10813
更新日期:2004-12-18 00:00:00
abstract:BACKGROUND:With its high incidence and subsequent adverse consequences in the intensive care setting, several instruments have been developed to screen for and detect delirium. One of the more commonly used is the Intensive Care Delirium Screening Checklist (ICDSC); however, the optimal cut-off score indicating deliriu...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2018.14597
更新日期:2018-03-14 00:00:00
abstract:OBJECTIVES:The sero-prevalence of co-infection with the hepatitis B virus (HBV) and the hepatitis D virus (HDV) is well known in many European countries, starting from 6.8% in Germany to more than 27% in some Turkish areas. To gain a better description of this infection in Switzerland, and to characterise those affecte...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2011.13176
更新日期:2011-03-18 00:00:00
abstract:BACKGROUND:Evaluation of the current clinical treatment of psoriasis in Switzerland remains to be measured with the parameters cost-of-illness and quality of life. OBJECTIVE:To obtain data on out-of-pocket expenses, costs of outpatient/office-based care and inpatient care for psoriasis, and to extrapolate total costs ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:smw-12756
更新日期:2010-02-06 00:00:00
abstract::Calcitonin was discovered in the early 1960s [1], at which time it was assumed to be a single hormone with a yet-to-be-determined role in human physiology. Since then it has been found to be only one entity among a large array of related circulating peptides, at least one of which has a pivotal role in the host respon...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2001/41/smw-09751
更新日期:2001-10-20 00:00:00
abstract:BACKGROUND:The number of individuals with autoimmune inflammatory rheumatic diseases (AIIRDs) treated with immunosuppressive drugs is increasing steadily. The variety of immunosuppressive drugs and, in particular, biological therapies is also rising. The immunosuppressants, as well as the AIIRD itself, increase the ris...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2015.14159
更新日期:2015-07-28 00:00:00
abstract:PRINCIPLES:Since the recommendation that infants sleep in the supine position, there has been an increase in cases of posterior positional plagiocephaly. Even though this condition is a purely cosmetic problem, if it is severe it may affect the child psychologically. Positioning may help in mild or moderate cases, but ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2007/25/smw-11702
更新日期:2007-06-30 00:00:00
abstract::The current situation of the biomedical sciences is critically discussed. It can be summarized as follows: 1. We have to acknowledge the presence of a serious credibility problem, which might undermine the foundations of medical science. ("Sliding on a slippery slope") 2. Multiple forces going beyond simple conflicts ...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2015.14120
更新日期:2015-03-13 00:00:00
abstract:BACKGROUND:Glomerulonephritis is a rare yet serious group of diseases with a high risk of progression to end-stage renal disease. For optimal healthcare planning, detailed epidemiological and demographic data are essential. Despite their clinical relevance, these data are largely lacking in Switzerland. OBJECTIVE:The ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20353
更新日期:2020-10-06 00:00:00
abstract:THEORETICAL BACKGROUND:Mental disorders emerge in childhood and adolescence and are important risk factors for mental disorders in adolescence and adulthood. Since paediatricians are typically the first to see children with psychological problems, the aim of this study was to obtain a survey of mental disorders of chil...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2010.13092
更新日期:2010-08-27 00:00:00
abstract:OBJECTIVE:To assess the presence of Mycoplasma pneumoniae-associated encephalitis in children in Switzerland and its likely pathogenesis. METHODS:M. pneumoniae-associated encephalitis cases seen at a single-centre during 2010-2013 were reviewed, and the Swiss Paediatric Surveillance Unit (SPSU) prospectively conducted...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2016.14222
更新日期:2016-01-11 00:00:00
abstract::The authors report on bilateral simultaneous knee arthroplasty in a 40-year-old male patient with haemophilia A, high inhibitor titre and an aneurysma spurium of the right popliteal artery. Both knees showed a fixed flexion deformity of 20 degrees. To build up haemostasis, treatment with activated prothrombin complex ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2010.13094
更新日期:2010-08-24 00:00:00
abstract:OBJECTIVE:To evaluate the current prevalence of self-reported interpersonal violence amongst patients consulting at the emergency department (ED) of a university hospital and to describe the characteristics of the violence sustained. METHODS:Ours was a cross-sectional study using a modified version of the Partner Viol...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2019.20147
更新日期:2019-12-17 00:00:00
abstract:QUESTIONS UNDER STUDY:Paraoxonase-1 (PON1) is an HDL-bound enzyme system which plays a key role in the protection of LDL and HDL from oxidation by hydrolysing activated phospholipids and lipid peroxide products. Oxidative stress has been involved in the pathogenesis of many complications of human pregnancy, including e...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:smw-12495
更新日期:2009-02-07 00:00:00