Abstract:
OBJECTIVE:To assess the presence of Mycoplasma pneumoniae-associated encephalitis in children in Switzerland and its likely pathogenesis. METHODS:M. pneumoniae-associated encephalitis cases seen at a single-centre during 2010-2013 were reviewed, and the Swiss Paediatric Surveillance Unit (SPSU) prospectively conducted a nationwide surveillance 2013-2015. Case definition included confirmed, probable and possible cases. RESULTS:Seven patients (median age 8.7 years, range 4.7-10.1 years) with confirmed or possible M. pneumoniae-associated encephalitis were observed. All patients manifested prodromal respiratory symptoms over at least 5 days and five out of the six who had a chest radiograph, showed pulmonary infiltrates. M. pneumoniae DNA in cerebrospinal fluid was negative in all patients. Intrathecally synthesised M. pneumoniae-specific immunoglobulin (IgM and IgG) were investigated and found positive in one patient (confirmed case). M. pneumoniae DNA in respiratory specimens and/or M. pneumoniae-specific IgM and IgG in serum were detected in the other six patients (possible cases). One confirmed and two possible cases had neurological sequelae at 4-19 months follow-up. CONCLUSION:The lack of detectable M. pneumoniae DNA in cerebrospinal fluid of our encephalitis patients suggests a likely immune-mediated pathogenesis ignited by a respiratory inflammatory process including pneumonia.
journal_name
Swiss Med Wklyjournal_title
Swiss medical weeklyauthors
Meyer Sauteur PM,Moeller A,Relly C,Berger C,Plecko B,Nadal D,Swiss Pediatric Surveillance Unit (SPSU).doi
10.4414/smw.2016.14222subject
Has Abstractpub_date
2016-01-11 00:00:00pages
w14222eissn
1424-7860issn
1424-3997pii
smw-14222journal_volume
146pub_type
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journal_title:Swiss medical weekly
pub_type: 杂志文章,多中心研究
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journal_title:Swiss medical weekly
pub_type: 杂志文章
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journal_title:Swiss medical weekly
pub_type: 临床试验,杂志文章
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journal_title:Swiss medical weekly
pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2007/27/smw-11868
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:smw-12377
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2006/39/smw-11357
更新日期:2006-09-30 00:00:00
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pub_type: 杂志文章
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2007/21/smw-11716
更新日期:2007-06-02 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2017.14529
更新日期:2017-10-27 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
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更新日期:2008-05-31 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2012.13684
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journal_title:Swiss medical weekly
pub_type: 杂志文章
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更新日期:2017-02-03 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
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journal_title:Swiss medical weekly
pub_type: 杂志文章
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更新日期:2010-02-06 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2016.14280
更新日期:2016-02-22 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2002/27/smw-09920
更新日期:2002-07-13 00:00:00
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pub_type: 杂志文章
doi:10.4414/smw.2020.20267
更新日期:2020-06-19 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2012.13574
更新日期:2012-05-09 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2005/11/smw-10926
更新日期:2005-03-19 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2011.13272
更新日期:2011-09-28 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,多中心研究
doi:2001/31/smw-09728
更新日期:2001-08-11 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2013.13860
更新日期:2013-09-06 00:00:00