Abstract:
BACKGROUND:Several publications reported on the safety and efficacy of bortezomib, a novel first-in-class anti-cancer agent, in the treatment of relapsed/refractory multiple myeloma in controlled clinical trials. Complementary data on the experience with bortezomib in daily oncology practice are needed. We report on the use of bortezomib to treat patients with relapsed/refractory multiple myeloma in routine clinical practice. METHODS:Patients were treated at investigators' discretion within a Compassionate Use Program, allowing third-line or subsequent treatment. Post-hoc safety and efficacy analysis of patient records was performed using predefined data capture forms. Marker response was defined as a decrease in paraprotein level of at least 25% as compared to baseline. RESULTS:Eighty-eight patients entered the program involving 62 oncologists/ haematologists (62% institutional). Median patient age was 66 years [44-86], median time since diagnosis 4 years [0.5-14], median number of previous treatments 3 [2-6]. Marker response was observed in 61% of patients (17% CR/nCR). At the time of data collection, median 4.75 months [0.5-13] after last bortezomib injection, overall median response duration was 4.5 months [1.5-22], and response was ongoing in 45% of patients. The most frequently reported adverse events were thrombocytopenia (34%), peripheral neuropathy (31%), diarrhoea (20%) and fatigue (19%). Among the cases of peripheral neuropathy, 68% were due to aggravation of a pre-existing condition and the remaining cases to onset under bortezomib. No cases of bortezomib-related haemorrhage were reported. CONCLUSIONS:Our results in daily oncology practice confirm findings from clinical trials, demonstrating high response rates and predictable adverse events in patients with relapsed/refractory multiple myeloma treated with bortezomib.
journal_name
Swiss Med Wklyjournal_title
Swiss medical weeklyauthors
Freimann H,Calderoni A,Cornu P,Olie Rdoi
2007/21/smw-11716subject
Has Abstractpub_date
2007-06-02 00:00:00pages
317-22issue
21-22eissn
1424-7860issn
1424-3997pii
smw-11716journal_volume
137pub_type
杂志文章abstract:OBJECTIVE:To measure medical care and pharmaceutical drug use among Swiss primary care physicians and its determinants. DESIGN:Cross-sectional mailed survey. SETTING:1784 randomly selected Swiss primary care physicians, including general practitioners, internists and paediatricians. RESULTS:Twenty one percent (95% C...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2007/07/smw-11606
更新日期:2007-02-24 00:00:00
abstract:PURPOSE:Stress ulcer prophylaxis prescriptions might not be sufficiently challenged throughout a patient's stay in an intensive care unit (ICU) and might be erroneously maintained after ICU discharge. This study aimed to determine (1) stress ulcer prophylaxis adequacy in ICU and (2) the proportion of patients recei...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20322
更新日期:2020-08-24 00:00:00
abstract::Beta-haemolytic streptococci of groups C and G have become increasingly recognized as causes of invasive human infections. We reviewed clinical and molecular characteristics of Streptococcus dysgalactiae isolates that caused bacteraemia in adults from 2006 to 2015. Among 67 episodes, skin and soft-tissue infections (4...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2017.14469
更新日期:2017-07-24 00:00:00
abstract:QUESTION UNDER STUDY:To investigate the change over time in the number of ED admissions with positive blood alcohol concentration (BAC) and to evaluate predictors of BAC level. METHODS:We conducted a single site retrospective study at the ED of a tertiary referral hospital (western part of Switzerland) and obtained al...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2014.13982
更新日期:2014-08-07 00:00:00
abstract::Cartilage hair hypoplasia (CHH) is a rare autosomal recessive ribosomopathy characterised by skeletal and integumentary system manifestations. It may also present with varied forms and intensities of haematopoietic and/or immune disorders. We report a 27-year-old female who presented a picture of combined immunodefici...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2018.14606
更新日期:2018-04-24 00:00:00
abstract:AIM:To test the hypothesis that rationing of medical management mainly based on age exists in our health care system today. METHODS:We studied 303 consecutive patients hospitalised for acute coronary syndrome (ACS) and 163 consecutive patients hospitalised with congestive heart failure (CHF). They were divided into tw...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2001/43/smw-09823
更新日期:2001-11-10 00:00:00
abstract:QUESTIONS UNDER STUDY:In the next Swiss National HIV and Sexually Transmitted Infection (STI) Strategy 2011-2017, STI control will be integrated with HIV prevention. Information is needed which will improve the targeting of professional education. The objective of this study was to describe the clinical specialities an...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2011.13143
更新日期:2011-01-20 00:00:00
abstract:OBJECTIVES:First, to test whether current injury is more closely related to acute intake than to usual consumption patterns, and second, to test whether repeated injury is more closely related to general consumption patterns than to acute intake. METHODS:Screening of alcohol consumption of 7,872 patients enrolling bet...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2007/45/smw-11697
更新日期:2007-11-17 00:00:00
abstract:INTRODUCTION:It has been proposed that reactive oxygen species play a role in renal fibrosis. 8-OHdG, a metabolite of oxidative damage to leukocyte DNA, has been identified as a marker of oxidative stress in patients with chronic renal failure. MATERIALS AND METHODS:Seventy-four patients following nephrectomy were ret...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2011.13268
更新日期:2011-10-12 00:00:00
abstract:BACKGROUND:The transition from undergraduate to postgraduate training is a crucial career step for physicians. Several international studies have shown that graduates feel insufficiently prepared to perform various aspects of clinical practice. The publication of a national framework for undergraduate medical education...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20370
更新日期:2020-11-24 00:00:00
abstract::Giant cell arteritis (GCA) is the most common of the vasculitis syndromes and, being a disease of the elderly, its incidence is increasing with the general ageing of the population. GCA is most feared for its early complications, namely blindness and stroke, resulting from inflammation and subsequent occlusion of ocul...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2011.13272
更新日期:2011-09-28 00:00:00
abstract::Amyloid fibrils are polymers composed of proteins in beta-sheet conformation, which are found in at least 20 diseases for which no cure is available. These diseases include Alzheimer's disease and spongiform encephalopathies, in which the amyloid beta-peptide and the prion protein (PrP), respectively, form amyloid. Al...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2003/19/smw-09987
更新日期:2003-05-17 00:00:00
abstract::Rheumatoid arthritis is a common chronic inflammatory disease that causes progressive synovial inflammation resulting in irreversible joint destruction, chronic disability and premature mortality. Although it is recognised that in rheumatoid arthritis, inflammation and its persistence result from complex interactions ...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2012.13529
更新日期:2012-02-24 00:00:00
abstract:QUESTIONS UNDER STUDY:To improve the response of deteriorating patients during their hospital stay, the University Hospital Bern has introduced a Medical Emergency Team (MET). Aim of this retrospective cohort study is to review the preceding factors, patient characteristics, process parameters and their correlation to ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2014.14027
更新日期:2014-10-08 00:00:00
abstract::Multicentric carpotarsal osteolysis (MCTO) is an autosomal dominant disease of the skeleton characterised by progressive destruction of carpal and tarsal bones. Recently, it has been demonstrated that this disease is caused by heterozygous mutations in the gene for the transcriptional repressor MAFB. We analysed genom...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2017.14529
更新日期:2017-10-27 00:00:00
abstract:BACKGROUND:High quality chest compression is one of the key factors in successful resuscitation. A high standard of training is therefore decisive. We aimed to investigate the strengths and weaknesses of teaching chest compression in a study designed to highlight where targeted improvements in the quality of our chest ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2011.13221
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Organs donated for transplantation remain a scarce resource in Switzerland. One of the reasons for this situation is the high percentage of patients or families who refuse to consent to donation. This study aimed to provide an overview of attitudes towards organ donation among Swiss residents, including any ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2017.14401
更新日期:2017-02-03 00:00:00
abstract:BACKGROUND:With the increase of the organ shortage, several authors assume that financial incentives would improve organ donation rates and fill the unbalance between the demand and the organs available for transplant medicine. This line of argument has been criticised with people arguing that an exchange of money for ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2011.13312
更新日期:2011-12-09 00:00:00
abstract:BACKGROUND:Evaluating the effects of a commercially available synbiotic preparation (contains both prebiotic and probiotic elements) on functional constipation in males. METHODS:In a randomised controlled trial, a total of 66 adult men with functional constipation were equally allocated to receive a synbiotic mixture ...
journal_title:Swiss medical weekly
pub_type: 杂志文章,随机对照试验
doi:10.4414/smw.2011.13239
更新日期:2011-07-30 00:00:00
abstract::Since 2010, awareness of the global threat caused by antimicrobial resistance (AMR) has risen considerably and multiple policy and research initiatives have been implemented. Research and development (R&D) of much-needed new antibiotics active against multiresistant pathogens is a key component of all programmes aimin...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2015.14167
更新日期:2015-07-31 00:00:00
abstract::A 36-year-old male with a known history of sickle cell disease (SCD) and acute chest syndrome (ACS) was treated in our hospital. Gas exchange deteriorated and the patient was transferred to our intensive care unit (ICU). Low dose inhaled nitric oxide (iNO) during pressure controlled mechanical ventilation (pcMV) induc...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2004/11/smw-10521
更新日期:2004-03-20 00:00:00
abstract::Over the last few years atypical antipsychotics have been used increasingly in the pharmacological treatment of schizophrenia. This review provides an overview of the pharmacological and clinical characteristics of atypical antipsychotics. In particular we discuss their efficacy in treating psychotic and negative symp...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2003/05/smw-10003
更新日期:2003-02-08 00:00:00
abstract::Perinatal care of pregnant women at high risk for preterm delivery and of preterm infants born at the limit of viability (22-26 completed weeks of gestation) requires a multidisciplinary approach by an experienced perinatal team. Limited precision in the determination of both gestational age and foetal weight, as well...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2011.13280
更新日期:2011-10-18 00:00:00
abstract:PRINCIPLES:Neuroendocrine neoplasms (NENs) are believed to be associated with an increased risk for additional malignancies (AMs). We aimed to (1) assess the occurrence of AM in NEN patients (2) investigate the characteristics and temporal relationship of NEN patients with and without AM. METHODS:The SwissNET registry...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2016.14362
更新日期:2016-11-12 00:00:00
abstract:PRINCIPLES:Drugs that either inhibit prostaglandin synthesis or antagonise angiotensin II effects are likely to impair renal function, especially in patients with an activated renin-angiotensin-aldosterone system. Of the former, nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used, and newer agents with cycloo...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2001/13/smw-09680
更新日期:2001-04-07 00:00:00
abstract:INTRODUCTION:Graft rejection and infection remain major morbidities following orthotopic liver transplantation (OLT). Rejection treatment may be associated with an increased rate of infectious complications. The aim of this study was to determine the relationship between rejection, rejection therapy and the risk of ass...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2005/39/smw-10399
更新日期:2005-10-01 00:00:00
abstract:PRINCIPLES:A decrease in plasma lipids occurs during severe sepsis and has prognostic implications in critical illness. Whether lipids have prognostic implications or could help to differentiate community-acquired pneumonia from other lower respiratory tract infections remains unknown. METHODS:We analysed data from pa...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:smw-12494
更新日期:2009-03-21 00:00:00
abstract::Atrial arrhythmias complicate the clinical course of adult patients with an atrial septal defect. Atrial flutter is more prevalent in younger patients, and frequently regresses after surgical defect closure. Atrial fibrillation however, which results from a chronic underlying disease, rarely reverts to sinus rhythm af...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2005/11/smw-10926
更新日期:2005-03-19 00:00:00
abstract::Patients with a solid organ transplant have increased in numbers and in individual survival in Switzerland over the last decades. As a consequence of long-term immunosuppression, skin cancer in solid organ recipients (SOTRs) has been recognized as an important problem. Screening and education of potential SOTRs about ...
journal_title:Swiss medical weekly
pub_type: 杂志文章,实务指引
doi:smw-12725
更新日期:2009-07-25 00:00:00
abstract::We report on two toddlers suffering from Mycobacterium bohemicum lymphadenitis. Acid-fast bacilli were cultured from submandibular lymph nodes and identified by molecular methods as Mycobacterium bohemicum. Surgical treatment was successful and complemented by oral treatment with clarithromycin and rifampicin. ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2004/15/smw-10558
更新日期:2004-04-17 00:00:00