Abstract:
INTRODUCTION:Graft rejection and infection remain major morbidities following orthotopic liver transplantation (OLT). Rejection treatment may be associated with an increased rate of infectious complications. The aim of this study was to determine the relationship between rejection, rejection therapy and the risk of associated infections. MATERIALS AND METHODS:A retrospective study of all adult patients undergoing OLT between July 1987 and July 1997 at a single university medical centre was carried out. Data for all transplant recipients were collected using predetermined definitions for infectious complications. RESULTS:One hundred OLTs were performed on 98 patients (two patients received a second transplant). The cohort consisted of 33 women and 65 men with a mean age of 47 years. Seventy-eight patients developed a total of 228 infectious episodes: 107 bacterial, 101 viral, 17 fungal and 3 protozoan. The majority of infections occurred within the first month of OLT. Thirty patients without rejection developed 42 infectious episodes, whereas 70 patients with at least one treated rejection episode developed 186 infectious episodes. The overall rate of infection was 44.4 episodes per 1000 patient-days in the 30 days before rejection, and 94.4 episodes per 1000 patient-days in the 30 days following rejection treatment. CONCLUSIONS:Infections occurred more frequently during the first month post-transplantation. Following OLT, rejection is associated with a higher incidence of infection, mainly of viral origin, concurrent with increased immunosuppressive therapy.
journal_name
Swiss Med Wklyjournal_title
Swiss medical weeklyauthors
Garbino J,Romand JA,Pittet D,Giostra E,Mentha G,Suter Pdoi
2005/39/smw-10399keywords:
subject
Has Abstractpub_date
2005-10-01 00:00:00pages
587-93issue
39-40eissn
1424-7860issn
1424-3997pii
smw-10399journal_volume
135pub_type
杂志文章abstract::With regard to HCV elimination in opioid agonist therapy patients by 2030, case finding and regular screening for new and re-infections remain a challenge, especially for non-cohort patients in a decentralised setting. Documentation of the HCV sero- and RNA status of each opioid agonist therapy patient by the ca...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20317
更新日期:2020-08-06 00:00:00
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journal_title:Swiss medical weekly
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abstract:QUESTIONS UNDER STUDY:The unexpected death of a preterm infant is an extremely painful situation for parents. Despite a number of quantitative studies, little is known about parents' inner experience. The aim of this study was to gather more in-depth information about what preoccupies parents in this situation of suffe...
journal_title:Swiss medical weekly
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doi:2007/27/smw-11868
更新日期:2007-07-14 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2011.13152
更新日期:2011-02-03 00:00:00
abstract:QUESTIONS UNDER STUDY:In HIV-infected patients, comprehension of medication instructions is an essential condition for adherence to Highly Active Antiretroviral Therapy (HAART). In this study, we used a self-reported questionnaire to know which sources of medication information HIV-infected patients used and their impa...
journal_title:Swiss medical weekly
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更新日期:2012-07-26 00:00:00
abstract:BACKGROUND:With the increase of the organ shortage, several authors assume that financial incentives would improve organ donation rates and fill the unbalance between the demand and the organs available for transplant medicine. This line of argument has been criticised with people arguing that an exchange of money for ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2011.13312
更新日期:2011-12-09 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:smw-12476
更新日期:2009-06-13 00:00:00
abstract::We report a case series of 11 patients with severe E. faecium infections treated with daptomycin. All strains were resistant to ampicillin (MIC >8 mg/l), but susceptible to vancomycin. Seven out of 11 strains were also highly resistant to gentamicin (MIC >500 mg/l). All patients were treated with multiple broad-spectr...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2012.13603
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abstract:INTRODUCTION:It has been proposed that reactive oxygen species play a role in renal fibrosis. 8-OHdG, a metabolite of oxidative damage to leukocyte DNA, has been identified as a marker of oxidative stress in patients with chronic renal failure. MATERIALS AND METHODS:Seventy-four patients following nephrectomy were ret...
journal_title:Swiss medical weekly
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doi:10.4414/smw.2011.13268
更新日期:2011-10-12 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2017.14419
更新日期:2017-03-07 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2018.14646
更新日期:2018-09-23 00:00:00
abstract::Current guidelines from the Swiss Association against Osteoporosis (SVGO) dating from 2015 recommend therapy for men and women at increased fracture risk, specifically those with a vertebral or hip fracture; those with bone mineral density T-score <−2.5 at spine or hip; and those with a high 10-year probability ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2020.20352
更新日期:2020-09-29 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2014.13972
更新日期:2014-06-25 00:00:00
abstract:PRINCIPALS:Accidents in agriculture are a problem of global importance. The hazards of working in agriculture are manifold (machines, animals, heights). We therefore assessed injury severity and mortality from accidents in farming. METHODS:We retrospectively analysed all farming accidents treated over a 12-year period...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2013.13846
更新日期:2013-08-27 00:00:00
abstract:OBJECTIVE:An increasing number of patients with asthma are attracted by complementary and alternative medicine (CAM). Therefore, it is of importance that scientific evidence about the efficacy of this type of therapy is regarded. METHOD:We searched the electronic databases Medline, Embase and the Cochrane Library for ...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2002/25/smw-09972
更新日期:2002-06-29 00:00:00
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pub_type: 杂志文章
doi:10.4414/smw.2016.14327
更新日期:2016-07-11 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2014.13948
更新日期:2014-04-24 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2014.13924
更新日期:2014-02-19 00:00:00
abstract:QUESTION UNDER STUDY:Domestic accidents are an important problem in paediatric medicine. This study was designed to gain a better understanding of burn mechanisms and target prevention. METHODS:Children treated for burn lesions in the Department of Paediatric Surgery between August 2004 and August 2005 were included i...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:smw-12605
更新日期:2009-09-19 00:00:00
abstract:QUESTIONS UNDER STUDY/PRINCIPLES:We describe the proportion of severely depressed outpatients reaching complete remission at the different stages of a drug treatment algorithm. We compare several treatment options for SSRI (selective serotonin reuptake inhibitor) non-responders and test the feasibility of the algorithm...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2006/05/smw-11267
更新日期:2006-02-04 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2008/21/smw-12013
更新日期:2008-05-31 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:/aop/smw-aop12294
更新日期:2008-11-15 00:00:00
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pub_type: 杂志文章
doi:10.4414/smw.2010.13094
更新日期:2010-08-24 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2013.13860
更新日期:2013-09-06 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2019.20033
更新日期:2019-03-24 00:00:00
abstract:PRINCIPLES:Since the recommendation that infants sleep in the supine position, there has been an increase in cases of posterior positional plagiocephaly. Even though this condition is a purely cosmetic problem, if it is severe it may affect the child psychologically. Positioning may help in mild or moderate cases, but ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2007/25/smw-11702
更新日期:2007-06-30 00:00:00
abstract:OBJECTIVE:To evaluate the impact of a voluntary termination of pregnancy (TOP) on contraceptive practice and sexual well-being in women. STUDY DESIGN AND METHODS:Comparative evaluation of a retrospective study conducted in Lugano in 1995 with 85 women interviewed 3-6 months post-TOP, and a prospective study carried ou...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2001/35/smw-09768
更新日期:2001-09-08 00:00:00
abstract:BACKGROUND:Although airway obstruction, as defined by improvement of forced expiratory volume in one second (FEV1) and/or forced vital capacity (FVC), is irreversible in patients with COPD, they clearly seem to benefit from treatment with inhaled bronchodilators. AIMS:To assess the response pattern of residual volume ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2008/17/smw-11992
更新日期:2008-05-03 00:00:00
abstract:QUESTIONS UNDER STUDY:Postmenopausal women are more likely to develop coronary artery disease than premenopausal women of the same age. Postmenopausal oral oestrogen therapy is associated with increased levels of high-density lipoprotein (HDL) cholesterol and decreased levels of lowdensity lipoprotein (LDL) cholesterol...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2006/31/smw-11390
更新日期:2006-08-05 00:00:00
abstract::Minimal residual disease (MRD) refers to the small number of malignant cells that remain after therapy when the patient is in remission and shows no symptoms or overt signs of disease. Current treatment protocols for haematological malignancies allow most patients to obtain some form of MRD state, but cure seldom foll...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2014.13907
更新日期:2014-01-22 00:00:00