Abstract:
QUESTIONS UNDER STUDY:Paraoxonase-1 (PON1) is an HDL-bound enzyme system which plays a key role in the protection of LDL and HDL from oxidation by hydrolysing activated phospholipids and lipid peroxide products. Oxidative stress has been involved in the pathogenesis of many complications of human pregnancy, including early pregnancy failure (EPF), preeclampsia and preterm labour. The purpose of this study was to determine serum paraoxonase/arylesterase activities and lipid hydroperoxide (LOOH) levels as an oxidative stress indicator in women with EPF. METHOD:Paraoxonase/arylesterase activities and LOOH levels were assessed in women with EPF (n = 40) and healthy continuum pregnant women without EPF (n = 38) before 12 weeks' gestation. Serum basal and salt-stimulated paraoxonase/arylesterase activities were measured spectrophotometrically. LOOH levels were measured by ferrous oxidation with a xylenol orange assay. Student's t-test and the Pearson correlation were used for statistical analysis. RESULTS:We found that basal and salt-stimulated paraoxonase/arylesterase activities were significantly lower in women with EPF than in women without EPF (all p <0.05), while LOOH levels were significantly higher (p = 0.009). CONCLUSION:Our study showed that decreased paraoxonase/arylesterase activities and increased LOOH levels may play a role in ethiopathogenesis through increased susceptibility to lipid peroxidation in women with EPF.
journal_name
Swiss Med Wklyjournal_title
Swiss medical weeklyauthors
Toy H,Camuzcuoglu H,Celik H,Erel O,Aksoy Ndoi
smw-12495subject
Has Abstractpub_date
2009-02-07 00:00:00pages
76-81issue
5-6eissn
1424-7860issn
1424-3997pii
smw-12495journal_volume
139pub_type
杂志文章abstract::We present the case of an oncology patient admitted to our hospital during the current COVID-19 pandemic with clinical and radiological features strongly suggestive of interstitial pneumonia. Multiple laboratory tests were negative for SARS-CoV-2 (polymerase chain reaction testing of nasopharyngeal swabs, and of induc...
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pub_type: 杂志文章
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更新日期:2020-07-11 00:00:00
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更新日期:2004-08-07 00:00:00
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更新日期:2010-07-11 00:00:00
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更新日期:2016-02-22 00:00:00
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更新日期:2003-09-26 00:00:00
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journal_title:Swiss medical weekly
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doi:2008/01/smw-11910
更新日期:2008-01-12 00:00:00
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doi:10.4414/smw.2012.13537
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doi:2004/25/smw-10322
更新日期:2004-06-26 00:00:00
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pub_type: 历史文章,杂志文章,评审
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更新日期:2012-05-31 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2008/19/smw-12124
更新日期:2008-05-03 00:00:00
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doi:2004/19/smw-10584
更新日期:2004-05-15 00:00:00
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doi:10.4414/smw.2012.13508
更新日期:2012-02-03 00:00:00
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doi:smw-12661
更新日期:2009-11-28 00:00:00
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pub_type: 杂志文章
doi:10.4414/smw.2015.14159
更新日期:2015-07-28 00:00:00
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pub_type: 杂志文章
doi:10.4414/smw.2010.13060
更新日期:2010-09-01 00:00:00
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doi:smw-12494
更新日期:2009-03-21 00:00:00
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pub_type: 杂志文章
doi:smw-12636
更新日期:2009-06-27 00:00:00
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doi:2001/17/smw-09718
更新日期:2001-05-05 00:00:00