Epidemiology and pathophysiology of obesity as cause of cancer.

Abstract:

:According to World Health Organisation estimates 1.1 billion people were overweight or obese worldwide in the year 2000 with the prevalence rapidly increasing. Compelling evidence suggests that excess body weight is a risk factor for several cancer types including cancer of the colon, breast, endometrium, kidney, oesophagus, as well as possibly additional sites. According to previous meta-analyses and systematic literature reviews, an important proportion of cancer has been estimated to be attributable to excess body weight. The extrapolation of a European meta-analysis [1] to the Swiss situation broadly estimates that around 700 cancers could be prevented in the absence of overweight and obesity in this country. The data presented highlights the public health relevance of preventing excess body weight. Several interacting metabolic and hormonal pathways seem to underlie the association between being overweight and cancer with insulin-resistance playing a central role. Since evidence is mounting that excess body weight can also adversely affect cancer prognosis, obesity is a primary target for cancer control programs.

journal_name

Swiss Med Wkly

journal_title

Swiss medical weekly

authors

Ceschi M,Gutzwiller F,Moch H,Eichholzer M,Probst-Hensch NM

doi

2007/03/smw-11435

subject

Has Abstract

pub_date

2007-01-27 00:00:00

pages

50-6

issue

3-4

eissn

1424-7860

issn

1424-3997

pii

smw-11435

journal_volume

137

pub_type

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