Pili of Mycobacterium tuberculosis: current knowledge and future prospects.

Abstract:

:Many pathogenic bacteria express filamentous appendages, termed pili, on their surface. These organelles function in several important bacterial processes, including mediating bacterial interaction with, and colonization of the host, signalling events, locomotion, DNA uptake, electric conductance, and biofilm formation. In the last decade, it has been established that the tuberculosis-causing bacterium, Mycobacterium tuberculosis, produces two pili types: curli and type IV pili. In this paper, we review studies on M. tuberculosis pili, highlighting their structure and biological significance to M. tuberculosis pathogenesis, and discuss their potential as targets for therapeutic intervention and diagnostic test development.

journal_name

Arch Microbiol

journal_title

Archives of microbiology

authors

Ramsugit S,Pillay M

doi

10.1007/s00203-015-1117-0

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

737-44

issue

6

eissn

0302-8933

issn

1432-072X

journal_volume

197

pub_type

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