Anaerobiosis and low specific growth rates enhance hemolysin BL production by Bacillus cereus F4430/73.

Abstract:

:Bacillus cereus F4430/73 produced the highest levels of hemolysin BL (HBL) when grown under anaerobiosis in MOD medium. Anaerobic cells grown in a chemostat at low specific growth rate (0.1-0.2 h(-1)) expressed up to sevenfold more HBL than did cells held at a faster growth rate. At 0.2 h(-1), the presence of 90 mM glucose resulted in inhibition of HBL production. Glucose was found to repress HBL induction at the mRNA level, indicating the potential involvement of catabolite repression in the regulation of HBL. Based on these data, it is suggested that growth rate could be an effector of catabolite regulation of HBL.

journal_name

Arch Microbiol

journal_title

Archives of microbiology

authors

Duport C,Thomassin S,Bourel G,Schmitt P

doi

10.1007/s00203-004-0688-y

keywords:

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

90-5

issue

1

eissn

0302-8933

issn

1432-072X

journal_volume

182

pub_type

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