The molecular regulation of the reductive pentose phosphate pathway in Proteobacteria and Cyanobacteria.

Abstract:

:In phototrophic and chemoautotrophic proteobacteria, genes encoding enzymes of the Calvin-Benson-Bassham pathway of CO2 fixation are often found in clusters that are transcribed from a single promoter under control of the LysR-type transcriptional activator, CbbR. Mutations affecting CbbR prevent induction of cbb genes. Gel-retardation assays have demonstrated CbbR binding to putative regulatory regions of cbb operons, and in two cases, footprinting experiments have delimited the nucleotide sequence protected by CbbR. Fusion of cbb control sequences to reporter genes has allowed the regions required for promoter activity to be defined, and recent experiments indicate that the cbb regulon in Rhodobacter is controlled by a global two-component signal transduction system that also regulates other metabolic processes in this organism. Different ways of regulating CBB cycle enzymes that also have roles in heterotrophic metabolism have recently been discovered. In cyanobacteria, the genes of the CBB pathway are organized and regulated differently, and these oxygen-evolving phototrophic bacteria have evolved different strategies to control the assimilation of CO2.

journal_name

Arch Microbiol

journal_title

Archives of microbiology

authors

Gibson JL,Tabita FR

doi

10.1007/s002030050369

subject

Has Abstract

pub_date

1996-09-01 00:00:00

pages

141-50

issue

3

eissn

0302-8933

issn

1432-072X

journal_volume

166

pub_type

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