Effect of Preexisting Cognitive Impairment on In-Patient Treatment and Discharge Management among Elderly Patients with Hip Fractures.

Abstract:

OBJECTIVE:To examine the influence of cognitive impairment on the functional outcomes and complication rates of patients with hip fracture during in-patient treatment. METHODS:A total of 402 patients who were surgically treated for hip fractures were consecutively enrolled at a single trauma center. The patients were grouped according to their results on the Mini-Mental State Examination (MMSE), i.e., ≥20 points (group I) and ≤19 points (group II). Complication and in-hospital mortality rates as well as postoperative functional outcomes according to the Barthel Index (BI) were compared between the groups. A multivariate regression analysis was performed to control for additional factors. RESULTS:33% of the patients had MMSE scores ≤19 points. The complication rates were similar between the groups (p > 0.05). Likewise, the overall in-hospital mortality rates were similar between the patients in group I (4.5%) and those in group II (9.8%; β = 0.218, p < 0.740). Functional outcomes, as assessed by the BI, were lower in group II (β = -0.266, p < 0.001). The patients in group II were transferred to a rehabilitation clinic less frequently (52.3 vs. 76.0%, p < 0.001). CONCLUSIONS:Patients with lower MMSE scores are at a higher risk for poorer functional outcomes. Perioperative care should focus on the preservation of functional abilities to protect these patients from an additional loss of independence and disadvantageous clinical course.

authors

Bliemel C,Lechler P,Oberkircher L,Colcuc C,Balzer-Geldsetzer M,Dodel R,Ruchholtz S,Buecking B

doi

10.1159/000381334

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

33-43

issue

1-2

eissn

1420-8008

issn

1421-9824

pii

000381334

journal_volume

40

pub_type

杂志文章
  • Polymorphisms in the catechol-o-methyltransferase gene and delirium in the elderly.

    abstract:BACKGROUND/AIMS:Catechol-O-methyltransferase, encoded by the COMT gene, is one of the enzymes that degrade dopamine. The aim of this study was to investigate whether polymorphisms in the COMT gene were associated with delirium. METHODS:Patients aged 65 years and older, acutely admitted to the medical department or to ...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000327353

    authors: van Munster BC,Baas F,Tanck MW,de Rooij SE

    更新日期:2011-01-01 00:00:00

  • Decreased theta event-related synchronization during working memory activation is associated with progressive mild cognitive impairment.

    abstract:BACKGROUND:Among the different quantitative electroencephalographic markers, theta activity is known to reflect neural resources involved in memory processes and directed attention. Previous studies suggested that synchronization likelihood analysis in theta-band frequency might be a sensitive method to identify early ...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000094974

    authors: Missonnier P,Gold G,Herrmann FR,Fazio-Costa L,Michel JP,Deiber MP,Michon A,Giannakopoulos P

    更新日期:2006-01-01 00:00:00

  • Functional Disconnectivity during Inter-Task Resting State in Dementia with Lewy Bodies.

    abstract:AIMS:Limited research has been done on the functional connectivity in visuoperceptual regions in dementia with Lewy bodies (DLB) patients. This study aimed to investigate the functional connectivity differences between a task condition and an inter-task resting state condition within a visuoperceptual paradigm, in DLB ...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000486780

    authors: Chabran E,Roquet D,Gounot D,Sourty M,Armspach JP,Blanc F

    更新日期:2018-01-01 00:00:00

  • The Montreal Cognitive Assessment and the mini-mental state examination as screening instruments for cognitive impairment: item analyses and threshold scores.

    abstract:AIMS:To perform an item analysis of the Montreal Cognitive Assessment (MoCA) versus the Mini-Mental State Examination (MMSE) in the prediction of cognitive impairment, and to examine the characteristics of different MoCA threshold scores. METHODS:135 subjects enrolled in a longitudinal clinicopathologic study were adm...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000323867

    authors: Damian AM,Jacobson SA,Hentz JG,Belden CM,Shill HA,Sabbagh MN,Caviness JN,Adler CH

    更新日期:2011-01-01 00:00:00

  • Health-related quality of life and self-efficacy of managing behavior problems for family caregivers of vascular dementia and Alzheimer's disease patients.

    abstract:BACKGROUND:Little is known about the differences in patients' behavioral problems and health outcomes of family caregivers of patients with vascular dementia (VaD) and Alzheimer's disease (AD). METHODS:A secondary analysis of baseline data on a subsample of caregiver-dementia patient dyads in a randomized clinical tri...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000360414

    authors: Kuo LM,Huang HL,Hsu WC,Shyu YI

    更新日期:2014-01-01 00:00:00

  • A Dementia Café as a Bridgehead for Community-Inclusive Care: Qualitative Analysis of Observations by On-the-Job Training Participants in a Dementia Café.

    abstract:BACKGROUND/AIMS:Dementia cafés are becoming widespread as a new approach to dementia care, but their operational procedures and significance have not been adequately studied. METHODS:On-the-job training (OJT) for professionals planning to operate a dementia café in the future was conducted in a pioneering dementia caf...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000492174

    authors: Takechi H,Sugihara Y,Matsumoto H,Yamada H

    更新日期:2018-01-01 00:00:00

  • Reduction of phosphorylated tau during memantine treatment of Alzheimer's disease.

    abstract:BACKGROUND:Memantine is a moderate affinity N-methyl-D-aspartate receptor antagonist approved for treatment of Alzheimer's disease (AD). In AD, tau is abnormally hyperphosphorylated. However, no significant changes of phosphorylated tau levels in CSF are found at follow-up in studies with AD patients. It has been shown...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000107099

    authors: Degerman Gunnarsson M,Kilander L,Basun H,Lannfelt L

    更新日期:2007-01-01 00:00:00

  • Insular hypoperfusion correlates with the severity of delusions in individuals with Alzheimer's disease.

    abstract:BACKGROUND:The aim of this study was to identify the brain regions associated with the severity of delusions in individuals with Alzheimer's disease (AD) using single-photon emission computed tomography. METHODS:Thirty-five AD patients participated in this study. Multiple regression analysis was performed to identify ...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000295115

    authors: Matsuoka T,Narumoto J,Shibata K,Okamura A,Nakamura K,Okuyama C,Nishimura T,Fukui K

    更新日期:2010-01-01 00:00:00

  • A follow-up study of the family with the Swedish APP 670/671 Alzheimer's disease mutation.

    abstract:OBJECTIVE:To study the progression of Alzheimer's disease (AD) at a very early stage and to evaluate clinical markers of presymptomatic AD. SETTING:Longitudinal study at a university hospital. SUBJECTS:A Swedish family harboring a double mutation at codons 670/671 of the APP gene on chromosome 21 was followed longitu...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 临床试验,杂志文章

    doi:10.1159/000017200

    authors: Wahlund LO,Basun H,Almkvist O,Julin P,Axelman K,Shigeta M,Jelic V,Nordberg A,Lannfelt L

    更新日期:1999-11-01 00:00:00

  • Neuropsychiatric symptoms in mild dementia with lewy bodies and Alzheimer's disease.

    abstract:BACKGROUND/AIMS:To compare neuropsychiatric symptoms in patients with Alzheimer's disease (AD) and dementia with Lewy bodies(DLB). METHODS:Neuropsychiatric symptoms and caregiver distress were assessed using the Neuropsychiatric Inventory (NPI) in mild DLB (n = 57) and AD (n = 126), and compared across the two groups ...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000339590

    authors: Bjoerke-Bertheussen J,Ehrt U,Rongve A,Ballard C,Aarsland D

    更新日期:2012-01-01 00:00:00

  • The pharmacological basis for metrifonate's favourable tolerability in the treatment of Alzheimer's disease.

    abstract::Metrifonate, through its pharmacologically active metabolite 2,2-dichlorovinyl dimethylphosphate (DDVP), is a long-acting cholinesterase inhibitor for the symptomatic treatment of mild-to-moderate Alzheimer's disease. Clinical studies with Alzheimer patients have demonstrated the favourable safety and tolerability pro...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章,评审

    doi:10.1159/000051194

    authors: Schmidt BH,Heinig R

    更新日期:1998-01-01 00:00:00

  • The Role of Gait Speed in Dementia: A Secondary Analysis from the SABE Colombia Study.

    abstract:INTRODUCTION:Gait speed (GS) is a predictor of negative outcomes in older adults and in those in risk to develop cognitive impairment; as such, it has been associated with dementia. Studies in Latin-American older adults showing this association are scarce. This study aimed to evaluate the relationship between GS and d...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000510494

    authors: Garcia-Cifuentes E,Márquez I,Vasquez D,Aguillon D,Borda MG,Lopera F,Cano-Gutierrez C

    更新日期:2020-11-18 00:00:00

  • Neuritogenic-neurotoxic effects of membrane-associated forms of amyloid precursor protein.

    abstract::The membrane-bound glycoprotein, amyloid precursor protein (APP), plays a central role in Alzheimer's disease (AD). The present paper investigates the neuritogenic-neurotoxic properties of this protein and relates them to possible aetiopathological mechanisms in AD. Marked differences in neuritic differentiation were ...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000051234

    authors: Neill D,Hughes D,Leake A,Morris C,Jones D,Oakley A,Edwardson J,Estibeiro P

    更新日期:2001-01-01 00:00:00

  • Increased serum levels of CD95 in Alzheimer's disease.

    abstract::There is growing evidence for a role of apoptosis in Alzheimer's disease (AD). Recent findings suggest an increased susceptibility of lymphocytes to apoptosis in AD. To prove the hypothesis of systemic alterations in the apoptotic balance in AD, serum and cerebrospinal fluid levels of soluble CD95, which is known to m...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000048650

    authors: Richartz E,Noda S,Schott K,Günthner A,Lewczuk P,Bartels M

    更新日期:2002-01-01 00:00:00

  • Neuroimaging and correlates of cognitive function among patients with heart failure.

    abstract:BACKGROUND/AIMS:We purposed to investigate the relationship between cerebral abnormalities detected by magnetic resonance imaging (MRI) and cognitive performance in nondemented outpatients with heart failure (HF). METHODS:In 58 patients with HF neuropsychological assessment was performed including tests of mental spee...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000109811

    authors: Vogels RL,Oosterman JM,van Harten B,Gouw AA,Schroeder-Tanka JM,Scheltens P,van der Flier WM,Weinstein HC

    更新日期:2007-01-01 00:00:00

  • Cognitive impairment related to apathy in early Huntington's disease.

    abstract:OBJECTIVE:To investigate the relationships between cognitive impairment and apathy in patients with early Huntington's disease (HD) and to further explore the influence of depression on the outcome of cognitive changes associated with apathy. METHODS:We included 36 early HD patients, among them 20 were apathetic (HDA)...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000091523

    authors: Baudic S,Maison P,Dolbeau G,Boissé MF,Bartolomeo P,Dalla Barba G,Traykov L,Bachoud-Lévi AC

    更新日期:2006-01-01 00:00:00

  • Usefulness of Discriminability and Response Bias Indices for the Evaluation of Recognition Memory in Mild Cognitive Impairment and Alzheimer Disease.

    abstract:BACKGROUND:Most studies examining episodic memory in Alzheimer disease (AD) have focused on patients' impaired ability to remember information. This approach provides only a partial picture of memory deficits since other factors involved are not considered. OBJECTIVE:To evaluate the recognition memory performance by u...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000452255

    authors: Russo MJ,Cohen G,Campos J,Martin ME,Clarens MF,Sabe L,Barcelo E,Allegri RF

    更新日期:2017-01-01 00:00:00

  • Altered expression of COX-2 in subdivisions of the hippocampus during aging and in Alzheimer's disease: the Hisayama Study.

    abstract:BACKGROUND:It has been reported that nonsteroidal anti-inflammatory drugs may delay the onset of Alzheimer's disease (AD). Since nonsteroidal anti-inflammatory drugs inhibit cyclooxygenase (COX), COX-2, an inducible form of COX, may be involved in the pathology of AD in association with the arachidonic acid cascade. In...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000101957

    authors: Fujimi K,Noda K,Sasaki K,Wakisaka Y,Tanizaki Y,Iida M,Kiyohara Y,Kanba S,Iwaki T

    更新日期:2007-01-01 00:00:00

  • Polymorphisms of fas gene: relationship with Alzheimer's disease and cognitive decline.

    abstract::The Fas antigen (CD95) is a cell surface receptor that mediates cell apoptosis signalling. Recent investigations have shown that Fas-regulated apoptosis was linked to neurodegenerative lesions in the brain of patients with Alzheimer's disease (AD). Here data regarding the association of two polymorphisms of the Fas pr...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000095160

    authors: Chiappelli M,Nasi M,Cossarizza A,Porcellini E,Tumini E,Pinti M,Troiano L,Franceschi M,Licastro F

    更新日期:2006-01-01 00:00:00

  • Clinical and neuroimaging correlates of mild cognitive impairment in a middle-aged community sample: the personality and total health through life 60+ study.

    abstract::This cross-sectional study aimed at determining the clinical and structural brain magnetic resonance imaging correlates of mild cognitive impairment (MCI). The data presented here are from the first wave of the longitudinal Personality and Total Health through Life 60+ project. 2,551 community-dwelling individuals in ...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000089251

    authors: Kumar R,Parslow RA,Jorm AF,Rosenman SJ,Maller J,Meslin C,Anstey KJ,Christensen H,Sachdev PS

    更新日期:2006-01-01 00:00:00

  • Improving Engagement of Mild to Moderate Dementia Alzheimer's Disease Patients Using Evidence-Based Visual Cognitive Stimulation Exercises.

    abstract:INTRODUCTION:Different studies have proven the effectiveness of cognitive stimulation (CS) for people with mild to moderate dementia, but further research is needed to gain insight into how CS interventions should be designed and developed. OBJECTIVES:The objective of this study was to gather and analyze data about th...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000504799

    authors: Tato-Colín S,Hurtado-Aznar LA,García-Rodríguez I,Benavides-Cuéllar C,Sánchez-Valdeón L

    更新日期:2019-01-01 00:00:00

  • Regional cerebral blood flow and prognostic evaluation in Alzheimer's disease.

    abstract::The present investigation reports the application of regional cerebral blood flow (rCBF; (133)Xe method) to prognostic purposes in a consecutive series of 76 patients (mean age 68.4 +/- 8.7 years) with probable Alzheimer's disease (AD; NINCDS-ADRDA criteria). The likelihood that rCBF from a posterior temporal-inferior...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000051241

    authors: Nobili F,Copello F,Buffoni F,Vitali P,Girtler N,Bordoni C,Safaie-Semnani E,Mariani G,Rodriguez G

    更新日期:2001-03-01 00:00:00

  • Changes in cognitive function over 3 years after first-ever stroke and predictors of cognitive impairment and long-term cognitive stability: the Erlangen Stroke Project.

    abstract:BACKGROUND AND PURPOSE:Cognitive impairment (CI) is frequent after stroke, but data from population-based stroke cohorts on the natural course of CI are limited. The purpose of this study was to determine changes in cognitive status over 3 years after stroke. METHODS:Data were collected from the Erlangen Stroke Projec...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000327358

    authors: Liman TG,Heuschmann PU,Endres M,Flöel A,Schwab S,Kolominsky-Rabas PL

    更新日期:2011-01-01 00:00:00

  • Comparative Diagnostic Accuracy of the ACE-III, MIS, MMSE, MoCA, and RUDAS for Screening of Alzheimer Disease.

    abstract:BACKGROUND:Our aim was to evaluate and compare the diagnostic properties of 5 screening tests for the diagnosis of mild Alzheimer disease (AD). METHODS:We conducted a prospective and cross-sectional study of 92 patients with mild AD and of 68 healthy controls from our Department of Neurology. The diagnostic properties...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000469658

    authors: Matías-Guiu JA,Valles-Salgado M,Rognoni T,Hamre-Gil F,Moreno-Ramos T,Matías-Guiu J

    更新日期:2017-01-01 00:00:00

  • A 26-week analysis of a double-blind, placebo-controlled trial of the ginkgo biloba extract EGb 761 in dementia.

    abstract::This intent-to-treat (ITT) analysis was performed to provide a realistic image of the efficacy that could be expected after 26 weeks treatment with a 120-mg dose (40 mg t.i.d.) of EGb 761 (EGb). The data were collected during a 52-week, double-blind, placebo-controlled, fixed dose, parallel-group, multicenter study. P...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1159/000017242

    authors: Le Bars PL,Kieser M,Itil KZ

    更新日期:2000-07-01 00:00:00

  • Memory for performed actions in dementia of Alzheimer type: further evidence for a global semantic memory deficit.

    abstract::Findings in patients with dementia of the Alzheimer type (AD patients) concerning the enactment effect, i.e. reaching a better memory performance after encoding actions by performing them in contrast to encoding them by reading, are ambiguous. In order to get more insight into memory deterioration in patients sufferin...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000089135

    authors: Mack W,Eberle C,Frölich L,Knopf M

    更新日期:2005-01-01 00:00:00

  • Conversion of mild cognitive impairment to dementia: predictive role of mild cognitive impairment subtypes and vascular risk factors.

    abstract::Mild cognitive impairment (MCI) is regarded as a precursor to dementia, but not all patients with MCI develop dementia. We followed up 165 elderly outpatients with MCI for a mean of 3 years. The aims were (1) to investigate the risk of conversion to dementia for different MCI subtypes diagnosed according to standardiz...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000089515

    authors: Ravaglia G,Forti P,Maioli F,Martelli M,Servadei L,Brunetti N,Pantieri G,Mariani E

    更新日期:2006-01-01 00:00:00

  • Postmortem MRI and histopathology of white matter changes in Alzheimer brains. A quantitative, comparative study.

    abstract::To evaluate whether magnetic resonance imaging (MRI) of white matter changes in Alzheimer's disease either under- or overestimates the findings on neuropathology. Postmortem MRI and neuropathological examination were performed on 6 brains from elderly individuals with a postmortem diagnosis of AD. Using a specially de...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000057698

    authors: Bronge L,Bogdanovic N,Wahlund LO

    更新日期:2002-01-01 00:00:00

  • Comparative effects of ageing and dementia of the Alzheimer type on orientation of visual attention.

    abstract::Age-related changes and the effects of dementia of the Alzheimer type (DAT) were investigated during a visual orienting attention task in which attention was pre-cued to one or other hemifields. Central cues were either valid, neutral, invalid or NoGo (inhibitory). The response time cost-benefit analysis showed a decr...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000106657

    authors: Wright M,Geffen G,Geffen L

    更新日期:1997-11-01 00:00:00

  • Neuroanatomical correlates of unawareness of memory deficits in early Alzheimer's disease.

    abstract:BACKGROUND/AIMS:To investigate neuroanatomical substrates of unawareness of memory deficits in patients with early Alzheimer's disease (AD). METHODS:We compared regional perfusion deficits between AD patients with awareness (n = 19) and unawareness (n = 19). SPECT data were analyzed by statistical brain imaging method...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000119594

    authors: Hanyu H,Sato T,Akai T,Shimizu S,Hirao K,Kanetaka H,Iwamoto T,Koizumi K

    更新日期:2008-01-01 00:00:00