Abstract:
BACKGROUND/AIMS:To compare neuropsychiatric symptoms in patients with Alzheimer's disease (AD) and dementia with Lewy bodies(DLB). METHODS:Neuropsychiatric symptoms and caregiver distress were assessed using the Neuropsychiatric Inventory (NPI) in mild DLB (n = 57) and AD (n = 126), and compared across the two groups using non-parametric tests. RESULTS:The DLB patients had a higher NPI totalscore (median 24 vs. 11.5, p < 0.005), more numerous symptoms (median 5 vs. 4, p = 0.001) and more clinically significant symptoms (3 vs. 1, p = 0.001). They also had higher item hallucinations (6 vs. 2, p < 0.005) and apathy (7 vs. 5, p = 0.002) subscores. Caregivers scored higher on the NPI total caregiver distress scale (12.5 vs. 6, p = 0.003). CONCLUSIONS:In mild dementia, DLB patients have more neuropsychiatric symptoms and more associated caregiver distress compared with AD.
journal_name
Dement Geriatr Cogn Disordjournal_title
Dementia and geriatric cognitive disordersauthors
Bjoerke-Bertheussen J,Ehrt U,Rongve A,Ballard C,Aarsland Ddoi
10.1159/000339590subject
Has Abstractpub_date
2012-01-01 00:00:00pages
1-6issue
1eissn
1420-8008issn
1421-9824pii
000339590journal_volume
34pub_type
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