Abstract：
AIM:To conduct a prospective analysis of the neuropsychiatric symptoms (NPS) across the three categories of primary progressive aphasia (PPA) and progressive apraxia of speech (PAOS), compare the prevalence and nature of the symptoms, and look at which symptoms could be helpful to better differentiate these PPA and PAOS categories. METHODS:A total of 106 consecutive patients with a diagnosis of semantic variant (n = 13), logopenic variant (n = 37), agrammatic variant (n = 15) or PAOS (n = 41) were included in this prospective study. The NPS were measured by the Neuropsychiatric Inventory Questionnaire. RESULTS:There were 65 patients with PPA and 41 with PAOS diagnosis. The most distinguishing features between the two groups were anxiety, apathy, aberrant motor behavior and appetite, while among the subtypes of PPA they were disinhibition and appetite changes. PPA and PAOS patients initially exhibited depression, but with increased disease duration, PAOS patients showed apathy (55.5%) while PPA patients showed disinhibition (28.6%) and aberrant motor behavior (14.3%). CONCLUSION:Mood symptoms like anxiety and appetite changes are more likely to be present at initial stages of PPA, whereas behavioral symptoms like aberrant motor behavior and apathy are likely to occur early in PAOS. The NPS seem to evolve with the progression of the disease in both PPA and PAOS.
journal_name
Dement Geriatr Cogn Disordjournal_title
Dementia and geriatric cognitive disordersauthors
Singh TD,Duffy JR,Strand EA,Machulda MM,Whitwell JL,Josephs KAdoi
10.1159/000369062subject
Has Abstractpub_date
2015-01-01 00:00:00pages
228-38issue
3-4eissn
1420-8008issn
1421-9824pii
000369062journal_volume
39pub_type
杂志文章abstract：:Donepezil HCI is a piperidine-based reversible acetylcholinesterase (AChE) inhibitor, chemically distinct from other cholinesterase (ChE) inhibitors and rationally designed to treat the symptoms of Alzheimer's disease (AD). It is highly selective for AChE in the central nervous system (CNS), with little or no affinity...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章,评审
doi：10.1159/000051201
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND/AIMS:Older people undergoing surgery are at risk of developing postoperative cognitive dysfunction (POCD), but little is known of risk factors predisposing patients to POCD. Our objective was to estimate the risk of POCD associated with exposure to preoperative diabetes, hypertension, and obesity. METHODS:O...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章,随机对照试验
doi：10.1159/000492962
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Neuropsychiatric symptoms (NPS) in dementia have received much attention due to their high prevalence and their significant implications. NPS in mild cognitive impairment (MCI), a clinical concept proposed as an intermediate state between normal aging and dementia, is now gradually gaining in interest. We ai...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章,评审
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更新日期：2020-01-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000323867
更新日期：2011-01-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000113415
更新日期：2008-01-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章,评审
doi：10.1159/000017161
更新日期：1999-09-01 00:00:00
abstract：BACKGROUND/AIMS:The logopenic variant of primary progressive aphasia (lvPPA) is characterized by impaired word-finding and sentence repetition with phonologic errors but spared motor speech and grammar and semantic knowledge. Although its language deficits have been well studied, the full spectrum of cognitive changes ...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000510501
更新日期：2020-01-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章,评审
doi：10.1159/000051185
更新日期：1998-07-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000051222
更新日期：1999-01-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000469658
更新日期：2017-01-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000305093
更新日期：2010-01-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000051255
更新日期：2001-05-01 00:00:00
abstract：BACKGROUND/AIMS:Differences in the gross shape of the corpus callosum (CC) and its subregional areas were investigated on brain MRI of patients with probable Alzheimer's disease (AD) and age- and gender-matched healthy normal control subjects. The AD patients differed from the normal control subjects in terms of a more...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000097371
更新日期：2007-01-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000082661
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND AND AIMS:Both personality changes and behavioural and psychological symptoms (BPS) may be associated with mild cognitive impairment (MCI) in later life and help identify incipient dementia. We wished to investigate the links between personality and BPS in MCI. METHOD:We studied premorbid personality traits ...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000346129
更新日期：2013-01-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000048639
更新日期：2002-01-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000017037
更新日期：1998-05-01 00:00:00
abstract：:The two most frequently examined biomarkers in the diagnosis of dementia are cerebrospinal fluid (CSF) tau and beta-amyloid(1-42) (Abeta(1-42)). An assay for tau phosphorylated at threonine 181 (phospho-tau) has recently been developed. We studied these three markers in patients with possible Alzheimer's disease (AD; ...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000066023
更新日期：2002-01-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章,评审
doi：10.1159/000080034
更新日期：2004-01-01 00:00:00
abstract：INTRODUCTION:Gait speed (GS) is a predictor of negative outcomes in older adults and in those in risk to develop cognitive impairment; as such, it has been associated with dementia. Studies in Latin-American older adults showing this association are scarce. This study aimed to evaluate the relationship between GS and d...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000510494
更新日期：2020-11-18 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000100850
更新日期：2007-01-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000381334
更新日期：2015-01-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000137671
更新日期：2008-01-01 00:00:00
abstract：:Primary central nervous system lymphoma (PCNSL) usually presents with clinical and neuroimaging findings consistent with single or multiple intracranial mass lesions. On cranial magnetic resonance imaging (MRI), such lesions are nearly always contrast enhancing, reflecting disruption of the blood-brain barrier at the ...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000017116
更新日期：1999-03-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000119123
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:The aim of this study was to identify the brain regions associated with the severity of delusions in individuals with Alzheimer's disease (AD) using single-photon emission computed tomography. METHODS:Thirty-five AD patients participated in this study. Multiple regression analysis was performed to identify ...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000295115
更新日期：2010-01-01 00:00:00
abstract：:Central cholinergic circuits of human brain can be tested non-invasively by coupling electrical peripheral stimulation with transcranial magnetic stimulation (TMS) of the motor cortex. The short-latency afferent inhibition (SAI) is reduced in cholinergic forms of dementia, such as Alzheimer disease (AD) and dementia w...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章,评审
doi：10.1159/000330016
更新日期：2011-01-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000084555
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Among the different quantitative electroencephalographic markers, theta activity is known to reflect neural resources involved in memory processes and directed attention. Previous studies suggested that synchronization likelihood analysis in theta-band frequency might be a sensitive method to identify early ...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000094974
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND/AIMS:This study aimed to investigate whether the serial position effects in memory can differentiate patients with different subtypes of mild cognitive impairment (MCI) from healthy controls and patients with different stages of Alzheimer's disease (AD). METHODS:The serial position effects was tested with t...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000351675
更新日期：2014-01-01 00:00:00
