Cognitive impairment related to apathy in early Huntington's disease.

abstract：:Delirium is one of the most frequent symptoms of disease in the elderly. A large variation of incidence and prevalence data is reported probably due to different patient populations and inconsistent diagnostic criteria. In medical and surgical elderly inpatients recent studies report a prevalence rate of approximately...

journal_title：Dementia and geriatric cognitive disorders

authors： Bucht G,Gustafson Y,Sandberg O

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND/AIMS:With an increasing life expectancy, the number of people suffering from dementia globally will rise to about 115.4 million by 2050. It is projected that in the 21st century, the majority of the world's older people will be living in Asia. This paper examines the global issues of family caregiving for ol...

journal_title：Dementia and geriatric cognitive disorders

authors： Chan SW

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:The apolipoprotein E (APOE) e4 genetic polymorphism is a major risk factor for Alzheimer' s disease, hence the possible prevention of its detrimental effects on cognition is of high relevance. METHODS:We used linear regression models to assess associations of APOE e4 with cognitive performance in a populati...

journal_title：Dementia and geriatric cognitive disorders

authors： Perna L,Mons U,Rujescu D,Kliegel M,Brenner H

更新日期：2016-01-01 00:00:00

abstract：:The present study investigated the sensitivity and specificity of the Hopkins Verbal Learning Test (HVLT) for demented patients (n = 82, using NINCDS criteria) and 114 healthy controls--equivalent in age, years of education and gender-ratio--from the Oxford Project to Investigate Memory and Ageing. The HVLT 'Total Rec...

journal_title：Dementia and geriatric cognitive disorders

authors： Hogervorst E,Combrinck M,Lapuerta P,Rue J,Swales K,Budge M

更新日期：2002-01-01 00:00:00

abstract：:There is growing evidence for a role of apoptosis in Alzheimer's disease (AD). Recent findings suggest an increased susceptibility of lymphocytes to apoptosis in AD. To prove the hypothesis of systemic alterations in the apoptotic balance in AD, serum and cerebrospinal fluid levels of soluble CD95, which is known to m...

journal_title：Dementia and geriatric cognitive disorders

authors： Richartz E,Noda S,Schott K,Günthner A,Lewczuk P,Bartels M

更新日期：2002-01-01 00:00:00

abstract：INTRODUCTION:Frontotemporal dementia (FTD) is a more common cause of dementia than previously recognised. Few data are available regarding the natural course of FTD in terms of survival, nursing home admission and causes of death. METHODS:An observational study of all consecutive patients referred to the memory centre...

journal_title：Dementia and geriatric cognitive disorders

authors： Pasquier F,Richard F,Lebert F

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:The Baylor Profound Mental Status Examination (BPMSE) was modeled to provide a brief patient-derived rating scale for staging and tracking patients with severe stages of Alzheimer's disease (AD). METHODS:The BPMSE was administered to 91 patients with probable AD (Korean version of the MMSE less than 16) acc...

journal_title：Dementia and geriatric cognitive disorders

authors： Na HR,Lee SH,Lee JS,Doody RS,Kim SY

更新日期：2009-01-01 00:00:00

abstract：AIMS:The goal of this study is to assess the relationship between quality of life (QoL), neuropsychiatric symptoms (NPS), psychotropic drug use (PDU) and patient characteristics in a large group of nursing home residents with dementia. METHODS:This cross-sectional observational study included 288 individuals with deme...

journal_title：Dementia and geriatric cognitive disorders

authors： Wetzels RB,Zuidema SU,de Jonghe JF,Verhey FR,Koopmans RT

更新日期：2010-01-01 00:00:00

abstract：:Although myoclonus commonly occurs in a later stage of Alzheimer's disease (AD), the pathological basis of this symptom is still unclear. In order to elucidate the neuropathological substrate of myoclonus in AD, we quantitatively assessed neuronal density and volume, with a discrimination between small and large neuro...

journal_title：Dementia and geriatric cognitive disorders

authors： Fukutani Y,Cairns NJ,Everall IP,Chadwick A,Isaki K,Lantos PL

更新日期：1999-03-01 00:00:00

abstract：:The following areas are discussed in this review: atherogenesis; cerebrovascular factors; hypoperfusion; beta-amyloid production; beta-amyloid fibril formation; beta-sheets; metal cations; reactive oxygen species/free radicals; chronic inflammatory factors; endogenous plasma heparin; lipoprotein lipase; polyamines; pr...

journal_title：Dementia and geriatric cognitive disorders

authors： Engelberg H

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:White matter injury is an important factor for cognitive impairment in memory clinic patients. We determined the added value of diffusion tensor imaging (DTI) of strategic white matter tracts in explaining variance in cognition in memory clinic patients with vascular brain injury. METHODS:We included 159 pa...

journal_title：Dementia and geriatric cognitive disorders

authors： Biesbroek JM,Leemans A,den Bakker H,Duering M,Gesierich B,Koek HL,van den Berg E,Postma A,Biessels GJ

更新日期：2017-01-01 00:00:00

abstract：AIM:To conduct a prospective analysis of the neuropsychiatric symptoms (NPS) across the three categories of primary progressive aphasia (PPA) and progressive apraxia of speech (PAOS), compare the prevalence and nature of the symptoms, and look at which symptoms could be helpful to better differentiate these PPA and PAO...

journal_title：Dementia and geriatric cognitive disorders

authors： Singh TD,Duffy JR,Strand EA,Machulda MM,Whitwell JL,Josephs KA

更新日期：2015-01-01 00:00:00

abstract：AIMS:To perform an item analysis of the Montreal Cognitive Assessment (MoCA) versus the Mini-Mental State Examination (MMSE) in the prediction of cognitive impairment, and to examine the characteristics of different MoCA threshold scores. METHODS:135 subjects enrolled in a longitudinal clinicopathologic study were adm...

journal_title：Dementia and geriatric cognitive disorders

authors： Damian AM,Jacobson SA,Hentz JG,Belden CM,Shill HA,Sabbagh MN,Caviness JN,Adler CH

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND/AIMS:Motor impairment is an important aspect of cognitive decline in older adults. It has been suggested that complex motor control is affected earlier than gross motor control. The aims were to investigate if complex hand motor function was more affected than gross motor function in cognitively impaired old...

journal_title：Dementia and geriatric cognitive disorders

authors： Bramell-Risberg E,Jarnlo GB,Elmståhl S

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND/AIMS:The beta amyloid aggregations present in Alzheimer's disease affect neurons through various toxic alterations. The aim of this study was to determine the expression of the vitamin D receptor (VDR), 25-hydroxyvitamin D3 24-hydroxylase (an accelerator of vitamin D catabolism), and the L-type voltage-sensi...

journal_title：Dementia and geriatric cognitive disorders

authors： Dursun E,Gezen-Ak D,Yilmazer S

更新日期：2013-01-01 00:00:00

abstract：:Metrifonate, through its pharmacologically active metabolite 2,2-dichlorovinyl dimethylphosphate (DDVP), is a long-acting cholinesterase inhibitor for the symptomatic treatment of mild-to-moderate Alzheimer's disease. Clinical studies with Alzheimer patients have demonstrated the favourable safety and tolerability pro...

journal_title：Dementia and geriatric cognitive disorders

authors： Schmidt BH,Heinig R

更新日期：1998-01-01 00:00:00

abstract：:The Fas antigen (CD95) is a cell surface receptor that mediates cell apoptosis signalling. Recent investigations have shown that Fas-regulated apoptosis was linked to neurodegenerative lesions in the brain of patients with Alzheimer's disease (AD). Here data regarding the association of two polymorphisms of the Fas pr...

journal_title：Dementia and geriatric cognitive disorders

authors： Chiappelli M,Nasi M,Cossarizza A,Porcellini E,Tumini E,Pinti M,Troiano L,Franceschi M,Licastro F

更新日期：2006-01-01 00:00:00

abstract：:Antiphospholipid antibodies (aPLAb) may cause both focal ischemic and diffuse brain damage and may be associated with dementia. We have examined the relationship of aPLAb to dementia in the elderly. Blood samples were obtained from 87 consecutive patients with dementia (74 +/- 11 years old) and 69 controls (78 +/- 9 y...

journal_title：Dementia and geriatric cognitive disorders

authors： Mosek A,Yust I,Treves TA,Vardinon N,Korczyn AD,Chapman J

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Little is known about the differences in patients' behavioral problems and health outcomes of family caregivers of patients with vascular dementia (VaD) and Alzheimer's disease (AD). METHODS:A secondary analysis of baseline data on a subsample of caregiver-dementia patient dyads in a randomized clinical tri...

journal_title：Dementia and geriatric cognitive disorders

authors： Kuo LM,Huang HL,Hsu WC,Shyu YI

更新日期：2014-01-01 00:00:00

abstract：:Alzheimer's disease (AD) represents a heterogeneous disorder, and several factors have been associated with its development. The presence of the apolipoprotein E type (APOE) epsilon 4 allele has been proposed as a risk factor for AD, but how it influences the development of the characteristic hallmarks of the disease ...

journal_title：Dementia and geriatric cognitive disorders

authors： Mukaetova-Ladinska EB,Harrington CR,Roth M,Wischik CM

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND/AIMS:Verbal fluency patterns can assist in differential diagnosis during neuropsychological assessment and identify individuals at risk for developing Alzheimer's disease (AD). While evidence suggests that subjects with AD perform worse on category fluency than letter fluency tasks, the pattern in mild cogni...

journal_title：Dementia and geriatric cognitive disorders

authors： Rinehardt E,Eichstaedt K,Schinka JA,Loewenstein DA,Mattingly M,Fils J,Duara R,Schoenberg MR

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:To evaluate whether dementia patients prescribed antipsychotic drugs have a higher mortality compared to unexposed patients, and to investigate whether there are differences in mortality associated with exposure to conventional versus atypical antipsychotic drugs. METHODS:Retrospective population cohor...

journal_title：Dementia and geriatric cognitive disorders

authors： Musicco M,Palmer K,Russo A,Caltagirone C,Adorni F,Pettenati C,Bisanti L

更新日期：2011-01-01 00:00:00

abstract：:Mild cognitive impairment (MCI) is regarded as a precursor to dementia, but not all patients with MCI develop dementia. We followed up 165 elderly outpatients with MCI for a mean of 3 years. The aims were (1) to investigate the risk of conversion to dementia for different MCI subtypes diagnosed according to standardiz...

journal_title：Dementia and geriatric cognitive disorders

authors： Ravaglia G,Forti P,Maioli F,Martelli M,Servadei L,Brunetti N,Pantieri G,Mariani E

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND/AIMS:The logopenic variant of primary progressive aphasia (lvPPA) is characterized by impaired word-finding and sentence repetition with phonologic errors but spared motor speech and grammar and semantic knowledge. Although its language deficits have been well studied, the full spectrum of cognitive changes ...

journal_title：Dementia and geriatric cognitive disorders

authors： Montreuil S,Poulin E,Bergeron D,Sellami L,Verret L,Fortin MP,Poulin S,Macoir J,Hudon C,Bouchard RW,Lavoie M,Laforce R

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIM:The objective was to examine cohort changes in cognitive function in 2 cohorts of centenarians born 10 years apart. METHODS:The Longitudinal Study of Danish Centenarians comprises all Danes reaching the age of 100 in the period April 1, 1995 through May 31, 1996. A total of 207 out of 276 persons partic...

journal_title：Dementia and geriatric cognitive disorders

authors： Engberg H,Christensen K,Andersen-Ranberg K,Jeune B

更新日期：2008-01-01 00:00:00

abstract：:The apolipoprotein E (APOE) gene epsilon 4 allele is known to be associated with late-onset familial and sporadic Alzheimer's disease (AD). We assessed the possible relationship between APOE genotypes and morphological or functional changes in AD brains by x-ray computed tomography (CT), magnetic resonance imaging (MR...

journal_title：Dementia and geriatric cognitive disorders

authors： Tanaka S,Kawamata J,Shimohama S,Akaki H,Akiguchi I,Kimura J,Ueda K

更新日期：1998-03-01 00:00:00

abstract：:The two most frequently examined biomarkers in the diagnosis of dementia are cerebrospinal fluid (CSF) tau and beta-amyloid(1-42) (Abeta(1-42)). An assay for tau phosphorylated at threonine 181 (phospho-tau) has recently been developed. We studied these three markers in patients with possible Alzheimer's disease (AD; ...

journal_title：Dementia and geriatric cognitive disorders

authors： Nägga K,Gottfries J,Blennow K,Marcusson J

更新日期：2002-01-01 00:00:00

abstract：:We evaluated the sensitivity and specificity of our French version of Addenbrooke's cognitive examination (ACE) to detect dementia in our patient population. One hundred and fifty-eight cases were included in the study. In our patient series, the sensitivity for diagnosing dementia with a Mini-Mental State Examination...

journal_title：Dementia and geriatric cognitive disorders

authors： Bier JC,Donckels V,Van Eyll E,Claes T,Slama H,Fery P,Vokaer M

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Predominant and progressive complex visual disorders are often due to posterior cortical atrophy (PCA), a rare early-onset dementing syndrome presenting with visual complaints. In clinicopathological studies, PCA is most commonly considered a form of Alzheimer's disease (AD); no prior study has evaluated cli...

journal_title：Dementia and geriatric cognitive disorders

authors： Mendez MF,Ghajarania M,Perryman KM

更新日期：2002-01-01 00:00:00

abstract：AIMS:The objective of this study was to investigate the relation between impaired fine motor skills in Parkinson disease (PD) patients and their cognitive status, and to determine whether fine motor skills are more impaired in PD patients with mild cognitive impairment (MCI) than in non-MCI patients. METHODS:Twenty PD...

journal_title：Dementia and geriatric cognitive disorders

authors： Dahdal P,Meyer A,Chaturvedi M,Nowak K,Roesch AD,Fuhr P,Gschwandtner U

更新日期：2016-01-01 00:00:00