Abstract:
AIMS:The goal of this study is to assess the relationship between quality of life (QoL), neuropsychiatric symptoms (NPS), psychotropic drug use (PDU) and patient characteristics in a large group of nursing home residents with dementia. METHODS:This cross-sectional observational study included 288 individuals with dementia who reside in 14 special care units in 9 nursing homes. The following measures were used: the Qualidem scale to assess QoL, the Neuropsychiatric Inventory-Nursing Home version, the Global Deterioration Scale (GDS), the Severe Impairment Battery-short version, an Activities of Daily Living scale and PDU. Associations between QoL and NPS were examined using multivariate linear regression models with corrections for potential covariates. RESULTS:The average age of the residents was 84 years (SD = +/-7). Agitation, depression, psychosis, psychomotor agitation and psychotropic drugs were independently associated with poor QoL. In patients with mild to moderately severe dementia (GDS 4-6), NPS, PDU and cognitive impairment explained almost half of the variance in QoL scores. Agitation and depression were particularly strong predictors of poor QoL. In patients with severe dementia (GDS 7), agitation, depression, psychosis and cognitive impairment were associated with poor QoL. CONCLUSIONS:NPS, cognition and PDU independently impair QoL for patients in both the moderate and advanced stages of dementia. These results challenge existing pharmacological intervention strategies and highlight the need for psychosocial interventions in the treatment of NPS.
journal_name
Dement Geriatr Cogn Disordjournal_title
Dementia and geriatric cognitive disordersauthors
Wetzels RB,Zuidema SU,de Jonghe JF,Verhey FR,Koopmans RTdoi
10.1159/000280437subject
Has Abstractpub_date
2010-01-01 00:00:00pages
189-97issue
3eissn
1420-8008issn
1421-9824pii
000280437journal_volume
29pub_type
杂志文章abstract::Alzheimer's disease (AD) represents a heterogeneous disorder, and several factors have been associated with its development. The presence of the apolipoprotein E type (APOE) epsilon 4 allele has been proposed as a risk factor for AD, but how it influences the development of the characteristic hallmarks of the disease ...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000106646
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:Semantic dementia (SD). OBJECTIVE:To identify the pattern of decline of cerebral glucose metabolism in SD using cerebral (18)F-fluoro-2-desoxy-D-glucose positron emission tomography scanning ((18)F-FDG-PET). METHODS:Eight patients with SD underwent (18)F-FDG-PET at baseline and at re-examination in average...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000095624
更新日期:2006-01-01 00:00:00
abstract::The current increase in aged individuals in number and proportion of the general population warrants dependable strategies to improve early detection of cognitive impairment. It was the goal of the present study to develop a triage for bedside testing and outpatient services. In a prospective clinical cohort study at ...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000088249
更新日期:2005-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000339366
更新日期:2012-01-01 00:00:00
abstract:AIMS:To investigate the effects of rivastigmine capsule 3-12 mg/day over 24 weeks on activities of daily living (ADLs) in patients with dementia associated with Parkinson's disease (PDD). METHODS:Post hocanalysis of a prospective, multicenter, randomized, double-blind, placebo-controlled trial in patients with PDD (>o...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000305100
更新日期:2010-01-01 00:00:00
abstract::Mild cognitive impairment (MCI) is regarded as a precursor to dementia, but not all patients with MCI develop dementia. We followed up 165 elderly outpatients with MCI for a mean of 3 years. The aims were (1) to investigate the risk of conversion to dementia for different MCI subtypes diagnosed according to standardiz...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000089515
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:To examine the influence of cognitive impairment on the functional outcomes and complication rates of patients with hip fracture during in-patient treatment. METHODS:A total of 402 patients who were surgically treated for hip fractures were consecutively enrolled at a single trauma center. The patients were ...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000381334
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the decline in specific neuropsychological functions in nondemented Parkinson's disease (PD) patients with a history of visual hallucinations (VH). METHODS:Twenty PD patients with VH, 20 PD patients without VH and 18 normal controls were followed up over a 1-year period and assessed for cognitive...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000100850
更新日期:2007-01-01 00:00:00
abstract::Metrifonate, through its pharmacologically active metabolite 2,2-dichlorovinyl dimethylphosphate (DDVP), is a long-acting cholinesterase inhibitor for the symptomatic treatment of mild-to-moderate Alzheimer's disease. Clinical studies with Alzheimer patients have demonstrated the favourable safety and tolerability pro...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,评审
doi:10.1159/000051194
更新日期:1998-01-01 00:00:00
abstract::Antiphospholipid antibodies (aPLAb) may cause both focal ischemic and diffuse brain damage and may be associated with dementia. We have examined the relationship of aPLAb to dementia in the elderly. Blood samples were obtained from 87 consecutive patients with dementia (74 +/- 11 years old) and 69 controls (78 +/- 9 y...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000017211
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:To describe a case of early-onset Alzheimer's disease (AD) in an apolipoprotein (Apo) ε2/ε2 homozygote. BACKGROUND:Apo ε2/ε2 is the rarest of the ApoE genotypes, representing only 1.4% of the population. Cognitive decline in ApoE ε2 homozygotes has rarely been reported. CASE REPORT/METHODS:We report a 58-ye...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000320589
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND/AIMS:Since detection of the prion protein gene (PRNP) more than 30 mutations have been discovered. Some have only been found in single case reports without known intrafamilial accumulation or neuropathological proof so that the causal connection between mutation and disease could not be proved. Those patient...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000345991
更新日期:2013-01-01 00:00:00
abstract::Currently used criteria for the diagnosis of probable Alzheimer's disease requires the presence of cognitive deficit in addition to loss of episodic memory. The recent developments in drug treatments for Alzheimer's disease have highlighted the importance of early diagnosis and the need to characterise the cognitive p...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 临床试验,杂志文章
doi:10.1159/000017264
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:Studies of associations between serum lipids and Alzheimer's disease (AD) or other dementias in the elderly show conflicting results, perhaps due to misclassification of the various dementias. METHODS:For 358 nursing home residents, serum lipids were studied at admission and diagnoses established at autopsy...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000189268
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cognitive impairment (CI) is frequent after stroke, but data from population-based stroke cohorts on the natural course of CI are limited. The purpose of this study was to determine changes in cognitive status over 3 years after stroke. METHODS:Data were collected from the Erlangen Stroke Projec...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000327358
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND/AIMS:To characterize loss of basic activities of daily living (BADL) in 687 Alzheimer's disease (AD) community-dwelling patients included in the French REAL cohort. METHODS:Patients had mild to moderately severe AD, and the mean age was 77.8 years. Patterns of loss of the 6 BADL were described at inclusion ...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000264632
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:The Baylor Profound Mental Status Examination (BPMSE) was modeled to provide a brief patient-derived rating scale for staging and tracking patients with severe stages of Alzheimer's disease (AD). METHODS:The BPMSE was administered to 91 patients with probable AD (Korean version of the MMSE less than 16) acc...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000192585
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND/AIMS:Conversion rates to dementia are known to be high for patients with mild cognitive impairment (MCI), but the diagnosis of MCI is very time-consuming. Since the Clock Drawing Test (CDT) is quick to administer, it will be of interest to compare the predictive validity of the CDT and of an MCI diagnosis fo...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000323317
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:We investigated the relationship between sleep disturbance and cognitive decline or clinical conversion in individuals with normal cognition (CN), as well as those with mild cognitive impairment (MCI) and dementia due to Alzheimer disease (AD-dementia). METHODS:Secondary analysis of 1,629 adults between 48 ...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000488671
更新日期:2018-01-01 00:00:00
abstract:AIMS:The study explores how speech measures may be linked to language profiles in participants with Alzheimer's disease (AD) and how these profiles could distinguish AD from changes associated with normal aging. METHODS:We analysed simple sentences spoken by older adults with and without AD. Spectrographic analysis of...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000356726
更新日期:2014-01-01 00:00:00
abstract::Apolipoprotein E (APOE) is the major genetic risk factor for late-onset Alzheimer's disease (AD) and has also been implicated in cardiovascular disease, cognitive decline and cognitive changes in healthy ageing. The aim of this paper is to systematically review and critically assess the association between the APOE ge...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,评审
doi:10.1159/000109150
更新日期:2007-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000447121
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:The study was designed to determine the acceptability, feasibility and validity of measuring quality of life in a representative sample of dementia patients with a generic instrument, the Duke Health Profile. METHOD:The French version of the Duke Health Profile was administered to 148 subjects with a mental ...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000051251
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND/AIMS:Although some patients with primary progressive aphasia (PPA) exhibit novel or improved skills after the onset of dementia, these changes have yet to be quantified. Therefore, this study systematically explored and identified the emergence of positive behaviours after dementia onset. METHODS:This study...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000478852
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:The relationship between subcortical hyperintensities (SH) on brain MRI and gait parameters in aging and Alzheimer's disease (AD) is unclear. This study compared gait in 42 mild AD patients to 22 normal controls (NC) based on their SH severity and correlated them to SH burden in these groups. METHODS:G...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000245158
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND/AIMS:To compare neuropsychiatric symptoms in patients with Alzheimer's disease (AD) and dementia with Lewy bodies(DLB). METHODS:Neuropsychiatric symptoms and caregiver distress were assessed using the Neuropsychiatric Inventory (NPI) in mild DLB (n = 57) and AD (n = 126), and compared across the two groups ...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000339590
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIMS:With an increasing life expectancy, the number of people suffering from dementia globally will rise to about 115.4 million by 2050. It is projected that in the 21st century, the majority of the world's older people will be living in Asia. This paper examines the global issues of family caregiving for ol...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000322086
更新日期:2010-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000082661
更新日期:2005-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 临床试验,杂志文章
doi:10.1159/000106669
更新日期:1997-03-01 00:00:00
abstract::We have previously localized a locus causing familial nonspecific dementia to the centromeric region of chromosome 3 in a pedigree from the Jutland area of Denmark. This pedigree shows anticipation. Here we present further analysis of these anticipation data which are suggestive of trinucleotide repeat expansion invol...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000051222
更新日期:1999-01-01 00:00:00