Abstract:
BACKGROUND:The apolipoprotein E (APOE) e4 genetic polymorphism is a major risk factor for Alzheimer' s disease, hence the possible prevention of its detrimental effects on cognition is of high relevance. METHODS:We used linear regression models to assess associations of APOE e4 with cognitive performance in a population-based cohort study (n = 1,434) and in a cohort of patients with coronary heart disease (n = 366), and restricted cubic splines to explore dose-response relationships between serum cholesterol levels and cognition depending on APOE polymorphism. RESULTS:The association of APOE e4 with cognitive function was strongly amplified in the presence of hypercholesterolemia and cardiovascular disease in both independent cohorts; hypercholesterolemia was associated with cognitive function only among APOE e4 carriers in the presence of cardiovascular disease. The interaction effect between APOE genotype and hypercholesterolemia was statistically significant in both cohorts. CONCLUSIONS:The detrimental effects of APOE e4 polymorphism on cognition may strongly depend on modifiable risk factors.
journal_name
Dement Geriatr Cogn Disordjournal_title
Dementia and geriatric cognitive disordersauthors
Perna L,Mons U,Rujescu D,Kliegel M,Brenner Hdoi
10.1159/000440697subject
Has Abstractpub_date
2016-01-01 00:00:00pages
35-45issue
1-2eissn
1420-8008issn
1421-9824pii
000440697journal_volume
41pub_type
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 临床试验,杂志文章
doi:10.1159/000017016
更新日期:1998-01-01 00:00:00
abstract::Antioxidants prevent oxidative stress that possibly causes neuronal loss in Alzheimer's disease (AD). We examined whether high plasma levels of the antioxidant vitamins A and E were associated with lower prevalence of AD or cognitive decline (CD). We performed a cross-sectional study within the Rotterdam Study. In an ...
journal_title:Dementia and geriatric cognitive disorders
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000089251
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journal_title:Dementia and geriatric cognitive disorders
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doi:10.1159/000366272
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journal_title:Dementia and geriatric cognitive disorders
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doi:10.1159/000109811
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journal_title:Dementia and geriatric cognitive disorders
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journal_title:Dementia and geriatric cognitive disorders
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doi:10.1159/000051234
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journal_title:Dementia and geriatric cognitive disorders
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journal_title:Dementia and geriatric cognitive disorders
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doi:10.1159/000106621
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000253845
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000017106
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000338185
更新日期:2012-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000017116
更新日期:1999-03-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000051285
更新日期:2001-11-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
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doi:10.1159/000017037
更新日期:1998-05-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000119594
更新日期:2008-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000017046
更新日期:1998-07-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000051274
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000189268
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journal_title:Dementia and geriatric cognitive disorders
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doi:10.1159/000089515
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journal_title:Dementia and geriatric cognitive disorders
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000351675
更新日期:2014-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000305093
更新日期:2010-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000478852
更新日期:2017-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000048628
更新日期:2002-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000447121
更新日期:2016-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000151241
更新日期:2008-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 临床试验,杂志文章
doi:10.1159/000017251
更新日期:2000-09-01 00:00:00