Apolipoprotein E e4 and Cognitive Function: A Modifiable Association Results from Two Independent Cohort Studies.

abstract：BACKGROUND:Omega-3 polyunsaturated fatty acids (PUFA) may affect the risk of cognitive decline in older adults. METHODS:Cross-sectional analysis was conducted among 720 (50.4% women) participants aged 68-92 years (mean age: 77.6, SD ±6.2) of the population-based KORA-Age study. Eicosapentaenoic acid and docosahexaenoi...

journal_title：Dementia and geriatric cognitive disorders

authors： Lukaschek K,von Schacky C,Kruse J,Ladwig KH

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:The study was designed to determine the acceptability, feasibility and validity of measuring quality of life in a representative sample of dementia patients with a generic instrument, the Duke Health Profile. METHOD:The French version of the Duke Health Profile was administered to 148 subjects with a mental ...

journal_title：Dementia and geriatric cognitive disorders

authors： Novella J,Ankri J,Morrone I,Guillemin F,Jolly D,Jochum C,Ploton L,Blanchard F

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Corpus callosum atrophy possibly indicates neuronal degeneration in association cortex in Alzheimer's disease (AD). Water diffusivity allows detecting physiological changes that probably occur earlier than structural shrinkage in cerebral regions during the development of AD. OBJECTIVE:To simultaneously inv...

journal_title：Dementia and geriatric cognitive disorders

authors： Wang H,Su MY

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:The familial aggregation of late-onset Alzheimer's disease (AD) might be caused by the clustering of genetic risk factors in families. This study investigates the influence of variants of candidate genes on the familial aggregation of AD. METHODS:The occurrence of AD was examined in 1,420 first-degree relati...

journal_title：Dementia and geriatric cognitive disorders

authors： Heun R,Ptok U,Kölsch H,Maier W,Jessen F

更新日期：2004-01-01 00:00:00

abstract：:Although myoclonus commonly occurs in a later stage of Alzheimer's disease (AD), the pathological basis of this symptom is still unclear. In order to elucidate the neuropathological substrate of myoclonus in AD, we quantitatively assessed neuronal density and volume, with a discrimination between small and large neuro...

journal_title：Dementia and geriatric cognitive disorders

authors： Fukutani Y,Cairns NJ,Everall IP,Chadwick A,Isaki K,Lantos PL

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Behavioral variant frontotemporal dementia (bvFTD) patients show prefrontal cortex dysfunction and atrophy. METHODS:We investigated whether executive function in conjunction with prefrontal cortex atrophy discriminates bvFTD and Alzheimer's disease (AD) patients efficiently at presentation. RESULTS:AD and ...

journal_title：Dementia and geriatric cognitive disorders

authors： Hornberger M,Savage S,Hsieh S,Mioshi E,Piguet O,Hodges JR

更新日期：2010-01-01 00:00:00

abstract：:Frontotemporal dementia (FTD) and Alzheimer's disease (AD) are two frequent causes of dementia that share both clinical and neuropathological features. Common to both disorders are the neurofibrillary tangles consisting of aggregations of hyperphosphorylated tau protein. Recently, a number of different pathogenic muta...

journal_title：Dementia and geriatric cognitive disorders

authors： Ostojic J,Elfgren C,Passant U,Nilsson K,Gustafson L,Lannfelt L,Froelich Fabre S

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND/AIMS:To investigate neuroanatomical substrates of unawareness of memory deficits in patients with early Alzheimer's disease (AD). METHODS:We compared regional perfusion deficits between AD patients with awareness (n = 19) and unawareness (n = 19). SPECT data were analyzed by statistical brain imaging method...

journal_title：Dementia and geriatric cognitive disorders

authors： Hanyu H,Sato T,Akai T,Shimizu S,Hirao K,Kanetaka H,Iwamoto T,Koizumi K

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Little is known about the differences in patients' behavioral problems and health outcomes of family caregivers of patients with vascular dementia (VaD) and Alzheimer's disease (AD). METHODS:A secondary analysis of baseline data on a subsample of caregiver-dementia patient dyads in a randomized clinical tri...

journal_title：Dementia and geriatric cognitive disorders

authors： Kuo LM,Huang HL,Hsu WC,Shyu YI

更新日期：2014-01-01 00:00:00

abstract：:In Switzerland (7 million inhabitants), the organization of health care is in the hand of the cantons and not of the Confederation. The canton of Vaud (600,000 inhabitants), in the south-west part of the country, counts 4 psychiatric sectors, each with a psychogeriatric service. Otherwise the canton has 146 long-stay ...

journal_title：Dementia and geriatric cognitive disorders

authors： Wertheimer J

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:Midlife hypertension followed by late life hypotension resulting from neurodegeneration increases amyloidogenesis and tauopathy. METHODS:Consecutive outpatients with late-onset Alzheimer's disease (AD) at various stages and their respective caregivers were assessed for score variations in 1 year of tests as...

journal_title：Dementia and geriatric cognitive disorders

authors： de Oliveira FF,Chen ES,Smith MC,Bertolucci PH

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:(1) To investigate the prevalence and characteristics of agitation in patients with Alzheimer's disease (AD) and other forms of dementia; (2) to explore the association between agitation and other clinical variables, including disease severity, functional impairment and other neuropsychiatric symptoms, and (...

journal_title：Dementia and geriatric cognitive disorders

authors： Senanarong V,Cummings JL,Fairbanks L,Mega M,Masterman DM,O'Connor SM,Strickland TL

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:To examine the influence of cognitive impairment on the functional outcomes and complication rates of patients with hip fracture during in-patient treatment. METHODS:A total of 402 patients who were surgically treated for hip fractures were consecutively enrolled at a single trauma center. The patients were ...

journal_title：Dementia and geriatric cognitive disorders

authors： Bliemel C,Lechler P,Oberkircher L,Colcuc C,Balzer-Geldsetzer M,Dodel R,Ruchholtz S,Buecking B

更新日期：2015-01-01 00:00:00

abstract：AIMS:We aimed to establish the prevalence of depression among recently admitted long-term care patients and to examine associations with diagnostic initiatives and treatment as recorded in patients' medical records. MATERIALS AND METHODS:Eighty-eight long-term care patients were included. Depression was diagnosed acco...

journal_title：Dementia and geriatric cognitive disorders

authors： Iden KR,Engedal K,Hjorleifsson S,Ruths S

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:This study investigated the relationship between serum levels of two neurotrophic factors, insulin-like growth factor-1 (IGF-1) and hepatocyte growth factor (HGF), and carotid atherosclerosis and cognitive function in the elderly. METHODS:Serum levels of IGF-1 and HGF, carotid artery intima-media thickness (...

journal_title：Dementia and geriatric cognitive disorders

authors： Watanabe T,Yamamoto H,Idei T,Iguchi T,Katagiri T

更新日期：2004-01-01 00:00:00

abstract：:The amygdala is severely atrophied at post-mortem in frontotemporal lobar degeneration (FTLD), and may contribute to the prominent behavioural changes that are early features of FTLD. The aim of this study was to assess amygdala atrophy using MRI in the main syndromic variants of FTLD and Alzheimer's disease (AD). Bra...

journal_title：Dementia and geriatric cognitive disorders

authors： Whitwell JL,Sampson EL,Watt HC,Harvey RJ,Rossor MN,Fox NC

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The Clinical Dementia Rating Scale (CDR) is used to rate dementia severity. Its utility in diagnosing mild cognitive impairment (MCI) and its predictive value remain unknown. AIMS:The aim of this study was to examine the association between CDR scores and expert MCI diagnosis, and to determine whether basel...

journal_title：Dementia and geriatric cognitive disorders

authors： Woolf C,Slavin MJ,Draper B,Thomassen F,Kochan NA,Reppermund S,Crawford JD,Trollor JN,Brodaty H,Sachdev PS

更新日期：2016-01-01 00:00:00

abstract：:The two most frequently examined biomarkers in the diagnosis of dementia are cerebrospinal fluid (CSF) tau and beta-amyloid(1-42) (Abeta(1-42)). An assay for tau phosphorylated at threonine 181 (phospho-tau) has recently been developed. We studied these three markers in patients with possible Alzheimer's disease (AD; ...

journal_title：Dementia and geriatric cognitive disorders

authors： Nägga K,Gottfries J,Blennow K,Marcusson J

更新日期：2002-01-01 00:00:00

abstract：:This intent-to-treat (ITT) analysis was performed to provide a realistic image of the efficacy that could be expected after 26 weeks treatment with a 120-mg dose (40 mg t.i.d.) of EGb 761 (EGb). The data were collected during a 52-week, double-blind, placebo-controlled, fixed dose, parallel-group, multicenter study. P...

journal_title：Dementia and geriatric cognitive disorders

authors： Le Bars PL,Kieser M,Itil KZ

更新日期：2000-07-01 00:00:00

abstract：:The following areas are discussed in this review: atherogenesis; cerebrovascular factors; hypoperfusion; beta-amyloid production; beta-amyloid fibril formation; beta-sheets; metal cations; reactive oxygen species/free radicals; chronic inflammatory factors; endogenous plasma heparin; lipoprotein lipase; polyamines; pr...

journal_title：Dementia and geriatric cognitive disorders

authors： Engelberg H

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:To describe how dementia assessment could be organized in primary health care and how it works. METHODS:The project had two phases. In phase one 104 elderly patients were assessed by a local authority dementia team that used a standardized examination protocol, which enabled the family doctors to establish ...

journal_title：Dementia and geriatric cognitive disorders

authors： Engedal K,Gausdal M,Gjøra L,Haugen PK

更新日期：2012-01-01 00:00:00

abstract：AIMS:To examine the effects of galantamine and risperidone on agitation in patients with dementia. METHODS:A total of 100 patients with dementia and neuropsychiatric symptoms (mean age ± SD: 78.6 ± 7.5 years; 67% female) were included in this 12-week, randomized, parallel-group, controlled, single-center trial. The pa...

journal_title：Dementia and geriatric cognitive disorders

authors： Freund-Levi Y,Bloniecki V,Auestad B,Tysen Bäckström AC,Lärksäter M,Aarsland D

更新日期：2014-01-01 00:00:00

abstract：:Apolipoprotein E (APOE) is the major genetic risk factor for late-onset Alzheimer's disease (AD) and has also been implicated in cardiovascular disease, cognitive decline and cognitive changes in healthy ageing. The aim of this paper is to systematically review and critically assess the association between the APOE ge...

journal_title：Dementia and geriatric cognitive disorders

authors： Cherbuin N,Leach LS,Christensen H,Anstey KJ

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Low muscle strength and muscle mass are associated with adverse outcomes in older hospitalized patients. The aim of this study was to assess the association between cognitive functioning and muscle strength and muscle mass in hospitalized older patients. METHODS:This prospective inception cohort included 37...

journal_title：Dementia and geriatric cognitive disorders

authors： van Dam R,Van Ancum JM,Verlaan S,Scheerman K,Meskers CGM,Maier AB

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The Baylor Profound Mental Status Examination (BPMSE) was modeled to provide a brief patient-derived rating scale for staging and tracking patients with severe stages of Alzheimer's disease (AD). METHODS:The BPMSE was administered to 91 patients with probable AD (Korean version of the MMSE less than 16) acc...

journal_title：Dementia and geriatric cognitive disorders

authors： Na HR,Lee SH,Lee JS,Doody RS,Kim SY

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Although QOL is an important indicator to assess multiple facets of life, the QOL of Alzheimer's disease (AD) subjects with impaired cognitive ability due to dementia has not yet been fully investigated. In this study, we developed the Japanese version of the Quality of Life-Alzheimer's disease (QOL-AD) scal...

journal_title：Dementia and geriatric cognitive disorders

authors： Matsui T,Nakaaki S,Murata Y,Sato J,Shinagawa Y,Tatsumi H,Furukawa TA

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Most studies examining episodic memory in Alzheimer disease (AD) have focused on patients' impaired ability to remember information. This approach provides only a partial picture of memory deficits since other factors involved are not considered. OBJECTIVE:To evaluate the recognition memory performance by u...

journal_title：Dementia and geriatric cognitive disorders

authors： Russo MJ,Cohen G,Campos J,Martin ME,Clarens MF,Sabe L,Barcelo E,Allegri RF

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:The frontal assessment battery (FAB) is reported to be a useful tool for screening frontal function. However, the neural substrates involved remain to be elucidated. The aim of the present study was to identify the brain regions responsible for FAB performance in patients with early dementia. We sought ...

journal_title：Dementia and geriatric cognitive disorders

authors： Yoshida H,Terada S,Sato S,Kishimoto Y,Ata T,Ohshima E,Honda H,Ishihara T,Kuroda S

更新日期：2009-01-01 00:00:00

abstract：AIM:The aims of the present study were to report on the psychometric properties of the Pain Assessment in Advanced Dementia (PAINAD) scale by comparing it with the gold standard method of self-reporting on a numerical rating scale (NRS), and to provide a categorical version of the PAINAD scale comparable with the verba...

journal_title：Dementia and geriatric cognitive disorders

authors： Mosele M,Inelmen EM,Toffanello ED,Girardi A,Coin A,Sergi G,Manzato E

更新日期：2012-01-01 00:00:00

abstract：:Donepezil HCI is a piperidine-based reversible acetylcholinesterase (AChE) inhibitor, chemically distinct from other cholinesterase (ChE) inhibitors and rationally designed to treat the symptoms of Alzheimer's disease (AD). It is highly selective for AChE in the central nervous system (CNS), with little or no affinity...

journal_title：Dementia and geriatric cognitive disorders

authors： Rogers SL

更新日期：1998-01-01 00:00:00