Usefulness of Discriminability and Response Bias Indices for the Evaluation of Recognition Memory in Mild Cognitive Impairment and Alzheimer Disease.

abstract：INTRODUCTION:Gait speed (GS) is a predictor of negative outcomes in older adults and in those in risk to develop cognitive impairment; as such, it has been associated with dementia. Studies in Latin-American older adults showing this association are scarce. This study aimed to evaluate the relationship between GS and d...

journal_title：Dementia and geriatric cognitive disorders

authors： Garcia-Cifuentes E,Márquez I,Vasquez D,Aguillon D,Borda MG,Lopera F,Cano-Gutierrez C

更新日期：2020-11-18 00:00:00

abstract：:Antiphospholipid antibodies (aPLAb) may cause both focal ischemic and diffuse brain damage and may be associated with dementia. We have examined the relationship of aPLAb to dementia in the elderly. Blood samples were obtained from 87 consecutive patients with dementia (74 +/- 11 years old) and 69 controls (78 +/- 9 y...

journal_title：Dementia and geriatric cognitive disorders

authors： Mosek A,Yust I,Treves TA,Vardinon N,Korczyn AD,Chapman J

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND/AIM:To investigate the influence of established genetic risk factors for Alzheimer's disease on the speed of disease progression. METHODS:Polymorphisms (in ACE, ApoE, BIN1, CLU, CR1, CST3, EXOC3L2, GWA14q32.13, IL8, LDLR, PICALM, TNK1) of 40 Alzheimer's disease patients from a longitudinal study were analyz...

journal_title：Dementia and geriatric cognitive disorders

authors： Schmidt C,Wolff M,von Ahsen N,Zerr I

更新日期：2012-01-01 00:00:00

abstract：AIM:The aims of the present study were to report on the psychometric properties of the Pain Assessment in Advanced Dementia (PAINAD) scale by comparing it with the gold standard method of self-reporting on a numerical rating scale (NRS), and to provide a categorical version of the PAINAD scale comparable with the verba...

journal_title：Dementia and geriatric cognitive disorders

authors： Mosele M,Inelmen EM,Toffanello ED,Girardi A,Coin A,Sergi G,Manzato E

更新日期：2012-01-01 00:00:00

abstract：:In epidemiological, cross-sectional studies, treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) prevented to a large extent the development of Alzheimer's disease (AD), but the results of randomized, placebo-controlled studies, focused on statin therapy in patients with ischemic heart ...

journal_title：Dementia and geriatric cognitive disorders

authors： Algotsson A,Winblad B

更新日期：2004-01-01 00:00:00

abstract：:The gene for apolipoprotein E (APOE) is polymorphic, and its variant APOE4 is a major risk factor for the development of Alzheimer-type dementia (AD). Another risk factor for AD appears to be negative cobalamin balance, which is very common in elderly people. Cobalamin and folate are interdependent and essential compo...

journal_title：Dementia and geriatric cognitive disorders

authors： Regland B,Blennow K,Germgård T,Koch-Schmidt AC,Gottfries CG

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Estimations of life expectancies (LE) in health and ill health are important for planning future health care support. This study aimed at quantifying whether an increased LE is accompanied by an increase in the duration of life with dementia (DemLE) in Hong Kong SAR. METHODS:Two parameters from a logistic m...

journal_title：Dementia and geriatric cognitive disorders

authors： Cheung SL,Yip SF,Branch LG,Robine JM

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative disorder with a strong genetic background. It has been reported that modifiable factors, i.e. education (E), might act as proxies for reserve capacity. OBJECTIVE:To evaluate the impact of genetic background (positive family history,...

journal_title：Dementia and geriatric cognitive disorders

authors： Premi E,Garibotto V,Alberici A,Paghera B,Giubbini R,Padovani A,Borroni B

更新日期：2012-01-01 00:00:00

abstract：:Numerous groups have confirmed that apolipoprotein E allelic variation accounts for a proportion of the genetic risk for late-onset Alzheimer's disease (AD). However, there is a paucity of data on the impact of this locus on the overall risk of dementia (as opposed to AD) in the elderly. Most studies have ascertained ...

journal_title：Dementia and geriatric cognitive disorders

authors： Tysoe C,Galinsky D,Robinson D,Brayne C,Huppert FA,Dening T,Paykel ES,Easton DF,Rubinsztein DC

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND/AIMS:To explore the presenting and early symptoms of dementia with Lewy bodies (DLB). METHOD:Patients with mild dementia fulfilling diagnostic criteria for DLB (n = 61) and Alzheimer's disease (AD) (n = 109) were recruited from outpatient dementia clinics in western Norway. At diagnosis, caregivers were ask...

journal_title：Dementia and geriatric cognitive disorders

authors： Auning E,Rongve A,Fladby T,Booij J,Hortobágyi T,Siepel FJ,Ballard C,Aarsland D

更新日期：2011-01-01 00:00:00

abstract：:Apolipoprotein E (APOE) is the major genetic risk factor for late-onset Alzheimer's disease (AD) and has also been implicated in cardiovascular disease, cognitive decline and cognitive changes in healthy ageing. The aim of this paper is to systematically review and critically assess the association between the APOE ge...

journal_title：Dementia and geriatric cognitive disorders

authors： Cherbuin N,Leach LS,Christensen H,Anstey KJ

更新日期：2007-01-01 00:00:00

abstract：:Psychosis is common in patients with Alzheimer's disease (AD) and contributes substantially to patient morbidity and caregiver distress. Antipsychotic medications are used to treat psychosis and other psychiatric or behavioral symptoms in AD, although optimal treatment guidelines have been elusive. Choosing the most a...

journal_title：Dementia and geriatric cognitive disorders

authors： Sultzer DL

更新日期：2004-01-01 00:00:00

abstract：:Accumulating evidence suggests that butyrylcholinesterase (BuChE) plays an important role in the progression of cognitive deficits and Alzheimer-type pathology in dementia patients. We examined the relationship between the K variant of BuChE and the severity of deposits of amyloid (Abeta(1-42)) and phosphorylated tau ...

journal_title：Dementia and geriatric cognitive disorders

authors： Ballard C,Morris C,Kalaria R,McKeith I,Perry R,Perry E

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:It has been reported that nonsteroidal anti-inflammatory drugs may delay the onset of Alzheimer's disease (AD). Since nonsteroidal anti-inflammatory drugs inhibit cyclooxygenase (COX), COX-2, an inducible form of COX, may be involved in the pathology of AD in association with the arachidonic acid cascade. In...

journal_title：Dementia and geriatric cognitive disorders

authors： Fujimi K,Noda K,Sasaki K,Wakisaka Y,Tanizaki Y,Iida M,Kiyohara Y,Kanba S,Iwaki T

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Midlife hypertension followed by late life hypotension resulting from neurodegeneration increases amyloidogenesis and tauopathy. METHODS:Consecutive outpatients with late-onset Alzheimer's disease (AD) at various stages and their respective caregivers were assessed for score variations in 1 year of tests as...

journal_title：Dementia and geriatric cognitive disorders

authors： de Oliveira FF,Chen ES,Smith MC,Bertolucci PH

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Frontotemporal dementia (FTD) is a more common cause of dementia than previously recognised. Few data are available regarding the natural course of FTD in terms of survival, nursing home admission and causes of death. METHODS:An observational study of all consecutive patients referred to the memory centre...

journal_title：Dementia and geriatric cognitive disorders

authors： Pasquier F,Richard F,Lebert F

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:The aim of this study was to identify the brain regions associated with the severity of delusions in individuals with Alzheimer's disease (AD) using single-photon emission computed tomography. METHODS:Thirty-five AD patients participated in this study. Multiple regression analysis was performed to identify ...

journal_title：Dementia and geriatric cognitive disorders

authors： Matsuoka T,Narumoto J,Shibata K,Okamura A,Nakamura K,Okuyama C,Nishimura T,Fukui K

更新日期：2010-01-01 00:00:00

abstract：:Findings in patients with dementia of the Alzheimer type (AD patients) concerning the enactment effect, i.e. reaching a better memory performance after encoding actions by performing them in contrast to encoding them by reading, are ambiguous. In order to get more insight into memory deterioration in patients sufferin...

journal_title：Dementia and geriatric cognitive disorders

authors： Mack W,Eberle C,Frölich L,Knopf M

更新日期：2005-01-01 00:00:00

abstract：:The following areas are discussed in this review: atherogenesis; cerebrovascular factors; hypoperfusion; beta-amyloid production; beta-amyloid fibril formation; beta-sheets; metal cations; reactive oxygen species/free radicals; chronic inflammatory factors; endogenous plasma heparin; lipoprotein lipase; polyamines; pr...

journal_title：Dementia and geriatric cognitive disorders

authors： Engelberg H

更新日期：2004-01-01 00:00:00

abstract：:Abnormal tau hyperphosphorylation has been suggested as being one of the central events in the development of neurofibrillary tangles, which are one of the characteristic neuropathological lesions found in Alzheimer's disease (AD) brains. 14-3-3 zeta protein is associated with tau in brain and stimulates tau phosphory...

journal_title：Dementia and geriatric cognitive disorders

authors： Mateo I,Sánchez-Juan P,Rodríguez-Rodríguez E,Infante J,Fernández-Viadero C,Peña N,Berciano J,Combarros O

更新日期：2008-01-01 00:00:00

abstract：:We evaluated the sensitivity and specificity of our French version of Addenbrooke's cognitive examination (ACE) to detect dementia in our patient population. One hundred and fifty-eight cases were included in the study. In our patient series, the sensitivity for diagnosing dementia with a Mini-Mental State Examination...

journal_title：Dementia and geriatric cognitive disorders

authors： Bier JC,Donckels V,Van Eyll E,Claes T,Slama H,Fery P,Vokaer M

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND/AIMS:Conversion rates to dementia are known to be high for patients with mild cognitive impairment (MCI), but the diagnosis of MCI is very time-consuming. Since the Clock Drawing Test (CDT) is quick to administer, it will be of interest to compare the predictive validity of the CDT and of an MCI diagnosis fo...

journal_title：Dementia and geriatric cognitive disorders

authors： Ehreke L,Luppa M,König HH,Villringer A,Riedel-Heller SG

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:To detect the main factors associated with the occurrence of specific geriatric syndromes (namely pressure sores, fecal incontinence, urinary incontinence and falls) in elderly patients during hospitalization. DESIGN:Observational prospective study. SETTING:Eighty-one community and university hospitals thro...

journal_title：Dementia and geriatric cognitive disorders

authors： Mecocci P,von Strauss E,Cherubini A,Ercolani S,Mariani E,Senin U,Winblad B,Fratiglioni L

更新日期：2005-01-01 00:00:00

abstract：:We have previously localized a locus causing familial nonspecific dementia to the centromeric region of chromosome 3 in a pedigree from the Jutland area of Denmark. This pedigree shows anticipation. Here we present further analysis of these anticipation data which are suggestive of trinucleotide repeat expansion invol...

journal_title：Dementia and geriatric cognitive disorders

authors： Ashworth A,Lloyd S,Brown J,Gydesen S,Sorensen SA,Brun A,Englund E,Humphreys C,Housman D,Badura M,Stanton V Jr,Taylor K,Cameron J,Munroe D,Johansson J,Rossor M,Fisher EM,Collinge J

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:To describe a case of early-onset Alzheimer's disease (AD) in an apolipoprotein (Apo) ε2/ε2 homozygote. BACKGROUND:Apo ε2/ε2 is the rarest of the ApoE genotypes, representing only 1.4% of the population. Cognitive decline in ApoE ε2 homozygotes has rarely been reported. CASE REPORT/METHODS:We report a 58-ye...

journal_title：Dementia and geriatric cognitive disorders

authors： Cole L,Belden C,Jacobson S,Liebsack C,Myers K,Reninger C,Berk C,Sabbagh MN

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND/AIMS:To compare neuropsychiatric symptoms in patients with Alzheimer's disease (AD) and dementia with Lewy bodies(DLB). METHODS:Neuropsychiatric symptoms and caregiver distress were assessed using the Neuropsychiatric Inventory (NPI) in mild DLB (n = 57) and AD (n = 126), and compared across the two groups ...

journal_title：Dementia and geriatric cognitive disorders

authors： Bjoerke-Bertheussen J,Ehrt U,Rongve A,Ballard C,Aarsland D

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIM:3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are thought to reduce the amount of Abeta peptides by reducing cholesterol from blood and/or cerebrospinal fluid. We performed this meta-analysis to evaluate the preventive and treatment effects of statins on dementia and Alzheimer dise...

journal_title：Dementia and geriatric cognitive disorders

authors： Zhou B,Teramukai S,Fukushima M

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Our aim was to evaluate and compare the diagnostic properties of 5 screening tests for the diagnosis of mild Alzheimer disease (AD). METHODS:We conducted a prospective and cross-sectional study of 92 patients with mild AD and of 68 healthy controls from our Department of Neurology. The diagnostic properties...

journal_title：Dementia and geriatric cognitive disorders

authors： Matías-Guiu JA,Valles-Salgado M,Rognoni T,Hamre-Gil F,Moreno-Ramos T,Matías-Guiu J

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The Clinical Dementia Rating Scale (CDR) is used to rate dementia severity. Its utility in diagnosing mild cognitive impairment (MCI) and its predictive value remain unknown. AIMS:The aim of this study was to examine the association between CDR scores and expert MCI diagnosis, and to determine whether basel...

journal_title：Dementia and geriatric cognitive disorders

authors： Woolf C,Slavin MJ,Draper B,Thomassen F,Kochan NA,Reppermund S,Crawford JD,Trollor JN,Brodaty H,Sachdev PS

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Memantine is a moderate affinity N-methyl-D-aspartate receptor antagonist approved for treatment of Alzheimer's disease (AD). In AD, tau is abnormally hyperphosphorylated. However, no significant changes of phosphorylated tau levels in CSF are found at follow-up in studies with AD patients. It has been shown...

journal_title：Dementia and geriatric cognitive disorders

authors： Degerman Gunnarsson M,Kilander L,Basun H,Lannfelt L

更新日期：2007-01-01 00:00:00