Regional pattern of increased water diffusivity in hippocampus and corpus callosum in mild cognitive impairment.

abstract：:The Fas antigen (CD95) is a cell surface receptor that mediates cell apoptosis signalling. Recent investigations have shown that Fas-regulated apoptosis was linked to neurodegenerative lesions in the brain of patients with Alzheimer's disease (AD). Here data regarding the association of two polymorphisms of the Fas pr...

journal_title：Dementia and geriatric cognitive disorders

authors： Chiappelli M,Nasi M,Cossarizza A,Porcellini E,Tumini E,Pinti M,Troiano L,Franceschi M,Licastro F

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND/AIM:The objective was to examine cohort changes in cognitive function in 2 cohorts of centenarians born 10 years apart. METHODS:The Longitudinal Study of Danish Centenarians comprises all Danes reaching the age of 100 in the period April 1, 1995 through May 31, 1996. A total of 207 out of 276 persons partic...

journal_title：Dementia and geriatric cognitive disorders

authors： Engberg H,Christensen K,Andersen-Ranberg K,Jeune B

更新日期：2008-01-01 00:00:00

abstract：:We assessed the role of the APOE genotype and prion protein polymorphism at codon 129 in predicting the clinical duration of 92 neuropathologically confirmed sporadic Alzheimer's disease patients. Analyses of survival showed that the absence of the APOE epsilon 4 allele in heterozygous codon 129 PRNP carriers is a neg...

journal_title：Dementia and geriatric cognitive disorders

authors： Giannattasio C,Poleggi A,Puopolo M,Pocchiari M,Antuono P,Dal Forno G,Wekstein DR,Matera MG,Seripa D,Acciarri A,Bizzarro A,Lauria A,Masullo C

更新日期：2008-01-01 00:00:00

abstract：:Data were derived from the Cochrane Collaboration meta-analyses of the efficacies of ginkgo, donepezil, rivastigmine and galantamine on changes in cognitive function in patients with dementia and, where necessary, were transformed to standardized mean differences. The proportion of patients discontinuing trials was us...

journal_title：Dementia and geriatric cognitive disorders

authors： Kurz A,Van Baelen B

更新日期：2004-01-01 00:00:00

abstract：:The current increase in aged individuals in number and proportion of the general population warrants dependable strategies to improve early detection of cognitive impairment. It was the goal of the present study to develop a triage for bedside testing and outpatient services. In a prospective clinical cohort study at ...

journal_title：Dementia and geriatric cognitive disorders

authors： Beinhoff U,Hilbert V,Bittner D,Gron G,Riepe MW

更新日期：2005-01-01 00:00:00

abstract：:Ten years after the introduction of the first drug, tacrine, in the treatment of Alzheimer's disease, it seems appropriate to re-appraise the pharmacological processes of innovation in the research field of dementia. The aim of this review is to pinpoint concrete improvements achieved in this field, regarding experime...

journal_title：Dementia and geriatric cognitive disorders

authors： Sellal F,Nieoullon A,Michel G,Michel BF,Lacomblez L,Geerts H,Delini Stula A,Bordet R,Bentué-Ferrer D,Allain H

更新日期：2005-01-01 00:00:00

abstract：UNLABELLED:The concept of the cognitive reserve (CR) hypothesizes that premorbid factors such as education enable compensation for the manifestation of brain pathology. Accordingly, pathology should be more prominent in individuals with higher CR before becoming clinically apparent. Previously, we found that patients s...

journal_title：Dementia and geriatric cognitive disorders

authors： Rolstad S,Nordlund A,Eckerström C,Gustavsson MH,Zetterberg H,Wallin A

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIMS:Differences in the gross shape of the corpus callosum (CC) and its subregional areas were investigated on brain MRI of patients with probable Alzheimer's disease (AD) and age- and gender-matched healthy normal control subjects. The AD patients differed from the normal control subjects in terms of a more...

journal_title：Dementia and geriatric cognitive disorders

authors： Tomaiuolo F,Scapin M,Di Paola M,Le Nezet P,Fadda L,Musicco M,Caltagirone C,Collins DL

更新日期：2007-01-01 00:00:00

abstract：:The present investigation reports the application of regional cerebral blood flow (rCBF; (133)Xe method) to prognostic purposes in a consecutive series of 76 patients (mean age 68.4 +/- 8.7 years) with probable Alzheimer's disease (AD; NINCDS-ADRDA criteria). The likelihood that rCBF from a posterior temporal-inferior...

journal_title：Dementia and geriatric cognitive disorders

authors： Nobili F,Copello F,Buffoni F,Vitali P,Girtler N,Bordoni C,Safaie-Semnani E,Mariani G,Rodriguez G

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cognitive impairment (CI) is frequent after stroke, but data from population-based stroke cohorts on the natural course of CI are limited. The purpose of this study was to determine changes in cognitive status over 3 years after stroke. METHODS:Data were collected from the Erlangen Stroke Projec...

journal_title：Dementia and geriatric cognitive disorders

authors： Liman TG,Heuschmann PU,Endres M,Flöel A,Schwab S,Kolominsky-Rabas PL

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Omega-3 polyunsaturated fatty acids (PUFA) may affect the risk of cognitive decline in older adults. METHODS:Cross-sectional analysis was conducted among 720 (50.4% women) participants aged 68-92 years (mean age: 77.6, SD ±6.2) of the population-based KORA-Age study. Eicosapentaenoic acid and docosahexaenoi...

journal_title：Dementia and geriatric cognitive disorders

authors： Lukaschek K,von Schacky C,Kruse J,Ladwig KH

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:Depressive symptoms are commonly observed in Alzheimer's disease (AD). The underlying mechanisms of depressive symptoms in AD remain unclear; frontolimbic circuitry dysfunction may play a role. We aimed to investigate the microstructural integrity of frontolimbic connectivity of specific fiber tracts in...

journal_title：Dementia and geriatric cognitive disorders

authors： Zhu Q,Lin M,Bi S,Ni Z,Zhao J,Chen B,Fan G,Shang X

更新日期：2016-01-01 00:00:00

abstract：:The degeneration of dopaminergic cells in dementia with Lewy bodies (DLB) may provide an important source of additional free radical generation. As a result, the oxidative stress status in DLB could be significantly enhanced. Subsequently, the levels of endogenous antioxidants, which are an indirect measure of free ra...

journal_title：Dementia and geriatric cognitive disorders

authors： Tabet N,Walker Z,Mantle D,Costa D,Orrell M

更新日期：2003-01-01 00:00:00

abstract：:Delirium is one of the most frequent symptoms of disease in the elderly. A large variation of incidence and prevalence data is reported probably due to different patient populations and inconsistent diagnostic criteria. In medical and surgical elderly inpatients recent studies report a prevalence rate of approximately...

journal_title：Dementia and geriatric cognitive disorders

authors： Bucht G,Gustafson Y,Sandberg O

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Most studies examining episodic memory in Alzheimer disease (AD) have focused on patients' impaired ability to remember information. This approach provides only a partial picture of memory deficits since other factors involved are not considered. OBJECTIVE:To evaluate the recognition memory performance by u...

journal_title：Dementia and geriatric cognitive disorders

authors： Russo MJ,Cohen G,Campos J,Martin ME,Clarens MF,Sabe L,Barcelo E,Allegri RF

更新日期：2017-01-01 00:00:00

abstract：:Psychosis is common in patients with Alzheimer's disease (AD) and contributes substantially to patient morbidity and caregiver distress. Antipsychotic medications are used to treat psychosis and other psychiatric or behavioral symptoms in AD, although optimal treatment guidelines have been elusive. Choosing the most a...

journal_title：Dementia and geriatric cognitive disorders

authors： Sultzer DL

更新日期：2004-01-01 00:00:00

abstract：:Antioxidants prevent oxidative stress that possibly causes neuronal loss in Alzheimer's disease (AD). We examined whether high plasma levels of the antioxidant vitamins A and E were associated with lower prevalence of AD or cognitive decline (CD). We performed a cross-sectional study within the Rotterdam Study. In an ...

journal_title：Dementia and geriatric cognitive disorders

authors： Engelhart MJ,Ruitenberg A,Meijer J,Kiliaan A,van Swieten JC,Hofman A,Witteman JC,Breteler MM

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND/AIMS:Motor impairment is an important aspect of cognitive decline in older adults. It has been suggested that complex motor control is affected earlier than gross motor control. The aims were to investigate if complex hand motor function was more affected than gross motor function in cognitively impaired old...

journal_title：Dementia and geriatric cognitive disorders

authors： Bramell-Risberg E,Jarnlo GB,Elmståhl S

更新日期：2010-01-01 00:00:00

abstract：:The following areas are discussed in this review: atherogenesis; cerebrovascular factors; hypoperfusion; beta-amyloid production; beta-amyloid fibril formation; beta-sheets; metal cations; reactive oxygen species/free radicals; chronic inflammatory factors; endogenous plasma heparin; lipoprotein lipase; polyamines; pr...

journal_title：Dementia and geriatric cognitive disorders

authors： Engelberg H

更新日期：2004-01-01 00:00:00

abstract：:The gene for apolipoprotein E (APOE) is polymorphic, and its variant APOE4 is a major risk factor for the development of Alzheimer-type dementia (AD). Another risk factor for AD appears to be negative cobalamin balance, which is very common in elderly people. Cobalamin and folate are interdependent and essential compo...

journal_title：Dementia and geriatric cognitive disorders

authors： Regland B,Blennow K,Germgård T,Koch-Schmidt AC,Gottfries CG

更新日期：1999-07-01 00:00:00

abstract：:In Switzerland (7 million inhabitants), the organization of health care is in the hand of the cantons and not of the Confederation. The canton of Vaud (600,000 inhabitants), in the south-west part of the country, counts 4 psychiatric sectors, each with a psychogeriatric service. Otherwise the canton has 146 long-stay ...

journal_title：Dementia and geriatric cognitive disorders

authors： Wertheimer J

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVE:To describe a case of early-onset Alzheimer's disease (AD) in an apolipoprotein (Apo) ε2/ε2 homozygote. BACKGROUND:Apo ε2/ε2 is the rarest of the ApoE genotypes, representing only 1.4% of the population. Cognitive decline in ApoE ε2 homozygotes has rarely been reported. CASE REPORT/METHODS:We report a 58-ye...

journal_title：Dementia and geriatric cognitive disorders

authors： Cole L,Belden C,Jacobson S,Liebsack C,Myers K,Reninger C,Berk C,Sabbagh MN

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND/AIMS:The diagnosis of delirium is not supported by specific biomarkers. In a previous study, high neopterin levels were found in patients with a postoperative delirium. In the present study, we investigated levels of neopterin, interleukin-6 (IL-6) and insulin-like growth factor-1 (IGF-1) in acutely ill admi...

journal_title：Dementia and geriatric cognitive disorders

authors： Egberts A,Wijnbeld EH,Fekkes D,van der Ploeg MA,Ziere G,Hooijkaas H,van der Cammen TJ,Mattace-Raso FU

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Possession of one or more apolipoprotein E (APOE) epsilon4 alleles may influence the distribution of atrophy and clinical phenotype. We aimed to assess the influence of APOE genotype on cortical thickness and regional brain volumes in AD (Alzheimer's disease). METHODS:We included 38 patients (9 epsilon4 non...

journal_title：Dementia and geriatric cognitive disorders

authors： Gutiérrez-Galve L,Lehmann M,Hobbs NZ,Clarkson MJ,Ridgway GR,Crutch S,Ourselin S,Schott JM,Fox NC,Barnes J

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Given the poorer prognosis of Alzheimer's disease (AD) patients with rapid cognitive decline (RCD), there is a need for a clinical assessment tool to detect these patients. OBJECTIVE:To investigate if there is a Mini Mental State Examination (MMSE) threshold of decline during 6 months of follow-up which pre...

journal_title：Dementia and geriatric cognitive disorders

authors： Soto ME,Andrieu S,Cantet C,Reynish E,Ousset PJ,Arbus C,Gillette-Guyonnet S,Nourhashémi F,Vellas B,REAL.FR group.

更新日期：2008-01-01 00:00:00

abstract：:Frontotemporal dementia (FTD) and Alzheimer's disease (AD) are two frequent causes of dementia that share both clinical and neuropathological features. Common to both disorders are the neurofibrillary tangles consisting of aggregations of hyperphosphorylated tau protein. Recently, a number of different pathogenic muta...

journal_title：Dementia and geriatric cognitive disorders

authors： Ostojic J,Elfgren C,Passant U,Nilsson K,Gustafson L,Lannfelt L,Froelich Fabre S

更新日期：2004-01-01 00:00:00

abstract：:We have previously reported that epidermal growth factor receptor (EGFR) was expressed on vascular endothelial cells from postmortem specimens of demented but not cognitively normal subjects. In the present study, we examined skin biopsies from 35 living patients who were either normal or had a clinical diagnosis of p...

journal_title：Dementia and geriatric cognitive disorders

authors： Styren SD,Styren GC,DeKosky ST

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND/AIMS:This study aimed to investigate whether the serial position effects in memory can differentiate patients with different subtypes of mild cognitive impairment (MCI) from healthy controls and patients with different stages of Alzheimer's disease (AD). METHODS:The serial position effects was tested with t...

journal_title：Dementia and geriatric cognitive disorders

authors： Moser B,Deisenhammer EA,Marksteiner J,Papousek I,Fink A,Weiss EM

更新日期：2014-01-01 00:00:00

abstract：:Frontotemporal dementia (FTD) is the second most prevalent dementia after Alzheimer's disease (AD). We compared 29 FTD and 90 AD caregivers with respect to burden, health-related quality of life (HQoL) and coping. FTD caregivers were more burdened than AD caregivers, and caregivers of patients who were demented for sh...

journal_title：Dementia and geriatric cognitive disorders

authors： Riedijk SR,De Vugt ME,Duivenvoorden HJ,Niermeijer MF,Van Swieten JC,Verhey FR,Tibben A

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:We investigated the relationship between sleep disturbance and cognitive decline or clinical conversion in individuals with normal cognition (CN), as well as those with mild cognitive impairment (MCI) and dementia due to Alzheimer disease (AD-dementia). METHODS:Secondary analysis of 1,629 adults between 48 ...

journal_title：Dementia and geriatric cognitive disorders

authors： Mecca AP,Michalak HR,McDonald JW,Kemp EC,Pugh EA,Becker ML,Mecca MC,van Dyck CH,The Alzheimer’s Disease Neuroimaging Initiative (ADNI).

更新日期：2018-01-01 00:00:00