Impaired Frontolimbic Connectivity and Depressive Symptoms in Patients with Alzheimer's Disease.

abstract：:Seventeen patients with probable Alzheimer's disease (AD), 7 patients with frontal lobe dementia (FLD) and 19 control subjects (NOR) were examined by (99m)Tc-d,l- hexamethylpropylene amine oxime ((99m)Tc-HMPAO) SPECT. Images were standardised in the same 3D space and averaged within each group. After normalisation, th...

journal_title：Dementia and geriatric cognitive disorders

authors： Pagani M,Salmaso D,Ramström C,Jonsson C,Lundqvist R,Thurfjell L,Schnell PO,Wägner A,Jacobsson H,Larsson SA

更新日期：2001-05-01 00:00:00

abstract：:The two most frequently examined biomarkers in the diagnosis of dementia are cerebrospinal fluid (CSF) tau and beta-amyloid(1-42) (Abeta(1-42)). An assay for tau phosphorylated at threonine 181 (phospho-tau) has recently been developed. We studied these three markers in patients with possible Alzheimer's disease (AD; ...

journal_title：Dementia and geriatric cognitive disorders

authors： Nägga K,Gottfries J,Blennow K,Marcusson J

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative disorder with a strong genetic background. It has been reported that modifiable factors, i.e. education (E), might act as proxies for reserve capacity. OBJECTIVE:To evaluate the impact of genetic background (positive family history,...

journal_title：Dementia and geriatric cognitive disorders

authors： Premi E,Garibotto V,Alberici A,Paghera B,Giubbini R,Padovani A,Borroni B

更新日期：2012-01-01 00:00:00

abstract：AIMS:The objective of this study was to investigate the relation between impaired fine motor skills in Parkinson disease (PD) patients and their cognitive status, and to determine whether fine motor skills are more impaired in PD patients with mild cognitive impairment (MCI) than in non-MCI patients. METHODS:Twenty PD...

journal_title：Dementia and geriatric cognitive disorders

authors： Dahdal P,Meyer A,Chaturvedi M,Nowak K,Roesch AD,Fuhr P,Gschwandtner U

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:This study aimed to investigate whether the serial position effects in memory can differentiate patients with different subtypes of mild cognitive impairment (MCI) from healthy controls and patients with different stages of Alzheimer's disease (AD). METHODS:The serial position effects was tested with t...

journal_title：Dementia and geriatric cognitive disorders

authors： Moser B,Deisenhammer EA,Marksteiner J,Papousek I,Fink A,Weiss EM

更新日期：2014-01-01 00:00:00

abstract：:Findings in patients with dementia of the Alzheimer type (AD patients) concerning the enactment effect, i.e. reaching a better memory performance after encoding actions by performing them in contrast to encoding them by reading, are ambiguous. In order to get more insight into memory deterioration in patients sufferin...

journal_title：Dementia and geriatric cognitive disorders

authors： Mack W,Eberle C,Frölich L,Knopf M

更新日期：2005-01-01 00:00:00

abstract：:Currently used criteria for the diagnosis of probable Alzheimer's disease requires the presence of cognitive deficit in addition to loss of episodic memory. The recent developments in drug treatments for Alzheimer's disease have highlighted the importance of early diagnosis and the need to characterise the cognitive p...

journal_title：Dementia and geriatric cognitive disorders

authors： Perry RJ,Hodges JR

更新日期：2000-11-01 00:00:00

abstract：AIMS:Limited research has been done on the functional connectivity in visuoperceptual regions in dementia with Lewy bodies (DLB) patients. This study aimed to investigate the functional connectivity differences between a task condition and an inter-task resting state condition within a visuoperceptual paradigm, in DLB ...

journal_title：Dementia and geriatric cognitive disorders

authors： Chabran E,Roquet D,Gounot D,Sourty M,Armspach JP,Blanc F

更新日期：2018-01-01 00:00:00

abstract：:Data were derived from the Cochrane Collaboration meta-analyses of the efficacies of ginkgo, donepezil, rivastigmine and galantamine on changes in cognitive function in patients with dementia and, where necessary, were transformed to standardized mean differences. The proportion of patients discontinuing trials was us...

journal_title：Dementia and geriatric cognitive disorders

authors： Kurz A,Van Baelen B

更新日期：2004-01-01 00:00:00

abstract：:The identification of the epsilon4 variant of apolipoprotein E as a genetic risk factor for late-onset Alzheimer's disease (AD) suggests that cholesterol may play a direct role in the pathogenesis of the disease. Recent studies have suggested that the ATP-binding cassette (ABC) protein G5 (ABCG5) may be involved in th...

journal_title：Dementia and geriatric cognitive disorders

authors： Ohkubo T,Shibata N,Ohnuma T,Higashi S,Usui C,Ueki A,Nagao M,Arai H

更新日期：2005-01-01 00:00:00

abstract：:Although myoclonus commonly occurs in a later stage of Alzheimer's disease (AD), the pathological basis of this symptom is still unclear. In order to elucidate the neuropathological substrate of myoclonus in AD, we quantitatively assessed neuronal density and volume, with a discrimination between small and large neuro...

journal_title：Dementia and geriatric cognitive disorders

authors： Fukutani Y,Cairns NJ,Everall IP,Chadwick A,Isaki K,Lantos PL

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND/AIMS:Conversion rates to dementia are known to be high for patients with mild cognitive impairment (MCI), but the diagnosis of MCI is very time-consuming. Since the Clock Drawing Test (CDT) is quick to administer, it will be of interest to compare the predictive validity of the CDT and of an MCI diagnosis fo...

journal_title：Dementia and geriatric cognitive disorders

authors： Ehreke L,Luppa M,König HH,Villringer A,Riedel-Heller SG

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND/AIMS:Dementia cafés are becoming widespread as a new approach to dementia care, but their operational procedures and significance have not been adequately studied. METHODS:On-the-job training (OJT) for professionals planning to operate a dementia café in the future was conducted in a pioneering dementia caf...

journal_title：Dementia and geriatric cognitive disorders

authors： Takechi H,Sugihara Y,Matsumoto H,Yamada H

更新日期：2018-01-01 00:00:00

abstract：:This cross-sectional study aimed at determining the clinical and structural brain magnetic resonance imaging correlates of mild cognitive impairment (MCI). The data presented here are from the first wave of the longitudinal Personality and Total Health through Life 60+ project. 2,551 community-dwelling individuals in ...

journal_title：Dementia and geriatric cognitive disorders

authors： Kumar R,Parslow RA,Jorm AF,Rosenman SJ,Maller J,Meslin C,Anstey KJ,Christensen H,Sachdev PS

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Total plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness, and patients with vascular disease have higher plasma tHcy concentrations than patients without vascular disease. Increasing evidence indicates that vascular risk factors play a role in the development of cogn...

journal_title：Dementia and geriatric cognitive disorders

authors： Nilsson K,Gustafson L,Hultberg B

更新日期：2010-01-01 00:00:00

abstract：:The present study investigated the sensitivity and specificity of the Hopkins Verbal Learning Test (HVLT) for demented patients (n = 82, using NINCDS criteria) and 114 healthy controls--equivalent in age, years of education and gender-ratio--from the Oxford Project to Investigate Memory and Ageing. The HVLT 'Total Rec...

journal_title：Dementia and geriatric cognitive disorders

authors： Hogervorst E,Combrinck M,Lapuerta P,Rue J,Swales K,Budge M

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVES:To estimate life expectancy of psychogeriatric patients having participated in a reactivation program. To identify prognostic characteristics - on admission - for survival after discharge. DESIGN:A prospective, clinical-empirical observational study. SETTING:A Dutch psychiatric-skilled nursing home. PARTI...

journal_title：Dementia and geriatric cognitive disorders

authors： Bakker TJ,Duivenvoorden HJ,van der Lee J,Schudel WJ

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND/AIMS:We evaluated the differential patterns of brain atrophy in early- and late-onset Alzheimer's disease (AD) by measuring regional z-scores of voxel-based morphometry and assessed the availability of the method for clinical use. METHODS:The first 50 patients with probable AD were compared to 83 age-matche...

journal_title：Dementia and geriatric cognitive disorders

authors： Shiino A,Watanabe T,Kitagawa T,Kotani E,Takahashi J,Morikawa S,Akiguchi I

更新日期：2008-01-01 00:00:00

abstract：:Age-related changes and the effects of dementia of the Alzheimer type (DAT) were investigated during a visual orienting attention task in which attention was pre-cued to one or other hemifields. Central cues were either valid, neutral, invalid or NoGo (inhibitory). The response time cost-benefit analysis showed a decr...

journal_title：Dementia and geriatric cognitive disorders

authors： Wright M,Geffen G,Geffen L

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND/AIMS:Current findings suggest the existence of a category of fast cognitive decliners with a poorer prognosis but better treatment response. Our study aimed at confirming the concept of fast decliners at the time of Alzheimer's disease (AD) diagnosis which best predicts mortality, in an unselected sample. M...

journal_title：Dementia and geriatric cognitive disorders

authors： Carcaillon L,Pérès K,Péré JJ,Helmer C,Orgogozo JM,Dartigues JF

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:This study investigated the relationship between serum levels of two neurotrophic factors, insulin-like growth factor-1 (IGF-1) and hepatocyte growth factor (HGF), and carotid atherosclerosis and cognitive function in the elderly. METHODS:Serum levels of IGF-1 and HGF, carotid artery intima-media thickness (...

journal_title：Dementia and geriatric cognitive disorders

authors： Watanabe T,Yamamoto H,Idei T,Iguchi T,Katagiri T

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND/AIMS:The logopenic variant of primary progressive aphasia (lvPPA) is characterized by impaired word-finding and sentence repetition with phonologic errors but spared motor speech and grammar and semantic knowledge. Although its language deficits have been well studied, the full spectrum of cognitive changes ...

journal_title：Dementia and geriatric cognitive disorders

authors： Montreuil S,Poulin E,Bergeron D,Sellami L,Verret L,Fortin MP,Poulin S,Macoir J,Hudon C,Bouchard RW,Lavoie M,Laforce R

更新日期：2020-01-01 00:00:00

abstract：:The Fas antigen (CD95) is a cell surface receptor that mediates cell apoptosis signalling. Recent investigations have shown that Fas-regulated apoptosis was linked to neurodegenerative lesions in the brain of patients with Alzheimer's disease (AD). Here data regarding the association of two polymorphisms of the Fas pr...

journal_title：Dementia and geriatric cognitive disorders

authors： Chiappelli M,Nasi M,Cossarizza A,Porcellini E,Tumini E,Pinti M,Troiano L,Franceschi M,Licastro F

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND/AIM:It has been questioned whether cognitive and behavioral scales sufficiently address the impact of dementia on the everyday life of patients. Therefore, other instruments are used, such as scales of activities of daily living (ADL). Our goal was to analyze variables influencing the appraisal of ADL. METH...

journal_title：Dementia and geriatric cognitive disorders

authors： Jonas C,Schiffczyk C,Lahmeyer C,Mueller F,Riepe MW

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND/AIMS:A large proportion of patients at memory disorders clinics are classified as having subjective cognitive impairment (SCI). Previous research has investigated whether particular lifestyle factors known to affect cognition can be useful in differentiating patients who do not show objective evidence of mem...

journal_title：Dementia and geriatric cognitive disorders

authors： Andersson C,Marklund K,Walles H,Hagman G,Miley-Akerstedt A

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Omega-3 polyunsaturated fatty acids (PUFA) may affect the risk of cognitive decline in older adults. METHODS:Cross-sectional analysis was conducted among 720 (50.4% women) participants aged 68-92 years (mean age: 77.6, SD ±6.2) of the population-based KORA-Age study. Eicosapentaenoic acid and docosahexaenoi...

journal_title：Dementia and geriatric cognitive disorders

authors： Lukaschek K,von Schacky C,Kruse J,Ladwig KH

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Studies of associations between serum lipids and Alzheimer's disease (AD) or other dementias in the elderly show conflicting results, perhaps due to misclassification of the various dementias. METHODS:For 358 nursing home residents, serum lipids were studied at admission and diagnoses established at autopsy...

journal_title：Dementia and geriatric cognitive disorders

authors： Lesser GT,Haroutunian V,Purohit DP,Schnaider Beeri M,Schmeidler J,Honkanen L,Neufeld R,Libow LS

更新日期：2009-01-01 00:00:00

abstract：:In Switzerland (7 million inhabitants), the organization of health care is in the hand of the cantons and not of the Confederation. The canton of Vaud (600,000 inhabitants), in the south-west part of the country, counts 4 psychiatric sectors, each with a psychogeriatric service. Otherwise the canton has 146 long-stay ...

journal_title：Dementia and geriatric cognitive disorders

authors： Wertheimer J

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the cognitive performance of institutionalized elderly in the city of Natal, state of Rio Grande do Norte, Brazil. METHODS:A descriptive, longitudinal study of 85 aged individuals via an interview conducted following the application of a classification form and the Mini-Mental State Examination (...

journal_title：Dementia and geriatric cognitive disorders

authors： Medeiros de A Nunes V,Alchieri JC,Azevedo LM,Varela de Oliveira KM,Pereira DA

更新日期：2014-01-01 00:00:00

abstract：:Abnormal tau hyperphosphorylation has been suggested as being one of the central events in the development of neurofibrillary tangles, which are one of the characteristic neuropathological lesions found in Alzheimer's disease (AD) brains. 14-3-3 zeta protein is associated with tau in brain and stimulates tau phosphory...

journal_title：Dementia and geriatric cognitive disorders

authors： Mateo I,Sánchez-Juan P,Rodríguez-Rodríguez E,Infante J,Fernández-Viadero C,Peña N,Berciano J,Combarros O

更新日期：2008-01-01 00:00:00