Patterns of cortical thickness according to APOE genotype in Alzheimer's disease.

abstract：BACKGROUND/AIMS:The diagnosis of delirium is not supported by specific biomarkers. In a previous study, high neopterin levels were found in patients with a postoperative delirium. In the present study, we investigated levels of neopterin, interleukin-6 (IL-6) and insulin-like growth factor-1 (IGF-1) in acutely ill admi...

journal_title：Dementia and geriatric cognitive disorders

authors： Egberts A,Wijnbeld EH,Fekkes D,van der Ploeg MA,Ziere G,Hooijkaas H,van der Cammen TJ,Mattace-Raso FU

更新日期：2015-01-01 00:00:00

abstract：:Ten years after the introduction of the first drug, tacrine, in the treatment of Alzheimer's disease, it seems appropriate to re-appraise the pharmacological processes of innovation in the research field of dementia. The aim of this review is to pinpoint concrete improvements achieved in this field, regarding experime...

journal_title：Dementia and geriatric cognitive disorders

authors： Sellal F,Nieoullon A,Michel G,Michel BF,Lacomblez L,Geerts H,Delini Stula A,Bordet R,Bentué-Ferrer D,Allain H

更新日期：2005-01-01 00:00:00

abstract：:The membrane-bound glycoprotein, amyloid precursor protein (APP), plays a central role in Alzheimer's disease (AD). The present paper investigates the neuritogenic-neurotoxic properties of this protein and relates them to possible aetiopathological mechanisms in AD. Marked differences in neuritic differentiation were ...

journal_title：Dementia and geriatric cognitive disorders

authors： Neill D,Hughes D,Leake A,Morris C,Jones D,Oakley A,Edwardson J,Estibeiro P

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to elucidate the relationship between Alzheimer's disease (AD) and the serotonin transporter gene (SLC6A4). METHODS:AD subjects (n = 43) and controls (n = 47) were recruited and evaluated. In leukocytes, we evaluated two polymorphisms in SLC6A4, the serotonin transporter length...

journal_title：Dementia and geriatric cognitive disorders

authors： Yamazaki K,Yoshino Y,Mori T,Okita M,Yoshida T,Mori Y,Ozaki Y,Sao T,Iga J,Ueno S

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of the study was to investigate the association of postoperative delirium with the outcomes of cognitive impairment, functional disability and death. METHODS:Hip surgery patients aged 60 years or over (n = 200) underwent preoperative and daily postoperative assessment of their cognitive status ...

journal_title：Dementia and geriatric cognitive disorders

authors： Bickel H,Gradinger R,Kochs E,Förstl H

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Total plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness, and patients with vascular disease have higher plasma tHcy concentrations than patients without vascular disease. Increasing evidence indicates that vascular risk factors play a role in the development of cogn...

journal_title：Dementia and geriatric cognitive disorders

authors： Nilsson K,Gustafson L,Hultberg B

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:In a previous study, low-frequency (0.5 Hz) cranial electrostimulation (CES) neither improved the rest-activity rhythm nor reduced the level of salivary cortisol in patients with probable Alzheimer's disease (AD). To investigate whether the frequency of CES was responsible for these negative findings, we set ...

journal_title：Dementia and geriatric cognitive disorders

authors： Scherder E,Knol D,van Tol MJ,van Someren E,Deijen JB,Swaab D,Scheltens P

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The assessment of executive function (EF) and activities of daily living (ADL) are important elements in the diagnosis of Alzheimer's disease. METHODS:Following a comprehensive search in three databases, a random-effects meta-analysis was used to investigate the association between ADL ability and seventeen...

journal_title：Dementia and geriatric cognitive disorders

authors： Martyr A,Clare L

更新日期：2012-01-01 00:00:00

abstract：:Delirium is one of the most frequent symptoms of disease in the elderly. A large variation of incidence and prevalence data is reported probably due to different patient populations and inconsistent diagnostic criteria. In medical and surgical elderly inpatients recent studies report a prevalence rate of approximately...

journal_title：Dementia and geriatric cognitive disorders

authors： Bucht G,Gustafson Y,Sandberg O

更新日期：1999-09-01 00:00:00

abstract：:This study examines the associations between education, cerebral perfusion, and cognitive test performance among 132 patients with Alzheimer's disease. The participants had had between 0 and 19 years of formal schooling, and had either mild or moderate dementia according to the Clinical Dementia Rating Scale. Cerebral...

journal_title：Dementia and geriatric cognitive disorders

authors： Liao YC,Liu RS,Teng EL,Lee YC,Wang PN,Lin KN,Chung CP,Liu HC

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Predominant and progressive complex visual disorders are often due to posterior cortical atrophy (PCA), a rare early-onset dementing syndrome presenting with visual complaints. In clinicopathological studies, PCA is most commonly considered a form of Alzheimer's disease (AD); no prior study has evaluated cli...

journal_title：Dementia and geriatric cognitive disorders

authors： Mendez MF,Ghajarania M,Perryman KM

更新日期：2002-01-01 00:00:00

abstract：:We investigated whether an index based on clinical features, electroencephalogram and computed tomography is useful to predict survival in early Alzheimer's disease. One hundred and sixty-three consecutively referred patients to an outpatient memory clinic and first diagnosed with Alzheimer's disease (105 'probable' a...

journal_title：Dementia and geriatric cognitive disorders

authors： Claus JJ,van Gool WA,Teunisse S,Walstra GJ,Kwa VI,Hijdra A,Verbeeten B Jr,Koelman JH,Bour LJ,Ongerboer De Visser BW

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVES:To estimate life expectancy of psychogeriatric patients having participated in a reactivation program. To identify prognostic characteristics - on admission - for survival after discharge. DESIGN:A prospective, clinical-empirical observational study. SETTING:A Dutch psychiatric-skilled nursing home. PARTI...

journal_title：Dementia and geriatric cognitive disorders

authors： Bakker TJ,Duivenvoorden HJ,van der Lee J,Schudel WJ

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND/AIMS:This study aimed to investigate whether the serial position effects in memory can differentiate patients with different subtypes of mild cognitive impairment (MCI) from healthy controls and patients with different stages of Alzheimer's disease (AD). METHODS:The serial position effects was tested with t...

journal_title：Dementia and geriatric cognitive disorders

authors： Moser B,Deisenhammer EA,Marksteiner J,Papousek I,Fink A,Weiss EM

更新日期：2014-01-01 00:00:00

abstract：:To evaluate whether magnetic resonance imaging (MRI) of white matter changes in Alzheimer's disease either under- or overestimates the findings on neuropathology. Postmortem MRI and neuropathological examination were performed on 6 brains from elderly individuals with a postmortem diagnosis of AD. Using a specially de...

journal_title：Dementia and geriatric cognitive disorders

authors： Bronge L,Bogdanovic N,Wahlund LO

更新日期：2002-01-01 00:00:00

abstract：:To test the hypothesis that the cerebral amyloid angiopathy (CAA) of Alzheimer's disease (AD) is quantitatively associated with white matter lesions (WML), the brains of 63 demented patients exhibiting varying degrees of Alzheimer encephalopathy (AE) were examined, along with those of 10 nondemented control cases. The...

journal_title：Dementia and geriatric cognitive disorders

authors： Haglund M,Englund E

更新日期：2002-01-01 00:00:00

abstract：:This intent-to-treat (ITT) analysis was performed to provide a realistic image of the efficacy that could be expected after 26 weeks treatment with a 120-mg dose (40 mg t.i.d.) of EGb 761 (EGb). The data were collected during a 52-week, double-blind, placebo-controlled, fixed dose, parallel-group, multicenter study. P...

journal_title：Dementia and geriatric cognitive disorders

authors： Le Bars PL,Kieser M,Itil KZ

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Our aim was to evaluate and compare the diagnostic properties of 5 screening tests for the diagnosis of mild Alzheimer disease (AD). METHODS:We conducted a prospective and cross-sectional study of 92 patients with mild AD and of 68 healthy controls from our Department of Neurology. The diagnostic properties...

journal_title：Dementia and geriatric cognitive disorders

authors： Matías-Guiu JA,Valles-Salgado M,Rognoni T,Hamre-Gil F,Moreno-Ramos T,Matías-Guiu J

更新日期：2017-01-01 00:00:00

abstract：:Findings in patients with dementia of the Alzheimer type (AD patients) concerning the enactment effect, i.e. reaching a better memory performance after encoding actions by performing them in contrast to encoding them by reading, are ambiguous. In order to get more insight into memory deterioration in patients sufferin...

journal_title：Dementia and geriatric cognitive disorders

authors： Mack W,Eberle C,Frölich L,Knopf M

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Estimations of life expectancies (LE) in health and ill health are important for planning future health care support. This study aimed at quantifying whether an increased LE is accompanied by an increase in the duration of life with dementia (DemLE) in Hong Kong SAR. METHODS:Two parameters from a logistic m...

journal_title：Dementia and geriatric cognitive disorders

authors： Cheung SL,Yip SF,Branch LG,Robine JM

更新日期：2015-01-01 00:00:00

abstract：:There is growing evidence for a role of apoptosis in Alzheimer's disease (AD). Recent findings suggest an increased susceptibility of lymphocytes to apoptosis in AD. To prove the hypothesis of systemic alterations in the apoptotic balance in AD, serum and cerebrospinal fluid levels of soluble CD95, which is known to m...

journal_title：Dementia and geriatric cognitive disorders

authors： Richartz E,Noda S,Schott K,Günthner A,Lewczuk P,Bartels M

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:The study was designed to determine the acceptability, feasibility and validity of measuring quality of life in a representative sample of dementia patients with a generic instrument, the Duke Health Profile. METHOD:The French version of the Duke Health Profile was administered to 148 subjects with a mental ...

journal_title：Dementia and geriatric cognitive disorders

authors： Novella J,Ankri J,Morrone I,Guillemin F,Jolly D,Jochum C,Ploton L,Blanchard F

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND/AIMS:A large proportion of patients at memory disorders clinics are classified as having subjective cognitive impairment (SCI). Previous research has investigated whether particular lifestyle factors known to affect cognition can be useful in differentiating patients who do not show objective evidence of mem...

journal_title：Dementia and geriatric cognitive disorders

authors： Andersson C,Marklund K,Walles H,Hagman G,Miley-Akerstedt A

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Previously, key studies of the risk profile for post-surgical delirium have focused on general medical and non-elective patients, few have examined elective cohorts. Accurate prediction is imperative for clinical trials and prevention strategies. AIMS/HYPOTHESIS:Our hypothesis was that subtle pre-operative ...

journal_title：Dementia and geriatric cognitive disorders

authors： Lowery DP,Wesnes K,Ballard CG

更新日期：2007-01-01 00:00:00

abstract：:Data were derived from the Cochrane Collaboration meta-analyses of the efficacies of ginkgo, donepezil, rivastigmine and galantamine on changes in cognitive function in patients with dementia and, where necessary, were transformed to standardized mean differences. The proportion of patients discontinuing trials was us...

journal_title：Dementia and geriatric cognitive disorders

authors： Kurz A,Van Baelen B

更新日期：2004-01-01 00:00:00

abstract：:In Switzerland (7 million inhabitants), the organization of health care is in the hand of the cantons and not of the Confederation. The canton of Vaud (600,000 inhabitants), in the south-west part of the country, counts 4 psychiatric sectors, each with a psychogeriatric service. Otherwise the canton has 146 long-stay ...

journal_title：Dementia and geriatric cognitive disorders

authors： Wertheimer J

更新日期：1997-03-01 00:00:00

abstract：:This paper reviews the history of the development of the American Psychiatric Association's Diagnostic and Statistical Manual (DSM) using the diagnostic category of delirium as an example. It also attempts to show how clinical practice and experience has molded the current conceptualization of delirium in DSM-IV. The ...

journal_title：Dementia and geriatric cognitive disorders

authors： Tucker GJ

更新日期：1999-09-01 00:00:00

abstract：:In epidemiological, cross-sectional studies, treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) prevented to a large extent the development of Alzheimer's disease (AD), but the results of randomized, placebo-controlled studies, focused on statin therapy in patients with ischemic heart ...

journal_title：Dementia and geriatric cognitive disorders

authors： Algotsson A,Winblad B

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Attention deficits are at the core of the defects in neuropsychological performance which define both dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). Most studies have used separate tasks to test different attention abilities in patients with these diagnoses, precluding the assessment of any in...

journal_title：Dementia and geriatric cognitive disorders

authors： Fuentes LJ,Fernández PJ,Campoy G,Antequera MM,García-Sevilla J,Antúnez C

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND/AIMS:Alzheimer's disease patients commonly suffer from behavioural and psychological symptoms of dementia (BPSD); a genetic component to the development of BPSD has been demonstrated. Genetic risk factors for other psychiatric disorders have been implicated in BPSD; however, this is the first known investiga...

journal_title：Dementia and geriatric cognitive disorders

authors： Pritchard AL,Pritchard CW,Bentham P,Lendon CL

更新日期：2008-01-01 00:00:00