Abstract：
BACKGROUND:Attention deficits are at the core of the defects in neuropsychological performance which define both dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). Most studies have used separate tasks to test different attention abilities in patients with these diagnoses, precluding the assessment of any interaction among the different attention components. METHODS:We used a version of the Attention Network Test in which the alerting, orienting and executive attention networks, along with their interactions, could be assessed with a single task. Three groups of participants were tested: DLB patients (n = 13), AD patients (n = 18) and healthy controls (n = 18). RESULTS:The alerting signal improved orienting attention and increased the conflict effect in the healthy controls, but they had no effect on these networks in the AD patients. The DLB patients only showed preserved orienting and conflict effects when the alerting signal was present, indicating that there was regulation of the orienting and executive attention networks by the alerting signal. CONCLUSIONS:The most important differences among the 3 groups were observed in the attention network interactions, where alerting played a more relevant role in the DLB than in the AD patients. Under alerting states, the DLB patients showed evidence of certain regulation in the orienting and executive attention networks.
journal_name
Dement Geriatr Cogn Disordjournal_title
Dementia and geriatric cognitive disordersauthors
Fuentes LJ,Fernández PJ,Campoy G,Antequera MM,García-Sevilla J,Antúnez Cdoi
10.1159/000275672subject
Has Abstractpub_date
2010-01-01 00:00:00pages
139-45issue
2eissn
1420-8008issn
1421-9824pii
000275672journal_volume
29pub_type
杂志文章abstract：OBJECTIVE:In a previous study, low-frequency (0.5 Hz) cranial electrostimulation (CES) neither improved the rest-activity rhythm nor reduced the level of salivary cortisol in patients with probable Alzheimer's disease (AD). To investigate whether the frequency of CES was responsible for these negative findings, we set ...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1159/000095108
更新日期：2006-01-01 00:00:00
abstract：:We screened for tau gene mutations among 24 Japanese (6 familial and 18 sporadic cases) and 4 Polish patients with frontotemporal dementia (FTD) using PCR-SSCP analysis followed by DNA sequencing. We identified 2 missense mutations in exon 10: N279K and P301L in 2 Japanese patients with familial FTD. Additionally 3 DN...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000051285
更新日期：2001-11-01 00:00:00
abstract：:The Fas antigen (CD95) is a cell surface receptor that mediates cell apoptosis signalling. Recent investigations have shown that Fas-regulated apoptosis was linked to neurodegenerative lesions in the brain of patients with Alzheimer's disease (AD). Here data regarding the association of two polymorphisms of the Fas pr...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000095160
更新日期：2006-01-01 00:00:00
abstract：:We evaluated the sensitivity and specificity of our French version of Addenbrooke's cognitive examination (ACE) to detect dementia in our patient population. One hundred and fifty-eight cases were included in the study. In our patient series, the sensitivity for diagnosing dementia with a Mini-Mental State Examination...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000080965
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:The aim of this study was to explore the relationship between cerebrospinal fluid biomarkers and neuropsychiatric symptoms in people with Alzheimer's disease. Psychosis, agitation, apathy and depression were assessed using standardised measures in 32 patients with mild Alzheimer's disease. METHODS:The level...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000137671
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND/AIM:To estimate the prevalence of Alzheimer's disease (AD) treatment in Aragon (Spain), analyzing differences according to age, gender and health area. METHODS:Retrospective study on AD treatment prevalence of cholinesterase inhibitors and memantine during 2005, using pharmaco-epidemiological data from pres...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000253845
更新日期：2009-01-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章,评审
doi：10.1159/000017181
更新日期：1999-09-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000493094
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND/AIMS:The diagnosis of delirium is not supported by specific biomarkers. In a previous study, high neopterin levels were found in patients with a postoperative delirium. In the present study, we investigated levels of neopterin, interleukin-6 (IL-6) and insulin-like growth factor-1 (IGF-1) in acutely ill admi...
journal_title：Dementia and geriatric cognitive disorders
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章,评审
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章,meta分析
doi：10.1159/000099037
更新日期：2007-01-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000017116
更新日期：1999-03-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000447585
更新日期：2016-01-01 00:00:00
abstract：:Frontotemporal dementia (FTD) and Alzheimer's disease (AD) are two frequent causes of dementia that share both clinical and neuropathological features. Common to both disorders are the neurofibrillary tangles consisting of aggregations of hyperphosphorylated tau protein. Recently, a number of different pathogenic muta...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000077158
更新日期：2004-01-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000480077
更新日期：2017-01-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000095624
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Estimations of life expectancies (LE) in health and ill health are important for planning future health care support. This study aimed at quantifying whether an increased LE is accompanied by an increase in the duration of life with dementia (DemLE) in Hong Kong SAR. METHODS:Two parameters from a logistic m...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000381848
更新日期：2015-01-01 00:00:00
abstract：INTRODUCTION:Gait speed (GS) is a predictor of negative outcomes in older adults and in those in risk to develop cognitive impairment; as such, it has been associated with dementia. Studies in Latin-American older adults showing this association are scarce. This study aimed to evaluate the relationship between GS and d...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000510494
更新日期：2020-11-18 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000295115
更新日期：2010-01-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
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journal_title：Dementia and geriatric cognitive disorders
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000203889
更新日期：2009-01-01 00:00:00
abstract：:Alcoholics often develop personality and behavioural changes, social and personal neglect, confabulation, lack of insight, empathy and emotional control. Such symptoms would increase the risk of engagement in and exposure to acts of violence and criminal activities carrying a risk of physical damage including head tra...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000051271
更新日期：2001-07-01 00:00:00
abstract：:In epidemiological, cross-sectional studies, treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) prevented to a large extent the development of Alzheimer's disease (AD), but the results of randomized, placebo-controlled studies, focused on statin therapy in patients with ischemic heart ...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章,评审
doi：10.1159/000076342
更新日期：2004-01-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000255600
更新日期：2009-01-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000048639
更新日期：2002-01-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 历史文章,杂志文章
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更新日期：1999-09-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000505573
更新日期：2019-01-01 00:00:00
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journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000327358
更新日期：2011-01-01 00:00:00
abstract：:Alzheimer's disease (AD) represents a heterogeneous disorder, and several factors have been associated with its development. The presence of the apolipoprotein E type (APOE) epsilon 4 allele has been proposed as a risk factor for AD, but how it influences the development of the characteristic hallmarks of the disease ...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000106646
更新日期：1997-09-01 00:00:00
