Neuritogenic-neurotoxic effects of membrane-associated forms of amyloid precursor protein.

abstract：OBJECTIVE:To study undiagnosed diseases in older people with and without dementia. DESIGN:Cross-sectional population-based study in Lieto, southwestern Finland. PARTICIPANTS:All the inhabitants aged 64 and more in Lieto. Participation rate was 82% (n = 1,260). MEASUREMENTS:Dementia and its subtypes were diagnosed ac...

journal_title：Dementia and geriatric cognitive disorders

authors： Löppönen MK,Isoaho RE,Räihä IJ,Vahlberg TJ,Loikas SM,Takala TI,Puolijoki H,Irjala KM,Kivelä SL

更新日期：2004-01-01 00:00:00

abstract：:Numerous groups have confirmed that apolipoprotein E allelic variation accounts for a proportion of the genetic risk for late-onset Alzheimer's disease (AD). However, there is a paucity of data on the impact of this locus on the overall risk of dementia (as opposed to AD) in the elderly. Most studies have ascertained ...

journal_title：Dementia and geriatric cognitive disorders

authors： Tysoe C,Galinsky D,Robinson D,Brayne C,Huppert FA,Dening T,Paykel ES,Easton DF,Rubinsztein DC

更新日期：1998-07-01 00:00:00

abstract：:We evaluated the sensitivity and specificity of our French version of Addenbrooke's cognitive examination (ACE) to detect dementia in our patient population. One hundred and fifty-eight cases were included in the study. In our patient series, the sensitivity for diagnosing dementia with a Mini-Mental State Examination...

journal_title：Dementia and geriatric cognitive disorders

authors： Bier JC,Donckels V,Van Eyll E,Claes T,Slama H,Fery P,Vokaer M

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The assessment of executive function (EF) and activities of daily living (ADL) are important elements in the diagnosis of Alzheimer's disease. METHODS:Following a comprehensive search in three databases, a random-effects meta-analysis was used to investigate the association between ADL ability and seventeen...

journal_title：Dementia and geriatric cognitive disorders

authors： Martyr A,Clare L

更新日期：2012-01-01 00:00:00

abstract：AIM:To conduct a prospective analysis of the neuropsychiatric symptoms (NPS) across the three categories of primary progressive aphasia (PPA) and progressive apraxia of speech (PAOS), compare the prevalence and nature of the symptoms, and look at which symptoms could be helpful to better differentiate these PPA and PAO...

journal_title：Dementia and geriatric cognitive disorders

authors： Singh TD,Duffy JR,Strand EA,Machulda MM,Whitwell JL,Josephs KA

更新日期：2015-01-01 00:00:00

abstract：AIM:The aim of this study was standardization and validation of the Mini-Mental State Examination (MMSE) in the general Croatian aging population. METHODS:Three-hundred and forty-four participants underwent the MMSE test, 217 cognitively healthy subjects without neurological and psychiatric disorders and 127 patients ...

journal_title：Dementia and geriatric cognitive disorders

authors： Boban M,Malojčić B,Mimica N,Vuković S,Zrilić I,Hof PR,Simić G

更新日期：2012-01-01 00:00:00

abstract：AIMS:We aimed to establish the prevalence of depression among recently admitted long-term care patients and to examine associations with diagnostic initiatives and treatment as recorded in patients' medical records. MATERIALS AND METHODS:Eighty-eight long-term care patients were included. Depression was diagnosed acco...

journal_title：Dementia and geriatric cognitive disorders

authors： Iden KR,Engedal K,Hjorleifsson S,Ruths S

更新日期：2014-01-01 00:00:00

abstract：AIMS:To perform an item analysis of the Montreal Cognitive Assessment (MoCA) versus the Mini-Mental State Examination (MMSE) in the prediction of cognitive impairment, and to examine the characteristics of different MoCA threshold scores. METHODS:135 subjects enrolled in a longitudinal clinicopathologic study were adm...

journal_title：Dementia and geriatric cognitive disorders

authors： Damian AM,Jacobson SA,Hentz JG,Belden CM,Shill HA,Sabbagh MN,Caviness JN,Adler CH

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Gait speed (GS) is a predictor of negative outcomes in older adults and in those in risk to develop cognitive impairment; as such, it has been associated with dementia. Studies in Latin-American older adults showing this association are scarce. This study aimed to evaluate the relationship between GS and d...

journal_title：Dementia and geriatric cognitive disorders

authors： Garcia-Cifuentes E,Márquez I,Vasquez D,Aguillon D,Borda MG,Lopera F,Cano-Gutierrez C

更新日期：2020-11-18 00:00:00

abstract：BACKGROUND:Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative disorder with a strong genetic background. It has been reported that modifiable factors, i.e. education (E), might act as proxies for reserve capacity. OBJECTIVE:To evaluate the impact of genetic background (positive family history,...

journal_title：Dementia and geriatric cognitive disorders

authors： Premi E,Garibotto V,Alberici A,Paghera B,Giubbini R,Padovani A,Borroni B

更新日期：2012-01-01 00:00:00

abstract：:To evaluate whether magnetic resonance imaging (MRI) of white matter changes in Alzheimer's disease either under- or overestimates the findings on neuropathology. Postmortem MRI and neuropathological examination were performed on 6 brains from elderly individuals with a postmortem diagnosis of AD. Using a specially de...

journal_title：Dementia and geriatric cognitive disorders

authors： Bronge L,Bogdanovic N,Wahlund LO

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of the study was to investigate the association of postoperative delirium with the outcomes of cognitive impairment, functional disability and death. METHODS:Hip surgery patients aged 60 years or over (n = 200) underwent preoperative and daily postoperative assessment of their cognitive status ...

journal_title：Dementia and geriatric cognitive disorders

authors： Bickel H,Gradinger R,Kochs E,Förstl H

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:To describe how dementia assessment could be organized in primary health care and how it works. METHODS:The project had two phases. In phase one 104 elderly patients were assessed by a local authority dementia team that used a standardized examination protocol, which enabled the family doctors to establish ...

journal_title：Dementia and geriatric cognitive disorders

authors： Engedal K,Gausdal M,Gjøra L,Haugen PK

更新日期：2012-01-01 00:00:00

abstract：:This study examines the associations between education, cerebral perfusion, and cognitive test performance among 132 patients with Alzheimer's disease. The participants had had between 0 and 19 years of formal schooling, and had either mild or moderate dementia according to the Clinical Dementia Rating Scale. Cerebral...

journal_title：Dementia and geriatric cognitive disorders

authors： Liao YC,Liu RS,Teng EL,Lee YC,Wang PN,Lin KN,Chung CP,Liu HC

更新日期：2005-01-01 00:00:00

abstract：:We have previously reported that epidermal growth factor receptor (EGFR) was expressed on vascular endothelial cells from postmortem specimens of demented but not cognitively normal subjects. In the present study, we examined skin biopsies from 35 living patients who were either normal or had a clinical diagnosis of p...

journal_title：Dementia and geriatric cognitive disorders

authors： Styren SD,Styren GC,DeKosky ST

更新日期：1998-01-01 00:00:00

abstract：:We compared the intact alpha7 nicotinic acetylcholine receptor (alpha7nAChR) protein levels in the peripheral blood leukocytes in 15 Alzheimer's disease (AD) patients and 13 normal elderly control subjects. Demographic data and Mini-Mental State Examination (MMSE) scores were obtained. Western blot analysis for alpha7...

journal_title：Dementia and geriatric cognitive disorders

authors： Chu LW,Ma ES,Lam KK,Chan MF,Lee DH

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) and frontotemporal dementia (FTD) are two common forms of primary neurodegenerative dementia. Mutations in 3 genes (PSEN1, PSEN2, and APP) have been identified in patients with early-onset AD. METHODS:We performed gene sequencing in PSEN1, PSEN2, and APP in 61 AD and 35 FTD Chinese ...

journal_title：Dementia and geriatric cognitive disorders

authors： Shi Z,Wang Y,Liu S,Liu M,Liu S,Zhou Y,Wang J,Cai L,Huo YR,Gao S,Ji Y

更新日期：2015-01-01 00:00:00

abstract：:In epidemiological, cross-sectional studies, treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) prevented to a large extent the development of Alzheimer's disease (AD), but the results of randomized, placebo-controlled studies, focused on statin therapy in patients with ischemic heart ...

journal_title：Dementia and geriatric cognitive disorders

authors： Algotsson A,Winblad B

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND/AIM:It has been questioned whether cognitive and behavioral scales sufficiently address the impact of dementia on the everyday life of patients. Therefore, other instruments are used, such as scales of activities of daily living (ADL). Our goal was to analyze variables influencing the appraisal of ADL. METH...

journal_title：Dementia and geriatric cognitive disorders

authors： Jonas C,Schiffczyk C,Lahmeyer C,Mueller F,Riepe MW

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cognitive impairment (CI) is frequent after stroke, but data from population-based stroke cohorts on the natural course of CI are limited. The purpose of this study was to determine changes in cognitive status over 3 years after stroke. METHODS:Data were collected from the Erlangen Stroke Projec...

journal_title：Dementia and geriatric cognitive disorders

authors： Liman TG,Heuschmann PU,Endres M,Flöel A,Schwab S,Kolominsky-Rabas PL

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:To estimate life expectancy of psychogeriatric patients having participated in a reactivation program. To identify prognostic characteristics - on admission - for survival after discharge. DESIGN:A prospective, clinical-empirical observational study. SETTING:A Dutch psychiatric-skilled nursing home. PARTI...

journal_title：Dementia and geriatric cognitive disorders

authors： Bakker TJ,Duivenvoorden HJ,van der Lee J,Schudel WJ

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND/AIMS:A large proportion of patients at memory disorders clinics are classified as having subjective cognitive impairment (SCI). Previous research has investigated whether particular lifestyle factors known to affect cognition can be useful in differentiating patients who do not show objective evidence of mem...

journal_title：Dementia and geriatric cognitive disorders

authors： Andersson C,Marklund K,Walles H,Hagman G,Miley-Akerstedt A

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Hypovitaminosis D is associated with executive dysfunction as a whole. The purpose of this cross-sectional study was to determine whether lower vitamin D levels were associated with mental flexibility, information updating, or cognitive and motor inhibition among older adults. METHODS:One hundred Caucasian ...

journal_title：Dementia and geriatric cognitive disorders

authors： Annweiler C,Maby E,Meyerber M,Beauchet O

更新日期：2014-01-01 00:00:00

abstract：:This paper reviews the history of the development of the American Psychiatric Association's Diagnostic and Statistical Manual (DSM) using the diagnostic category of delirium as an example. It also attempts to show how clinical practice and experience has molded the current conceptualization of delirium in DSM-IV. The ...

journal_title：Dementia and geriatric cognitive disorders

authors： Tucker GJ

更新日期：1999-09-01 00:00:00

abstract：:We tested the interobserver reliability of visual rating of HMPAO-SPECT imaging in 271 outpatients referred to a memory clinic, and followed over 1 year. The clinical diagnoses were Alzheimer's disease (n = 156), frontotemporal dementia (n = 47); vascular dementia (n = 21), senile dementia of Lewy body type (n = 12), ...

journal_title：Dementia and geriatric cognitive disorders

authors： Pasquier F,Lavenu I,Lebert F,Jacob B,Steinling M,Petit H

更新日期：1997-03-01 00:00:00

abstract：AIMS:The objective of this study was to investigate the relation between impaired fine motor skills in Parkinson disease (PD) patients and their cognitive status, and to determine whether fine motor skills are more impaired in PD patients with mild cognitive impairment (MCI) than in non-MCI patients. METHODS:Twenty PD...

journal_title：Dementia and geriatric cognitive disorders

authors： Dahdal P,Meyer A,Chaturvedi M,Nowak K,Roesch AD,Fuhr P,Gschwandtner U

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Neuropsychiatric symptoms (NPS) in dementia have received much attention due to their high prevalence and their significant implications. NPS in mild cognitive impairment (MCI), a clinical concept proposed as an intermediate state between normal aging and dementia, is now gradually gaining in interest. We ai...

journal_title：Dementia and geriatric cognitive disorders

authors： Martin E,Velayudhan L

更新日期：2020-01-01 00:00:00

abstract：:The Fas antigen (CD95) is a cell surface receptor that mediates cell apoptosis signalling. Recent investigations have shown that Fas-regulated apoptosis was linked to neurodegenerative lesions in the brain of patients with Alzheimer's disease (AD). Here data regarding the association of two polymorphisms of the Fas pr...

journal_title：Dementia and geriatric cognitive disorders

authors： Chiappelli M,Nasi M,Cossarizza A,Porcellini E,Tumini E,Pinti M,Troiano L,Franceschi M,Licastro F

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND/AIMS:This study aimed to investigate the possible association of regional cerebral perfusion and sleep loss in Alzheimer's disease (AD). METHODS:55 AD patients were characterized as having (SL) or not having (NSL) nocturnal sleep loss based on standard AD scales assessing sleep over the previous 4 weeks. (9...

journal_title：Dementia and geriatric cognitive disorders

authors： Ismail Z,Herrmann N,Francis PL,Rothenburg LS,Lobaugh NJ,Leibovitch FS,Black SE,Lanctôt KL

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Lifestyle and vascular factors have been linked to dementia and Alzheimer's disease (AD), but the role of dietary fats in the development of dementia is less clear. METHODS:Participants were derived from random, population-based samples initially studied in midlife (1972, 1977, 1982, or 1987). Fat intake fr...

journal_title：Dementia and geriatric cognitive disorders

authors： Laitinen MH,Ngandu T,Rovio S,Helkala EL,Uusitalo U,Viitanen M,Nissinen A,Tuomilehto J,Soininen H,Kivipelto M

更新日期：2006-01-01 00:00:00