Comparative Diagnostic Accuracy of the ACE-III, MIS, MMSE, MoCA, and RUDAS for Screening of Alzheimer Disease.

abstract：BACKGROUND:Alzheimer's disease (AD) and frontotemporal dementia (FTD) are two common forms of primary neurodegenerative dementia. Mutations in 3 genes (PSEN1, PSEN2, and APP) have been identified in patients with early-onset AD. METHODS:We performed gene sequencing in PSEN1, PSEN2, and APP in 61 AD and 35 FTD Chinese ...

journal_title：Dementia and geriatric cognitive disorders

authors： Shi Z,Wang Y,Liu S,Liu M,Liu S,Zhou Y,Wang J,Cai L,Huo YR,Gao S,Ji Y

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND/AIMS:The aims of this study were to determine baseline factors related to the progression of subjective memory impairment (SMI) in elderly subjects and to develop a new modeling scale to predict progression. METHODS:Elderly subjects with SMI were recruited from the nationwide Clinical Research Centers for D...

journal_title：Dementia and geriatric cognitive disorders

authors： Hong YJ,Yoon B,Shim YS,Kim SO,Kim HJ,Choi SH,Jeong JH,Yoon SJ,Yang DW,Lee JH

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND/AIMS:The beta amyloid aggregations present in Alzheimer's disease affect neurons through various toxic alterations. The aim of this study was to determine the expression of the vitamin D receptor (VDR), 25-hydroxyvitamin D3 24-hydroxylase (an accelerator of vitamin D catabolism), and the L-type voltage-sensi...

journal_title：Dementia and geriatric cognitive disorders

authors： Dursun E,Gezen-Ak D,Yilmazer S

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The ε4 allele of apolipoprotein E (APOE) is associated with Alzheimer's disease (AD). However, attributable risk due to APOE4 varies by region and by race/ethnicity. METHODS:A literature review and meta-analysis were conducted to estimate the prevalence of APOE4 by geographic area among AD patients. RESULT...

journal_title：Dementia and geriatric cognitive disorders

authors： Crean S,Ward A,Mercaldi CJ,Collins JM,Cook MN,Baker NL,Arrighi HM

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Predominant and progressive complex visual disorders are often due to posterior cortical atrophy (PCA), a rare early-onset dementing syndrome presenting with visual complaints. In clinicopathological studies, PCA is most commonly considered a form of Alzheimer's disease (AD); no prior study has evaluated cli...

journal_title：Dementia and geriatric cognitive disorders

authors： Mendez MF,Ghajarania M,Perryman KM

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to elucidate the relationship between Alzheimer's disease (AD) and the serotonin transporter gene (SLC6A4). METHODS:AD subjects (n = 43) and controls (n = 47) were recruited and evaluated. In leukocytes, we evaluated two polymorphisms in SLC6A4, the serotonin transporter length...

journal_title：Dementia and geriatric cognitive disorders

authors： Yamazaki K,Yoshino Y,Mori T,Okita M,Yoshida T,Mori Y,Ozaki Y,Sao T,Iga J,Ueno S

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:The diagnosis of delirium is not supported by specific biomarkers. In a previous study, high neopterin levels were found in patients with a postoperative delirium. In the present study, we investigated levels of neopterin, interleukin-6 (IL-6) and insulin-like growth factor-1 (IGF-1) in acutely ill admi...

journal_title：Dementia and geriatric cognitive disorders

authors： Egberts A,Wijnbeld EH,Fekkes D,van der Ploeg MA,Ziere G,Hooijkaas H,van der Cammen TJ,Mattace-Raso FU

更新日期：2015-01-01 00:00:00

abstract：:Delirium is one of the most frequent symptoms of disease in the elderly. A large variation of incidence and prevalence data is reported probably due to different patient populations and inconsistent diagnostic criteria. In medical and surgical elderly inpatients recent studies report a prevalence rate of approximately...

journal_title：Dementia and geriatric cognitive disorders

authors： Bucht G,Gustafson Y,Sandberg O

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND/AIMS:To investigate neuroanatomical substrates of unawareness of memory deficits in patients with early Alzheimer's disease (AD). METHODS:We compared regional perfusion deficits between AD patients with awareness (n = 19) and unawareness (n = 19). SPECT data were analyzed by statistical brain imaging method...

journal_title：Dementia and geriatric cognitive disorders

authors： Hanyu H,Sato T,Akai T,Shimizu S,Hirao K,Kanetaka H,Iwamoto T,Koizumi K

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND/AIMS:Healthcare systems face an increased prevalence of Alzheimer's disease and increasing costs. The use of molecular biomarkers and imaging could offer an effective solution for these issues. The objective of this study was to assess amyloid imaging regarding clinical utility and impact. METHODS:A literat...

journal_title：Dementia and geriatric cognitive disorders

authors： Wahlster P,Niederländer C,Kriza C,Schaller S,Kolominsky-Rabas PL

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Memantine is a moderate affinity N-methyl-D-aspartate receptor antagonist approved for treatment of Alzheimer's disease (AD). In AD, tau is abnormally hyperphosphorylated. However, no significant changes of phosphorylated tau levels in CSF are found at follow-up in studies with AD patients. It has been shown...

journal_title：Dementia and geriatric cognitive disorders

authors： Degerman Gunnarsson M,Kilander L,Basun H,Lannfelt L

更新日期：2007-01-01 00:00:00

abstract：AIM:The aim of this study was standardization and validation of the Mini-Mental State Examination (MMSE) in the general Croatian aging population. METHODS:Three-hundred and forty-four participants underwent the MMSE test, 217 cognitively healthy subjects without neurological and psychiatric disorders and 127 patients ...

journal_title：Dementia and geriatric cognitive disorders

authors： Boban M,Malojčić B,Mimica N,Vuković S,Zrilić I,Hof PR,Simić G

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIMS:Existing cognitive measures for moderate-to-severe dementia have shown floor effects and an inability to assess the remaining cognitive function, especially for profound dementia. METHODS:We constructed the Cognitive Test for Severe Dementia (CTSD), which consists of 13 items covering 7 cognitive domai...

journal_title：Dementia and geriatric cognitive disorders

authors： Tanaka H,Nagata Y,Uematsu M,Takebayashi T,Hanada K,Inokawa M,Fukuhara K,Ogawa Y,Haga D,Kakegawa Y,Nishikawa T

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND/AIMS:Elderly patients with dementia have a higher risk of falls and fractures as compared to cognitively intact elderly subjects. To investigate whether psychological distress of the caregiver might predispose older persons with Alzheimer disease (AD) to falls and fractures, we performed a prospective cohort...

journal_title：Dementia and geriatric cognitive disorders

authors： Maggio D,Ercolani S,Andreani S,Ruggiero C,Mariani E,Mangialasche F,Palmari N,Mecocci P

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Studies of associations between serum lipids and Alzheimer's disease (AD) or other dementias in the elderly show conflicting results, perhaps due to misclassification of the various dementias. METHODS:For 358 nursing home residents, serum lipids were studied at admission and diagnoses established at autopsy...

journal_title：Dementia and geriatric cognitive disorders

authors： Lesser GT,Haroutunian V,Purohit DP,Schnaider Beeri M,Schmeidler J,Honkanen L,Neufeld R,Libow LS

更新日期：2009-01-01 00:00:00

abstract：:The identification of the epsilon4 variant of apolipoprotein E as a genetic risk factor for late-onset Alzheimer's disease (AD) suggests that cholesterol may play a direct role in the pathogenesis of the disease. Recent studies have suggested that the ATP-binding cassette (ABC) protein G5 (ABCG5) may be involved in th...

journal_title：Dementia and geriatric cognitive disorders

authors： Ohkubo T,Shibata N,Ohnuma T,Higashi S,Usui C,Ueki A,Nagao M,Arai H

更新日期：2005-01-01 00:00:00

abstract：AIM:To determine the applicability and psychometric properties of the Italian version of the Disability Assessment of Dementia scale (DAD-I) in a community-residing population with early-stage Alzheimer's disease (AD). METHODS:The DAD-I was administered to the primary caregivers of 159 patients (mean age +/- SD 77.1 +...

journal_title：Dementia and geriatric cognitive disorders

authors： De Vreese LP,Caffarra P,Savarè R,Cerutti R,Franceschi M,Grossi E,Multicentre Study Group.

更新日期：2008-01-01 00:00:00

abstract：:We evaluated the sensitivity and specificity of our French version of Addenbrooke's cognitive examination (ACE) to detect dementia in our patient population. One hundred and fifty-eight cases were included in the study. In our patient series, the sensitivity for diagnosing dementia with a Mini-Mental State Examination...

journal_title：Dementia and geriatric cognitive disorders

authors： Bier JC,Donckels V,Van Eyll E,Claes T,Slama H,Fery P,Vokaer M

更新日期：2005-01-01 00:00:00

abstract：:Donepezil HCI is a piperidine-based reversible acetylcholinesterase (AChE) inhibitor, chemically distinct from other cholinesterase (ChE) inhibitors and rationally designed to treat the symptoms of Alzheimer's disease (AD). It is highly selective for AChE in the central nervous system (CNS), with little or no affinity...

journal_title：Dementia and geriatric cognitive disorders

authors： Rogers SL

更新日期：1998-01-01 00:00:00

abstract：UNLABELLED:The concept of the cognitive reserve (CR) hypothesizes that premorbid factors such as education enable compensation for the manifestation of brain pathology. Accordingly, pathology should be more prominent in individuals with higher CR before becoming clinically apparent. Previously, we found that patients s...

journal_title：Dementia and geriatric cognitive disorders

authors： Rolstad S,Nordlund A,Eckerström C,Gustavsson MH,Zetterberg H,Wallin A

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIMS:To explore the presenting and early symptoms of dementia with Lewy bodies (DLB). METHOD:Patients with mild dementia fulfilling diagnostic criteria for DLB (n = 61) and Alzheimer's disease (AD) (n = 109) were recruited from outpatient dementia clinics in western Norway. At diagnosis, caregivers were ask...

journal_title：Dementia and geriatric cognitive disorders

authors： Auning E,Rongve A,Fladby T,Booij J,Hortobágyi T,Siepel FJ,Ballard C,Aarsland D

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:To describe how dementia assessment could be organized in primary health care and how it works. METHODS:The project had two phases. In phase one 104 elderly patients were assessed by a local authority dementia team that used a standardized examination protocol, which enabled the family doctors to establish ...

journal_title：Dementia and geriatric cognitive disorders

authors： Engedal K,Gausdal M,Gjøra L,Haugen PK

更新日期：2012-01-01 00:00:00

abstract：:Although myoclonus commonly occurs in a later stage of Alzheimer's disease (AD), the pathological basis of this symptom is still unclear. In order to elucidate the neuropathological substrate of myoclonus in AD, we quantitatively assessed neuronal density and volume, with a discrimination between small and large neuro...

journal_title：Dementia and geriatric cognitive disorders

authors： Fukutani Y,Cairns NJ,Everall IP,Chadwick A,Isaki K,Lantos PL

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND/AIMS:With an increasing life expectancy, the number of people suffering from dementia globally will rise to about 115.4 million by 2050. It is projected that in the 21st century, the majority of the world's older people will be living in Asia. This paper examines the global issues of family caregiving for ol...

journal_title：Dementia and geriatric cognitive disorders

authors： Chan SW

更新日期：2010-01-01 00:00:00

abstract：:The gene for apolipoprotein E (APOE) is polymorphic, and its variant APOE4 is a major risk factor for the development of Alzheimer-type dementia (AD). Another risk factor for AD appears to be negative cobalamin balance, which is very common in elderly people. Cobalamin and folate are interdependent and essential compo...

journal_title：Dementia and geriatric cognitive disorders

authors： Regland B,Blennow K,Germgård T,Koch-Schmidt AC,Gottfries CG

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Little is known about the differences in patients' behavioral problems and health outcomes of family caregivers of patients with vascular dementia (VaD) and Alzheimer's disease (AD). METHODS:A secondary analysis of baseline data on a subsample of caregiver-dementia patient dyads in a randomized clinical tri...

journal_title：Dementia and geriatric cognitive disorders

authors： Kuo LM,Huang HL,Hsu WC,Shyu YI

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:(1) To investigate the prevalence and characteristics of agitation in patients with Alzheimer's disease (AD) and other forms of dementia; (2) to explore the association between agitation and other clinical variables, including disease severity, functional impairment and other neuropsychiatric symptoms, and (...

journal_title：Dementia and geriatric cognitive disorders

authors： Senanarong V,Cummings JL,Fairbanks L,Mega M,Masterman DM,O'Connor SM,Strickland TL

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Corpus callosum atrophy possibly indicates neuronal degeneration in association cortex in Alzheimer's disease (AD). Water diffusivity allows detecting physiological changes that probably occur earlier than structural shrinkage in cerebral regions during the development of AD. OBJECTIVE:To simultaneously inv...

journal_title：Dementia and geriatric cognitive disorders

authors： Wang H,Su MY

更新日期：2006-01-01 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) receptor dysfunction has been implicated in the pathogenesis of Alzheimer's disease (AD). The NMDA receptor is composed of several subunits, of which the receptor 2b subunit (NR2b) is of particular significance for AD. Abundant in the hippocampus of normal subjects, reductions in NR2b have ...

journal_title：Dementia and geriatric cognitive disorders

authors： Tsai SJ,Liu HC,Liu TY,Cheng CY,Hong CJ

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:It has been reported that nonsteroidal anti-inflammatory drugs may delay the onset of Alzheimer's disease (AD). Since nonsteroidal anti-inflammatory drugs inhibit cyclooxygenase (COX), COX-2, an inducible form of COX, may be involved in the pathology of AD in association with the arachidonic acid cascade. In...

journal_title：Dementia and geriatric cognitive disorders

authors： Fujimi K,Noda K,Sasaki K,Wakisaka Y,Tanizaki Y,Iida M,Kiyohara Y,Kanba S,Iwaki T

更新日期：2007-01-01 00:00:00