Predicting survival in patients with early Alzheimer's disease.

Abstract:

:We investigated whether an index based on clinical features, electroencephalogram and computed tomography is useful to predict survival in early Alzheimer's disease. One hundred and sixty-three consecutively referred patients to an outpatient memory clinic and first diagnosed with Alzheimer's disease (105 'probable' and 58 'possible', NINCDS-ADRDA criteria) were studied and outcome measure was death. Cox proportional hazards regression analysis and Kaplan-Meier survival curves were used to investigate relations between baseline parameters and survival. Eighty-four patients (51. 5%) died during the follow-up period that extended to 5.8 years, with a median duration of survival after entry of 4.3 years. Baseline factors that were statistically significant and independently related to increased risk of mortality were high age, male sex, poor cognitive function as measured with the CAMCOG, low alpha and beta power on electroencephalogram, and temporoparietal atrophy on computed tomography scan. These results were independent of the diagnosis probable or possible Alzheimer's disease. Based on the coefficients from the regression equation, we computed a survival index for each patient and we constructed three groups according to tertiles of this index. After 5.2 years of follow-up, survival curves showed a low mortality group with 81.7% patients alive (median survival at least 5.7 years), an intermediate mortality group with 35.9% patients alive (median survival 3.8 years), and a high mortality group with no patients alive (median survival 2.3 years). Log rank tests were statistically significant for comparisons between all three groups. We conclude that an overall index combining demographic, cognitive, electroencephalogram and computed tomography features is a strong predictor of survival in early Alzheimer's disease.

authors

Claus JJ,van Gool WA,Teunisse S,Walstra GJ,Kwa VI,Hijdra A,Verbeeten B Jr,Koelman JH,Bour LJ,Ongerboer De Visser BW

doi

10.1159/000017073

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

284-93

issue

5

eissn

1420-8008

issn

1421-9824

pii

dem09284

journal_volume

9

pub_type

杂志文章
  • Subtle attentional deficits in the absence of dementia are associated with an increased risk of post-operative delirium.

    abstract:BACKGROUND:Previously, key studies of the risk profile for post-surgical delirium have focused on general medical and non-elective patients, few have examined elective cohorts. Accurate prediction is imperative for clinical trials and prevention strategies. AIMS/HYPOTHESIS:Our hypothesis was that subtle pre-operative ...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000101453

    authors: Lowery DP,Wesnes K,Ballard CG

    更新日期:2007-01-01 00:00:00

  • The k variant of the butyrylcholinesterase gene is associated with reduced phosphorylation of tau in dementia patients.

    abstract::Accumulating evidence suggests that butyrylcholinesterase (BuChE) plays an important role in the progression of cognitive deficits and Alzheimer-type pathology in dementia patients. We examined the relationship between the K variant of BuChE and the severity of deposits of amyloid (Abeta(1-42)) and phosphorylated tau ...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000084705

    authors: Ballard C,Morris C,Kalaria R,McKeith I,Perry R,Perry E

    更新日期:2005-01-01 00:00:00

  • Fate of patients with questionable (very mild) Alzheimer's disease: longitudinal profiles of individual subjects' decline.

    abstract::Currently used criteria for the diagnosis of probable Alzheimer's disease requires the presence of cognitive deficit in addition to loss of episodic memory. The recent developments in drug treatments for Alzheimer's disease have highlighted the importance of early diagnosis and the need to characterise the cognitive p...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 临床试验,杂志文章

    doi:10.1159/000017264

    authors: Perry RJ,Hodges JR

    更新日期:2000-11-01 00:00:00

  • White Matter Changes and Cognitive Decline in a Ten-Year Follow-Up Period: A Pilot Study on a Single-Center Cohort from the Leukoaraiosis and Disability Study.

    abstract:AIMS:To describe the contribution of white matter lesions to the long-term neuropsychological profiles of different groups of clinical diagnoses, and to identify neuropsychological predictors of cognitive impairment in a 10-year follow-up. METHODS:The Lisbon subcohort of the Leukoaraiosis and Disability (LADIS) study ...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000447121

    authors: Madureira S,Verdelho A,Moleiro C,Santos C,Scheltens P,Gouw A,Ferro J

    更新日期:2016-01-01 00:00:00

  • Neuropsychiatric correlates of cerebrospinal fluid biomarkers in Alzheimer's disease.

    abstract:BACKGROUND:The aim of this study was to explore the relationship between cerebrospinal fluid biomarkers and neuropsychiatric symptoms in people with Alzheimer's disease. Psychosis, agitation, apathy and depression were assessed using standardised measures in 32 patients with mild Alzheimer's disease. METHODS:The level...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000137671

    authors: Skogseth R,Mulugeta E,Jones E,Ballard C,Rongve A,Nore S,Alves G,Aarsland D

    更新日期:2008-01-01 00:00:00

  • The tau R406W mutation causes progressive presenile dementia with bitemporal atrophy.

    abstract::Frontotemporal dementia (FTD) and Alzheimer's disease (AD) are two frequent causes of dementia that share both clinical and neuropathological features. Common to both disorders are the neurofibrillary tangles consisting of aggregations of hyperphosphorylated tau protein. Recently, a number of different pathogenic muta...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000077158

    authors: Ostojic J,Elfgren C,Passant U,Nilsson K,Gustafson L,Lannfelt L,Froelich Fabre S

    更新日期:2004-01-01 00:00:00

  • Postoperative Treatment of Pain after Hip Fracture in Elderly Patients with Dementia.

    abstract:BACKGROUND/AIMS:Prior studies have shown that patients with dementia are at risk of receiving insufficient treatment for pain after a hip fracture. We therefore hypothesized that elderly hip fracture patients with dementia received less postoperative pain treatment than those without dementia. METHOD:All patients (age...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000444704

    authors: Jensen-Dahm C,Palm H,Gasse C,Dahl JB,Waldemar G

    更新日期:2016-01-01 00:00:00

  • Interaction of the H63D mutation in the hemochromatosis gene with the apolipoprotein E epsilon 4 allele modulates age at onset of Alzheimer's disease.

    abstract::The H63D mutation in the hemochromatosis gene (HFE) has recently been considered as a risk factor in Alzheimer's disease (AD) with advancing age at onset of the disease, independently of the apolipoprotein E (ApoE) epsilon4 allele effect. We examined the distribution of the H63D mutation and ApoE genotypes as a functi...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000068480

    authors: Combarros O,García-Román M,Fontalba A,Fernández-Luna JL,Llorca J,Infante J,Berciano J

    更新日期:2003-01-01 00:00:00

  • Influence of insulin-like growth factor-1 and hepatocyte growth factor on carotid atherosclerosis and cognitive function in the elderly.

    abstract:OBJECTIVE:This study investigated the relationship between serum levels of two neurotrophic factors, insulin-like growth factor-1 (IGF-1) and hepatocyte growth factor (HGF), and carotid atherosclerosis and cognitive function in the elderly. METHODS:Serum levels of IGF-1 and HGF, carotid artery intima-media thickness (...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 临床试验,杂志文章

    doi:10.1159/000077812

    authors: Watanabe T,Yamamoto H,Idei T,Iguchi T,Katagiri T

    更新日期:2004-01-01 00:00:00

  • Memory impairment, in mild cognitive impairment without significant cerebrovascular disease, predicts progression to Alzheimer's disease.

    abstract:AIMS:Mild cognitive impairment (MCI) usually represents a transitional phase between normal cognitive function and dementia, but not all people with MCI develop dementia because MCI is a clinically and etiologically heterogeneous grouping. The aim of this study was to compare progression rates to Alzheimer's disease (A...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000339159

    authors: Lee YM,Park JM,Lee BD,Moon E,Chung YI,Kang CJ

    更新日期:2012-01-01 00:00:00

  • A SPECT study of sleep disturbance and Alzheimer's disease.

    abstract:BACKGROUND/AIMS:This study aimed to investigate the possible association of regional cerebral perfusion and sleep loss in Alzheimer's disease (AD). METHODS:55 AD patients were characterized as having (SL) or not having (NSL) nocturnal sleep loss based on standard AD scales assessing sleep over the previous 4 weeks. (9...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000203889

    authors: Ismail Z,Herrmann N,Francis PL,Rothenburg LS,Lobaugh NJ,Leibovitch FS,Black SE,Lanctôt KL

    更新日期:2009-01-01 00:00:00

  • Different atrophic patterns in early- and late-onset Alzheimer's disease and evaluation of clinical utility of a method of regional z-score analysis using voxel-based morphometry.

    abstract:BACKGROUND/AIMS:We evaluated the differential patterns of brain atrophy in early- and late-onset Alzheimer's disease (AD) by measuring regional z-scores of voxel-based morphometry and assessed the availability of the method for clinical use. METHODS:The first 50 patients with probable AD were compared to 83 age-matche...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000151241

    authors: Shiino A,Watanabe T,Kitagawa T,Kotani E,Takahashi J,Morikawa S,Akiguchi I

    更新日期:2008-01-01 00:00:00

  • Lower Cognitive Function in Older Patients with Lower Muscle Strength and Muscle Mass.

    abstract:BACKGROUND:Low muscle strength and muscle mass are associated with adverse outcomes in older hospitalized patients. The aim of this study was to assess the association between cognitive functioning and muscle strength and muscle mass in hospitalized older patients. METHODS:This prospective inception cohort included 37...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000486711

    authors: van Dam R,Van Ancum JM,Verlaan S,Scheerman K,Meskers CGM,Maier AB

    更新日期:2018-01-01 00:00:00

  • Undiagnosed diseases in patients with dementia--a potential target group for intervention.

    abstract:OBJECTIVE:To study undiagnosed diseases in older people with and without dementia. DESIGN:Cross-sectional population-based study in Lieto, southwestern Finland. PARTICIPANTS:All the inhabitants aged 64 and more in Lieto. Participation rate was 82% (n = 1,260). MEASUREMENTS:Dementia and its subtypes were diagnosed ac...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000080126

    authors: Löppönen MK,Isoaho RE,Räihä IJ,Vahlberg TJ,Loikas SM,Takala TI,Puolijoki H,Irjala KM,Kivelä SL

    更新日期:2004-01-01 00:00:00

  • Cerebrospinal Fluid Biomarker-Based Diagnosis of Sporadic Creutzfeldt-Jakob Disease: A Validation Study for Previously Established Cutoffs.

    abstract:BACKGROUND:Several biomarkers have been proposed to discriminate sporadic Creutzfeldt-Jakob disease (sCJD) from other dementias and control cases. However, their clinical accuracy depends on the PRNP codon 129 genotype, leaving it unclear how well established markers behave in untested conditions. METHODS:We analyzed ...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000454802

    authors: Llorens F,Karch A,Golanska E,Schmitz M,Lange P,Sikorska B,Liberski PP,Zerr I

    更新日期:2017-01-01 00:00:00

  • Lack of genetic associations of alpha-1-antichymotrypsin polymorphism with alzheimer-type neuropathological changes or sporadic Alzheimer's disease.

    abstract::To elucidate the influence of the alpha1-antichymotrypsin (ACT) polymorphism on Alzheimer-type neuropathological changes and the development of sporadic Alzheimer's disease (AD), we studied the relationship between the ACT polymorphism and the severity of Alzheimer-type neuropathological changes in the brains from AD ...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000017123

    authors: Sodeyama N,Yamada M,Itoh Y,Suematsu N,Matsushita M,Otomo E,Mizusawa H

    更新日期:1999-05-01 00:00:00

  • Cognitive reserve in relation to abeta42 in patients converting from MCI to dementia - a follow-up report.

    abstract:UNLABELLED:The concept of the cognitive reserve (CR) hypothesizes that premorbid factors such as education enable compensation for the manifestation of brain pathology. Accordingly, pathology should be more prominent in individuals with higher CR before becoming clinically apparent. Previously, we found that patients s...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000234912

    authors: Rolstad S,Nordlund A,Eckerström C,Gustavsson MH,Zetterberg H,Wallin A

    更新日期:2009-01-01 00:00:00

  • Psychogeriatric organization in the medico-social network: the experience of the canton of Vaud, Switzerland.

    abstract::In Switzerland (7 million inhabitants), the organization of health care is in the hand of the cantons and not of the Confederation. The canton of Vaud (600,000 inhabitants), in the south-west part of the country, counts 4 psychiatric sectors, each with a psychogeriatric service. Otherwise the canton has 146 long-stay ...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000106621

    authors: Wertheimer J

    更新日期:1997-03-01 00:00:00

  • Regional cerebral blood flow and prognostic evaluation in Alzheimer's disease.

    abstract::The present investigation reports the application of regional cerebral blood flow (rCBF; (133)Xe method) to prognostic purposes in a consecutive series of 76 patients (mean age 68.4 +/- 8.7 years) with probable Alzheimer's disease (AD; NINCDS-ADRDA criteria). The likelihood that rCBF from a posterior temporal-inferior...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000051241

    authors: Nobili F,Copello F,Buffoni F,Vitali P,Girtler N,Bordoni C,Safaie-Semnani E,Mariani G,Rodriguez G

    更新日期:2001-03-01 00:00:00

  • Patients with Alzheimer's disease may be particularly susceptible to adverse effects of statins.

    abstract::In epidemiological, cross-sectional studies, treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) prevented to a large extent the development of Alzheimer's disease (AD), but the results of randomized, placebo-controlled studies, focused on statin therapy in patients with ischemic heart ...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章,评审

    doi:10.1159/000076342

    authors: Algotsson A,Winblad B

    更新日期:2004-01-01 00:00:00

  • Cerebrospinal fluid phospho-tau, total tau and beta-amyloid(1-42) in the differentiation between Alzheimer's disease and vascular dementia.

    abstract::The two most frequently examined biomarkers in the diagnosis of dementia are cerebrospinal fluid (CSF) tau and beta-amyloid(1-42) (Abeta(1-42)). An assay for tau phosphorylated at threonine 181 (phospho-tau) has recently been developed. We studied these three markers in patients with possible Alzheimer's disease (AD; ...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000066023

    authors: Nägga K,Gottfries J,Blennow K,Marcusson J

    更新日期:2002-01-01 00:00:00

  • Diabetes, but Not Hypertension and Obesity, Is Associated with Postoperative Cognitive Dysfunction.

    abstract:BACKGROUND/AIMS:Older people undergoing surgery are at risk of developing postoperative cognitive dysfunction (POCD), but little is known of risk factors predisposing patients to POCD. Our objective was to estimate the risk of POCD associated with exposure to preoperative diabetes, hypertension, and obesity. METHODS:O...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000492962

    authors: Lachmann G,Feinkohl I,Borchers F,Ottens TH,Nathoe HM,Sauer AM,Dieleman JM,Radtke FM,van Dijk D,Spies C,Pischon T

    更新日期:2018-01-01 00:00:00

  • Neuroanatomy of apathy and disinhibition in frontotemporal lobar degeneration.

    abstract:OBJECTIVE:To investigate the neural basis for the behavioral symptoms of frontotemporal lobar degeneration (FTLD) that cause the greatest caregiver distress. BACKGROUND:FTLD is a progressive neurodegenerative disease associated with behavioral disturbances. Group studies have related these behaviors to volume loss on ...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000194658

    authors: Massimo L,Powers C,Moore P,Vesely L,Avants B,Gee J,Libon DJ,Grossman M

    更新日期:2009-01-01 00:00:00

  • Postmortem MRI and histopathology of white matter changes in Alzheimer brains. A quantitative, comparative study.

    abstract::To evaluate whether magnetic resonance imaging (MRI) of white matter changes in Alzheimer's disease either under- or overestimates the findings on neuropathology. Postmortem MRI and neuropathological examination were performed on 6 brains from elderly individuals with a postmortem diagnosis of AD. Using a specially de...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000057698

    authors: Bronge L,Bogdanovic N,Wahlund LO

    更新日期:2002-01-01 00:00:00

  • Galantamine versus risperidone for agitation in people with dementia: a randomized, twelve-week, single-center study.

    abstract:AIMS:To examine the effects of galantamine and risperidone on agitation in patients with dementia. METHODS:A total of 100 patients with dementia and neuropsychiatric symptoms (mean age ± SD: 78.6 ± 7.5 years; 67% female) were included in this 12-week, randomized, parallel-group, controlled, single-center trial. The pa...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000362204

    authors: Freund-Levi Y,Bloniecki V,Auestad B,Tysen Bäckström AC,Lärksäter M,Aarsland D

    更新日期:2014-01-01 00:00:00

  • Clinical and neuroimaging correlates of mild cognitive impairment in a middle-aged community sample: the personality and total health through life 60+ study.

    abstract::This cross-sectional study aimed at determining the clinical and structural brain magnetic resonance imaging correlates of mild cognitive impairment (MCI). The data presented here are from the first wave of the longitudinal Personality and Total Health through Life 60+ project. 2,551 community-dwelling individuals in ...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000089251

    authors: Kumar R,Parslow RA,Jorm AF,Rosenman SJ,Maller J,Meslin C,Anstey KJ,Christensen H,Sachdev PS

    更新日期:2006-01-01 00:00:00

  • Reduction of phosphorylated tau during memantine treatment of Alzheimer's disease.

    abstract:BACKGROUND:Memantine is a moderate affinity N-methyl-D-aspartate receptor antagonist approved for treatment of Alzheimer's disease (AD). In AD, tau is abnormally hyperphosphorylated. However, no significant changes of phosphorylated tau levels in CSF are found at follow-up in studies with AD patients. It has been shown...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000107099

    authors: Degerman Gunnarsson M,Kilander L,Basun H,Lannfelt L

    更新日期:2007-01-01 00:00:00

  • Linkage analysis of autopsy-confirmed familial Alzheimer disease supports an Alzheimer disease locus in 8q24.

    abstract:BACKGROUND/AIMS:We have previously reported the results of an extended genome-wide scan of Swedish Alzheimer disease (AD)-affected families; in this paper, we analyzed a subset of these families with autopsy-confirmed AD. METHODS:We report the fine-mapping, using both microsatellite markers and single-nucleotide polym...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000323808

    authors: Sillén A,Brohede J,Forsell C,Lilius L,Andrade J,Odeberg J,Kimura T,Winblad B,Graff C

    更新日期:2011-01-01 00:00:00

  • The Role of Gait Speed in Dementia: A Secondary Analysis from the SABE Colombia Study.

    abstract:INTRODUCTION:Gait speed (GS) is a predictor of negative outcomes in older adults and in those in risk to develop cognitive impairment; as such, it has been associated with dementia. Studies in Latin-American older adults showing this association are scarce. This study aimed to evaluate the relationship between GS and d...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000510494

    authors: Garcia-Cifuentes E,Márquez I,Vasquez D,Aguillon D,Borda MG,Lopera F,Cano-Gutierrez C

    更新日期:2020-11-18 00:00:00

  • Cognitive assessment in elderly residents of long-stay institutions.

    abstract:OBJECTIVE:To evaluate the cognitive performance of institutionalized elderly in the city of Natal, state of Rio Grande do Norte, Brazil. METHODS:A descriptive, longitudinal study of 85 aged individuals via an interview conducted following the application of a classification form and the Mini-Mental State Examination (...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000348348

    authors: Medeiros de A Nunes V,Alchieri JC,Azevedo LM,Varela de Oliveira KM,Pereira DA

    更新日期:2014-01-01 00:00:00