Increased serum levels of CD95 in Alzheimer's disease.

abstract：AIMS:To perform an item analysis of the Montreal Cognitive Assessment (MoCA) versus the Mini-Mental State Examination (MMSE) in the prediction of cognitive impairment, and to examine the characteristics of different MoCA threshold scores. METHODS:135 subjects enrolled in a longitudinal clinicopathologic study were adm...

journal_title：Dementia and geriatric cognitive disorders

authors： Damian AM,Jacobson SA,Hentz JG,Belden CM,Shill HA,Sabbagh MN,Caviness JN,Adler CH

更新日期：2011-01-01 00:00:00

abstract：:A correlation between a 5-nucleotide deletion polymorphism in the A2M gene and an enhanced risk of developing Alzheimer's disease (AD) was reported. We studied this polymorphism in sporadic AD patients and patients with frontotemporal dementia (FTD) by using an electrophoretical separation of PCR products on a Metapho...

journal_title：Dementia and geriatric cognitive disorders

authors： Nicosia F,Alberici A,Benussi L,Gasparini L,Ghidoni R,Mazzoli F,Zanetti O,Frisoni GB,Geroldi C,Binetti G

更新日期：2001-09-01 00:00:00

abstract：:To evaluate whether magnetic resonance imaging (MRI) of white matter changes in Alzheimer's disease either under- or overestimates the findings on neuropathology. Postmortem MRI and neuropathological examination were performed on 6 brains from elderly individuals with a postmortem diagnosis of AD. Using a specially de...

journal_title：Dementia and geriatric cognitive disorders

authors： Bronge L,Bogdanovic N,Wahlund LO

更新日期：2002-01-01 00:00:00

abstract：:We tested the interobserver reliability of visual rating of HMPAO-SPECT imaging in 271 outpatients referred to a memory clinic, and followed over 1 year. The clinical diagnoses were Alzheimer's disease (n = 156), frontotemporal dementia (n = 47); vascular dementia (n = 21), senile dementia of Lewy body type (n = 12), ...

journal_title：Dementia and geriatric cognitive disorders

authors： Pasquier F,Lavenu I,Lebert F,Jacob B,Steinling M,Petit H

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND/AIMS:Although some patients with primary progressive aphasia (PPA) exhibit novel or improved skills after the onset of dementia, these changes have yet to be quantified. Therefore, this study systematically explored and identified the emergence of positive behaviours after dementia onset. METHODS:This study...

journal_title：Dementia and geriatric cognitive disorders

authors： Midorikawa A,Kumfor F,Leyton CE,Foxe D,Landin-Romero R,Hodges JR,Piguet O

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The Clinical Dementia Rating Scale (CDR) is used to rate dementia severity. Its utility in diagnosing mild cognitive impairment (MCI) and its predictive value remain unknown. AIMS:The aim of this study was to examine the association between CDR scores and expert MCI diagnosis, and to determine whether basel...

journal_title：Dementia and geriatric cognitive disorders

authors： Woolf C,Slavin MJ,Draper B,Thomassen F,Kochan NA,Reppermund S,Crawford JD,Trollor JN,Brodaty H,Sachdev PS

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Corpus callosum atrophy possibly indicates neuronal degeneration in association cortex in Alzheimer's disease (AD). Water diffusivity allows detecting physiological changes that probably occur earlier than structural shrinkage in cerebral regions during the development of AD. OBJECTIVE:To simultaneously inv...

journal_title：Dementia and geriatric cognitive disorders

authors： Wang H,Su MY

更新日期：2006-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is generally understood as primarily affecting cognition while sparing motor function, at least until the later stages of the disease. Studies reported over the past 10 years, however, have documented a prevalence of falls in AD patients significantly higher than in age-matched normal elders; ...

journal_title：Dementia and geriatric cognitive disorders

authors： Sheridan PL,Hausdorff JM

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between quantitative EEG (qEEG) measurements in frontotemporal dementia (FTD), Alzheimer's disease (AD) and healthy controls and to study to what extent qEEG in FTD and AD or neuropsychological test results of FTD and AD patients or a combination of both contribute to classific...

journal_title：Dementia and geriatric cognitive disorders

authors： Lindau M,Jelic V,Johansson SE,Andersen C,Wahlund LO,Almkvist O

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND/AIMS:We investigated the histopathological correlates of white matter hyperintensities (WMHs) in participants with Alzheimer's disease (AD) or cerebrovascular disease, and in aged controls. METHODS:We reviewed 57 participants who had neuropathology and in whom neuroimaging was done. In addition to AD pathol...

journal_title：Dementia and geriatric cognitive disorders

authors： Shim YS,Yang DW,Roe CM,Coats MA,Benzinger TL,Xiong C,Galvin JE,Cairns NJ,Morris JC

更新日期：2015-01-01 00:00:00

abstract：AIMS:We aimed to establish the prevalence of depression among recently admitted long-term care patients and to examine associations with diagnostic initiatives and treatment as recorded in patients' medical records. MATERIALS AND METHODS:Eighty-eight long-term care patients were included. Depression was diagnosed acco...

journal_title：Dementia and geriatric cognitive disorders

authors： Iden KR,Engedal K,Hjorleifsson S,Ruths S

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIM:To investigate the influence of established genetic risk factors for Alzheimer's disease on the speed of disease progression. METHODS:Polymorphisms (in ACE, ApoE, BIN1, CLU, CR1, CST3, EXOC3L2, GWA14q32.13, IL8, LDLR, PICALM, TNK1) of 40 Alzheimer's disease patients from a longitudinal study were analyz...

journal_title：Dementia and geriatric cognitive disorders

authors： Schmidt C,Wolff M,von Ahsen N,Zerr I

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIMS:Catechol-O-methyltransferase, encoded by the COMT gene, is one of the enzymes that degrade dopamine. The aim of this study was to investigate whether polymorphisms in the COMT gene were associated with delirium. METHODS:Patients aged 65 years and older, acutely admitted to the medical department or to ...

journal_title：Dementia and geriatric cognitive disorders

authors： van Munster BC,Baas F,Tanck MW,de Rooij SE

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Midlife hypertension followed by late life hypotension resulting from neurodegeneration increases amyloidogenesis and tauopathy. METHODS:Consecutive outpatients with late-onset Alzheimer's disease (AD) at various stages and their respective caregivers were assessed for score variations in 1 year of tests as...

journal_title：Dementia and geriatric cognitive disorders

authors： de Oliveira FF,Chen ES,Smith MC,Bertolucci PH

更新日期：2016-01-01 00:00:00

abstract：AIM:The aims of the present study were to report on the psychometric properties of the Pain Assessment in Advanced Dementia (PAINAD) scale by comparing it with the gold standard method of self-reporting on a numerical rating scale (NRS), and to provide a categorical version of the PAINAD scale comparable with the verba...

journal_title：Dementia and geriatric cognitive disorders

authors： Mosele M,Inelmen EM,Toffanello ED,Girardi A,Coin A,Sergi G,Manzato E

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIMS:The frontal assessment battery (FAB) is reported to be a useful tool for screening frontal function. However, the neural substrates involved remain to be elucidated. The aim of the present study was to identify the brain regions responsible for FAB performance in patients with early dementia. We sought ...

journal_title：Dementia and geriatric cognitive disorders

authors： Yoshida H,Terada S,Sato S,Kishimoto Y,Ata T,Ohshima E,Honda H,Ishihara T,Kuroda S

更新日期：2009-01-01 00:00:00

abstract：:Delirium is one of the most frequent symptoms of disease in the elderly. A large variation of incidence and prevalence data is reported probably due to different patient populations and inconsistent diagnostic criteria. In medical and surgical elderly inpatients recent studies report a prevalence rate of approximately...

journal_title：Dementia and geriatric cognitive disorders

authors： Bucht G,Gustafson Y,Sandberg O

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Studies of associations between serum lipids and Alzheimer's disease (AD) or other dementias in the elderly show conflicting results, perhaps due to misclassification of the various dementias. METHODS:For 358 nursing home residents, serum lipids were studied at admission and diagnoses established at autopsy...

journal_title：Dementia and geriatric cognitive disorders

authors： Lesser GT,Haroutunian V,Purohit DP,Schnaider Beeri M,Schmeidler J,Honkanen L,Neufeld R,Libow LS

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIMS:We examined the potential impact of vascular risk factors including copeptin - a robust surrogate marker of arginine vasopressin associated with the metabolic syndrome and diabetes risk - on future cognitive abilities in a population-based cohort. METHODS:Participants (n = 933) were investigated using ...

journal_title：Dementia and geriatric cognitive disorders

authors： Tufvesson E,Melander O,Minthon L,Persson M,Nilsson PM,Struck J,Nägga K

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND/AIM:The objective was to examine cohort changes in cognitive function in 2 cohorts of centenarians born 10 years apart. METHODS:The Longitudinal Study of Danish Centenarians comprises all Danes reaching the age of 100 in the period April 1, 1995 through May 31, 1996. A total of 207 out of 276 persons partic...

journal_title：Dementia and geriatric cognitive disorders

authors： Engberg H,Christensen K,Andersen-Ranberg K,Jeune B

更新日期：2008-01-01 00:00:00

abstract：:We assessed the role of the APOE genotype and prion protein polymorphism at codon 129 in predicting the clinical duration of 92 neuropathologically confirmed sporadic Alzheimer's disease patients. Analyses of survival showed that the absence of the APOE epsilon 4 allele in heterozygous codon 129 PRNP carriers is a neg...

journal_title：Dementia and geriatric cognitive disorders

authors： Giannattasio C,Poleggi A,Puopolo M,Pocchiari M,Antuono P,Dal Forno G,Wekstein DR,Matera MG,Seripa D,Acciarri A,Bizzarro A,Lauria A,Masullo C

更新日期：2008-01-01 00:00:00

abstract：:Alzheimer's disease (AD) represents a heterogeneous disorder, and several factors have been associated with its development. The presence of the apolipoprotein E type (APOE) epsilon 4 allele has been proposed as a risk factor for AD, but how it influences the development of the characteristic hallmarks of the disease ...

journal_title：Dementia and geriatric cognitive disorders

authors： Mukaetova-Ladinska EB,Harrington CR,Roth M,Wischik CM

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND/AIMS:Elderly patients with dementia have a higher risk of falls and fractures as compared to cognitively intact elderly subjects. To investigate whether psychological distress of the caregiver might predispose older persons with Alzheimer disease (AD) to falls and fractures, we performed a prospective cohort...

journal_title：Dementia and geriatric cognitive disorders

authors： Maggio D,Ercolani S,Andreani S,Ruggiero C,Mariani E,Mangialasche F,Palmari N,Mecocci P

更新日期：2010-01-01 00:00:00

abstract：:Currently used criteria for the diagnosis of probable Alzheimer's disease requires the presence of cognitive deficit in addition to loss of episodic memory. The recent developments in drug treatments for Alzheimer's disease have highlighted the importance of early diagnosis and the need to characterise the cognitive p...

journal_title：Dementia and geriatric cognitive disorders

authors： Perry RJ,Hodges JR

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND/AIMS:Verbal fluency patterns can assist in differential diagnosis during neuropsychological assessment and identify individuals at risk for developing Alzheimer's disease (AD). While evidence suggests that subjects with AD perform worse on category fluency than letter fluency tasks, the pattern in mild cogni...

journal_title：Dementia and geriatric cognitive disorders

authors： Rinehardt E,Eichstaedt K,Schinka JA,Loewenstein DA,Mattingly M,Fils J,Duara R,Schoenberg MR

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:The logopenic variant of primary progressive aphasia (lvPPA) is characterized by impaired word-finding and sentence repetition with phonologic errors but spared motor speech and grammar and semantic knowledge. Although its language deficits have been well studied, the full spectrum of cognitive changes ...

journal_title：Dementia and geriatric cognitive disorders

authors： Montreuil S,Poulin E,Bergeron D,Sellami L,Verret L,Fortin MP,Poulin S,Macoir J,Hudon C,Bouchard RW,Lavoie M,Laforce R

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The ε4 allele of apolipoprotein E (APOE) is associated with Alzheimer's disease (AD). However, attributable risk due to APOE4 varies by region and by race/ethnicity. METHODS:A literature review and meta-analysis were conducted to estimate the prevalence of APOE4 by geographic area among AD patients. RESULT...

journal_title：Dementia and geriatric cognitive disorders

authors： Crean S,Ward A,Mercaldi CJ,Collins JM,Cook MN,Baker NL,Arrighi HM

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the decline in specific neuropsychological functions in nondemented Parkinson's disease (PD) patients with a history of visual hallucinations (VH). METHODS:Twenty PD patients with VH, 20 PD patients without VH and 18 normal controls were followed up over a 1-year period and assessed for cognitive...

journal_title：Dementia and geriatric cognitive disorders

authors： Ramirez-Ruiz B,Junque C,Marti MJ,Valldeoriola F,Tolosa E

更新日期：2007-01-01 00:00:00

abstract：:The present investigation reports the application of regional cerebral blood flow (rCBF; (133)Xe method) to prognostic purposes in a consecutive series of 76 patients (mean age 68.4 +/- 8.7 years) with probable Alzheimer's disease (AD; NINCDS-ADRDA criteria). The likelihood that rCBF from a posterior temporal-inferior...

journal_title：Dementia and geriatric cognitive disorders

authors： Nobili F,Copello F,Buffoni F,Vitali P,Girtler N,Bordoni C,Safaie-Semnani E,Mariani G,Rodriguez G

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND/AIMS:Increased cerebrospinal fluid (CSF) tau, decreased CSF amyloid-beta42 (Abeta42) and the apolipoprotein E gene (APOE) epsilon4 allele predict progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD). Here, we investigated these markers to assess their predictive value and influence on...

journal_title：Dementia and geriatric cognitive disorders

authors： Blom ES,Giedraitis V,Zetterberg H,Fukumoto H,Blennow K,Hyman BT,Irizarry MC,Wahlund LO,Lannfelt L,Ingelsson M

更新日期：2009-01-01 00:00:00