Apolipoprotein E ε4 prevalence in Alzheimer's disease patients varies across global populations: a systematic literature review and meta-analysis.

abstract：BACKGROUND/AIMS:Dementia cafés are becoming widespread as a new approach to dementia care, but their operational procedures and significance have not been adequately studied. METHODS:On-the-job training (OJT) for professionals planning to operate a dementia café in the future was conducted in a pioneering dementia caf...

journal_title：Dementia and geriatric cognitive disorders

authors： Takechi H,Sugihara Y,Matsumoto H,Yamada H

更新日期：2018-01-01 00:00:00

abstract：UNLABELLED:The concept of the cognitive reserve (CR) hypothesizes that premorbid factors such as education enable compensation for the manifestation of brain pathology. Accordingly, pathology should be more prominent in individuals with higher CR before becoming clinically apparent. Previously, we found that patients s...

journal_title：Dementia and geriatric cognitive disorders

authors： Rolstad S,Nordlund A,Eckerström C,Gustavsson MH,Zetterberg H,Wallin A

更新日期：2009-01-01 00:00:00

abstract：:We evaluated the sensitivity and specificity of our French version of Addenbrooke's cognitive examination (ACE) to detect dementia in our patient population. One hundred and fifty-eight cases were included in the study. In our patient series, the sensitivity for diagnosing dementia with a Mini-Mental State Examination...

journal_title：Dementia and geriatric cognitive disorders

authors： Bier JC,Donckels V,Van Eyll E,Claes T,Slama H,Fery P,Vokaer M

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND/AIMS:Prior studies have shown that patients with dementia are at risk of receiving insufficient treatment for pain after a hip fracture. We therefore hypothesized that elderly hip fracture patients with dementia received less postoperative pain treatment than those without dementia. METHOD:All patients (age...

journal_title：Dementia and geriatric cognitive disorders

authors： Jensen-Dahm C,Palm H,Gasse C,Dahl JB,Waldemar G

更新日期：2016-01-01 00:00:00

abstract：:A substantive overlap between the clinical syndromes of frontal lobe dementia (FLD), frontotemporal dementia (FTD), or primary progressive aphasia (PPA), and corticobasal degeneration syndrome (CBDS) has been demonstrated in a population of 55 patients followed for more than 3 years in a cognitive neurology clinic. Pa...

journal_title：Dementia and geriatric cognitive disorders

authors： Kertesz A,Davidson W,Munoz DG

更新日期：1999-01-01 00:00:00

abstract：:The following areas are discussed in this review: atherogenesis; cerebrovascular factors; hypoperfusion; beta-amyloid production; beta-amyloid fibril formation; beta-sheets; metal cations; reactive oxygen species/free radicals; chronic inflammatory factors; endogenous plasma heparin; lipoprotein lipase; polyamines; pr...

journal_title：Dementia and geriatric cognitive disorders

authors： Engelberg H

更新日期：2004-01-01 00:00:00

abstract：:In spite of the fact that delirium is a common and often severe cognitive disturbance in the elderly, quite few intervention studies are performed. Descriptive studies of variable quality are much more common. For example, in hip fracture patients delirium is a common complication and the cause of nursing problems tha...

journal_title：Dementia and geriatric cognitive disorders

authors： Brännström B

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Given the poorer prognosis of Alzheimer's disease (AD) patients with rapid cognitive decline (RCD), there is a need for a clinical assessment tool to detect these patients. OBJECTIVE:To investigate if there is a Mini Mental State Examination (MMSE) threshold of decline during 6 months of follow-up which pre...

journal_title：Dementia and geriatric cognitive disorders

authors： Soto ME,Andrieu S,Cantet C,Reynish E,Ousset PJ,Arbus C,Gillette-Guyonnet S,Nourhashémi F,Vellas B,REAL.FR group.

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:To study the progression of Alzheimer's disease (AD) at a very early stage and to evaluate clinical markers of presymptomatic AD. SETTING:Longitudinal study at a university hospital. SUBJECTS:A Swedish family harboring a double mutation at codons 670/671 of the APP gene on chromosome 21 was followed longitu...

journal_title：Dementia and geriatric cognitive disorders

authors： Wahlund LO,Basun H,Almkvist O,Julin P,Axelman K,Shigeta M,Jelic V,Nordberg A,Lannfelt L

更新日期：1999-11-01 00:00:00

abstract：AIMS:We aimed to establish the prevalence of depression among recently admitted long-term care patients and to examine associations with diagnostic initiatives and treatment as recorded in patients' medical records. MATERIALS AND METHODS:Eighty-eight long-term care patients were included. Depression was diagnosed acco...

journal_title：Dementia and geriatric cognitive disorders

authors： Iden KR,Engedal K,Hjorleifsson S,Ruths S

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:The diagnosis of delirium is not supported by specific biomarkers. In a previous study, high neopterin levels were found in patients with a postoperative delirium. In the present study, we investigated levels of neopterin, interleukin-6 (IL-6) and insulin-like growth factor-1 (IGF-1) in acutely ill admi...

journal_title：Dementia and geriatric cognitive disorders

authors： Egberts A,Wijnbeld EH,Fekkes D,van der Ploeg MA,Ziere G,Hooijkaas H,van der Cammen TJ,Mattace-Raso FU

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND/AIMS:With an increasing life expectancy, the number of people suffering from dementia globally will rise to about 115.4 million by 2050. It is projected that in the 21st century, the majority of the world's older people will be living in Asia. This paper examines the global issues of family caregiving for ol...

journal_title：Dementia and geriatric cognitive disorders

authors： Chan SW

更新日期：2010-01-01 00:00:00

abstract：:We screened for tau gene mutations among 24 Japanese (6 familial and 18 sporadic cases) and 4 Polish patients with frontotemporal dementia (FTD) using PCR-SSCP analysis followed by DNA sequencing. We identified 2 missense mutations in exon 10: N279K and P301L in 2 Japanese patients with familial FTD. Additionally 3 DN...

journal_title：Dementia and geriatric cognitive disorders

authors： Kowalska A,Asada T,Arima K,Kumakiri C,Kozubski W,Takahashi K,Tabira T

更新日期：2001-11-01 00:00:00

abstract：:The identification of the epsilon4 variant of apolipoprotein E as a genetic risk factor for late-onset Alzheimer's disease (AD) suggests that cholesterol may play a direct role in the pathogenesis of the disease. Recent studies have suggested that the ATP-binding cassette (ABC) protein G5 (ABCG5) may be involved in th...

journal_title：Dementia and geriatric cognitive disorders

authors： Ohkubo T,Shibata N,Ohnuma T,Higashi S,Usui C,Ueki A,Nagao M,Arai H

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Bright light treatment is a therapeutic intervention mainly used to treat sleep and circadian disturbances in Alzheimer's disease (AD) patients. Recently, a handful of studies also focused on the effect on cognition and behavior. Conflicting findings are reported in the literature, and no definite conclusion...

journal_title：Dementia and geriatric cognitive disorders

authors： Mitolo M,Tonon C,La Morgia C,Testa C,Carelli V,Lodi R

更新日期：2018-01-01 00:00:00

abstract：:Heart rate variability is used to assess cardiovascular autonomic function. The cholinesterase inhibitor donepezil potentially affects parasympathetic activity. Twenty participants with Alzheimer's disease or dementia with Lewy bodies were treated with donepezil in a pilot study. Power spectral analysis was used to an...

journal_title：Dementia and geriatric cognitive disorders

authors： McLaren AT,Allen J,Murray A,Ballard CG,Kenny RA

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND/AIM:The prevalence of cognitive symptoms in recently diagnosed Parkinson's disease (PD) patients may be as high as 60%. We report a novel deep brain stimulation (DBS) strategy targeting both motor and cognitive symptoms. METHODS:A PD patient diagnosed with mild cognitive impairment underwent DBS surgery tar...

journal_title：Dementia and geriatric cognitive disorders

authors： Nombela C,Lozano A,Villanueva C,Barcia JA

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND/AIMS:Existing cognitive measures for moderate-to-severe dementia have shown floor effects and an inability to assess the remaining cognitive function, especially for profound dementia. METHODS:We constructed the Cognitive Test for Severe Dementia (CTSD), which consists of 13 items covering 7 cognitive domai...

journal_title：Dementia and geriatric cognitive disorders

authors： Tanaka H,Nagata Y,Uematsu M,Takebayashi T,Hanada K,Inokawa M,Fukuhara K,Ogawa Y,Haga D,Kakegawa Y,Nishikawa T

更新日期：2015-01-01 00:00:00

abstract：:We have previously reported that epidermal growth factor receptor (EGFR) was expressed on vascular endothelial cells from postmortem specimens of demented but not cognitively normal subjects. In the present study, we examined skin biopsies from 35 living patients who were either normal or had a clinical diagnosis of p...

journal_title：Dementia and geriatric cognitive disorders

authors： Styren SD,Styren GC,DeKosky ST

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cognitive impairment (CI) is frequent after stroke, but data from population-based stroke cohorts on the natural course of CI are limited. The purpose of this study was to determine changes in cognitive status over 3 years after stroke. METHODS:Data were collected from the Erlangen Stroke Projec...

journal_title：Dementia and geriatric cognitive disorders

authors： Liman TG,Heuschmann PU,Endres M,Flöel A,Schwab S,Kolominsky-Rabas PL

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The Baylor Profound Mental Status Examination (BPMSE) was modeled to provide a brief patient-derived rating scale for staging and tracking patients with severe stages of Alzheimer's disease (AD). METHODS:The BPMSE was administered to 91 patients with probable AD (Korean version of the MMSE less than 16) acc...

journal_title：Dementia and geriatric cognitive disorders

authors： Na HR,Lee SH,Lee JS,Doody RS,Kim SY

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIMS:Because poor lung function may be a risk factor for cognitive decline, we aimed to test the association of respiratory function with cognitive function and dementia later in life, as well as potential effect modification by APOE epsilon4 carrier status. METHODS:In a prospective population-based cohort ...

journal_title：Dementia and geriatric cognitive disorders

authors： Giltay EJ,Nissinen A,Giampaoli S,Kromhout D

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Several biomarkers have been proposed to discriminate sporadic Creutzfeldt-Jakob disease (sCJD) from other dementias and control cases. However, their clinical accuracy depends on the PRNP codon 129 genotype, leaving it unclear how well established markers behave in untested conditions. METHODS:We analyzed ...

journal_title：Dementia and geriatric cognitive disorders

authors： Llorens F,Karch A,Golanska E,Schmitz M,Lange P,Sikorska B,Liberski PP,Zerr I

更新日期：2017-01-01 00:00:00

abstract：:We tested the interobserver reliability of visual rating of HMPAO-SPECT imaging in 271 outpatients referred to a memory clinic, and followed over 1 year. The clinical diagnoses were Alzheimer's disease (n = 156), frontotemporal dementia (n = 47); vascular dementia (n = 21), senile dementia of Lewy body type (n = 12), ...

journal_title：Dementia and geriatric cognitive disorders

authors： Pasquier F,Lavenu I,Lebert F,Jacob B,Steinling M,Petit H

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:The Clinical Dementia Rating Scale (CDR) is used to rate dementia severity. Its utility in diagnosing mild cognitive impairment (MCI) and its predictive value remain unknown. AIMS:The aim of this study was to examine the association between CDR scores and expert MCI diagnosis, and to determine whether basel...

journal_title：Dementia and geriatric cognitive disorders

authors： Woolf C,Slavin MJ,Draper B,Thomassen F,Kochan NA,Reppermund S,Crawford JD,Trollor JN,Brodaty H,Sachdev PS

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Studies of associations between serum lipids and Alzheimer's disease (AD) or other dementias in the elderly show conflicting results, perhaps due to misclassification of the various dementias. METHODS:For 358 nursing home residents, serum lipids were studied at admission and diagnoses established at autopsy...

journal_title：Dementia and geriatric cognitive disorders

authors： Lesser GT,Haroutunian V,Purohit DP,Schnaider Beeri M,Schmeidler J,Honkanen L,Neufeld R,Libow LS

更新日期：2009-01-01 00:00:00

abstract：:In Switzerland (7 million inhabitants), the organization of health care is in the hand of the cantons and not of the Confederation. The canton of Vaud (600,000 inhabitants), in the south-west part of the country, counts 4 psychiatric sectors, each with a psychogeriatric service. Otherwise the canton has 146 long-stay ...

journal_title：Dementia and geriatric cognitive disorders

authors： Wertheimer J

更新日期：1997-03-01 00:00:00

abstract：:Antioxidants prevent oxidative stress that possibly causes neuronal loss in Alzheimer's disease (AD). We examined whether high plasma levels of the antioxidant vitamins A and E were associated with lower prevalence of AD or cognitive decline (CD). We performed a cross-sectional study within the Rotterdam Study. In an ...

journal_title：Dementia and geriatric cognitive disorders

authors： Engelhart MJ,Ruitenberg A,Meijer J,Kiliaan A,van Swieten JC,Hofman A,Witteman JC,Breteler MM

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND/AIMS:Catechol-O-methyltransferase, encoded by the COMT gene, is one of the enzymes that degrade dopamine. The aim of this study was to investigate whether polymorphisms in the COMT gene were associated with delirium. METHODS:Patients aged 65 years and older, acutely admitted to the medical department or to ...

journal_title：Dementia and geriatric cognitive disorders

authors： van Munster BC,Baas F,Tanck MW,de Rooij SE

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Behavioral variant frontotemporal dementia (bvFTD) patients show prefrontal cortex dysfunction and atrophy. METHODS:We investigated whether executive function in conjunction with prefrontal cortex atrophy discriminates bvFTD and Alzheimer's disease (AD) patients efficiently at presentation. RESULTS:AD and ...

journal_title：Dementia and geriatric cognitive disorders

authors： Hornberger M,Savage S,Hsieh S,Mioshi E,Piguet O,Hodges JR

更新日期：2010-01-01 00:00:00